Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: Physiological Functions of Editing and Modifications
7:40 pm - 8:10 pm
"Canonical and Non-Canonical Functions of Uridine Modifying Enzymes in Health and Disease"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:40 pm
"Substrates for APOBEC Mutagenesis in Cancer"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 9:05 pm
"Identification of ADAR1 Inhibitors: Promising Cancer Therapeutics & Immunotherapy Synergyzers"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:20 pm
"Identification of Novel Regulators of the Immunogenicity of Unedited Cellular dsRNA"
9:20 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
General Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Dynamics and Mechanism of Editing and Modification Reactions
9:00 am - 9:20 am
"Investigating Tissue-Specific Regulation of ADARs Uncovers New Biological Functions"
9:20 am - 9:25 am
Discussion
9:25 am - 9:45 am
"Insights from the Biology of Modifications in Evolutionarily Distant Yeast Species"
9:45 am - 9:50 am
Discussion
9:50 am - 10:10 am
"How tRNA Modifications Affect mRNA and Protein Dynamics."
10:10 am - 10:15 am
Discussion
10:15 am - 10:50 am
Coffee Break
10:50 am - 11:10 am
"tRNA Processing and m1 A Modification in Mitochondria"
11:10 am - 11:15 am
Discussion
11:15 am - 11:35 am
"Alternative Mechanisms of Substrate Recognition by Atypical tRNA Modification Enzymes"
11:35 am - 11:40 am
Discussion
11:40 am - 12:00 pm
"Dynamic Interplay Between tRNA Processing, Transport and Modification in T. brucei "
12:00 pm - 12:05 pm
Discussion
12:05 pm - 12:25 pm
"Molecular Level Consequence of RNA Modifications on Translation"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Evolution of Editing and Modification Systems
7:30 pm - 7:50 pm
"Landscape of C-to-U RNA Editing Across Human Tissues"
7:50 pm - 7:55 pm
Discussion
7:55 pm - 8:15 pm
"Synthesis and Salvage of Queuosine in Bacterial Pathogens"
8:15 pm - 8:20 pm
Discussion
8:20 pm - 8:40 pm
"Insights into Cytidine Deaminase Evolution"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 9:05 pm
"A-to-I RNA Editing Alterations in Autoimmune Diseases"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:20 pm
"Regulation of the Metastatic Proteome Through tRNA Modification"
9:20 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
General Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
New Tools for the Study and Detection of Nucleic Acid Modifications
9:00 am - 9:20 am
"Dynamic RNA Acetylation Revealed by Quantitative Cross-Evolutionary Mapping"
9:20 am - 9:25 am
Discussion
9:25 am - 9:45 am
"New Sequencing & Mass Spectrometry Tools for Quantitative Analysis of the Epitranscriptome"
9:45 am - 9:50 am
Discussion
9:50 am - 10:10 am
"Antibody-Free Methylation Mapping in mRNA by Metabolic Propargyl Labeling and Sequencing"
10:10 am - 10:15 am
Discussion
10:15 am - 10:50 am
Coffee Break
10:50 am - 11:10 am
"Decoding the Epigenome with DNA Modifying Enzymes"
11:10 am - 11:15 am
Discussion
11:15 am - 11:35 am
"How to Engineer Riboswitches into Ribozymes by Rational Design"
11:35 am - 11:40 am
Discussion
11:40 am - 12:00 pm
"RNA Binding Protein Networks by STAMP"
12:00 pm - 12:05 pm
Discussion
12:05 pm - 12:25 pm
"Connecting RNA Modification and RNA Damage"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Structures of Editing and Modification Enzymes
7:30 pm - 7:50 pm
"Seeing “A” to “I”: Structural Basis for RNA Selectivity and Editing by ADARs"
7:50 pm - 7:55 pm
Discussion
7:55 pm - 8:15 pm
"The Arms Race Between Host Antiviral Factor APOBEC3G and HIV-1 Vif Hinges on a Shared RNA Recognition Mechanism"
8:15 pm - 8:20 pm
Discussion
8:20 pm - 8:40 pm
"tRNA Splicing: The Gift that Keeps on Giving"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 9:05 pm
"The ABC of Mitochondrial RNA Editing in Trypanosomes"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:20 pm
"Structural and Functional Characterization of the Fully Assembled Elongator Complex"
9:20 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
General Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Engineering Novel Base Editors and Modification Systems
9:00 am - 9:20 am
"Base Editors: Development and Application"
9:20 am - 9:25 am
Discussion
9:25 am - 9:45 am
"Development and Characterization of Multiplexed Orthogonal Base Editing Systems"
9:45 am - 9:50 am
Discussion
9:50 am - 10:00 am
"An RNA Microcode for Bootstrapping Embryonic Development"
10:00 am - 10:05 am
Discussion
10:05 am - 10:15 am
"RNA Helicase Controls Novel Regulatory gRNAs and Repressive RNA Structure in Trypanosome Editing During Development"
10:15 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:10 am
"Programmable Modulation of RNA Editing: New Approaches, New Challenges"
11:10 am - 11:15 am
Discussion
11:15 am - 11:35 am
"Gene Expression Modulation by RNA-Guided Pseudouridylation"
11:35 am - 11:40 am
Discussion
11:40 am - 12:00 pm
"RNA as a Regulator of DNA Editing Levels in Antibody Diversification"
12:00 pm - 12:05 pm
Discussion
12:05 pm - 12:25 pm
"Understanding the Molecular Mechanism of Current Precision Genome Editing Tools: How Adenine Base Editors Modify DNA"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Modification and Editing in Immunity
7:30 pm - 7:50 pm
"Targeted RNA Editing for the Generation of Neoepitopes"
7:50 pm - 7:55 pm
Discussion
7:55 pm - 8:15 pm
"Double-Stranded RNA Editing and Sensing in Health and Disease"
8:15 pm - 8:20 pm
Discussion
8:20 pm - 8:40 pm
"The Nuclear m6A-Machinery Modifies a Viral RNA in the Cytoplasm"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
"Activity-Based Profiling of RNA Modifying Enzymes"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
"A Molecular and Computational Toolbox to Enable Therapeutic A-to-I RNA Editing ?"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"tRNA Methylation Resolves Codon Usage Bias at the Limit of Cell Viability"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Defects in Editing and Modification in Disease
9:00 am - 9:20 am
"Interfering with Innate Immune Signaling Through Editing Patterns"
9:20 am - 9:25 am
Discussion
9:25 am - 9:45 am
"A-to-I RNA Edits in Cancer: Are They Silent?"
9:45 am - 9:50 am
Discussion
9:50 am - 10:10 am
"Structural Recognition of Methylation Targets for RNA Modification Enzymes"
10:10 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 11:05 am
"A-to-I RNA Editing in Human T-Lymphoid Progenitor Development and Acute T-Cell Lymphoblastic Leukemia Initiating Cell"
11:05 am - 11:10 am
Discussion
11:10 am - 11:30 am
"Deciphering the Role of APOBEC3 and ADAR1 Deaminase Deregulation in Accelerated and Malignant Stem Cell Aging"
11:30 am - 11:35 am
Discussion
11:35 am - 11:55 am
"Biological Functions of tRNA Modifications and Human Diseases"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Unlocking the Potential of Innovative Editing Oligonucleotides (EONs) to Address Liver Originated Disorders"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"DHX9 and ADAR1 Redundantly Suppress Activation of dsRNA Sensors in Breast Cancer"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Keynote Session: Editing and Modification Pathways as Therapeutic Modality or Target
7:30 pm - 7:40 pm
"Programmable RNA Editing in Parkinson’s Disease"
7:40 pm - 7:45 pm
Discussion
7:55 pm - 8:05 pm
"Uncovering Substrate Recognition by A-To-I RNA Editing Enzymes In Vivo"
8:05 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
"RNA Demethylation in Chromatin Regulation"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:10 pm
"A Chemical Biology Toolbox for Probing A-to-I RNA Editing"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:35 pm
"Building a Therapeutic RNA Base Editing Platform"
9:35 pm - 9:40 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure