Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: Complex Substrates and Complex Products
7:40 pm - 8:25 pm
"A Radical Approach to Asymmetric Synthesis"
8:25 pm - 8:35 pm
Discussion
8:35 pm - 9:20 pm
"Asymmetric Catalysis at the Interface of Enzymes and Small Molecules"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
9:00 am - 9:35 am
"Harnessing Non-Covalent Interactions for Stereochemical Control"
9:35 am - 9:45 am
Discussion
9:45 am - 10:20 am
"Toward Catalytic Control of Photoinduced Radical Reactions"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:35 am
"Harnessing Radicals and Carbenes (Asymmetrically)"
11:35 am - 11:45 am
Discussion
11:45 am - 12:20 pm
"Geometric and Stereocontrol Enabled by Boron"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
7:30 pm - 8:00 pm
"Exploring New Reaction Pathways for Photochemical Deracemization"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
"Light-Driven Asymmetric Catalysis"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
"The Design of Enantioselective Photocatalysis"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Stereochemistry in Pharma
9:00 am - 9:35 am
"Strategies for Controlling Stereochemistry in the Development of Innovative Pharmaceuticals"
9:35 am - 9:45 am
Discussion
9:45 am - 10:20 am
"Photochemical Alkene Isomerization from Lab to Multi-Kg Scale in Flow"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:35 am
"Innovation in the Synthesis of Complex Pharmaceuticals"
11:35 am - 11:45 am
Discussion
11:45 am - 12:20 pm
"Enabling Technologies to Drive Stereochemistry in the Merck Portfolio"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Sugars: The Perennial Frontier
7:30 pm - 8:00 pm
"Carbohydrates as Substrates for Catalysis: Stereoselective and Site-Selective Transformations"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
"A New Roadmap for Automated Glycan Synthesis in the Age of Artificial Intelligence"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
"Chemical Probes of Glycan Biosynthesis and Recognition"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
9:00 am - 9:35 am
"Leveraging Modern Asymmetric Catalysis for the Development of Stereoselective and Stereoconvergent Polymerization Methods"
9:35 am - 9:45 am
Discussion
9:45 am - 10:20 am
"Stereochemical Control in Macromolecular Synthesis: Asset or Liability?"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:35 am
"Stereocontrolled Synthesis of Macromolecular Silanes"
11:35 am - 11:45 am
Discussion
11:45 am - 12:20 pm
"Stereoelectronic Effects on Protein Structure"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Transition Metals in Stereochemistry
7:30 pm - 8:00 pm
"Selective C-H Functionalizations Guided by Non-Bonding Interactions"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
"Wakening Pd(OAc)2 for C-H Activation through Bifunctional Ligands: From Curiosity to Industrialization"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
"Radical and Polar(izing) Methods for C(sp3)–H Cross-Coupling"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
9:00 am - 9:15 am
"Single-Atom Chiral Profiling of the Mitochondrial Proteome Enabled by Chiral Oxaziridine Probes"
9:15 am - 9:20 am
Discussion
9:20 am - 9:35 am
"Deoxyfluorination of 1º, 2º, and 3º Alcohols by Nonbasic O–H Activation and Lewis Acid-Catalyzed Fluoride Shuttling"
9:35 am - 9:40 am
Discussion
9:40 am - 10:20 am
"Deciphering the Human Microbiome with Chemistry"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:35 am
"New Strategies for Stereoselective Radical Biocatalysis"
11:35 am - 11:45 am
Discussion
11:45 am - 12:20 pm
"A Radical Solution for C(sp3)–C(sp3) Bond Formation During the Biosynthesis of Macrocyclic Membrane Lipids"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Keynote Session: Mechanistic Frontiers in Stereochemistry
7:30 pm - 8:20 pm
"Data Science Meets Asymmetric Catalysis"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 9:20 pm
"Models for the Origin of Biological Homochirality"
9:20 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure