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Single-Cell Cancer Biology (GRS)

Gordon Research Seminar

A Multidimensional View of Cancer at Single-Cell Resolution

June 8 - 9, 2024

Chairs

and

Southern New Hampshire University

2500 North River Road

Manchester, New Hampshire, United States

Venue and Travel Information

Conference Description

The Single-Cell Cancer Biology GRS provides a unique forum for young doctoral and post-doctoral researchers to present their work, discuss new methods, cutting edge ideas, and pre-published data, as well as to build collaborative relationships with their peers. Experienced mentors and trainee moderators will facilitate active participation in scientific discussion to allow all attendees to be engaged participants rather than spectators.

The focus of this meeting will be on recent biological discoveries as well as novel experimental and computational approaches using single-cell and spatial technologies in the field of cancer biology. Advances in single-cell omics and imaging technologies are providing an unprecedented understanding of the molecular components, lineages, and spatial relationships of single cells that dictate cancer initiation and progression. Our program will embrace research that spans all facets of cancer biology, ranging from cellular plasticity, clonal dynamics, tumor heterogeneity, tumor-stroma interactions, the immune microenvironment, pre-malignancy and tumor initiation, to metastasis and therapy resistance.

Kindly submit your application by April 30, 2024, if you would like it to be considered for an oral presentation.

Related Meeting

This GRS will be held in conjunction with the "Single-Cell Cancer Biology" Gordon Research Conference (GRC). Those interested in attending both meetings must submit an application for the GRC in addition to an application for the GRS. Refer to the associated GRC program page for more information.

Conference Program

Saturday
1:00 pm - 5:00 pm	Arrival and Check-in
3:30 pm - 3:45 pm	Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
3:45 pm - 4:30 pm	Keynote Session: Spatial Biology of Tumor Ecosystems Discussion Leader:
3:45 pm - 4:20 pm	"Single Cell Spatial Genomic Profiling of Tumor Ecosystems"
4:20 pm - 4:30 pm	Discussion
4:30 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Dissecting Cancer Initiation, Evolution and Drug Resistance using Single-Cell and Spatial Multi-Omics Discussion Leader:
7:30 pm - 7:40 pm	"The Temporal Influence of the Tumor Microenvironment in Response to Checkpoint Blockade"
7:40 pm - 7:45 pm	Discussion
7:45 pm - 7:55 pm	"Malignant Cell Driven Immune Evasion in Ovarian Cancer"
7:55 pm - 8:00 pm	Discussion
8:00 pm - 8:10 pm	"Neoadjuvant PARPi and Chemotherapy in Ovarian Cancer Inform Targeting Effector Regulatory T Cells for Tumors with Homologous Recombination Deficiency"
8:10 pm - 8:15 pm	Discussion
8:15 pm - 8:25 pm	"Deciphering Sarcoma Tumor Ecosystems: Cell by Cell and Spatially Resolved"
8:25 pm - 8:30 pm	Discussion
8:30 pm - 8:40 pm	"Patterns of Therapy Resistance Encoded in the Microenvironment of Urothelial Carcinoma: A Myeloid Focus"
8:40 pm - 8:45 pm	Discussion
8:45 pm - 8:55 pm	"Regulation of Pancreatic Cancer Metastasis by Signal Conversion in the Epigenome"
8:55 pm - 9:00 pm	Discussion
9:00 pm - 9:10 pm	"Whole Genome Methylation Sequencing Reveals the Cellular Origins of Human Lung Adenocarcinoma"
9:10 pm - 9:15 pm	Discussion
9:15 pm - 9:25 pm	"Longitudinal Multi-Omics Characterization of Circulating Tumor Cells for ALK Positive NSCLC Patients at Single Cell Level"
9:25 pm - 9:30 pm	Discussion
Sunday
7:30 am - 8:30 am	Breakfast
9:00 am - 11:00 am	Computational Methods to Profile and Perturb Cellular States Discussion Leader:
9:00 am - 9:10 am	"Dissecting Cell State Plasticity in Glioblastoma through Single-Cell Lineage Tracing"
9:10 am - 9:15 am	Discussion
9:15 am - 9:25 am	"Inference for Rates of Selection and Copy Number Aberrations from DNA-Sequencing Data"
9:25 am - 9:30 am	Discussion
9:30 am - 9:40 am	"High-Resolution Detection of Copy Number Alterations in Single Cells with HiScanner"
9:40 am - 9:45 am	Discussion
9:45 am - 9:55 am	"SatSeq: A Scalable Platform to Map Protein Sequence to Cellular and In Vivo Functions"
9:55 am - 10:00 am	Discussion
10:00 am - 10:10 am	"Characterizing Cell Morphology and Subcellular Protein Localization using Optimal Transport"
10:10 am - 10:15 am	Discussion
10:15 am - 10:25 am	"mxTRex: Uncovering T-Cell Transcriptional Programs Associated with Antigen Specificity in Single Cell Genomics"
10:25 am - 10:30 am	Discussion
10:30 am - 10:40 am	"Agent-Based Modeling of Tumor Microenvironment Dynamics in Adoptive Cell Therapy"
10:40 am - 10:45 am	Discussion
10:45 am - 10:55 am	"CRISPRmap: Sequencing-Free Optical Pooled Screens Mapping Multi-Omic Phenotypes in Cells and Tissue"
10:55 am - 11:00 am	Discussion
11:00 am - 12:30 pm	Poster Session Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm	Lunch
1:30 pm - 2:30 pm	Mentorship Component: Shaping the Future of Single-Cell Cancer Biology Discussion Leader:
1:30 pm - 2:30 pm	Panel Discussion Shaping the Future of Single-Cell Cancer Biology
2:30 pm - 3:00 pm	Evaluation Period Complete the GRS Evaluation Forms; Election of Future Chair(s)
3:00 pm	Seminar Concludes

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Conference History Single-Cell Cancer Biology

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Single-Cell Cancer Biology

March 22 - 27, 2026

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