Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: Hematopoietic Differentiation and Development
7:40 pm - 8:10 pm
"HbF Silencing by BCL11A"
8:10 pm - 8:25 pm
Discussion
8:25 pm - 8:40 pm
"Mechanisms of Hematopoietic Fate Specification in Megakaryocytic Erythroid Progenitors"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 9:00 pm
"Erythroid Specification Mechanisms at the Top of the Hematopoietic Hierarchy"
9:00 pm - 9:05 pm
Discussion
9:05 pm - 9:20 pm
"Regulation of Primitive and Definitive Erythropoiesis"
9:20 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
General Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Cell Intrinsic Factors: Signaling Pathways and Metabolism
9:00 am - 9:15 am
"Regulation of Red Blood Cell Differentiation through Metabolic and Epigenetic Network of S-Adenosylmethionine"
9:15 am - 9:20 am
Discussion
9:20 am - 9:35 am
"Metabolism and Signaling Pathways"
9:35 am - 9:40 am
Discussion
9:40 am - 9:55 am
"Mitochondrial Metabolic Checkpoint, Hematopoietic Stem Cell Aging and Rejuvenation"
9:55 am - 10:00 am
Discussion
10:00 am - 10:15 am
"Lipoprotein Metabolism Mediates Hematopoietic Stem Cell Responses Under Acute Anemic Conditions"
10:15 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:05 am
"Leveraging NMD to Target Gene Expression in Erythropoiesis"
11:05 am - 11:10 am
Discussion
11:10 am - 11:25 am
"Mitochondrial Supersulfides and Erythroid Development"
11:25 am - 11:30 am
Discussion
11:30 am - 11:45 am
"The Inflammatory Cytokine IL17 Tunes and Amplifies the Erythropoietic Response to Erythropoietin In Vivo"
11:45 am - 11:50 am
Discussion
11:50 am - 12:05 pm
Short Talk Selected from Poster Abstracts
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
Short Talk Selected from Poster Abstracts
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address the interests and needs of all scientists and the challenges they face in their careers. Specifically, the program promotes meaningful conversations amongst colleagues of all career stages about barriers to career advancement and strategies to support the professional growth of all members of the community. The GRC Power Hour™ is open to all conference participants.
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Cell Extrinsic Factors: Microenvironment and Iron
7:30 pm - 7:45 pm
"Modulation of Ineffective Erythropoiesis by Monoferric Transferrins"
7:45 pm - 7:50 pm
Discussion
7:50 pm - 8:05 pm
"Erythroblastic Island Macrophages in Normal and Disordered Erythropoiesis"
8:05 pm - 8:10 pm
Discussion
8:10 pm - 8:25 pm
"Spic Is a Unifying Marker for the Heterogeneous Groups of Erythromyeloblastic Island Macrophages that Support Baseline and Stress Erythropoiesis"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:45 pm
"Mechanistic Role of Erythroferrone in the Crosstalk between Erythropoiesis, Iron Metabolism, and Bone Homeostasis"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
"Heme Trafficking at the Birth and Death of Red Cells"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
"Mitochondria-Based Iron Monitoring System and its Role in Erythroid Survival"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Modeling Erythropoiesis and Clinical Translation
9:00 am - 9:15 am
"Luspatercept Modulates Expression Kinetics and Improves Aberrant mRNA Splicing in Sf3b1 -Mutant Erythroid Cells"
9:15 am - 9:20 am
Discussion
9:20 am - 9:35 am
"Erythropoiesis: Clinical Translation"
9:35 am - 9:40 am
Discussion
9:40 am - 9:55 am
"Modeling Erythropoiesis"
9:55 am - 10:00 am
Discussion
10:00 am - 10:15 am
"Congenital Dyserythropoietic Anemia Type II: From Fundamental Biology to Novel Therapeutic Development"
10:15 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:05 am
"An Erythroid-Biased FOShi Hematopoietic Multipotent Progenitor Subpopulation Contributes to Adaptation to Chronic Hypoxia"
11:05 am - 11:10 am
Discussion
11:10 am - 11:25 am
"Hemolysis and the Immunobiology of Sickle Cell Disease"
11:25 am - 11:30 am
Discussion
11:30 am - 11:45 am
"Red Cells from Excessive Erythropoiesis of Chronic Mountain Sickness Patients: Observations and Clinical Perspectives"
11:45 am - 11:50 am
Discussion
11:50 am - 12:05 pm
Short Talk Selected from Poster Abstracts
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
Short Talk Selected from Poster Abstracts
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Inflammation, Infection, and Anemia
7:30 pm - 7:45 pm
"Role of Pro-Inflammatory Signals in Stress Erythropoiesis"
7:45 pm - 7:50 pm
Discussion
7:50 pm - 8:05 pm
"Elucidating Inflammation Mechanisms in Erythropoiesis Through Multiomics"
8:05 pm - 8:10 pm
Discussion
8:10 pm - 8:25 pm
"Mechanisms of Thrombo-Inflammation in Sickle Cell Disease"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:45 pm
"Malaria and Erythropoiesis"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
Short Talk Selected from Poster Abstracts
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:30 pm
General Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Genome Science: Epigenetics and Transcription
9:00 am - 9:15 am
"LDB1 Enhancer Network Modulates Chromatin Structure in Pluripotency and Erythroid Lineage Choice"
9:15 am - 9:20 am
Discussion
9:20 am - 9:35 am
"The Role of “Facilitators” at the Alpha-Globin Cluster and Beyond"
9:35 am - 9:40 am
Discussion
9:40 am - 9:55 am
"LDB1 Establishes Multi-Enhancer Networks to Regulate Erythroid Gene Expression"
9:55 am - 10:00 am
Discussion
10:00 am - 10:15 am
"Reactivation of Developmentally Silenced Globin Genes through Genomic Deletions Reveals that Enhancer Distance Matters"
10:15 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:05 am
"Regulation of Transcription"
11:05 am - 11:10 am
Discussion
11:10 am - 11:25 am
"Aberrant Properties of Anemia-Causing Variants of EKLF/KLF1"
11:25 am - 11:30 am
Discussion
11:30 am - 11:45 am
"Non-Canonical BAF Chromatin Remodeling Complex in Erythropoiesis and Globin Gene Regulation"
11:45 am - 11:50 am
Discussion
11:50 am - 12:05 pm
"Transcription Factor Networks Disproportionately Enrich for Heritability of Blood Cell Phenotypes"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
Short Talk Selected from Poster Abstracts
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
DBA, Ribosomopathies, and Translational Regulation
7:30 pm - 7:45 pm
"A Cas9-Based Human Model System To Understand Hematopoietic Defects in Diamond-Blackfan Anemia"
7:45 pm - 7:50 pm
Discussion
7:50 pm - 8:05 pm
"Harnessing Single-Cell Technologies to Elucidate Disease Mechanisms in Diamond-Blackfan Anemia Syndrome"
8:05 pm - 8:10 pm
Discussion
8:10 pm - 8:25 pm
"Targeting Nemo-like Kinase for Treatment of Diamond Blackfan Anemia"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:45 pm
"Translation and Erythroid Cells"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
"DBA and Ribosomopathies"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
Short Talk Selected from Poster Abstracts
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Cell Biology and Disorders of the Erythrocyte
9:00 am - 9:10 am
"Characterization of the Erythroid Iron Restriction Response"
9:10 am - 9:15 am
Discussion
9:15 am - 9:25 am
"Generation of Definitive Red Cells from Induced Pluripotent Stem Cells"
9:25 am - 9:30 am
Discussion
9:30 am - 9:40 am
"Production of Culture Red Blood Cells"
9:40 am - 9:45 am
Discussion
9:45 am - 10:00 am
"New Insights into Cellular Defects of Erythropoiesis and Hematopoiesis in Sickle Cell Disease"
10:00 am - 10:05 am
Discussion
10:05 am - 10:35 am
Coffee Break
10:35 am - 10:50 am
"Erythroid Islands in Mice and Humans and How They are Dysregulated in Red-Cell Diseases"
10:50 am - 10:55 am
Discussion
10:55 am - 11:05 am
"How Do Erythroblasts Enucleate?"
11:05 am - 11:10 am
Discussion
11:10 am - 11:25 am
"Regulation of Terminal Erythropoiesis"
11:25 am - 11:30 am
Discussion
11:30 am - 11:45 am
"Understanding the Vulnerability of Erythropoiesis during PARP Inhibitor Therapy"
11:45 am - 11:50 am
Discussion
11:50 am - 12:05 pm
"Gene Therapy and DNA Damage"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
Short Talk Selected from Poster Abstracts
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Genome, Proteome, and Multiome Technologies
7:30 pm - 7:45 pm
"Mass Spectrometry Based Approaches for the Study of Transcriptional Regulation During Erythropoiesis"
7:45 pm - 7:50 pm
Discussion
7:50 pm - 8:05 pm
"A Novel Genome-Scale CRISPR-Cas12a Screen Identifies PTPA as a Fetal Hemoglobin Regulator via BCL11A"
8:05 pm - 8:10 pm
Discussion
8:10 pm - 8:25 pm
"Insights from Proteome Technologies"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:45 pm
"Insights into Erythroid Biology"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
"Understanding and Targeting Dysfunctional Metabolism in Erythropoiesis"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
"Insights into Erythroid Biology"
9:25 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure