Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: Tissue Repair and Neoplasia
7:40 pm - 7:50 pm
Introduction by Discussion Leader
7:50 pm - 8:05 pm
"From One Niche to Another: Human Stem/Progenitor Cells for Salivary Gland Regeneration"
8:05 pm - 8:10 pm
Discussion
8:10 pm - 9:10 pm
"Back to the Future: Links Between Tissue Repair, Reprogramming to an Embryonic-Like State, and Cancer"
9:10 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
Monday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Ex-Vivo Development and Re-Engineering of Tissues
9:00 am - 9:20 am
"Cell Plasticity and Tissue Remodeling in Exocrine Glands"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Biofabrication and Today’s Regenerative Engineering"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
"Cleaning up the Neighborhood: Remediating Fibrosis to Facilitate Regeneration"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Progenitor Niches in the Developing Pancreas: Regulation of Cell Fate and Beyond"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
"A Human iPSC-Derived Salivary Gland Organoid Model for Diabetic Salivary Gland Dysfunction"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
"Early Epithelial-Mesenchymal Interactions Controlling Development of the Salivary Gland Mesenchyme"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Outspread Limits Myosin II Activity to Control Epithelial Tube Architecture"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Break Free From Locked Fate: Targeted Regeneration of Radiation Damaged Salivary Epithelium"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address the interests and needs of all scientists and the challenges they face in their careers. Specifically, the program promotes meaningful conversations amongst colleagues of all career stages about barriers to career advancement and strategies to support the professional growth of all members of the community. The GRC Power Hour™ is open to all conference participants.
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Cancer and Radiation Impact in Exocrine Tissues
7:30 pm - 7:50 pm
"CRTCal Links Between Development and Salivary Tumor Progression"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"PKCδ and Radioprotection: The Role of the Mitochondria in DNA Damage and Repair"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"Pre-Clinical Models for the Determination of Chemoresistance in Salivary Gland Adenoid Cystic Carcinoma"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"The Role of Macrophages in Murine Radiation Induced Salivary Gland Damage"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Saliva, the Oral Microbiota and Taste
9:00 am - 9:25 am
"How Bugs Stick to Spit: Glycan Recognition at the Saliva-Microbiome Interface"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
"Leveraging Metaproteomics to Investigate Saliva and the Oral Microbiome"
10:00 am - 10:10 am
Discussion
10:10 am - 10:40 am
Coffee Break
10:40 am - 11:05 am
"Salivary Proteins Alter Both Oral and Post-Oral Responding to Taste Stimuli"
11:05 am - 11:15 am
Discussion
11:15 am - 11:25 am
"A Cross-Sectional Observational Study of Sicca Patients with Salivary Autoantibodies Defines a Potential New Phenotype of Sjögren’s Disease"
11:25 am - 11:30 am
Discussion
11:30 am - 11:40 am
"Evaluation of Oral Care Method using MA-T Technology for the Oral Microbiota of High-Risk Patients"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
"Understanding the Role of Myoepithelial Cells in Salivary Gland Regeneration"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Novel Trigeminal Sensory Innervation of the Submandibular Gland: Trpv1+ Neurons Detect Changes in Ductal pH"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Purinergic Receptors as Therapeutic Targets for Salivary Gland Dysfunction"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Exocrine Glands of Eye and Airways
7:30 pm - 7:50 pm
"Effects of Age and Stress on Meibomian Gland Growth and Differentiation"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Sebaceous Glands During Homeostasis and Regeneration"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"Dynamics of the Airway Immune Niche and its Role in Regulating Gland Development"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
"Aging Mouse Lacrimal Glands: Uncovering Shared Features and Individual Heterogeneity"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Epithelial and Mesenchymal Progenitor Cells in Normal and Inflamed Human Lacrimal Glands"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
9:00 am - 9:20 am
"Innovative Treatments for Hyposalivation: A Multifaceted Approach to Restoring Saliva Production"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Sowing Seeds in Arid Lands: Challenges in Cell-Based Therapies for Radiation-Induced Xerostomia"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
"Tissue-Resident Salivary Gland Macrophages Prime Epithelial Progenitor Cells to Regenerate Tissue"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Generation of Salivary Gland Organoids from Pluripotent Stem Cells"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
Short Talk Selected from Poster Abstracts
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
"Dissection of Salivary Glands by Autoantibody Profile in Sjögren's Syndrome Reveals Common and Distinct T-Cell Subsets and Fibroblast-Mediated Inflammation"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Spatial Mapping and 3D Bioprinted Tumoroids to Uncover Molecular Targets in Salivary Gland Mucoepidermoid Carcinoma in Southeast Asia"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Identifying Acinar Cell Fate Modulators for Regenerating Salivary Glands in Sjögren’s Disease"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Exocrine Tissue-Related Aging, Metabolism, and Senescence
7:30 pm - 7:50 pm
"Exploring the Immune Cell Landscape and Sex Differences in Aging Salivary Glands"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Lipid Dysregulation in the Aged Lacrimal Gland"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"Environmental Changes associated with Radiation-Induced Salivary Gland Dysfunction"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"Metmorfin for Diabetes in Sjögren's Disease"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Clinical Trials and Autoimmune Diseases
9:00 am - 9:20 am
"Genetics and Genomics of Sjögren’s Disease"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Sjögren’s Disease Endotypes: Towards Precision Medicine"
9:50 am - 10:00 am
Discussion
10:00 am - 10:30 am
Coffee Break
10:30 am - 10:50 am
"Calcium Channels Mediate Salivary Gland Function Locally and Systemically"
10:50 am - 11:00 am
Discussion
11:00 am - 11:20 am
"Transplantation of Autologous Stem Cells for Post-Radiotherapy Regeneration of the Submandibular Gland (RESTART): Preliminary Phase I/II Study Results"
11:20 am - 11:30 am
Discussion
11:30 am - 11:45 am
"Efficacy of Low-Dose IL-2 Therapy in Stratified Subgroups of Primary Sjögren’s Syndrome Patients"
11:45 am - 11:50 am
Discussion
11:50 am - 12:05 pm
"Long Covid in Patients with Sjögren’s Disease"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
"Results of a Phase 1, Open-Label, Dose-Escalation Study of Gene Therapy with AAV2-hAQP1 as Treatment for Grade 2 and 3 Radiation-Induced Late Xerostomia and Parotid Gland Hypofunction"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Keynote Session: The Impact of Cellular Aging on Chronic Disease
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 7:55 pm
"Senescence of Salivary Gland Progenitor Cells in Sjögren’s Disease"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:50 pm
"Cellular Senescence and Senolytics: The Path to Translation"
8:50 pm - 9:10 pm
Discussion
9:10 pm - 9:30 pm
General Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure