Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: Fundamental Properties of Staphylococci
7:40 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:05 pm
"Dual Pathogenicity Island Transfer by a Novel Form of Lateral Transduction"
8:05 pm - 8:10 pm
Discussion
8:10 pm - 8:30 pm
"How Bacteria Move Acyl Groups from the Cytoplasm to Extracellular Polymers"
8:30 pm - 8:35 pm
Discussion
8:35 pm - 8:55 pm
"Teichoic Acids at the Staphylococcus -Host Interface"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"Harnessing Monoclonal Antibodies Against the Antibody-Loving Microbe"
9:20 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
General Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Staphylococcal Interactions within the Microbial Community
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
"Interspecies Quorum Sensing Communication with Impact on Phage Susceptibility"
9:25 am - 9:35 am
Discussion
9:35 am - 9:55 am
"Staphylococcus -Mediated Immunopathology and Healing Outcomes in Cutaneous Leishmaniasis Infections"
9:55 am - 10:05 am
Discussion
10:05 am - 10:25 am
"Molecular Mechanisms of Staphylococcal Modulation of Skin Homeostasis"
10:25 am - 10:35 am
Discussion
10:35 am - 11:00 am
Group Photo / Coffee Break
11:00 am - 11:20 am
"Community Assembly of the Skin Microbiome at the Strain and Mutation Level"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"Defining Microbial Community Function in Chronic Human Infection with Metatranscriptomics"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Mycobiota-Mediated Colonization Resistance Against S. aureus "
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Genomic Epidemiology and Antimicrobial Resistance of MRSA Isolates Causing Eye Infections"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Interconnections Between Staphylococcal Metabolism and Virulence
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:55 pm
"Lipids and Fatty acid Derivatives as Mediators of S. aureus Metabolism and Virulence"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Immunometabolism and Staphylococcus aureus Skin Infections"
8:20 pm - 8:25 pm
Discussion
8:25 pm - 8:45 pm
"Growth of S. aureus Using Amino Acids as a Carbon Source"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:00 pm
"Staphylococcus aureus Scavenging of Host Cysteine and Methionine Synthesis Intermediates Satisfies the Nutrient Sulfur Requirement"
9:00 pm - 9:05 pm
Discussion
9:05 pm - 9:15 pm
"Regulation of S. aureus SrrB: A Two-Component System at the Interface of Metabolism and Virulence"
9:15 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Signaling and Gene Regulation in Staphylococci
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
"Secreted Proteases Have a Biphasic Impact on S aureus Pathogenesis"
9:25 am - 9:35 am
Discussion
9:35 am - 9:55 am
"Mechanistic Basis of Staphylococcal Interspecies Competition for Skin Colonization"
9:55 am - 10:05 am
Discussion
10:05 am - 10:25 am
"Deciphering Signaling Regulation of Ceftaroline Resistance in MRSA and Implications for Treatment"
10:25 am - 10:35 am
Discussion
10:35 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"(p)ppGpp - Key Players in S. aureus GTP Homeostasis, Long-Term Viability and Infection"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
"Host Signals that Regulate Staphylococcus aureus Virulence in the Skin"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
"Airway Immunometabolites Drive S. aureus Adaptation by Targeting Global Transcriptional Regulators"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"?Sa3 Prophage as a Molecular Regulatory Switch of Staphylococcus aureus ß-toxin Production"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Single-Cell RNA Sequencing of Staphylococcus aureus Biofilm Captures Transcriptionally Diverse Subpopulations"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Host-Pathogen Interactions
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:55 pm
"A Toxic Relationship: Candida-Staphylococcus Cross-Kingdom Interactions Shape Virulence"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"S. aureus Drives Itch and Skin Damage Through a V8 Rotease-PAR1 Axis"
8:20 pm - 8:25 pm
Discussion
8:25 pm - 8:45 pm
"Antibodies and Complement in Human Immunity Against Staphylococci"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:10 pm
"Cell Wall Shock and the Adaptation of S. aureus to the Bloodstream"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:30 pm
General Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Immune Responses to Staphylococcal Infections
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
"Staphylococcal Survival in Kupffer Cells: Molecular Mechanism and Implications for Bloodstream Infections"
9:25 am - 9:35 am
Discussion
9:35 am - 9:55 am
"Allergic to Staphylococcus aureus ?"
9:55 am - 10:05 am
Discussion
10:05 am - 10:25 am
"Understanding How S. aureus Shapes Host Immunity During Asymptomatic Colonization and the Broader Consequences of This for the Host"
10:25 am - 10:35 am
Discussion
10:35 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Mechanisms of Staphylococcal Interference with S. aureus Vaccines"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
"TSST-1 Promotes Staphylococcus aureus Vaginal Colonization Through the Reduction of Pro-Inflammatory Signals"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
"Modeling Staphylococcus aureus Nasal Colonization on Human Nasal Organoids (HNOs)"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Talk Selected from GRS
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Talk Selected from GRS
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Genomics and Molecular Epidemiology of Staphylococcal Disease
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:55 pm
"Molecular Dissection of the Host-Adaptive Evolutionary History of Staphylococcus aureus "
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"S. aureus Genome Diversity at Different Evolutionary Scales"
8:20 pm - 8:25 pm
Discussion
8:25 pm - 8:45 pm
"Evolution and Epidemiology of S. aureus : Horizontal Gene Transfer in Action"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:10 pm
"Strategies of Adaptation to a Pathogenic Lifestyle of the Commensal Skin Bacterium Staphylococcus epidermidis "
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:30 pm
General Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Clinical Staphylococcal Disease
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
"Live Imaging of Alveolar Responses to Influenza that Promote Secondary Staphylococcal Lung Infection"
9:25 am - 9:35 am
Discussion
9:35 am - 9:55 am
"S. aureus Adaptation During Infection"
9:55 am - 10:05 am
Discussion
10:05 am - 10:25 am
"Preventing Staphylococcus aureus Colonization and Infections in Critically Ill Neonates"
10:25 am - 10:35 am
Discussion
10:35 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Epidemiology of Pediatric S. aureus Disease"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
"Staphylococcus aureus : Localization and Responses to Antibiotics in Human Patients"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
"Clonal Transmission and Recurrence of Methicillin-Resistant Staphylococcus aureus Causing Bloodstream Infections in Hospitalized Adults Detected Using Whole Genome Sequencing"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Investigating the Spatiotemporal Regulation of Staphylococcus aureus Virulence Factor Expression During Kidney Infection"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Probiotic for Pathogen-Specific Staphylococcus aureus Decolonization: A Phase 2, Double-Blind, Randomized, Placebo-Controlled Trial"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
7:30 pm - 7:40 pm
"Mechanisms of T-Cell Immunity to Staphylococcus aureus "
7:40 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
"Human OTULIN Haploinsufficiency Impairs Cell-Intrinsic Immunity to Staphylococcal Alpha-Toxin"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:10 pm
"RNA Modifications Modulate Staphylococcus aureus Responses to Stress and Toxin Production"
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:25 pm
"SSR42 is a Regulatory RNA that Governs Proteolysis, Hemolysis and Cytolysis in Staphylococcus aureus "
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:40 pm
"Staphylococcus epidermidis Clones Express Staphylococcus aureus -type Wall Teichoic Acid to Shift from a Commensal to Pathogen Lifestyle"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
"Sialic Acid Cross-Feeding and Quorum Sensing Dysfunction Synergize to Enhance Staphylococcus aureus Chronic Lifestyle"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
"Staphylococcal Superantigens can Promote Persistence During Chronic Orthopedic Infection"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Prophage-Encoded Methyltransferase Increases Community-Acquired Methicillin-Resistant Staphylococcus aureus Virulence Through Fibronectin Binding Protein A"
9:25 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure
