Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Clinical Findings that Indicate the Significance of Streptococcal Infections
7:40 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:15 pm
"Group A Strep: Extreme Clinical and Epidemiological Phenotypes"
8:15 pm - 8:25 pm
Discussion
8:25 pm - 8:50 pm
"Effect of Influenza on Group A Streptococci in the Upper Respiratory Tract"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
"Group B Streptococcus Glycolipids During Pathogenesis"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Understanding and Exploiting Group A Streptococcal Anti-Chemotactic Proteases in Vaccines for Infection"
9:25 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Approaches in Microbiology and Infection Biology
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
"Characterizing Individual Host-Pathogen Encounters at Early Stages of Infection"
9:30 am - 9:40 am
Discussion
9:40 am - 10:05 am
"Using CRISPR Interference to Study Group B Streptococcus Perinatal Infections"
10:05 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 11:05 am
"NK Cells Sense and are Transcriptionally Reprogramed Following Streptococcus Pneumoniae Infection"
11:05 am - 11:15 am
Discussion
11:15 am - 11:35 am
"Techniques for Analyzing Single Cell Behaviors of Streptococci within Biofilm Populations"
11:35 am - 11:45 am
Discussion
11:45 am - 12:05 pm
"Application of mRNA Technology to Group A Streptococcal Vaccine Development"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Host-Extracellular Vesicles in Pneumococcal Infections- Small Entities With Big Impact"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hourâ„¢
The GRC Power Hourâ„¢ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Rise of the Resistance: Evolution, Phages and Mobile Genetic Elements
7:30 pm - 7:55 pm
"Combining Antibiotic and Host-Directed Biologic in Pneumococcal Pneumonia: Impact on Efficacy and Antibiotic Resistance"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:30 pm
"Antibiotic Cartography for the Visualization and Analyses of Beta-Lactam Resistance in Streptococci"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 8:55 pm
"Understanding the Mechanism of a Programmed Cell Growth Arrest During Competence for Transformation in Streptococcus Pneumoniae "
8:55 pm - 9:05 pm
Discussion
9:05 pm - 9:20 pm
"Plasmid-Encoded Bacteriolysin Promotes Horizontal Gene Transfer"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Host-Pathogen Interactions and Cellular Heterogeneity
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
"The Oxidation of Hemoproteins Facilitates Encapsulation of Pneumococci in the Lung"
9:30 am - 9:40 am
Discussion
9:40 am - 10:05 am
"Conserved 3D Patterns in M Proteins as Strep A Vaccine Immunogens"
10:05 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 11:05 am
"Stress Adaptation During Streptococcal Infections and Early Detection"
11:05 am - 11:15 am
Discussion
11:15 am - 11:35 am
"Immune Activation by the Group A Streptococcus Protease Virulence Factor SpeB"
11:35 am - 11:45 am
Discussion
11:45 am - 12:05 pm
"Human Genetic Determinants of Invasive Group A Streptococcal Host-Pathogen Interactions"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"A Skin-Deep Interaction? A Zinc-Modulated Effector of Skin and Soft Tissue Infection"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Insights from Commensal Streptococci and Other Lactic Acid Bacteria
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:00 pm
"Disorder Regulates Homeostasis of Extracytoplasmic Proteins in Streptococci"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:35 pm
"Probing Oral Biofilms by Small Molecules"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 9:05 pm
"Crosstalk Between Commensal Streptococci and Streptococcus Pneumoniae"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"A Pentavalent Vaccine Targeting Surface Adhesins and Metal-Binding Lipoproteins Confers Robust Protection Against Enterococcal Infections"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Essential Cell Biology of Streptococci
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
"Click and Collect in the Wall: Streptococcal Division at the Nanoscale"
9:30 am - 9:40 am
Discussion
9:40 am - 10:05 am
"Reverting Antibiotic Resistance in Streptococcus Pneumoniae: Targeting the Mevalonate Pathway to Potentiate Amoxicillin"
10:05 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 11:05 am
"Transcriptomic Overlap Between Fructose Metabolism and Methylglyoxal-Mediated Response in Streptococcus Mutans"
11:05 am - 11:15 am
Discussion
11:15 am - 11:35 am
"The Role of the Proteins Acetyltranferase SktA in Streptococcus Gordonii Physiology"
11:35 am - 11:45 am
Discussion
11:45 am - 12:05 pm
"Capsular Polysaccharide Structure Impacts S. Pneumoniae Surface Determinant Exposure"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Daptomycin Tolerance in Vancomycin-Resistant Enterococcus Faecium from Patients with Recurrent Bloodstream Infections"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Therapeutics and Host Responses
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:00 pm
"Pneumococcus Reveals an Innate Developmental Pathway Regulating Neuronal Proliferation"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:30 pm
"Discovery and Engineering of Protective Human Monoclonal Antibodies Against Group A Streptococci"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 8:50 pm
"Arginine-Induced Changes in Gene Expression and Biofilm Formation in Enterococcus Faecalis "
8:50 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
"Why a Commensal Misbehaves"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Streptococcal Ecology and Genomics
9:00 am - 9:25 am
"Experimental Evolution of S. Pneumoniae in Mice Defines Causes of Tissue Tropism, Drug Tolerance, and Immune Evasion"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
"Phage Strategies for Host Manipulation and Evasion of Recombination in Pneumococci"
10:00 am - 10:10 am
Discussion
10:10 am - 10:40 am
Coffee Break
10:40 am - 11:00 am
"Recombinational Exchange of M-Fibril and T-Pilus Genes Generates Extensive Cell Surface Diversity in the Global Group A Streptococcus Population "
11:00 am - 11:10 am
Discussion
11:10 am - 11:25 am
"Diet as a Tool to Understand Group B Streptococcus Gastrointestinal Colonization"
11:25 am - 11:35 am
Discussion
11:35 am - 11:55 am
"Genetic Diversity and Adaptation within Streptococcus Pyogenes Populations"
11:55 am - 12:05 pm
Discussion
12:05 pm - 12:20 pm
"GBS Navigation of Oxidative Stress in the Reproductive Tract"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Keynote Session: Gene Regulation and Systems Biology
7:30 pm - 8:00 pm
"The Fight for Survival by Group B Streptococcus in the Diabetic Wound: Finding the Sweet Spot"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:15 pm
Introduction by Discussion Leader
8:15 pm - 8:25 pm
"Multiomics Profiling of Pneumococcal Niche Adaptation Identifies Unconventional Carbon Catabolite Repression and a Membrane Composition Regulator"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:40 pm
"Neonatal Colonization by Clostridioides Difficile Promotes Translocation of GBS and Enterococci"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
"Identifying the Mechanisms of Group B Streptococcus Heme Homeostasis Using Library Screening Approaches"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
"E. faecalis Overcomes Iron Starvation Through Cooperation of 5 Iron Transporters and Heme Degradation by RS05575"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Candida Albicans Triggers Virulence Programming in Group B Streptococcus"
9:25 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure