Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: Redox Regulation of Cell Life and Death
Discussion Leaders: Uladzimir Barayeu (Tohoku University , Japan) and Lisa Knoke (Ruhr University Bochum, Germany)
7:40 pm - 8:20 pm
Kate Carroll (UF Scripps Biomedical Research, United States)
"Reimagining Druggability Using Redox Chemoproteomic Platforms"
8:20 pm - 8:35 pm
Discussion
8:35 pm - 9:15 pm
Marcus Conrad (Helmholtz Zentrum Munich, Germany)
"Ferroptosis as the Root Cause of Neurodegenerative Disease?"
9:15 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Tools and Technologies for Redox Biology
Discussion Leader: Bruce Morgan (Universität des Saarlandes, Biochemie, Germany)
9:00 am - 9:20 am
Vsevolod Belousov (Federal Center of Brain Research and Neurotechnologies, Russia)
"Further Expanding the Redox Biology Toolbox"
9:20 am - 9:30 am
Discussion
9:30 am - 9:40 am
Brandan Pedre Perez (KU Leuven, Belgium)
"Genetically-Encoded Biosensors to Monitor Cysteine in Living Cells"
9:40 am - 9:45 am
Discussion
9:45 am - 10:05 am
Keriann Backus (University of California, Los Angeles, United States)
"Deciphering Stress-Mediated Changes to the Proteome using Multi-Dimensional Redox Proteomics"
10:05 am - 10:15 am
Discussion
10:15 am - 10:25 am
Clive Yik-Sham Chung (The University of Hong Kong, Hong Kong SAR China)
"Superoxide-Responsive Quinone Methide Precursors (QMP-SOs) to Study Superoxide Biology by Proximity Labeling and Chemoproteomics"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Jing Yang (Guangzhou National Laboratory, China)
"How Many Cysteine Modifications are there in Humans?"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Yimon Aye (Swiss Federal Institute of Technology Lausanne (EPFL), Switzerland)
"Gut Feeling: Illuminating Atypical Reactive Metabolite Sensing and Signaling Programs in the Gut"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizer: Kathrin Ulrich (University of Cologne, Germany)
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Signaling via Low Molecular Weight Thiols and Post-Translational Modifications
Discussion Leader: Ivan Gout (University College London, United Kingdom)
6:00 pm - 6:20 pm
Haike Antelmann (Freie Universität Berlin, Germany)
"Adaptation Mechanisms of Staphylococcus Aureus Towards Oxidants and Redox-Active Antimicrobials"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:50 pm
Pablo Rivera-Fuentes (University of Zurich, Switzerland)
"Chemigenetic Tools to Measure Glutathione in Intracellular Organelles"
6:50 pm - 7:00 pm
Discussion
7:00 pm - 7:20 pm
Yvonne Janssen-Heininger (Larner College of Medicine, University of Vermont, United States)
"S -Glutathionylation of Ovarian Tumor Deubiquitinase 1 at Cysteine 23 Alters Epithelial Cell Plasticity in Association with Lung Fibrosis"
7:20 pm - 7:30 pm
Discussion
7:30 pm - 7:40 pm
Leonie Thewes (Heinrich-Heine Universität Düsseldorf, Germany, Germany)
"Glutaredoxin-Dependent Thiol Redox Regulation as Modulator of Ferroptosis"
7:40 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
Talk Selected from GRS
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Redox Control of Protein Biogenesis and Turnover
Discussion Leader: Johannes Herrmann (University of Kaiserslautern, Germany)
9:00 am - 9:20 am
Gustavo Silva (Duke University, United States)
"Thriving Under Pressure: Redox Regulation of Protein Synthesis during Oxidative Stress"
9:20 am - 9:30 am
Discussion
9:30 am - 9:40 am
Koji Ishikawa (Center for Molecular Biology of Heidelberg University, Germany)
"Cellular Redox Homeostasis by a Ribosome-Associated Chaperone"
9:40 am - 9:45 am
Discussion
9:45 am - 10:05 am
Kathrin Ulrich (University of Cologne, Germany)
"Redox-Regulated Chaperones: From a Tightly Controlled Thiol Switch to Proteostasis Regulation"
10:05 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 11:05 am
Deborah Fass (Weizmann Institute of Science, Israel)
"Thiol-Disulfide Rearrangement and Redox Regulation in the Biosynthesis of Mucin Polymers"
11:05 am - 11:15 am
Discussion
11:15 am - 11:35 am
Viktor Korolchuk (Newcastle University, United Kingdom)
"Mitophagy as an Antioxidant Pathway"
11:35 am - 11:45 am
Discussion
11:45 am - 11:55 am
Helena Cocheme (MRC Laboratory of Medical Sciences (LMS), United Kingdom)
"Enhancing Autophagy by Redox Regulation Extends Lifespan"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Reactive Sulfur Species and Protein Redox Switches
Discussion Leader: Leslie Poole (Wake Forest University School of Medicine, United States)
6:00 pm - 6:20 pm
Christopher Horst Lillig (University Medicine Greifswald, Germany)
"Cysteinyl and Methionyl Redox Switches: Structural Prerequisites and Consequences."
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:50 pm
Hozumi Motohashi (Tohoku University, Japan)
"Environmental Stress Response and Sulfur Metabolism"
6:50 pm - 7:00 pm
Discussion
7:00 pm - 7:20 pm
Milos Filipovic (Leibniz Institute for Analytical Sciences ISAS, e.V., Germany)
"Age-Induced Thiol Oxidation Predisposes Brain for Neurodegeneration via Aberrant Phase Separation"
7:20 pm - 7:30 pm
Discussion
7:30 pm - 7:40 pm
Eszter Petra Jurányi (National Institute of Oncology, Hungary)
"Fluxomic and Metabolomic Analyses Reveal the Origin of Cysteine in Disulfide Reductase Deficient Mouse Liver"
7:40 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
Manuela Gellert (University Medicine Greifswald, Germany)
"NADPH-Dependent Oxidation of Target Proteins Through a MICAL1-Prx1 Redox Relay"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Inter-Organelle and Inter-Cellular Redox Crosstalk
Discussion Leader: Beatriz Alvarez (Universidad de la Republica, Uruguay)
9:00 am - 9:20 am
Andrew Wojtovich (University of Rochester Medical Center, United States)
"Controlling Mitochondrial ROS Production with Light"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Tobias Dansen (University Medical Center Utrecht, The Netherlands)
"Differential Damage, Signalling, and Cell Fate Downstream of Localized H2 O2 Production"
9:50 am - 10:00 am
Discussion
10:00 am - 10:10 am
Lianne Jacobs (universität zu Köln, Germany)
"Mapping the Dynamic Landscape of Redox Molecules with Subcellular Resolution"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
Paraskevi Kritsiligkou (German Cancer Research Center (DKFZ), Germany)
"Proteome-Wide roGFP2-Tagging Reveals Novel Redox-Regulated Metabolic Switches"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Liron Bar-Peled (MGH Cancer Center and Harvard Medical School, United States)
"Identification of Druggable and Redox Vulnerabilities in Cancer"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Guenter Schwarz (University of Cologne, Germany)
"Redox-Dependent Synaptic Clustering of Gephyrin"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Lipid Oxidation and Redox-Dependent Cell Death
Discussion Leader: Jörg Mansfeld (Institute of Cancer Research, London, UK, United Kingdom)
6:00 pm - 6:20 pm
Boyi Gan (MD Anderson Cancer Center, United States)
"Targeting Disulfidptosis as a Thiol-Based Redox Vulnerability in Cancer"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:50 pm
Maria Fedorova (Technical University Dresden, Germany)
"Lipid Metabolic Networks in Human Pathologies"
6:50 pm - 7:00 pm
Discussion
7:00 pm - 7:20 pm
Jennifer Watts (Washington State University, United States)
"Dietary Regulation of Ferroptosis"
7:20 pm - 7:30 pm
Discussion
7:30 pm - 7:40 pm
Hayley Sharpe (EMBO YIP - Babraham Institute, United Kingdom)
"Redox Regulation of Phosphotyrosine Signaling"
7:40 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
Daniel de Jesus (Queen Mary University of London, United Kingdom)
"KCTD12 Redox State as a Determinant and Therapeutic Target in Pulmonary Remodelling"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Redox Homeostasis in Connection to Host-Pathogen and Immune Responses
Discussion Leader: David Giedroc (Indiana University, United States)
9:00 am - 9:20 am
Stavroula Hatzios (Yale University, United States)
"Redox Regulation of Host–Microbe Interactions"
9:20 am - 9:30 am
Discussion
9:30 am - 9:40 am
Jan-Ulrik Dahl (Illinois State University, United States)
"The Increased Resistance of Uropathogenic Escherichia Coli to Reactive Chlorine Species and Phagocytosis is Mediated by the Membrane Protein RcrB"
9:40 am - 9:45 am
Discussion
9:45 am - 10:05 am
Marcelo Bonini (Northwestern University, United States)
"Mitochondria Driven Chromatin Remodeling via Histone H3.1 Oxidation: Implications for EMT and Breast Cancer Metastasis"
10:05 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 11:05 am
Xinnian Dong (Duke University / Howard Hughes Medical Institute Inc., United States)
"H2 O2 Sulfenylates CHE Transcription Factor Linking Local Infection to Establishment of Systemic Acquired Resistance in Plants"
11:05 am - 11:15 am
Discussion
11:15 am - 11:35 am
Daniel Bachovchin (Memorial Sloan Kettering Cancer Center, United States)
"Oxidized Thioredoxin-1 Restrains the NLRP1 Inflammasome"
11:35 am - 11:45 am
Discussion
11:45 am - 11:55 am
Tianli Zhang (Akita University, Japan)
"Supersulfides Regulate NLRP3 Inflammasome Activation through Sensing Homeostasis-Altering Molecular Processes"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Redox Signaling in Metabolism and Age-Associated Disease
Discussion Leader: Cristina Furdui (Wake Forest University School of Medicine, United States)
6:00 pm - 6:20 pm
Danqian Liu (Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, China)
"Reactive Oxygen Species in Sleep-Promoting Neurons Encode Sleep Drive in Mice"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:50 pm
Elena Piskounova (Weill Cornell Medicine, United States)
"The Role and Regulation of Selenoproteins in Oxidative Stress Resistance and Metastasis"
6:50 pm - 7:00 pm
Discussion
7:00 pm - 7:10 pm
Olena Rudyk (King's College London, United Kingdom)
"A Redox Switch in Cyclin D-CDK4 Inhibits Kinase Activity to Regulate Pulmonary Vascular Cell Proliferation and Alleviate Pulmonary Hypertension"
7:10 pm - 7:15 pm
Discussion
7:15 pm - 7:25 pm
Minkyung Jung (Tohoku University, Japan)
"A Novel Mechanism of Sulfur Metabolism Catalyzed by NOX and NOS"
7:25 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
Tobias Dick (German Cancer Research Center (DKFZ), Germany)
"A New Mechanism of Action for Proton Pump Inhibitors"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure