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RNA Nanotechnology (GRS)

Gordon Research Seminar

RNA Revolution: Unraveling Principles, Powering Therapeutics

January 4 - 5, 2025

Chairs

and

Four Points Sheraton / Holiday Inn Express

1050 Schooner Drive

Ventura, California, United States

Venue and Travel Information

Conference Description

The RNA Nanotechnology GRS provides a unique forum for young doctoral and post-doctoral researchers to present their work, discuss new methods, cutting edge ideas, and pre-published data, as well as to build collaborative relationships with their peers. Experienced mentors and trainee moderators will facilitate active participation in scientific discussion to allow all attendees to be engaged participants rather than spectators.

The 2025 RNA Nanotechnology GRS is set to immerse attendees in the forefront of RNA research, with a particular focus on elucidating how RNA structure affects its function and harnessing its potential in crafting sophisticated nanostructures. Sessions will cover topics from natural RNA structure and modifications to engineering RNA nanostructures for tailored applications, such as therapeutics, delivery, or diagnostics. Challenges facing the field, including the cellular delivery of these formulations and the immune stimulation of nucleic acid-based nanostructures, will also be explored. The schedule will include talks on research findings as well as poster presentations to drive discussion on these topics and beyond.

Related Meeting

This GRS will be held in conjunction with the "RNA Nanotechnology" Gordon Research Conference (GRC). Those interested in attending both meetings must submit an application for the GRC in addition to an application for the GRS. Refer to the associated GRC program page for more information.

Conference Program

Saturday
1:00 pm - 5:00 pm	Arrival and Check-in
3:30 pm - 3:45 pm	Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
3:45 pm - 4:30 pm	Keynote Session: Circular RNA: Engineering, Manufacturing, Medicine Discussion Leader:
3:45 pm - 4:20 pm	"Circular RNA: Engineering, Manufacturing, Medicine"
4:20 pm - 4:30 pm	Discussion
4:30 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Principles of RNA Structure, Function, and Modification Discussion Leader:
7:30 pm - 7:45 pm	"How Does RNA Structure Affect Intermolecular Interactions?"
7:45 pm - 7:50 pm	Discussion
7:50 pm - 8:05 pm	"Switchback RNA: A Double Helix with a Difference"
8:05 pm - 8:10 pm	Discussion
8:10 pm - 8:25 pm	"Resolving Altered Base-Pairing of RNA Modifications with DNA Nanoswitches"
8:25 pm - 8:30 pm	Discussion
8:30 pm - 8:45 pm	"3D RNA Inverse Design with Geometric Deep Learning"
8:45 pm - 8:50 pm	Discussion
8:50 pm - 9:05 pm	"Efficient Synthesis of Pseudouridine-Modified Circular mRNA using Group I Intron Assisted Circularization"
9:05 pm - 9:10 pm	Discussion
9:10 pm - 9:25 pm	"NAMIX: A Tool for Modeling of Chemically Modified RNA Structures"
9:25 pm - 9:30 pm	Discussion
Sunday
7:30 am - 8:30 am	Breakfast
9:00 am - 11:00 am	RNA Nanotechnology in Therapeutics, Diagnostics, and Vaccines Discussion Leader:
9:00 am - 9:15 am	"Programmable Translational Inhibition by a Molecular Glue-Oligonucleotide Conjugate"
9:15 am - 9:20 am	Discussion
9:20 am - 9:35 am	"Computationally Designed mRNA-Launched Protein Nanoparticle Vaccines"
9:35 am - 9:40 am	Discussion
9:40 am - 9:55 am	"Beyond Lipid Nanoparticles: Efficient and Selective Delivery of RNA with Charge-Altering Releasable Transporters in Vivo"
9:55 am - 10:00 am	Discussion
10:00 am - 10:15 am	"A G-Quadruplex Inducing RNA Antisense Strategy to Reduce MAOB Protein Level in Parkinson’s Disease"
10:15 am - 10:20 am	Discussion
10:20 am - 10:35 am	"Adjuvant-Derived mRNA Lipid Nanoparticles for Enhanced HIV Vaccination"
10:35 am - 10:40 am	Discussion
10:40 am - 10:55 am	"Optimizing the Chemistry and Sequence of Self-Amplifying RNAs to Suppress Inflammatory Responses and Improve Potency"
10:55 am - 11:00 am	Discussion
11:00 am - 12:30 pm	Poster Session Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm	Lunch
1:30 pm - 2:30 pm	Mentorship Component: Roles of Industry, Academia, and Publishing in RNA Discoveries Discussion Leader:
1:30 pm - 2:30 pm	Panel Discussion Roles of Industry, Academia, and Publishing in RNA Discoveries
2:30 pm - 3:00 pm	Evaluation Period Complete the GRS Evaluation Forms; Election of Future Chair(s)
3:00 pm	Seminar Concludes

Contributors

Research reported in this publication was supported by the National Cancer Institute of the National Institutes of Health under Award Number R13CA298641. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

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Conference History RNA Nanotechnology

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