Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: Cell Motility and Invasion: Signals From the Cell-ECM Interphase
7:40 pm - 7:50 pm
Introduction by Discussion Leader
7:50 pm - 8:30 pm
"Adhesion-Regulated Pulsatile MAP Kinase Signaling Enables Resistance to Targeted Cancer Therapies"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:20 pm
"Interplay Between Tissue Tension, Inflammation and Tumor Initiation and Progression"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Cell-Cell Adhesion: Assembly and Signaling Platforms
9:00 am - 9:25 am
"Mechanisms Linking Cell Mechanics and Metabolism"
9:25 am - 9:30 am
Discussion
9:30 am - 9:55 am
"Probing the Effects of Molecular Tension on Protein Function in Cellulo"
9:55 am - 10:00 am
Discussion
10:00 am - 10:25 am
"Echinoderm Embryos as Models for Cell-Evo-Devo"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:25 am
"Adherens Junctions: Mechanical Homeostasis and Epithelial Homeostasis"
11:25 am - 11:30 am
Discussion
11:30 am - 11:55 am
"Towards a Phospho-Code for Adherens Junction Organization and Barrier Function"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:25 pm
"The Integrin-Actin Linker Tensin1 Plays an Important Role to Focal Adhesion Disassembly at Mitosis to Relieve an Integrin-Inactivation G2-M Checkpoint"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Cell-Matrix Adhesion: A Dual Carriageway of Signaling Cues
7:30 pm - 7:55 pm
"Protocadherins in Vascular Mechanotransduction, Inflammation and Disease"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:25 pm
"Cadherin Mechanotransduction: Getting by With a Little Help From Friends"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:55 pm
"Intermediate Filaments, Desmosomes and Epithelial Morphogenesis in Zebrafish Embryos"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:25 pm
"Cis-Regulators of Integrin, Cellular Mechanoperception and Genomic Reprogramming"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Mechanical Regulation of Adhesion Signaling
9:00 am - 9:25 am
"Extracellular Matrix and it's Role as a Biophysical Regulator of Tumor Heterogeneity"
9:25 am - 9:30 am
Discussion
9:30 am - 9:55 am
"Exploring The Role of Integrins in Nuclear Mechanosignalling"
9:55 am - 10:00 am
Discussion
10:00 am - 10:25 am
"From Adhesions to the Nucleus: Force-Dependent Actin Polymerization Regulates Nuclear Mechanotransduction and Cell Programming"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:25 am
"Mechanoregulation of Desmosome Architecture"
11:25 am - 11:30 am
Discussion
11:30 am - 11:55 am
"The Mechanical Role of Tight Junctions for Lumen Growth and Morphology"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:25 pm
"T Cell Receptors as Mechanosensors in the Lung Environment"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Crosstalk at the Plasma Membrane
7:30 pm - 7:55 pm
"Building the Body: The Miracle of Morphogenesis"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:25 pm
"Novel Signalling Players Underlying Breast Cancer Cell Motility"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"Mechanosensing in Platelet Migration and Clot Formation"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:25 pm
"Changes in Adhesion Enabling Macrophage Tissue Invasion"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Adhesion in Tissue Remodeling and Disease
9:00 am - 9:20 am
"Keratinocyte Desmosome Remodeling and Melanoma Development"
9:20 am - 9:30 am
Discussion
9:30 am - 9:55 am
"Distinct Roles of ECM Molecules for Melanocyte Differentiation"
9:55 am - 10:00 am
Discussion
10:00 am - 10:30 am
Coffee Break
10:30 am - 10:55 am
"Maintenance and Remodeling of Epithelial Cell-Cell Junctions in Response to Cell Shape Changes"
10:55 am - 11:00 am
Discussion
11:00 am - 11:25 am
"Adhesion Signaling in the Mesenchyme"
11:25 am - 11:30 am
Discussion
11:30 am - 11:55 am
"Self-Organization of MAPK Signaling in Epithelial Homeostasis and Developmental Patterning"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:25 pm
"Desmosome Functions in Tissue Homeostasis"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Orchestrating Adhesion and Migration
7:30 pm - 7:55 pm
"Follow Thy Neighbor: Profiling Collective Cell Motility With Distinct Mechanical Properties and Geometric Confinement"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:25 pm
"A Cadherin, Integrin, ECM Code for Tissue Viscoelasticity"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:55 pm
"Mechanobiology of Myeloid Cells: From Podosome Nanoscale Architecture to T Cell Immune Suppression"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:25 pm
"Phase Separation Promotes Integrin Clustering and Downstream Signaling"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Evolving Concepts of Adhesion Signaling in Pathology
9:00 am - 9:25 am
"Glypican-3 Modulates Wnt Signaling in Liver Cancer"
9:25 am - 9:30 am
Discussion
9:30 am - 9:55 am
"Integrated Biochemical and Genetic Analysis of E-Cadherin's Role in Cancer Cell Survival During Metastasis"
9:55 am - 10:00 am
Discussion
10:00 am - 10:10 am
"SKT, A Novel Mechanosensitive Focal Adhesion Protein Linking Cell Adhesion and Cancer Metabolism Via Novel Activation of mTORC2"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
"Determination of Single-Molecule Loading Rate During Mechanotransduction in Cell Adhesion"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:25 am
"Cytoskeletal Crosstalk at Focal Adhesions"
11:25 am - 11:30 am
Discussion
11:30 am - 11:55 am
"Mechanobiology Ties the Knot With Motility in Glioblastoma Invasion"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:25 pm
"Investigating the Mechanoregulatory Role of Fibronectin During Wound Repair"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Modulation of Adhesion Receptor Signaling: Translational and Clinical Applications
7:30 pm - 7:55 pm
"CDK1- Dependent Regulation of Cell-Cell Junctions Maintains Epithelial Barrier Function Throughtout the Cell Cycle"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:25 pm
"Focal Adhesion Kinase (FAK) Signaling: Uncovering Tumor Vulnerabilities and Expanding Clinical Opportunities"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:55 pm
"Understanding the Impact of Intra-Tumor Heterogeneity of Metaplastic Breast Cancer on Tumor Progression"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:25 pm
"Targeting TGFβ-Activating Integrins to Enhance Immune Responses to Solid Tumors"
9:25 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure