Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
7:40 pm - 7:50 pm
Opening Remarks
7:50 pm - 8:10 pm
"Interventions that Slow Aging"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:40 pm
"Drugs and Mutations that Slow Aging in Mice"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:10 pm
"Somatic Mutations and Clonal Expansions in Ageing"
9:10 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Epigenetic Reprogramming and Rejuvenation
9:00 am - 9:20 am
"Understanding and Manipulating In Vivo Reprogramming and Its Effects on Aging"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Transient Reprogramming for Multifaceted Reversal of Aging"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
"Reprogramming Strategies to Restore Youthful Gene Expression"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"DNA Methylation Landscapes in Aging and Reprogramming"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
"Reprogramming to Recover Youthful Epigenetic Information and Restore Vision"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
"Multi-Omic Rejuvenation of Human Cells by Maturation Phase Transient Reprogramming"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hourâ„¢
The GRC Power Hourâ„¢ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
7:30 pm - 7:50 pm
"Integrated Approaches to Characterizing the Polygenic Basis of Longevity"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Technologies for Mapping and Controlling Aging-Related Processes"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"Using Pooled In Vivo Perturbation Screens to Understand How Aging Mechanisms Manifest Across Tissues and Cell Types"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"Identification and Functional Characterization of Genetic Variants Linked to Human Longevity"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
9:00 am - 9:10 am
"Rejuvenome: Toward a Functional and Multiomics Understanding of Aging and Rejuvenation"
9:10 am - 9:15 am
Discussion
9:15 am - 9:25 am
"Misexpression of Genes Lacking CpG Islands is a Shared Trait of Mammalian Aging"
9:25 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Comparing Epigenetic Clocks, Proteins and Protein Epigenetic Scores for Disease Prediction"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
"Universal DNA Methylation Age Across Mammalian Tissues"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Repurposing Drugs for Geroprotection in Human Cohorts"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
"TIME-Seq Enables Inexpensive and Scalable Epigenetic Age Predictions for Large Studies in Mice and Humans"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
"Rejuvenome: Toward a Functional and Multiomics Understanding of Aging and Rejuvenation"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Clinical and Molecular Biomarkers
7:30 pm - 7:50 pm
"Air Pollution and Accelerated Aging: The Role of Epigenetic Aging Biomarkers in Environmental Health"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Modulating DNA Repair for Healthy Ageing"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"Targeting Aging Directly"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"Molecular Signatures of Aging and Extreme Old Age"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Artificial Intelligence and Machine Learning
9:00 am - 9:20 am
"Construction and Analysis of the Physiology Clock for Human Aging"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Applications of Deep Aging Clocks in Clinical Practice"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
"Data-Informed Drug Discovery for Aging: From Human Omics to Clinical Trials"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"The Dark Matter of Nutrition: From the Foodome to Network Medicine"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
"Quantifying Changes in Expression State and Variability in Single-Cell Sample Panels"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
"Artificial Intelligence and Machine Learning for Cognitive Aging: Novel Diagnosis and Precision Intervention"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Insights into Biological Aging from Longitudinal Multi-Omics Monitoring of Thousands of People"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Aging as a Systemic Process
7:30 pm - 7:50 pm
"Systemic Understanding Lysosomal Signals in Longevity Regulation"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Mitochondrial Metabolic Checkpoint, Stem Cell Aging and Rejuvenation"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:40 pm
"Time to Live Healthier and Longer? The Tale of Mice on Time-Restricted Feeding"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
"Transcripts and Proteins Reveal Distinct Tissue-Specific Features of Aging"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
"In vivo Perturb-seq: Scalable Genetic Screen in Brain Disease and Aging"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Age-associated Changes in Lineage Composition of the Enteric Nervous System Regulate Gut Health and Disease"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Comparative Genomics of Aging
9:00 am - 9:20 am
"Omics Signatures of Longevity Across Species"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Genetic Basis of Exceptional Longevity of Bats"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
"Integrative Genomics of Ageing: New Approaches for an 'Old' Problem"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:10 am
"Exploring the Evolution of Exceptional Mammalian Traits at Single Base Resolution"
11:10 am - 11:15 am
Discussion
11:15 am - 11:25 am
"Smart Tanks: a Scalable Platform for Rapid Phenotype-Based Intervention Testing"
11:25 am - 11:30 am
Discussion
11:30 am - 11:40 am
"Mechanisms of Mutational Processes Operative in Cancer and Aging"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
"Targeting Iron Homeostasis to Promote Longer Lifespan"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"The Study of Muscle Mobility and Aging (SOMMA) - a Resource for Studying the Biology of Human Aging"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Dissecting Cellular Senescence and Cell Death with Genetic Screens"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 5:30 pm
Poster Session
5:30 pm - 7:30 pm
Fundamental Bases of Aging
5:30 pm - 5:50 pm
"The Relationship Between Hallmarks of Aging and Epigenetic Aging"
5:50 pm - 6:00 pm
Discussion
6:00 pm - 6:20 pm
"A System Biology Perspective on Genetic Variation and Aging"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:40 pm
"Is Aging Accompanied by ‘Biological Wisdom’?"
6:40 pm - 6:45 pm
Discussion
6:45 pm - 6:55 pm
"A Spatiotemporal Map of the Mouse Central Nervous System Reveals White Matter as a Foci of Brain Aging"
6:55 pm - 7:00 pm
Discussion
7:00 pm - 7:10 pm
"Defining the Aging Trajectories of Single Cells and Complex Tissues Using Novel Live Sensors of Cellular Age"
7:10 pm - 7:15 pm
Discussion
7:15 pm - 7:25 pm
"Intracellular Lipid Surveillance in Aging"
7:25 pm - 7:30 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure