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Stochastic Physics in Biology

Gordon Research Conference

Information Processing in Noisy Biological Systems

October 10 - 15, 2021

Chair

Vice Chair

Four Points Sheraton / Holiday Inn Express

1050 Schooner Drive

Ventura, California, United States

Venue and Travel Information

Conference Description

Biological systems need to process information accurately with noisy components and stochastic chemical reactions, and in fluctuating environments. How do we quantify these different noise sources? What are the origins of the different noises? How do biological systems overcome these different levels of noises to carry out their normal functions in particular information processing? On the other hand, biological diversity is needed to improve fitness of a population in changing environment. Whether and how do biological systems take advantage of and control their intrinsic variability to improve the population level fitness? These are some of the questions we will focus on to address in this Gordon Research Conference.

Related Meeting

This GRC will be held in conjunction with the "Stochastic Physics in Biology" Gordon Research Seminar (GRS). Those interested in attending both meetings must submit an application for the GRS in addition to an application for the GRC. Refer to the associated GRS program page for more information.

Conference Program

Sunday
4:00 pm - 8:00 pm	Arrival and Check-in
6:00 pm - 7:00 pm	Dinner
7:30 pm - 7:40 pm	Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm	Machine Learning and Data Driven Analysis in Biology Discussion Leader:
7:40 pm - 8:00 pm	"Harnessing Peak Transmission Around Symptom Onset for Non-Pharmaceutical Intervention and Containment of the COVID-19 Pandemic"
8:00 pm - 8:10 pm	Discussion
8:10 pm - 8:30 pm	"Insight into Protein Allostery from Persistent Homology"
8:30 pm - 8:40 pm	Discussion
8:40 pm - 9:00 pm	"AI-Driven Design of Biological Systems"
9:00 pm - 9:10 pm	Discussion
9:10 pm - 9:25 pm	"Using Interpretable Machine Learning to Decipher the Determinants of Exon Inclusion"
9:25 pm - 9:30 pm	Discussion
Monday
7:30 am - 8:30 am	Breakfast
8:30 am - 9:00 am	Group Photo
9:00 am - 12:30 pm	Nonequilibrium Physics in Active Living Systems Discussion Leader:
9:00 am - 9:25 am	"Cytoskeletal Energetics and Energy Metabolism"
9:25 am - 9:35 am	Discussion
9:35 am - 10:00 am	"Active Matter and Transport in Living Cells"
10:00 am - 10:10 am	Discussion
10:10 am - 10:20 am	"Active Folding via Bilayer Morphogenesis In Vivo"
10:20 am - 10:25 am	Discussion
10:25 am - 10:55 am	Coffee Break
10:55 am - 11:20 am	"Shear-Driven Solidification and Nonlinear Elasticity in Epithelial Tissues"
11:20 am - 11:30 am	Discussion
11:30 am - 11:55 am	"The Maximum Caliber Principle for Modeling Stochastic Dynamics"
11:55 am - 12:05 pm	Discussion
12:05 pm - 12:15 pm	"Stochastic Physics of Stator Assembly in the Bacterial Flagellar Motor"
12:15 pm - 12:20 pm	Discussion
12:20 pm - 12:30 pm	General Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
3:00 pm - 4:00 pm	The GRC Power Hour™ The GRC Power Hour™ is designed to address challenges women face in science and issues of diversity and inclusion. The program supports the professional growth of all members of our communities by providing an open forum for discussion and mentoring. Organizer:
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Noise in Gene Expression and Cellular Systems Discussion Leader:
7:30 pm - 7:50 pm	"Multicellular Circuit Design"
7:50 pm - 8:00 pm	Discussion
8:00 pm - 8:20 pm	"Multiple Timescales in Bacterial Growth Homeostasis"
8:20 pm - 8:30 pm	Discussion
8:30 pm - 8:50 pm	"Bacterial Replication Initiation as a Tractable Problem for Deriving Principles of Precision Control in Biology"
8:50 pm - 9:00 pm	Discussion
9:00 pm - 9:10 pm	"A DNA-Repair Pathway Controls Transcriptional Noise to Promote Cell-Fate Transitions"
9:10 pm - 9:15 pm	Discussion
9:15 pm - 9:25 pm	"Protein Concentration Fluctuations in the High Expression Regime"
9:25 pm - 9:30 pm	Discussion
Tuesday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Information Processing in Neuroscience and Immunology Discussion Leader:
9:00 am - 9:20 am	"The Search for Neural Computational Primitives"
9:20 am - 9:30 am	Discussion
9:30 am - 9:50 am	"Online Learning in Networks of Neurons Constrained by Data"
9:50 am - 10:00 am	Discussion
10:00 am - 10:20 am	"Towards Lossless Transformation of Neural Responses"
10:20 am - 10:30 am	Discussion
10:30 am - 11:00 am	Coffee Break
11:00 am - 11:10 am	"Dynamics of Drifting Receptive Fields During Noisy Representation Learning"
11:10 am - 11:15 am	Discussion
11:15 am - 11:35 am	"Physical Constraints and Driving Forces of Adaptive Immunity"
11:35 am - 11:45 am	Discussion
11:45 am - 12:05 pm	"Immune Memory Strategies in Light of Host-Pathogen Coevolution"
12:05 pm - 12:15 pm	Discussion
12:15 pm - 12:25 pm	"Peering into the Antibody Repertoire: Functionally Characterizing Individual Antibodies Within Polyclonal Mixtures"
12:25 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Stochastic Physics in Cancer Biology Discussion Leader:
7:30 pm - 7:50 pm	"Epigenetic Effects on the Epithelial-Mesenchymal Transition"
7:50 pm - 8:00 pm	Discussion
8:00 pm - 8:20 pm	"Physics Approaches to the Spatial Distribution of Immune Cells in Tumors"
8:20 pm - 8:30 pm	Discussion
8:30 pm - 8:50 pm	"Roles of Tumor Microenvironment in Tumor Cell Heterogeneity"
8:50 pm - 9:00 pm	Discussion
9:00 pm - 9:20 pm	"Non-Gaussian Statistics in Biological Systems"
9:20 pm - 9:30 pm	Discussion
Wednesday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Information Processing in Cellular Systems Discussion Leader:
9:00 am - 9:20 am	"Scaling in Drosophila Embryogenesis"
9:20 am - 9:30 am	Discussion
9:30 am - 9:50 am	"Dimensionality Reduction and Network Adaptation in Biochemical Signaling"
9:50 am - 10:00 am	Discussion
10:00 am - 10:10 am	"Robust, Coherent and Synchronized Circadian Clock-Controlled Oscillations Along Multicellular Cyanobacterial Filaments"
10:10 am - 10:15 am	Discussion
10:15 am - 10:25 am	"Noisy Circadian Clocks Gate Cell Division in Anabaena"
10:25 am - 10:30 am	Discussion
10:30 am - 11:00 am	Coffee Break
11:00 am - 11:20 am	"A Unicellular Walker Embodies a Finite State Machine"
11:20 am - 11:30 am	Discussion
11:30 am - 11:50 am	"Segmentation Clock Gene Pairing Drives Robust Pattern Formation"
11:50 am - 12:00 pm	Discussion
12:00 pm - 12:10 pm	"Physics of Flow Sensing in Cancer Metastasis"
12:10 pm - 12:15 pm	Discussion
12:15 pm - 12:25 pm	"Principles of Gene Regulation Quantitatively Connect DNA to RNA and Proteins in Bacteria"
12:25 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:00 pm - 7:30 pm	Business Meeting Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm	Dynamics of Evolution and Ecology Discussion Leader:
7:30 pm - 8:00 pm	"Drift, Mutation and the Origin of Cellular Features"
8:00 pm - 8:15 pm	Discussion
8:15 pm - 8:45 pm	"Stress-Induced Cross-Feeding Provides a Dynamic Mechanism of Microbial Cooperation"
8:45 pm - 9:00 pm	Discussion
9:00 pm - 9:10 pm	"A Computational Model of Fractal Interface Formation in Bacterial Biofilms"
9:10 pm - 9:15 pm	Discussion
9:15 pm - 9:25 pm	"Reconstructing the Evolutionary Dynamics of Liposarcoma"
9:25 pm - 9:30 pm	Discussion
Thursday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Cellular Metabolism and Ageing Discussion Leader:
9:00 am - 9:20 am	"Gene Expression and Noise Dynamics During Single-Cell Aging"
9:20 am - 9:30 am	Discussion
9:30 am - 9:50 am	"Single Cell Aging from a Dynamic System's Perspective"
9:50 am - 10:00 am	Discussion
10:00 am - 10:20 am	"Towards Quantitative Models of Metabolism Regulation"
10:20 am - 10:30 am	Discussion
10:30 am - 11:00 am	Coffee Break
11:00 am - 11:20 am	"Mitochondrial Metabolic Checkpoint, Stem Cell Aging and Rejuvenation"
11:20 am - 11:30 am	Discussion
11:30 am - 11:50 am	"Harnessing A.I. and Robotics to Accelerate Longevity Drug Discovery"
11:50 am - 12:00 pm	Discussion
12:00 pm - 12:10 pm	"A Coarse-Grained NADH Redox Model Enables Inference of Subcellular Metabolic Fluxes from Fluorescence Lifetime Imaging"
12:10 pm - 12:15 pm	Discussion
12:15 pm - 12:25 pm	"Is Aging Accompanied By 'Biological Wisdom'?"
12:25 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Phase Separation and Macromolecular Assembly in Biology Discussion Leader:
7:30 pm - 7:50 pm	"Bacteria Stabilize Transcriptional Condensates During Acid Stress"
7:50 pm - 8:00 pm	Discussion
8:00 pm - 8:20 pm	"Multi-Cellular Phase Separation: Clustered Cooperating Macrophages Engulf Solid Tumors and Initiate Anti-Cancer Immunity"
8:20 pm - 8:30 pm	Discussion
8:30 pm - 8:50 pm	"Chromosomal Organization in Space and Time"
8:50 pm - 9:00 pm	Discussion
9:00 pm - 9:10 pm	"At the Interface of Phase Separation: Simple Mechanisms for Complex RNA Processing"
9:10 pm - 9:15 pm	Discussion
9:15 pm - 9:25 pm	"Optimizing Against Kinetic Trapping in Hetero- and Homo-Subunit Protein Assemblies"
9:25 pm - 9:30 pm	Discussion
Friday
7:30 am - 8:30 am	Breakfast
9:00 am	Departure

Contributors

Conference Links

Conference History Stochastic Physics in Biology (GRS)

Registration Fees Additional Fee Info

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