Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: New Insights on Old Pathways
7:40 pm - 8:25 pm
"Cancer Therapy Resistance: A Cell Biologist’s Perspective"
8:25 pm - 8:35 pm
Discussion
8:35 pm - 9:20 pm
"Regulation of Multicellularity in Choanoflagellates: An Evolutionary Perspective on Adhesion"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Cell-Cell Adhesion Assembly and Disassembly
9:00 am - 9:25 am
"Mechanochemical Feedback and Signaling at the Epithelial Adherens Junction"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
"Desmosomes in Morphogenesis"
10:00 am - 10:10 am
Discussion
10:10 am - 10:25 am
"Tumor Suppressive, Non-Canonical Notch1 Regulation of Epithelial Adherens Junctions and Mitogenic Signaling"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:25 am
"Non-Junctional Cadherin in Regulating Actomyosin and Cortical Dynamics"
11:25 am - 11:35 am
Discussion
11:35 am - 11:50 am
"Desmosome Regulates the Junctional Interface and Actomyosin Dynamics During Apoptotic Cell Extrusion"
11:50 am - 11:55 am
Discussion
11:55 am - 12:20 pm
"Alpha-Catenin Integrates Cytoskeletal Networks at Cardiomyocyte Adherens Junctions"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
Power Hour
The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring.
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Cell-Matrix Adhesion Assembly and Disassembly
7:30 pm - 7:55 pm
"Un Menage à Trois, Controlling Integrin Activation and Clustering by Talin and Kindlin"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:30 pm
"Src and Focal Adhesion Signaling Dynamics"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:05 pm
"Cytoskeletal Dynamics, Adhesion Assembly and Force"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Mechanical Regulation of RNA Localization Contributes to Cell Migration"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Mechanical Regulation of Adhesion
9:00 am - 9:25 am
"Mechanical Homeostasis of the Extracellular Matrix"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
"Dynamics of Force Transduction at Single Integrin Complexes in Living Cells"
10:00 am - 10:10 am
Discussion
10:10 am - 10:25 am
"Tension-Dependent Regulation of Mammalian Hippo Signaling Through LIMD1"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:25 am
"Mechanotransduction Mechanisms at Cadherin Adhesions"
11:25 am - 11:35 am
Discussion
11:35 am - 11:50 am
"Mechanical Coupling of β2 Integrins to the Actin Cytoskeleton by a Molecular Clutch Drives Phagocytosis"
11:50 am - 11:55 am
Discussion
11:55 am - 12:20 pm
"Detecting Vinculin Load-Dependent Protein Recruitment to Focal Adhesions"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Orchestrating Adhesion and Migration
7:30 pm - 7:55 pm
"Building the Body Plan: The Miracle of Morphogenesis"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:30 pm
"Force Loading Rate as a Fundamental Magnitude in Mechanosensing"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:05 pm
"Invasion Mechanisms in Metastasis"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Interplay Between Caveolae and Junctional Mechanics"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Adhesion and Tissue Remodeling
9:00 am - 9:25 am
"Regulation of Cell-Cell Junctions During Tissue Remodeling"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
"The Physical and Cellular Basis of Branching Morphogenesis"
10:00 am - 10:10 am
Discussion
10:10 am - 10:25 am
"Multiscale Model Predicts Increasing Focal Adhesion Size with Decreasing Stiffness in Fibrous Matrices"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:25 am
"Coupling of Adhesive and Metabolic Pathways at Cell-Cell Junctions"
11:25 am - 11:35 am
Discussion
11:35 am - 11:50 am
"The Polarity Protein aPKCi: A New Key Player of Basal Cell Extrusion, an Emergent Mechanism for Early Tumor Cell Dissemination"
11:50 am - 11:55 am
Discussion
11:55 am - 12:20 pm
"Harnessing Actin Polymerization to Maintain Epithelial Sheets"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Cell-Matrix, Cell-Cell and Growth Factor Receptor Cross-Talk
7:30 pm - 7:55 pm
"Role of Cell-Cell Adhesion, Merlin and ERM Proteins in EGFR Distribution"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:30 pm
"Regulation of TGFb Signaling and Fibrogenesis by Adhesion and Matrix"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:05 pm
"Cell-Matrix Crosstalk in Cancer and Pluripotency"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Tumor Invasion Through Hyaluronic Acid Matrices Is Mediated by CD44-Dependent Microtentacles"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Evolving Concepts of Adhesion Signaling and Cancer Progression
9:00 am - 9:25 am
"The Varied Roles of Adhesions During Steps of Metastasis"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
"MAP4K4, an Integrin-FERM Regulator in Cell-Cell Adhesion"
10:00 am - 10:10 am
Discussion
10:10 am - 10:25 am
"A Rab40b:Cullin-5 Interaction Regulates Elplin Levels to Control Stress Fiber and Focal Adhesion Formation and Affect Cell Cell Migration and Invasion"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:25 am
"Big Data Approaches to Cancer Migration"
11:25 am - 11:35 am
Discussion
11:35 am - 11:50 am
"Swiprosin1 Links Rab21-Containing Vesicles with the Actin Cytoskeleton to Drive Integrin Transport in Breast Cancer Cells"
11:50 am - 11:55 am
Discussion
11:55 am - 12:20 pm
"Deciphering the Talin Code: Understanding Mechanotransduction Using Structural Mechanobiology"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Clinical Applications of Adhesion Modulation
7:30 pm - 7:55 pm
"An Update on Anti-Integrin Therapeutic Programs"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:30 pm
"Adhesion Signals as Cancer Targets"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 8:50 pm
"Collagen Fibril Architecture Regulates Cell Adhesion, Metabolic Stress and Collective Migration"
8:50 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
"Integrins in Inflammation and Fibrosis"
9:20 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure