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RNA Nanotechnology

Gordon Research Conference

RNA Self-Assembly, Packaging, Imaging and Therapeutics

January 8 - 13, 2023

Chairs

and

Vice Chairs

and

Four Points Sheraton / Holiday Inn Express

1050 Schooner Drive

Ventura, California, United States

Venue and Travel Information

Conference Description

The RNA Nanotechnology GRC is a premier, international scientific conference focused on advancing the frontiers of science through the presentation of cutting-edge and unpublished research, prioritizing time for discussion after each talk and fostering informal interactions among scientists of all career stages. The conference program includes a diverse range of speakers and discussion leaders from institutions and organizations worldwide, concentrating on the latest developments in the field. The conference is five days long and held in a remote location to increase the sense of camaraderie and create scientific communities, with lasting collaborations and friendships. In addition to premier talks, the conference has designated time for poster sessions from individuals of all career stages, and afternoon free time and communal meals allow for informal networking opportunities with leaders in the field.

The 2023 GRC on RNA Nanotechnology will promote scientific exchange and cross-disciplinary collaborations among scientists working in RNA chemistry, biology, biophysics, medicine, engineering and biotechnology. The nine sessions will feature presentations on nucleic acid structure and assembly, RNA modification, synthetic biology, nanostructures, biomaterials, extracellular vesicles, therapeutics, diagnostics, and imaging. Each session will also include short talks selected from abstracts submitted by poster presenters. Ample opportunities for extended discussions will be provided after each presentation and during breaks.

This conference aims to expand participation in the young and dynamic field of RNA Nanotechnology. A Power Hour will offer all attendees an opportunity to discuss topics and challenges of diversity and inclusion in the sciences. The 2023 GRC will be preceded by a Gordon Research Seminar (GRS) organized by young researchers, who are strongly encouraged to also participate in the main conference.

We hope you join the conversation at the leading edge of RNA science and technology!

Related Meeting

This GRC will be held in conjunction with the "RNA Nanotechnology" Gordon Research Seminar (GRS). Those interested in attending both meetings must submit an application for the GRS in addition to an application for the GRC. Refer to the associated GRS program page for more information.

Conference Program

Sunday
2:00 pm - 9:00 pm	Arrival and Check-in
6:00 pm - 7:00 pm	Dinner
7:30 pm - 7:40 pm	Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm	RNA Structure and Assembly Discussion Leader:
7:40 pm - 7:50 pm	Introduction by Discussion Leader
7:50 pm - 8:10 pm	"Modeling and Design of RNA-only Structures"
8:10 pm - 8:20 pm	Discussion
8:20 pm - 8:40 pm	"RNA Kinks, Knots, and Switches Controlling Gene Expression"
8:40 pm - 8:50 pm	Discussion
8:50 pm - 9:00 pm	"Structural Basis for RNA-Based Strategy of Enteroviral Genome Replication"
9:00 pm - 9:05 pm	Discussion
9:05 pm - 9:25 pm	"Dynamic Intracellular Condensation of RNA:Protein Complexes"
9:25 pm - 9:30 pm	Discussion
Monday
7:30 am - 8:30 am	Breakfast
8:30 am - 9:00 am	Group Photo
9:00 am - 12:30 pm	RNA Therapeutics Discussion Leader:
9:00 am - 9:15 am	Introduction by Discussion Leader
9:15 am - 9:35 am	"Extracellular Vesicles as an RNA Delivery Platform"
9:35 am - 9:45 am	Discussion
9:45 am - 10:05 am	"Aptamer-Targeted Gene Knockdown for Cancer Immune Therapy"
10:05 am - 10:15 am	Discussion
10:15 am - 10:25 am	"SNPD-siRNA: A New Technology of RNA Interference That Can Knockdown the Gene with Single Nucleotide Mutation Without Suppressing The Wild-type Gene"
10:25 am - 10:30 am	Discussion
10:30 am - 11:00 am	Coffee Break
11:00 am - 11:20 am	"Expanding the Chemical Diversity of Therapeutic Oligonucleotides"
11:20 am - 11:30 am	Discussion
11:30 am - 11:50 am	"Living in the World of RNA Therapeutics Utilizing Chemistry"
11:50 am - 12:00 pm	Discussion
12:00 pm - 12:10 pm	"Role of the Type 1 Interferon Response in Humoral Immunity Elicited by Self-Replicating RNA Vaccines"
12:10 pm - 12:15 pm	Discussion
12:15 pm - 12:30 pm	Poster Previews
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
3:00 pm - 4:00 pm	The GRC Power Hour™ The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring. Organizer:
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	RNA Aptamers and Riboswitches Discussion Leader:
7:30 pm - 7:45 pm	Introduction by Discussion Leader
7:45 pm - 8:10 pm	"How Do RNAs Fold Dynamically?"
8:10 pm - 8:20 pm	Discussion
8:20 pm - 8:45 pm	"Natural Riboswitches Selective for Lithium and Sodium"
8:45 pm - 8:55 pm	Discussion
8:55 pm - 9:20 pm	"RNA-Based Fluorescent Biosensors"
9:20 pm - 9:30 pm	Discussion
Tuesday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	RNA Encapsulation and Delivery Discussion Leader:
9:00 am - 9:15 am	Introduction by Discussion Leader
9:15 am - 9:35 am	"Opportunities Across Kingdoms for RNAi Delivery"
9:35 am - 9:45 am	Discussion
9:45 am - 10:05 am	"RNA-Launched and RNA-Packaging Self-Assembling Protein Nanomaterials"
10:05 am - 10:15 am	Discussion
10:15 am - 10:25 am	"PAMAM Dendrimers as A Carrier for Nucleic Acid Nanoparticles"
10:25 am - 10:30 am	Discussion
10:30 am - 11:00 am	Coffee Break
11:00 am - 11:20 am	"Nucleoside-Modified mRNA-LNP Therapeutics"
11:20 am - 11:30 am	Discussion
11:30 am - 11:50 am	"Tissue Specific RNA Profiling from Plasma Extracellular Vesicles"
11:50 am - 12:00 pm	Discussion
12:00 pm - 12:10 pm	"Surface-Functionalized Polymeric siRNA Nanoparticles for Tunable Targeting and Intracellular Delivery to Hematologic Cancer Cells"
12:10 pm - 12:15 pm	Discussion
12:15 pm - 12:30 pm	Poster Previews
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	RNA Modifications and Biotypes Discussion Leader:
7:30 pm - 7:45 pm	Introduction by Discussion Leader
7:45 pm - 8:05 pm	"Canonical and Non-Canonical Functions of Uridine Modifying Enzymes in Health and Disease"
8:05 pm - 8:10 pm	Discussion
8:10 pm - 8:30 pm	"The Leap in tRNA Molecule Evolution in Vertebrates"
8:30 pm - 8:35 pm	Discussion
8:35 pm - 8:55 pm	"GlycoRNAs: Bridging the Gap Between Glycobiology and RNA biology"
8:55 pm - 9:00 pm	Discussion
9:00 pm - 9:10 pm	"Modular RNA Motifs for Phase Separation and Molecular Organization"
9:10 pm - 9:15 pm	Discussion
9:15 pm - 9:25 pm	"Circulating Extracellular Vesicle RNA of Glioma Patients"
9:25 pm - 9:30 pm	Discussion
Wednesday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	RNA Imaging Discussion Leader:
9:00 am - 9:05 am	Introduction by Discussion Leader
9:05 am - 9:25 am	"Riboswitch-Based Tools for RNA Imaging"
9:25 am - 9:35 am	Discussion
9:35 am - 9:55 am	"Aptamers for Super-Resolution RNA Imaging and Single-Molecule Tracking"
9:55 am - 10:05 am	Discussion
10:05 am - 10:15 am	"Imaging the Spatial Coordination of Cytosolic and Mitochondrial Translation"
10:15 am - 10:20 am	Discussion
10:20 am - 10:50 am	Coffee Break
10:50 am - 11:10 am	"Molecular Imaging of Extracellular Vesicles to Define Their Size and Content"
11:10 am - 11:20 am	Discussion
11:20 am - 11:40 am	"Meet the Neighbors: A Universal Technology for Probing RNA-Interactions and RNA-Scaffolded Subcellular Compartments In Situ."
11:40 am - 11:50 am	Discussion
11:50 am - 12:10 pm	"Massively-parallel, Quantitative Assays for Linking RNA Sequence, Structure, and Function"
12:10 pm - 12:15 pm	Discussion
12:15 pm - 12:25 pm	"Determining RNA motifs' 3D Structure and Dynamics Using RNA Nanostructures"
12:25 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	RNA Cargo Selection in EVs Discussion Leader:
7:30 pm - 7:45 pm	Introduction by Discussion Leader
7:45 pm - 8:05 pm	"Engineering Extracellular Vesicles for Targeted Delivery of RNA and Protein Therapeutics"
8:05 pm - 8:15 pm	Discussion
8:15 pm - 8:35 pm	"Biogenesis of RNA-Containing Extracellular Vesicles"
8:35 pm - 8:45 pm	Discussion
8:45 pm - 9:05 pm	"Secretory Autophagy and Cargo Specification in EVPs"
9:05 pm - 9:15 pm	Discussion
9:15 pm - 9:25 pm	"Extracellular Vesicle Cargo Transcriptome Reveals Cellular Origin and Pathways Specific to Heart Failure Subtype"
9:25 pm - 9:30 pm	Discussion
Thursday
7:30 am - 8:30 am	Breakfast
8:30 am - 9:00 am	Business Meeting Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm	RNA-Based Biomarkers and Diagnostics Discussion Leader:
9:00 am - 9:15 am	Introduction by Discussion Leader
9:15 am - 9:35 am	"Aptamers at Work – Effective Neutralization of SARS-CoV-2 and Identifying Protein Biomarkers in Biofluids Using Highly Parallelized RNA Aptamer Screens"
9:35 am - 9:45 am	Discussion
9:45 am - 9:55 am	"Traptamer: Trapping and release of fluorescent aptamers in RNA origami frames"
9:55 am - 10:00 am	Discussion
10:00 am - 10:30 am	Coffee Break
10:30 am - 10:50 am	"Leveraging the Circulating EV-Transcriptome for Insights into Disease Pathogenesis"
10:50 am - 11:00 am	Discussion
11:00 am - 11:20 am	"Exploiting Vesicular MicroRNAs as Cancer Therapeutics"
11:20 am - 11:30 am	Discussion
11:30 am - 11:50 am	"Methods for Single-Molecule Analysis Powered by Nanotechnology"
11:50 am - 12:00 pm	Discussion
12:00 pm - 12:20 pm	"Hybrid DNA/RNA Nanostructures"
12:20 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Synthetic and Programmed Nucleic Acid Assemblies Discussion Leader:
7:30 pm - 7:45 pm	Introduction by Discussion Leader
7:45 pm - 8:05 pm	"Interchangeable Parts for In Vitro Transcriptional Networks"
8:05 pm - 8:15 pm	Discussion
8:15 pm - 8:35 pm	"Using Strand Displacement for Genetic Switching"
8:35 pm - 8:45 pm	Discussion
8:45 pm - 9:05 pm	"Towards in Vivo Nucleic Acid Self-Assembly"
9:05 pm - 9:15 pm	Discussion
9:15 pm - 9:25 pm	"Functionalizing Nucleic Acid Nanoparticles for the Delivery of Nucleic Acid Therapeutics"
9:25 pm - 9:30 pm	Discussion
Friday
7:30 am - 8:30 am	Breakfast
9:00 am	Departure

Contributors

Research reported in this publication was supported by the National Cancer Institute and the National Center for Advancing Translational Sciences of the National Institutes of Health under Award Number R13CA277856. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

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