Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Structure-Based Elucidation of RNA Function
7:40 pm - 8:00 pm
Introduction by Discussion Leader
8:00 pm - 8:25 pm
"A Universal Chemical Handle for Modifying RNA"
8:25 pm - 8:35 pm
Discussion
8:35 pm - 8:50 pm
"Systematic Analysis of Cotranscriptional RNA Folding Using Transcription Elongation Complex Display"
8:50 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
"Stick-Slip Unfolding and Aggregation of Triplet Repeat RNA"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
9:00 am - 9:15 am
Introduction by Discussion Leader
9:15 am - 9:35 am
"Re-Engineering RNA Molecules into Therapeutic Agents: Chemistry Has No Limits"
9:35 am - 9:45 am
Discussion
9:45 am - 10:05 am
"Chemistry-Based mRNA Design for Enhancing Translation Ability"
10:05 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 11:05 am
"Harnessing Endogenous ADAR for Oligo-Directed RNA Editing"
11:05 am - 11:15 am
Discussion
11:15 am - 11:25 am
"Modified Spermine for Elevated Intracellular Oxidative Stress-Triggered mRNA Delivery via Complex Coacervates"
11:25 am - 11:30 am
Discussion
11:30 am - 11:40 am
"Modular Nanoparticles for Efficient and Targeted Delivery of Nucleic Acids"
11:40 am - 11:45 am
Discussion
11:45 am - 12:05 pm
"Broadening the Understanding of Peptide Conjugated Oligonucleotides Platform to Expand Therapeutic Use"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hourâ„¢
The GRC Power Hourâ„¢ is designed to address the interests and needs of all scientists and the challenges they face in their careers. Specifically, the program promotes meaningful conversations amongst colleagues of all career stages about barriers to career advancement and strategies to support the professional growth of all members of the community. The GRC Power Hourâ„¢ is open to all conference participants.
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
7:30 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:05 pm
"Expanding the Scope of mRNA by Non-Natural Modifications"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:25 pm
"Effects of Modified Nucleotide Bases on RNA 3D Structure"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"Exploring the Utility and Mechanisms of N4-Acetylcytidine in mRNA Therapeutics"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"Impact of Modified mRNA Nucleosides on Translation"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
9:00 am - 9:15 am
Introduction by Discussion Leader
9:15 am - 9:35 am
"Targeted Lipid Nanoparticles with RNAs: From Vaccines to Efficient Therapeutic Genome Editing"
9:35 am - 9:45 am
Discussion
9:45 am - 9:55 am
"Design Considerations for Lung Delivery of Aerosolized mRNA LNPs"
9:55 am - 10:00 am
Discussion
10:00 am - 10:20 am
"Testing Thousands of LNPs In Vivo "
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Identifying Codon Constraints Through Large Unsupervised Learning Models and Genome-Wide Screens"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
"Efficient and Selective Delivery of RNA with Charge-Altering Releasable Transporters In Vivo"
11:40 am - 11:45 am
Discussion
11:45 am - 12:05 pm
"Modified Nucleotides in Self-Amplifying RNAs Suppress the Interferon Response and Increase Protein Expression and Duration: The Next Frontier in RNA Therapeutics"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
RNA Imaging and Characterization In Situ
7:30 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:05 pm
"Spatially Resolved Single-Cell Omics"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:25 pm
"RNA Aptamer-Based Biosensors for Measuring Microenvironment-Induced Cell Heterogeneity in Industrial Fermentations"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"Single-Molecule Imaging of RNA Transcription and Translation in Living Cells"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"What Do We Learn from Spatial Biology?"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
9:00 am - 9:15 am
Introduction by Discussion Leader
9:15 am - 9:35 am
"Engineering RNA Vaccines for Enhanced Cellular and Humoral Immunity"
9:35 am - 9:45 am
Discussion
9:45 am - 9:55 am
"Programmable Display of HIV Immunogens on Inert Nucleic Acid Scaffolds"
9:55 am - 10:00 am
Discussion
10:00 am - 10:30 am
Coffee Break
10:30 am - 10:50 am
"Engineered Protein Cages for RNA Delivery"
10:50 am - 11:00 am
Discussion
11:00 am - 11:20 am
"Engineering Circular RNA Therapeutics"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
"Computationally Designed mRNA-Launched Protein Nanoparticle Vaccines"
11:40 am - 11:45 am
Discussion
11:45 am - 12:05 pm
"Endogenous ('Self') Double-Stranded RNAs as a Trigger for Neuroinflammation"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Controlling RNA Vaccine Kinetics with Small Molecule Drugs"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
RNA Cargo Selection, Transport, and Processing
7:30 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:05 pm
"Efficient Delivery of RNA with Small Extracellular Vesicles in Animal Models"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:25 pm
"A Programmable Trigger-Activated Dual-Self-Cleaving Ribozyme and Exploration of Its Use for Cell Context-Specific Release of RNA Therapeutics"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"RNA Delivery to Microvesicles"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"Gymnotic Uptake and Immune Sensing of Naked Extracellular RNAs"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
RNA-Based Diagnostics and Biomarkers
9:00 am - 9:15 am
Introduction by Discussion Leader
9:15 am - 9:40 am
"Heterogeneity in exRNA Carriers is Revealed by Molecular and Single-Particle Analysis"
9:40 am - 9:50 am
Discussion
9:50 am - 10:00 am
"High-Throughput, Purification-Free, and Ultrasensitive Transmembrane Nanosensor Arrays for Digital Counting of microRNA Biomarkers of Intact Exosomes"
10:00 am - 10:10 am
Discussion
10:10 am - 10:40 am
Coffee Break
10:40 am - 11:05 am
"Utility of Targeting Cell Type-Enriched RNAs in the CNS"
11:05 am - 11:15 am
Discussion
11:15 am - 11:25 am
"How Does RNA Structure Affect Intermolecular Interactions?"
11:25 am - 11:35 am
Discussion
11:35 am - 12:00 pm
"RNA Liquid Biopsy for Cancer Early Detection"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:20 pm
"Structural Basis for Spirocyclic Ring-Opening Fluorescence by the RhoBAST RNA Aptamer"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
7:30 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:05 pm
"RNA Origami Robots: Genetically Expressible Nanodevices That Can Sense, Compute, and Actuate"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:25 pm
"Cryo-EM Structures of Serum-Stable RNA Origami Nanodevices for Sensing and Targeting"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"Folding of mRNA-DNA Origami for Controlled Translation and Viral Vector Packaging"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"Programmable Artificial RNA Condensates in Mammalian Cells"
9:20 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure