Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Insights into Pathogen and Host Biology
7:40 pm - 7:50 pm
Introduction by Discussion Leader
7:50 pm - 8:15 pm
"Origins of the Enterococci and Streptococci, and What They Infer About Their Biology"
8:15 pm - 8:25 pm
Discussion
8:25 pm - 8:50 pm
"Why Strep are the Best (and by Best I Mean Worst) Pathogens"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
"Arachnoid Barrier Breakdown during GBS-Mediated Meningitis Infections"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Heterogeneous Single Cell Responses Underlie Host-Pathogen Signaling During Pneumococcal Infection"
9:25 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Evolution of Genomes: From Genomics to Function
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:35 am
"Translating Observations from Streptococcal Surveillance into Knowledge About Disease Pathogenesis"
9:35 am - 9:45 am
Discussion
9:45 am - 10:10 am
"Streptococcal Evolution - The Role of Frequency Dependent Selection on the Accessory Genome"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:15 am
"The Ecological Shift to Increased Virulence and Zoonosis in Streptococcus suis "
11:15 am - 11:25 am
Discussion
11:25 am - 11:50 am
"Evolution and Transmission Dynamics of Streptococcal Pathovars"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Examining Nasopharyngeal Carriage by GAS Strains in Patient Samples"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"A Functional Pan-Genome Study of Streptococcus pneumoniae Reveals Which Genes Are Species-wide or Strain-dependent Required for a Successful Host Infection"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hourâ„¢
The GRC Power Hourâ„¢ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Regulation and Virulence Mechanisms
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:00 pm
"How Pneumococcus Overcomes Copper Stress at the Host Pathogen Interface"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:35 pm
"Streptococcus pneumoniae Mediated Histone Modifications and Lasting Impact"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 9:05 pm
"Virulence Regulation in Group A Streptococcus"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Circadian Regulation of Host Response to Streptococcus pneumoniae"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Host-Pathogen Interactions and the Fight for Survival
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:35 am
"Why Are Invasive Streptococcus pyogenes Infections So Difficult to Treat?"
9:35 am - 9:45 am
Discussion
9:45 am - 10:10 am
"Therapeutic Potential of a Novel P-type ATPase that Protects Streptococcus mutans from Zinc Intoxication"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Group Photo / Coffee Break
10:50 am - 11:15 am
"GBS and Intestinal Immunity – A Balancing Act"
11:15 am - 11:25 am
Discussion
11:25 am - 11:50 am
"Antibody Hydrolyzing Enzymes from Pathogenic Streptococci - in Virulence, as Drugs, and in Biotechnology"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"A Novel Pathogenic Mechanism for Streptococcus gallolyticus – Type VII Secretion, Host Receptor, and Role in Colorectal Cancer"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"The Effect of FXIIIA in Group B Streptococcal Infections"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
At the Surface of the Bacterial-Host Encounter
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:00 pm
"The Contributions of Peptides and Vesicles to the Pneumococcal Social Network"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:35 pm
"Alveolar Glycosaminoglycan Shedding Mediates Post-Viral Secondary Bacterial Pneumonia"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 9:05 pm
"Causes and Consequences of Candida-GBS Interactions"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Streptococcus mutans Membrane-localized Chaperone/Insertases, YidC1 and YidC2, Differ in Their Interactions with Anionic Phospholipids"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Interactions Within the Microbial Community
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:35 am
"Picking Sides: Microbe-Microbe Interactions in the Human Nose"
9:35 am - 9:45 am
Discussion
9:45 am - 10:10 am
"Secondary Metabolites from Human Microbiome Streptococci"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:15 am
"Group B Streptococcus and the Vaginal Microenvironment"
11:15 am - 11:25 am
Discussion
11:25 am - 11:50 am
"Mechanisms of Interaction Between Enterococci and Clostridioides difficile During Infection"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Airway Prevotella Promote TLR2-Dependent Neutrophil Activation and Rapid Clearance of Streptococcus pneumoniae from the Lung"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Direct Imaging of Dual-species Streptococcus mutans & Streptococcus gordonii Biofilms Grown Under Simulated Microgravity"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 5:30 pm
Poster Session
5:30 pm - 7:30 pm
Phage and Mobile Genetic Elements
5:30 pm - 5:40 pm
Introduction by Discussion Leader
5:40 pm - 6:05 pm
"Enterococcal CRISPR-Cas Defense Against Conjugative Plasmids"
6:05 pm - 6:15 pm
Discussion
6:15 pm - 6:40 pm
"Broadening Phage Horizons: Co-evolution of Bacteriophage Infecting Enterococcus"
6:40 pm - 6:50 pm
Discussion
6:50 pm - 7:05 pm
"Prophage Integration into CRISPR Loci Enables Evasion of Antiviral Immunity in Streptococcus pyogenes "
7:05 pm - 7:15 pm
Discussion
7:15 pm - 7:25 pm
"Pheromone Responsive Plasmid pCF10 Increases Hydrogen Peroxide Resistance and Remodels Enterococcus faecalis Biofilms to Produce Heterologous Rigid Structures and Microaggregates"
7:25 pm - 7:30 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Evolving Therapeutic Approaches and Methodologies
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:35 am
"Conjugate Vaccine Development for the Prevention of Streptococcal Diseases: Evolving Approaches"
9:35 am - 9:45 am
Discussion
9:45 am - 10:10 am
"One Small Strep for Man: Dispatches from the Experimental Human Infection Frontier"
10:10 am - 10:20 am
Discussion
10:20 am - 10:55 am
Coffee Break
10:55 am - 11:10 am
"Enterococcus faecalis Zinc and Manganese-binding Lipoproteins as Candidates for the Development of Protein-Based Enterococcal Vaccine"
11:10 am - 11:20 am
Discussion
11:20 am - 11:45 am
"Host-directed Interventions Against Pneumococcal Infection: The Role of Extracellular Adenosine Signaling"
11:45 am - 11:55 am
Discussion
11:55 am - 12:20 pm
"Effects of Nasal Administration of Live Attenuated Streptococcus pneumoniae in a Human Infection Challenge Model"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Early-Career Investigator Presentations
7:30 pm - 7:40 pm
"Heterogeneity of the Group B Streptococcal Type VII Secretion System and Impact on Colonization and Infection"
7:40 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
"A Novel Protein in Streptococcus Agalactiae, BvaP, is the Target for Vaccination"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:10 pm
"Unsaturated Fatty Acids Mediate Tolerance of Oxidative and Acid Stresses in Lactobacillales"
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:25 pm
"Genomic Profiling Reveals Novel Routes to Complement Evasion in Streptococcus Pneumoniae"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:40 pm
"Mechanisms of Group B Streptococcal Pathogenesis in the Diabetic Wound Environment"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
"RofA: A PRD-Containing Virulence Regulator Connecting Sugar Utilization to Virulence Regulation in Group A Streptococcus"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
"Through the SpyGLASS: Visualizing 100 Years of Genomic Evolution of M1 S. Pyogenes with a New Interactive Web App"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Identifying the Mechanism of Direct Binding Between Streptococcus Pneumoniae and Influenza"
9:25 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure