Sunday
4:00 pm - 8:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
RNA Folding and Structure
7:40 pm - 7:50 pm
Introduction by Discussion Leader
7:50 pm - 8:10 pm
"Learning and Applying the Language of RNA Tertiary Interactions: Lessons from High Resolution RNA Structures"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:35 pm
"From Descriptive to Predictive Understanding: The RNA Reconstitution Model"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 9:00 pm
"The Multiple Flavors of GoU Pairs"
9:00 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
"RNA Self-Assembly from 5' to 3"
9:25 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
"The Ribosome: The Cornerstone for Creating Novel RNA Nanostructures"
9:30 am - 9:40 am
Discussion
9:40 am - 10:00 am
"Construction of 3D and 4D RNA Nanostructures for Applications in Medical and Material Science"
10:00 am - 10:10 am
Discussion
10:10 am - 10:30 am
"Structures, Dynamics and Metal Ion Binding in Prohead RNA"
10:30 am - 10:40 am
Discussion
10:40 am - 11:10 am
Coffee Break
11:10 am - 11:20 am
"Understanding Immunogenic Properties of Nucleic Acid Nanoparticles"
11:20 am - 11:25 am
Discussion
11:25 am - 11:35 am
"Versatile Kit of Robust Nanoshapes from RNA and DNA Modules"
11:35 am - 11:40 am
Discussion
11:40 am - 11:55 am
"Nucleic Acid Nano-Scaffolds Designed from Flexible Tetra-U/T Helix Linking Module"
11:55 am - 12:05 pm
Discussion
12:05 pm - 12:20 pm
"Homooligomeric Self-Assembly Structures Based on a Single RNA Tile"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hourâ„¢
The GRC Power Hourâ„¢ is designed to address challenges women face in science and issues of diversity and inclusion. The program supports the professional growth of all members of our communities by providing an open forum for discussion and mentoring.
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Nucleic Acid Modeling and Computation
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:00 pm
"A Model for DNA Structure Kinetics Prediction with Arrhenius Rates"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:25 pm
"RNA Nanostructures: Integrating Computation with Experiments"
8:25 pm - 8:35 pm
Discussion
8:35 pm - 8:45 pm
"Computer-Aided Design of Cotranscriptionally-Folding RNA Origami"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:00 pm
"Computational Protocol for Ligand Docking to RNA Can Aid in the Design of Ligand-Dependent Nanostructures"
9:00 pm - 9:05 pm
Discussion
9:05 pm - 9:20 pm
"RNA-Cleaving DNA Machines and Logic Gates for Gene Therapy"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Biological RNA Nanoparticles
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
"Biological Functions and Methods of Detection of Large Oncosomes in Cancer"
9:30 am - 9:40 am
Discussion
9:40 am - 10:00 am
"Deconvolution Analysis of Small RNAseq Data from exRNAs Reveals Multiple Carrier Subclasses"
10:00 am - 10:10 am
Discussion
10:10 am - 10:25 am
"Functional Role of Exosomal DNA and RNA in Cancer"
10:25 am - 10:35 am
Discussion
10:35 am - 11:05 am
Coffee Break
11:05 am - 11:15 am
"Molecular Crowding Regulates RNA Phase Separations in Repeat Expansion Disorders"
11:15 am - 11:20 am
Discussion
11:20 am - 11:30 am
"Self-Assembled Nucleic Acid-Protein-Lipid Devices for Bioimaging and Drug Delivery"
11:30 am - 11:35 am
Discussion
11:35 am - 11:50 am
"Human RNA Analysis Using a New Reference Transcriptome and Computational Framework"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
"Exosome Biogenesis at Plasma and Endosome Membranes"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Nucleic Acid Based Sensors and Devices
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:00 pm
"Liquid Biopsy on a Chip: Circulating Tumor Exosomes' Lineage Tracing Using NanoDLD Chip Technology"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:25 pm
"Miniaturized Devices for Nucleic Acid Detection: Robust Sensors for Point-of-Care Applications"
8:25 pm - 8:35 pm
Discussion
8:35 pm - 8:50 pm
"Modular Cell-Internalizing Aptamer Nanostructures for Targeted Delivery of Large Functional RNAs"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
"Design and Calibration of a Nanoscale Instrument for Dynamic Measurements of Nucleic Acid Bending"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Movers and Shakers: How to Accelerate Nucleic Acid Based Devices"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Synthetic and Biological Nucleic Acid Based Nanotherapeutics
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
"Challenges and Opportunities for Engineering Extracellular Vesicles as Therapeutic Delivery Vehicles"
9:30 am - 9:40 am
Discussion
9:40 am - 10:00 am
"Extracellular Vesicles as Senotherapeutics for Extending Healthspan"
10:00 am - 10:10 am
Discussion
10:10 am - 10:20 am
"Universal Synthetic Technique for Nucleic Acid-Based Nanodetectors and Carrier-Free siRNA Delivery Systems"
10:20 am - 10:25 am
Discussion
10:25 am - 11:00 am
Coffee Break
11:00 am - 11:10 am
"Genetically Encoding Functional RNA Origami: Anti-Coagulants"
11:10 am - 11:15 am
Discussion
11:15 am - 11:25 am
"Heterochiral DNA Circuitry: Interfacing Mirror-Image DNA with Endogenous Nucleic Acids in Living Cells"
11:25 am - 11:30 am
Discussion
11:30 am - 11:50 am
"Towards Biomarkers for CNS Injuries and Neurodegenerative Diseases"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
"The Developmental Path of MSC-EV Therapeutics from Preclinical to Clinical Studies"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Extracellular RNA Based Diagnostics
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:00 pm
"Extracellular Vesicle-Associated Biomarker Discovery in Liquid Biopsies"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:25 pm
"Salivaomics, ExRNA and Liquid Biopsy"
8:25 pm - 8:35 pm
Discussion
8:35 pm - 8:45 pm
"De Novo -Designed Ultra-Specific Riboregulators for Gene Regulation and Low Cost Paper-Based Diagnostics"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:00 pm
"Ligand-Guided Selection (LIGS): A SELEX Variant to Develop Nucleic Acid Aptamers Against Cell-Surface Markers"
9:00 pm - 9:05 pm
Discussion
9:05 pm - 9:20 pm
"Current State of Clinical Exosome Based Biomarkers"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
"Molecular Systems Engineering with DNA"
9:30 am - 9:40 am
Discussion
9:40 am - 10:00 am
"Amphiphilic DNA Nanostructures: Self-Assembly and Biological Properties"
10:00 am - 10:10 am
Discussion
10:10 am - 10:30 am
"Polymers and Proteins in DNA Nanostructures"
10:30 am - 10:40 am
Discussion
10:40 am - 11:10 am
Coffee Break
11:10 am - 11:30 am
"Recreating Complex Biochemical Mechanisms Using DNA: From Fundamentals to Applications"
11:30 am - 11:40 am
Discussion
11:40 am - 11:55 am
"Using DNA Origami to Reveal Spatial Effects in Biology"
11:55 am - 12:05 pm
Discussion
12:05 pm - 12:20 pm
"Programming 3D Nanoscale Architectures"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:00 pm
"RNA Aptamers as Genetic Control Devices: The Potential of Riboswitches as Synthetic Elements for Regulating Gene Expression"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:25 pm
"Using RNA to Fuel Dynamic Self-Assembly"
8:25 pm - 8:35 pm
Discussion
8:35 pm - 8:50 pm
"RNA Origami-Based Sensors and Devices In Vivo "
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
"sxRNA: Controlling the Expression of a Therapeutic mRNA Based on the Unique microRNA Profile of a Cell"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Small Molecule Activated gRNAs Enable High-Throughput and Multiplex Genome Editing in E. coli by Cas9"
9:25 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure