Linking Form to Function: Developmental, Regenerative and Evolutionary Processes Defining Secretory Organs

February 3 - 8, 2019

Chairs

and

Vice Chairs

and

Grand Galvez

2024 Seawall Boulevard

Galveston, Texas, United States

Venue and Travel Information

Conference Description

The Gordon Research Conference (GRC) on Salivary Glands and Exocrine Biology will include cutting edge sessions on exocrine gland development, regenerative and tissue engineering approaches, new insights into organ aging and autoimmune disease, functional relevance of salivary proteins, membrane functions in exocrine glands, salivary gland and head and neck cancer etiology and treatments, and current topics in cell biology of exocrine glands. Invited speakers for the GRC will include eminent scientists from academia, industry and government and talks will include both senior and junior scientists from diverse fields who will present unpublished research findings on subjects of greatest interest to the field. A Gordon Research Seminar (GRS) will be held just prior to the GRC that will invite only speakers who are graduate students and postdoctoral associates in a wide variety of laboratories worldwide. In addition, poster sessions will be held daily at the GRC and GRS to enable all attendees to present and discuss their data in an open forum. The overall goals of these two meetings are to disseminate the newest findings, foster scientific exchanges and engender research collaborations in exocrine biology, moving the field forward into the future.

Related Meeting

This GRC will be held in conjunction with the "Salivary Glands and Exocrine Biology" Gordon Research Seminar (GRS). Those interested in attending both meetings must submit an application for the GRS in addition to an application for the GRC. Refer to the associated GRS program page for more information.

Conference Program

Sunday
4:00 pm - 8:00 pm	Arrival and Check-in
6:00 pm - 7:00 pm	Dinner
7:30 pm - 7:40 pm	Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm	Keynote Session: Aging and Glycobiology: New Frontiers in Exocrine Biology Discussion Leaders: and
7:40 pm - 7:50 pm	Opening Remarks
7:50 pm - 8:30 pm	"Evolution of the 'Molecular Frontier', the Sialome of the Sialome"
8:30 pm - 8:40 pm	Discussion
8:40 pm - 9:20 pm	"Longevity Mechanisms: Lessons from the Naked Mole Rat and Other Long-Lived Mammals"
9:20 pm - 9:30 pm	Discussion
Monday
7:30 am - 8:30 am	Breakfast
8:30 am - 9:00 am	Group Photo
9:00 am - 12:30 pm	Exocrine Gland Development: Cell Plasticity, Fate and Morphology Discussion Leaders: and
9:00 am - 9:05 am	Introduction by Discussion Leader
9:05 am - 9:25 am	"Submandibular Gland Development: Insights from Single Cell Transcriptomic Analysis"
9:25 am - 9:35 am	Discussion
9:35 am - 9:55 am	"From Discovery of Sweat Gland Stem Cells to Future Sweat Gland Regeneration"
9:55 am - 10:05 am	Discussion
10:05 am - 10:15 am	Selected from Poster Abstracts: "Fgf10/Fgfr2b Signaling Plays Distinct Roles in Submandibular Gland Morphogenesis, Homeostasis and Repair"
10:15 am - 10:20 am	Discussion
10:20 am - 10:50 am	Coffee Break
10:50 am - 11:10 am	Selected from Poster Abstracts: "CFTR Acts as an Essential Regulator of Exocrine Gland Morphogenesis"
11:10 am - 11:20 am	Discussion
11:20 am - 11:40 am	"Molecular Influences During Cell Fate Changes Towards Secretory Units"
11:40 am - 11:50 am	Discussion
11:50 am - 12:00 pm	Selected from Poster Abstracts: "Irradiation Acutely Suppresses Intracellular Ca²⁺ Signaling in Mice Submandibular Gland"
12:00 pm - 12:05 pm	Discussion
12:05 pm - 12:15 pm	Selected from Poster Abstracts: "Acinar-to-Ductal Metaplasia in Salivary Gland Acinar Cells upon Stress or Injury"
12:15 pm - 12:20 pm	Discussion
12:20 pm - 12:30 pm	Poster Previews
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
3:00 pm - 4:00 pm	The GRC Power Hour™ The GRC Power Hour™ is designed to address challenges women face in science and issues of diversity and inclusion. The program supports the professional growth of all members of our communities by providing an open forum for discussion and mentoring. Organizers: and
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Engineering the Glandular Epithelium Discussion Leaders: and
7:30 pm - 7:35 pm	Introduction by Discussion Leader
7:35 pm - 7:55 pm	"Lineage Hierarchies and Plasticity in Epithelial Stem Cells"
7:55 pm - 8:05 pm	Discussion
8:05 pm - 8:25 pm	"Creating 3D Tubes from 2D Primordia: The Role of Fkh (Drosophila FoxA) and Its Downstream Targets"
8:25 pm - 8:35 pm	Discussion
8:35 pm - 8:55 pm	"Engineering the Endocrine Pancreas"
8:55 pm - 9:05 pm	Discussion
9:05 pm - 9:25 pm	"The Physical and Chemical Contributions to the Self-Organization (and Disorganization) of the Human Mammary Gland"
9:25 pm - 9:30 pm	Discussion
Tuesday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Regenerating a Secretory Organ: Current Models and Outcomes Discussion Leaders: and
9:00 am - 9:05 am	Introduction by Discussion Leader
9:05 am - 9:25 am	"Potential of Endogenous Cells in Salivary Gland Regenerative Strategies"
9:25 am - 9:35 am	Discussion
9:35 am - 9:55 am	"Regeneration of Secretory Glands After Cancer Therapy: Towards Clinical Application?"
9:55 am - 10:05 am	Discussion
10:05 am - 10:15 am	Selected from Poster Abstracts: "PKCd Regulates Chromatin Conformation and DNA Double Stranded Break Repair in Response to Irradiation"
10:15 am - 10:20 am	Discussion
10:20 am - 10:30 am	Selected from Poster Abstracts: "Probing the Role of the CRTC1-MAML2 Fusion Oncogene-Induced lncRNA LINC00473 in Human Mucoepidermoid Carcinoma"
10:30 am - 10:35 am	Discussion
10:35 am - 11:05 am	Coffee Break
11:05 am - 11:25 am	"Regenerating the Lacrimal Gland: Current Progress and Future Challenges"
11:25 am - 11:35 am	Discussion
11:35 am - 11:55 am	"Wnt/TCF Control of Glandular Myoepithelial Stem Cell Regenerative Responses in the Airway"
11:55 am - 12:05 pm	Discussion
12:05 pm - 12:15 pm	Selected from Poster Abstracts: "Regeneration of Salivary Glands In Vivo Using Double Layer Cell Sheets"
12:15 pm - 12:20 pm	Discussion
12:20 pm - 12:30 pm	Poster Previews
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Current Concepts in Salivary Cancer: From Etiology to Treatments Discussion Leaders: and
7:30 pm - 7:35 pm	Introduction by Discussion Leader
7:35 pm - 7:55 pm	"Myb-NFIB Interactions in Adenoid Cystic Carcinoma"
7:55 pm - 8:05 pm	Discussion
8:05 pm - 8:25 pm	"Mucoepidermoid Carcinoma: CRTCal Links Between CREB and MYC Signaling"
8:25 pm - 8:35 pm	Discussion
8:35 pm - 8:55 pm	"Perineural Invasion in Cancer: A Dynamic Process"
8:55 pm - 9:05 pm	Discussion
9:05 pm - 9:25 pm	"Therapeutic Targeting of Salivary Gland Cancer Stem Cells"
9:25 pm - 9:30 pm	Discussion
Wednesday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Mucins and Salivary Proteins Discussion Leaders: and
9:00 am - 9:05 am	Introduction by Discussion Leader
9:05 am - 9:25 am	"Amylase Copy Number Analysis in Several Mammalian Lineages Reveals Convergent Adaptive Bursts Shaped by Diet"
9:25 am - 9:35 am	Discussion
9:35 am - 9:45 am	Selected from Poster Abstracts: "Salivary Proteome of Individuals with Moebius Syndrome"
9:45 am - 9:50 am	Discussion
9:50 am - 10:10 am	"Human Salivary Proteome Wiki"
10:10 am - 10:20 am	Discussion
10:20 am - 10:30 am	Selected from Poster Abstracts: "Mapping Quantitative Differences in Human Salivary Gland Secretions by Dried Saliva Spot Sampling and NanoLC-MS/MS"
10:30 am - 10:35 am	Discussion
10:35 am - 11:05 am	Coffee Break
11:05 am - 11:25 am	"Influence of Salivary Mucins on Oral Streptococci Physiology"
11:25 am - 11:35 am	Discussion
11:35 am - 11:55 am	"A Role for Salivary Proteins in Taste and Feeding"
11:55 am - 12:05 pm	Discussion
12:05 pm - 12:15 pm	Selected from Poster Abstracts: "Loss of Galnt3 Results in Altered Glycosylation of the Major SMG Mucin Muc10"
12:15 pm - 12:20 pm	Discussion
12:20 pm - 12:30 pm	Poster Previews
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:00 pm - 7:30 pm	Business Meeting Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm	Membrane Dynamics: Signaling and Function Discussion Leaders: and
7:30 pm - 7:35 pm	Introduction by Discussion Leader
7:35 pm - 7:55 pm	"Functional Relevance of STIM Proteins: Tuning Store-Operated Ca²⁺ Entry and More"
7:55 pm - 8:05 pm	Discussion
8:05 pm - 8:25 pm	"P2 Nucleotide Receptor Structure and Salivary Gland Function in Sjögren's Syndrome"
8:25 pm - 8:35 pm	Discussion
8:35 pm - 8:55 pm	"Ion Channel Control of Dynamic Release of BMP"
8:55 pm - 9:05 pm	Discussion
9:05 pm - 9:25 pm	"Modeling Saliva Secretion in Three Dimensions: How Much Detail Do You Really Need?"
9:25 pm - 9:30 pm	Discussion
Thursday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Autoimmune Disease and Aging: Models and Outcomes Discussion Leaders: and
9:00 am - 9:05 am	Introduction by Discussion Leader
9:05 am - 9:25 am	"Genetic Studies of Sjogren's Syndrome Highlight Disease Heterogeneity According to Ancestry and Phenotypic Features"
9:25 am - 9:35 am	Discussion
9:35 am - 9:55 am	"Interplay of Antigen Presenting Cells and Aging and the Development of Dry Eye"
9:55 am - 10:05 am	Discussion
10:05 am - 10:15 am	Selected from Poster Abstracts: "Excessive Cholesterol Synthesis Causes Sjögren's Syndrome"
10:15 am - 10:20 am	Discussion
10:20 am - 10:30 am	Selected from Poster Abstracts: "Cdc42 Negatively Regulates Endocytosis During Apical Membrane Maintenance in Live Animals"
10:30 am - 10:35 am	Discussion
10:35 am - 11:05 am	Coffee Break
11:05 am - 11:25 am	"Genomic Characterization of Sjogren's Syndrome"
11:25 am - 11:35 am	Discussion
11:35 am - 11:55 am	"Dissecting Ubiquitin-Dependent Stem Cell-Fate Decisions During Human Development and Disease"
11:55 am - 12:05 pm	Discussion
12:05 pm - 12:15 pm	Selected from Poster Abstracts: "Calcium Signaling via CRAC Channels in the Pathogenesis of Sjögren's Syndrome"
12:15 pm - 12:20 pm	Discussion
12:20 pm - 12:30 pm	Poster Previews
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Keynote Session: Metabolic Regulation and Adaptation Discussion Leaders: and
7:30 pm - 7:40 pm	Introduction by Discussion Leader
7:40 pm - 8:40 pm	"Metabolic Adaptation in Physiology and Disease"
8:40 pm - 9:00 pm	Discussion
9:00 pm - 9:20 pm	General Discussion
9:20 pm - 9:30 pm	Closing Remarks
Friday
7:30 am - 8:30 am	Breakfast
9:00 am	Departure

Contributors

University of Utah School of Dentistry

UCSF School of Dentistry - Department of Cell and Tissue Biology

Research reported in this publication was supported by the National Institute Of Dental & Craniofacial Research of the National Institutes of Health under Award Number R13DE028494. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

Conference Links

Conference History Salivary Glands and Exocrine Biology (GRS)