Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Structure-Based Elucidation of RNA Function
7:40 pm - 8:00 pm
Introduction by Discussion Leader
8:00 pm - 8:25 pm
"A Universal Chemical Handle for Modifying RNA"
8:25 pm - 8:35 pm
Discussion
8:35 pm - 8:50 pm
"Systematic Analysis of Cotranscriptional RNA Folding Using Transcription Elongation Complex Display"
8:50 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
"Stick-Slip Unfolding and Aggregation of Triplet Repeat RNA"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
9:00 am - 9:15 am
Introduction by Discussion Leader
9:15 am - 9:35 am
"Re-Engineering RNA Molecules into Therapeutic Agents: Chemistry Has No Limits"
9:35 am - 9:45 am
Discussion
9:45 am - 10:05 am
"Chemistry-Based mRNA Design for Enhancing Translation Ability"
10:05 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 11:05 am
"Harnessing Endogenous ADAR for Oligo-Directed RNA Editing"
11:05 am - 11:15 am
Discussion
11:15 am - 11:25 am
"Modified Spermine for Elevated Intracellular Oxidative Stress-Triggered mRNA Delivery via Complex Coacervates"
11:25 am - 11:30 am
Discussion
11:30 am - 11:40 am
"Modular Nanoparticles for Efficient and Targeted Delivery of Nucleic Acids"
11:40 am - 11:45 am
Discussion
11:45 am - 12:05 pm
"Broadening the Understanding of Peptide Conjugated Oligonucleotides Platform to Expand Therapeutic Use"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hourâ„¢
The GRC Power Hourâ„¢ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
7:30 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:05 pm
"Expanding the Scope of mRNA by Non-Natural Modifications"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:25 pm
"Effects of Modified Nucleotide Bases on RNA 3D Structure"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"Exploring the Utility and Mechanisms of N4-Acetylcytidine in mRNA Therapeutics"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"Impact of Modified mRNA Nucleosides on Translation"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
9:00 am - 9:15 am
Introduction by Discussion Leader
9:15 am - 9:35 am
"Targeted Lipid Nanoparticles with RNAs: From Vaccines to Efficient Therapeutic Genome Editing"
9:35 am - 9:45 am
Discussion
9:45 am - 9:55 am
"Design Considerations for Lung Delivery of Aerosolized mRNA LNPs"
9:55 am - 10:00 am
Discussion
10:00 am - 10:20 am
"Testing Thousands of LNPs In Vivo "
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Identifying Codon Constraints Through Large Unsupervised Learning Models and Genome-Wide Screens"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
"Efficient and Selective Delivery of RNA with Charge-Altering Releasable Transporters In Vivo"
11:40 am - 11:45 am
Discussion
11:45 am - 12:05 pm
"Modified Nucleotides in Self-Amplifying RNAs Suppress the Interferon Response and Increase Protein Expression and Duration: The Next Frontier in RNA Therapeutics"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
RNA Imaging and Characterization In Situ
7:30 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:05 pm
"Spatially Resolved Single-Cell Omics"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:25 pm
"RNA Aptamer-Based Biosensors for Measuring Microenvironment-Induced Cell Heterogeneity in Industrial Fermentations"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"Single-Molecule Imaging of RNA Transcription and Translation in Living Cells"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"What Do We Learn from Spatial Biology?"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
9:00 am - 9:15 am
Introduction by Discussion Leader
9:15 am - 9:35 am
"Engineering RNA Vaccines for Enhanced Cellular and Humoral Immunity"
9:35 am - 9:45 am
Discussion
9:45 am - 9:55 am
"Programmable Display of HIV Immunogens on Inert Nucleic Acid Scaffolds"
9:55 am - 10:00 am
Discussion
10:00 am - 10:20 am
"Sensing and Signaling of Endogenous RNAs in Cancer Immunotherapy Resistance"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Engineering Circular RNA Therapeutics"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
"Computationally Designed mRNA-Launched Protein Nanoparticle Vaccines"
11:40 am - 11:45 am
Discussion
11:45 am - 12:05 pm
"Endogenous ('Self') Double-Stranded RNAs as a Trigger for Neuroinflammation"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Controlling RNA Vaccine Kinetics with Small Molecule Drugs"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
RNA Cargo Selection, Transport, and Processing
7:30 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:05 pm
"Efficient Delivery of RNA with Small Extracellular Vesicles in Animal Models"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:25 pm
"A Programmable Trigger-Activated Dual-Self-Cleaving Ribozyme and Exploration of Its Use for Cell Context-Specific Release of RNA Therapeutics"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"RNA Delivery to Microvesicles"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"Gymnotic Uptake and Immune Sensing of Naked Extracellular RNAs"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
RNA-Based Diagnostics and Biomarkers
9:00 am - 9:15 am
Introduction by Discussion Leader
9:15 am - 9:40 am
"Heterogeneity in exRNA Carriers is Revealed by Molecular and Single-Particle Analysis"
9:40 am - 9:50 am
Discussion
9:50 am - 10:00 am
"High-Throughput, Purification-Free, and Ultrasensitive Transmembrane Nanosensor Arrays for Digital Counting of microRNA Biomarkers of Intact Exosomes"
10:00 am - 10:10 am
Discussion
10:10 am - 10:40 am
Coffee Break
10:40 am - 11:05 am
"Utility of Targeting Cell Type-Enriched RNAs in the CNS"
11:05 am - 11:15 am
Discussion
11:15 am - 11:25 am
"How Does RNA Structure Affect Intermolecular Interactions?"
11:25 am - 11:35 am
Discussion
11:35 am - 12:00 pm
"RNA Liquid Biopsy for Cancer Early Detection"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:20 pm
"Structural Basis for Spirocyclic Ring-Opening Fluorescence by the RhoBAST RNA Aptamer"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
7:30 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:05 pm
"RNA Origami Robots: Genetically Expressible Nanodevices That Can Sense, Compute, and Actuate"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:25 pm
"Cryo-EM Structures of Serum-Stable RNA Origami Nanodevices for Sensing and Targeting"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"Folding of mRNA-DNA Origami for Controlled Translation and Viral Vector Packaging"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"Programmable Artificial RNA Condensates in Mammalian Cells"
9:20 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure