Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: RNA Editing and Modifications in Cancer
7:40 pm - 8:10 pm
"Targeting RNA Modifications in Cancer"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:40 pm
"Advances in Understanding the Molecular Mechanism of APOBEC Mutagenesis in Cancer"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 9:05 pm
"Co-Opting RNA Editing for Cancer Immunotherapy"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:20 pm
"Tumor Warm-Up: Leveraging ADAR-Mediated Targeted RNA Editing to Induce Cancer Immunogenic "'Editopes'"
9:20 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
General Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
RNA Editing and Modification in Development and Disease
9:00 am - 9:20 am
"Decoding Mechanism Mediated by tRNA Modifications"
9:20 am - 9:25 am
Discussion
9:25 am - 9:45 am
"Advances in Functional Understanding of Queuosine-tRNA Modification"
9:45 am - 9:50 am
Discussion
9:50 am - 10:00 am
"Edited Filamin A in Myeloid Cells Protects From Colitis"
10:00 am - 10:05 am
Discussion
10:05 am - 10:15 am
"The RNA Methyl-Transferase FTSJ1: Conserved Role in Neuron Morphology, Learning Performance and Translational Control"
10:15 am - 10:20 am
Discussion
10:20 am - 10:45 am
Coffee Break
10:45 am - 11:05 am
"RNA Editing and Immune Evasion: Insights into ADAR1’s Role in Cancer"
11:05 am - 11:10 am
Discussion
11:10 am - 11:30 am
"Exploring Editing Independent Functions of ADAR1"
11:30 am - 11:35 am
Discussion
11:35 am - 11:55 am
"Harnessing Epitranscriptomic Pathways for Anticancer Therapy via Functionalized Extracellular Vesicles"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Extrachromosomal DNA Formation Through APOBEC Deamination"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"An RNA Editing Approach for Treatment of Rett Syndrome"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hourâ„¢
The GRC Power Hourâ„¢ is designed to address the interests and needs of all scientists and the challenges they face in their careers. Specifically, the program promotes meaningful conversations amongst colleagues of all career stages about barriers to career advancement and strategies to support the professional growth of all members of the community. The GRC Power Hourâ„¢ is open to all conference participants.
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
RNA Editing and Modifications Across Life
6:00 pm - 6:20 pm
"RNA Recoding of Microtubule-Based Motor Proteins"
6:20 pm - 6:25 pm
Discussion
6:25 pm - 6:45 pm
"Synthesis and Function of Wobble Base Modifications in tRNA"
6:45 pm - 6:50 pm
Discussion
6:50 pm - 7:10 pm
"The Best of Two Worlds: RNAylation Covalently Links RNA to Proteins"
7:10 pm - 7:15 pm
Discussion
7:15 pm - 7:35 pm
"A-to-I RNA Editing in Bacteria: Occurrence, Regulation, and Function"
7:35 pm - 7:40 pm
Discussion
7:40 pm - 7:50 pm
"Deciphering High-Level A-to-I RNA Recoding in Cephalopods"
7:50 pm - 7:55 pm
Discussion
7:55 pm - 8:00 pm
General Discussion
8:00 pm - 9:00 pm
Dinner
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Biological Functions of RNA Editing and RNA Modification
9:00 am - 9:20 am
"How do ADAR1 Mutations Cause Immunopathology"
9:20 am - 9:25 am
Discussion
9:25 am - 9:45 am
"m6 Am Sequesters its Reader to Suppress Premature Termination and Drive Neuroblastoma Differentiation"
9:45 am - 9:50 am
Discussion
9:50 am - 10:00 am
"MDA5-Associated Endogenous dsRNA Targets in hnRNPM-Deficient Cells and Immune Activation"
10:00 am - 10:05 am
Discussion
10:05 am - 10:15 am
"Unraveling the Interplay Between tRNA Epitranscriptome and Codon Bias in Development and Stress Responses"
10:15 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:10 am
"An Unexpected Role for the ADAR p150 and p110 Zβ Domain in Nonsynonymous Editing, and Alternative Splicing"
11:10 am - 11:15 am
Discussion
11:15 am - 11:35 am
"mRNAs Function as m5C Sponges to Reduce Cellular SAM Level in Response to Glucose Starvation"
11:35 am - 11:40 am
Discussion
11:40 am - 12:00 pm
"Decoding the Epitranscriptome at Single Molecule Resolution: Towards Clinical Applications"
12:00 pm - 12:05 pm
Discussion
12:05 pm - 12:25 pm
"Controlling Vascularlzation and Bone Stiffness via RNA Editing"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Function and Applications of Epitranscriptomics
6:00 pm - 6:20 pm
"Charting the Dynamic rRNA Epitranscriptome"
6:20 pm - 6:25 pm
Discussion
6:25 pm - 6:45 pm
"tRNA Modifications and Translation Quality Control"
6:45 pm - 6:50 pm
Discussion
6:50 pm - 7:10 pm
"Charting tRNA Modifications Across All Domains of Life: The Power of Combined OTTR-Seq and Nanopore Approaches"
7:10 pm - 7:15 pm
Discussion
7:15 pm - 7:35 pm
"Engineering Covalent Small Molecule–RNA Complexes in Living Cells"
7:35 pm - 7:40 pm
Discussion
7:40 pm - 7:50 pm
"Coordinated Changes of tRNA Modifications for Protein Homeostasis"
7:50 pm - 7:55 pm
Discussion
7:55 pm - 8:00 pm
General Discussion
8:00 pm - 9:00 pm
Dinner
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
RNA Modification and Deamination Mechanisms
9:00 am - 9:20 am
"Nucleotide Deamination by the RADAR Supramolecular Anti-Phage Defense Complex"
9:20 am - 9:25 am
Discussion
9:25 am - 9:45 am
"tRNAslational Control of Eukaryotic Gene Expression"
9:45 am - 9:50 am
Discussion
9:50 am - 10:00 am
"Comprehensive Prediction of dsRNA Formation and Distribution in the Human Genome"
10:00 am - 10:05 am
Discussion
10:05 am - 10:35 am
Coffee Break
10:35 am - 10:55 am
"Dual C-to-U and U-to-C Base Editing Mechanisms By DYW Enzymes"
10:55 am - 11:00 am
Discussion
11:00 am - 11:20 am
"rRNA 2'-O-Methylation Modulates Ribosome Structure and Biogenesis Assembly"
11:20 am - 11:25 am
Discussion
11:25 am - 11:45 am
"Monitoring tRNA Splicing and Nucleotide Chemical Modification by Nuclear Magnetic Resonance"
11:45 am - 11:50 am
Discussion
11:50 am - 12:10 pm
"Structural Insights into Substrate Binding and Editing Specificity by ADAR2"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
RNA Editing and Modifications in Infectious Organisms and Their Hosts
6:00 pm - 6:20 pm
"The magic of ADAR proteins"
6:20 pm - 6:25 pm
Discussion
6:25 pm - 6:45 pm
"RNA Modifications at the Virus-Host Interface"
6:45 pm - 6:50 pm
Discussion
6:50 pm - 7:10 pm
"Epitranscriptomics and Beyond: The Importance of Modification Enzymes in Response to Stress in Vibrio cholerae "
7:10 pm - 7:15 pm
Discussion
7:15 pm - 7:35 pm
"tRNA Hypomodification Facilitates Antifungal Drug Resistance in Aspergillus fumigatus "
7:35 pm - 7:40 pm
Discussion
7:40 pm - 7:50 pm
"Decoding the tRNA Epitranscriptome and Its Role in Pseudomonas aeruginosa Pathogenicity"
7:50 pm - 7:55 pm
Discussion
7:55 pm - 8:00 pm
General Discussion
8:00 pm - 9:00 pm
Dinner
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Therapeutic Applications Using RNA Editing and Modifications
9:00 am - 9:20 am
"Functional Mapping and Modulation of ADAR Activity for Cellular Engineering"
9:20 am - 9:25 am
Discussion
9:25 am - 9:45 am
"Optimizing LEAPER for Enhanced Versatility and Precision in RNA Editing"
9:45 am - 9:50 am
Discussion
9:50 am - 10:00 am
"A Versatile High-Throughput Platform for Epitranscriptomic Drug Discovery"
10:00 am - 10:05 am
Discussion
10:05 am - 10:15 am
"Employment of nanoVAST-gRNA for Efficient Intracellular Delivery of Therapeutic cargos"
10:15 am - 10:20 am
Discussion
10:20 am - 10:45 am
Coffee Break
10:45 am - 11:05 am
"Programmable Pseudouridylation to Suppress Nonsense Mutations"
11:05 am - 11:10 am
Discussion
11:10 am - 11:30 am
"Developing Axiomerâ„¢ RNA Editing Technology Towards Application in Liver and CNS Disease"
11:30 am - 11:35 am
Discussion
11:35 am - 11:45 am
"Leveraging Purified Human ADARs to Elucidate Oligonucleotide-Directed RNA Editing Kinetics and Predict In Vivo Outcomes"
11:45 am - 11:50 am
Discussion
11:50 am - 12:00 pm
"Key Factors for Precise and Efficient RNA Base Editing in the CNS"
12:00 pm - 12:05 pm
Discussion
12:05 pm - 12:25 pm
"Large Language Models for RNA Editing Prediction"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Keynote Session: New Tools Using RNA Editing and Modifications
6:00 pm - 6:30 pm
"Structure-Activity Relationships in ADAR Reactions"
6:30 pm - 6:40 pm
Discussion
6:40 pm - 7:00 pm
"Molecular Architectures of RNA-Modifying Ribozymes"
7:00 pm - 7:05 pm
Discussion
7:05 pm - 7:25 pm
"Targeted RNA Base Editing with Endogenous ADAR"
7:25 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
"RNA Programmable Cell Editing"
7:50 pm - 7:55 pm
Discussion
7:55 pm - 8:00 pm
General Discussion
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure