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Sunday, June 11
- 2:00-11:00 pm - Arrival and Registration
- 6:00 pm - Dinner
| 7:30-9:30 pm | Session 1: Phosphodiesterases |
- Session Chair: Jackie Corbin (Vanderbilt): Overview of PDEs
- Marco Conti (Stanford): Phosphodiesterases and cAMP signaling: New insights from the PDE-KO mice
- Sharron Francis (Vanderbilt): PDE5, PKG, and the action of Viagra
- Robert Nolte (Glaxo): Insights into phosphodiesterase mechanism and specificity revealed by the atomic structure of PDE4
- Vince Manganiello (NIH): Phosphodiesterase3(PDE3): A regulator of certain actions of insulin and IGF-1
- Lisa Burden (NIH): Modeling allosteric cGMP-binding sites of PDEs using GAF structure
Monday, June 12
- 7:30-8:30 am - Breakfast
- 8:45 am - Conference Photo
| 9:00am -12:30 pm | Session 2: G Protein Function and Regulation |
- Session Chair: Steve Sprang (Southwestern): G-protein regulation: baiting the switches
- Suzanne Scarlata (SUNY): Big G protein activation through small PLC-beta domains
- Bruce Conklin (UCSF): Using engineered receptors and genomic responses to investigate the normal and pathogenic roles of G protein signals
- Rick Neubig (Michigan): G protein activation and deactivation: role of RGS
- Ron Taussig (Michigan): Genetic analysis of mammalian adenylyl cyclase regulation
- 12:30-1:30 pm - Lunch
- 1:30-4:00 pm - Free Time
- 4:30-6:00 pm - Poster Session #1
- 6:00 pm - Dinner
| 7:30-9:30 pm | Session 3: Metabolic Regulation in Yeast |
Session Chair: Marian Carlson (Columbia): Snf1 Protein kinase and glucose signaling
- Erin O'Shea (UCSF): Dynamics of signal transduction in budding yeast
- Joe Heitman (Duke): Yeast as model-T cells
- Peter Roach (Indiana): Kinase targeting subunits in yeast
Tuesday, June 13
| 9:00 am - 12:30 pm | Session 4: Calcium and Calmodulin Regulation |
Session Chair: Anthony Means (Duke): Unique roles for CaMKIV in terminal cell differentiation in vivo
- Angjana Rao (Harvard): Gene regulation by calcineurin and NFAT
- Kathy Beckingham (Rice): Unexpected insights into calmodulin function from genetic analysis in the whole organism
- Howard Schulman (UCSF): Frequency-dependent regulation of CaM kinase II activity and intracellular targeting
- 12:30-1:30 pm - Lunch
- 1:30-4:00 pm - Free Time
- 4:30-6:00 pm - Poster Session #2
- 6:00 pm - Dinner
| 7:30-9:30 pm | Session 5: Protein Phosphatases |
Session Chair: Nicholas Tonks (Cold Spring Harbor): From structure to function of PTPs
- Ben Neel (Harvard): Tyrosine phosphatases in health and disease
- Jack Dixon (Michigan): PTEN and other phospholipid phosphatases
- Anna Depaoli-Roach (Indiana): Glycogen-associated protein phosphatase PP1G/RGL
- Ping Lu (Harvard): Regulation of protein dephosphorylation by a conformational change in the substrate
Wednesday, June 14
| 9:00 am - 12:30 pm | Session 6: Tyrosine Kinases |
Session Chair: Anthony Pawson (Toronto): Modular protein interactions in cytoplasmic signaling pathways
- John Kuriyan (Rockefeller): Structural and computational analysis of the regulation of protein kinases
- Lewis Cantley (Harvard): Predicting protein kinase signaling pathways from gene sequences
- Joan Brugge (Harvard): Vav family Rho exchange factors
- 12:30-1:30 pm - Lunch
- 1:30-4:00 pm - Free Time
- 4:30-6:00 pm - Poster Session #3
- 6:00 pm - Dinner
| 7:30-9:30 pm | Session 7: Protein Kinase B: Regulation and Targets |
Session Chair: Philip Cohen (Dundee): Overview of PDK1, PKB and GSK3 cascades
- Dario Alessi (Dundee): Role of PDK1 in activating AGC kinases
- Brian Hemmings (Basel): Protein kinase B (Akt) regulation
- Gary Ruvkun (Harvard): Identification of DAF-16/FKHR as the key target of the C. elegans (and probably most) insulin signaling pathways
Thursday, June 15
| 9:00 am - 12:30 pm | Session 8: Insulin Signaling Pathways |
Session Chair: Morris White (Harvard): IRS-proteins coordinate multiple signaling pathway to regulate nutrient homeostasis and reproduction
- Mike Czech (UMass): Interfacing insulin signaling elements with membrane trafficking and the cytoskeleton
- Cynthia Kenyon (UCSF): An insulin/IGF-1-like endocrine system that regulates the lifespan of C. elegans
- Laurie Goodyear (Harvard): AMP-activated kinase: A critical signaling Intermediary for insulin-independent glucose transport in skeletal muscle
- David Carling (Imperial College): Regulation of the AMP-activated protein kinase and SNF1 complexes
- Rob Hooft (Serono): A systematic approach to finding PTPs that dephosphorylate the insulin-receptor using mutant trapping assays
- 12:30-1:30 pm - Lunch
- 1:30-4:00 pm - Free Time
- 6:00 pm - Banquet Dinner
| 7:30-9:30 pm | Session 9: Keynote Session |
- Brian Chait (Rockefeller): Mass spectrometry as a probe of protein interaction and phosphorylation
- Robert Lefkowitz (Duke): Signalling networks for the new millenium: Hypothesis versus non-hypothesis-driven research (Dr. Lefkowitz has been designated as the Alexander M. Cruickshank Lecturer for the GRC.)
- 10:00 pm - Conference Awards (Dunce Committee, T. Sturgill, Chair)
Friday, June 16
- 7:30-8:30 am - Breakfast
- 9:00 am - Bus Departs
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