Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: Molecular Approaches in Age Reversal Research
7:40 pm - 7:50 pm
Introduction by Discussion Leader
7:50 pm - 8:15 pm
"Quantifying Aging, Longevity and Rejuvenation"
8:15 pm - 8:20 pm
Discussion
8:20 pm - 8:45 pm
"Putting The Information Theory of Aging (ITOA) through Its Paces"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:10 pm
"Towards Evidence-Based Precision Healthy Longevity Medicine: Geroprotective Interventions"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Rejuvenation Strategies Based on Lifestyle Interventions in Epidemiological Studies: Addressing Challenges and Exploring Mechanisms"
9:25 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Systems Studies of Animal Models
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:35 am
"Network Analysis[FM([1] of Longitudinal Trajectories in the Study of Longitudinal Aging in Mice: A Systems-Level Approach to Understand Aging"
9:35 am - 9:40 am
Discussion
9:40 am - 10:00 am
"Mouse Genetic Reference Panels for Integrative Genomics: Modeling Human Longitudinal Studies of Aging and Interventions"
10:00 am - 10:05 am
Discussion
10:05 am - 10:35 am
Coffee Break
10:35 am - 10:55 am
"Studying Lifespan Interventions in Short-Lived Giant Mice"
10:55 am - 11:00 am
Discussion
11:00 am - 11:20 am
"In Situ Partial Cardiomyocyte Reprogramming Induces Epigenetic Rejuvenation and Alleviates Cardiac Failure in Aged Mice"
11:20 am - 11:25 am
Discussion
11:25 am - 11:40 am
"Ultraviolet Light Acts as a Dietary Restriction Mimetic by Targeting Mitochondrial Bioenergetics"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
"Aging Rate Indicators: Speedometers for Aging Research"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Biological Age Clocks Predict Health Trajectory and Mortality Risk in Dogs"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Multi-Omic Studies of Aging
6:00 pm - 6:05 pm
Introduction by Discussion Leader
6:05 pm - 6:25 pm
"Inter-Tissue Biological Age Dynamics Revealed by Heterochronic Transplantation"
6:25 pm - 6:30 pm
Discussion
6:30 pm - 6:50 pm
"Investigating the Molecular Mechanics of Epigenetic Rejuvenation"
6:50 pm - 6:55 pm
Discussion
6:55 pm - 7:15 pm
"Acyl Coenzyme A Binding Protein (ACBP): An Aging and Disease-Relevant Autophagy Checkpoint"
7:15 pm - 7:20 pm
Discussion
7:20 pm - 7:35 pm
"Traumatic Brain Injury as a Model of Accelerated Aging to Study Brain Rejuvenation"
7:35 pm - 7:40 pm
Discussion
7:40 pm - 7:55 pm
"A Metabolic Atlas of Aging"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Human Rejuvenation Studies and Clinical Trials
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
"Data Driven Interventions in Human Aging"
9:30 am - 9:35 am
Discussion
9:35 am - 9:45 am
"Effects of Nicotinamide Riboside Supplementation During Acute Illness: A RCT from Oslo University Hospital, Norway"
9:45 am - 9:50 am
Discussion
9:50 am - 10:15 am
"Epigenetic Reprogramming Attenuates Neuronal Aging and Improves Cognitive Performance"
10:15 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:00 am
"Endpoints for Clinical Trials of Geroprotective Treatments: Searching for the Holy Grail"
11:00 am - 11:05 am
Discussion
11:05 am - 11:20 am
"Valuing Life and Health"
11:20 am - 11:25 am
Discussion
11:25 am - 11:45 am
"Harnessing Patient-Derived Organoids as a Cutting-Edge Preclinical Model for Aging Research"
11:45 am - 11:50 am
Discussion
11:50 am - 12:05 pm
"Unifying Geroscience: Comparative Analysis of 100+ DNAm Biomarkers Across 50+ Interventions"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
"Partial Epigenetic Reprogramming: A Novel Gene Therapy That Restores Visual Function and Increases RGC Axon Density in a Nonhuman Primate Model of NAION"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Quantitative Models of Aging
6:00 pm - 6:05 pm
Introduction by Discussion Leader
6:05 pm - 6:15 pm
"Age and Feeding Regime Alters Metabolic Rhythms"
6:15 pm - 6:20 pm
Discussion
6:20 pm - 6:30 pm
"Quantitative Analysis of Cellular Ageing via Nanopillar-Guided Sub-Nuclear Deformation Patterns"
6:30 pm - 6:35 pm
Discussion
6:35 pm - 6:55 pm
"Beyond Clocks: What Drives Age-Related Methylation Dynamics?"
6:55 pm - 7:00 pm
Discussion
7:00 pm - 7:25 pm
"The Genome, Stochasticity, and the Mechanisms of Aging"
7:25 pm - 7:30 pm
Discussion
7:30 pm - 7:55 pm
"Systems Biology of Aging and Compression of Sickspan"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Artificial Intelligence and Multi-Omics
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:35 am
"Measuring Aging with Artificial Intelligence"
9:35 am - 9:40 am
Discussion
9:40 am - 10:05 am
"Building Rejuvenation Therapeutics in the Age of Artificial Intelligence"
10:05 am - 10:10 am
Discussion
10:10 am - 10:40 am
Coffee Break
10:40 am - 11:05 am
"Generative Artificial Intelligence and Next-Generation Robotics for Drug Discovery and Longevity Research"
11:05 am - 11:10 am
Discussion
11:10 am - 11:25 am
"IgG Glycans as Biomarkers and Functional Effectors of Aging and Age-Related Diseases"
11:25 am - 11:30 am
Discussion
11:30 am - 11:45 am
"A Molecular Systems Biology View of Aging in Human Muscle"
11:45 am - 11:50 am
Discussion
11:50 am - 12:05 pm
"Proteomics of Germ Line Reset in Vertebrate Oocytes"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
"Validation of Biomarkers of Aging: Biomarkers of Aging Consortium"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Exceptional Longevity and Comparative Biology
6:00 pm - 6:05 pm
Introduction by Discussion Leader
6:05 pm - 6:25 pm
"Mechanisms of Aging and Suspended Animation"
6:25 pm - 6:30 pm
Discussion
6:30 pm - 6:50 pm
"Epigenome Stability and Longevity"
6:50 pm - 6:55 pm
Discussion
6:55 pm - 7:10 pm
"Tackling the Complexity of Aging with Systems Approaches"
7:10 pm - 7:15 pm
Discussion
7:15 pm - 7:30 pm
"Mitochondria Oxidative Phosphorylation in Healthy Longevity: Resilience Craves Energy"
7:30 pm - 7:35 pm
Discussion
7:35 pm - 7:45 pm
"Uncovering the Mechanisms of Exceptional Longevity through iPSC-Based Modeling of Resiliency"
7:45 pm - 7:50 pm
Discussion
7:50 pm - 8:00 pm
General Discussion
8:00 pm - 9:00 pm
Dinner
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Measuring Age in Single Cells
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
"Insights into Aging and Rejuvenation at Single-Cell Resolution"
9:30 am - 9:35 am
Discussion
9:35 am - 9:55 am
"Blood-Based Biomarkers of Longevity and a Path to Their Implementation in Clinical Trials"
9:55 am - 10:00 am
Discussion
10:00 am - 10:15 am
"An Accurate Single-Cell Clock Unlocks Discovery of Safe Rejuvenation Genes"
10:15 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:05 am
"Epigenetics and Epitranscriptomics in Aging: From Biology to Applications"
11:05 am - 11:10 am
Discussion
11:10 am - 11:25 am
"Sex Differences in Immune Aging and Vaccine Responses"
11:25 am - 11:30 am
Discussion
11:30 am - 11:45 am
"Upon Perturbations Transcriptomes Often Resemble Biological Aging"
11:45 am - 11:50 am
Discussion
11:50 am - 12:05 pm
"The Identification of a Distinct Astrocyte Subtype that Diminishes in Alzheimer’s Disease"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:20 pm
"Combining Transcriptomics and Artificial Intelligence to Study Human Aging: From Single-Cells to Individuals"
12:20 pm - 12:25 pm
Discussion
12:25 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Organoids and Brain Aging
6:00 pm - 6:05 pm
Introduction by Discussion Leader
6:05 pm - 6:30 pm
"Advances in Epigenetic Reprogramming"
6:30 pm - 6:35 pm
Discussion
6:35 pm - 6:55 pm
"Organoid Models to Study Disease"
6:55 pm - 7:00 pm
Discussion
7:00 pm - 7:20 pm
"Functional Characterization of Rare Variants in Genes Encoding the MAPK/ERK Signaling Pathway Identified in Long-Lived Leiden Longevity Study Participants"
7:20 pm - 7:25 pm
Discussion
7:25 pm - 7:45 pm
"Reducing Nuclear Stretching Rejuvenates Aged Hematopoietic Stem Cells"
7:45 pm - 7:50 pm
Discussion
7:50 pm - 8:00 pm
General Discussion
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure