Saturday
1:00 pm - 5:00 pm
Arrival and Check-in
3:00 pm - 3:15 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
3:15 pm - 4:00 pm
Lipids in Redox Biology
Discussion Leaders: Maria Fedorova (Technical University Dresden, Germany) and Paraskevi Kritsiligkou (German Cancer Research Center (DKFZ), Germany)
3:15 pm - 3:25 pm
Martina Steglich (Universidad de la República, Uruguay)
"Human Glutathione Transferases Catalyze the Inactivation of Nitrooleic Acid"
3:25 pm - 3:30 pm
Discussion
3:30 pm - 3:40 pm
Neha (Indian Institute of Science Education and Research Kolkata, India)
"Effect of p-Benzoquinone, a Cigarette Smoke-Derived Component, on the Architecture of Red Blood Cell Membrane"
3:40 pm - 3:45 pm
Discussion
3:45 pm - 3:55 pm
Meg Shieh (Brown University, United States)
"2H-Thiopyran-2-Thione Sulfine and its Analogues: Unique Compounds For Converting H2S to HSOH/H2S2"
3:55 pm - 4:00 pm
Discussion
4:00 pm - 5:30 pm
Poster Session
5:30 pm - 7:30 pm
Cellular Redox Signaling and Regulation
Discussion Leaders: Jan-Ulrik Dahl (Illinois State University, United States) and Simran Gupta (Indian Institute of Science Education and Research, Pune, India)
5:30 pm - 5:40 pm
Ragini Agrawal (Indian Institute of Science, Bengaluru, India)
"Precision Persulfide Generation Provides Insight into the Mitochondrial Sulfane Sulfur Pool"
5:40 pm - 5:45 pm
Discussion
5:45 pm - 5:55 pm
Hussain Beig (Indian Institute of Science, India)
"Regulation and Effects of Hydrogen Sulfide Production by Mycobacterium tuberculosis in Response to Hypochlorous Acid"
5:55 pm - 6:00 pm
Discussion
6:00 pm - 6:10 pm
Jonathan Petrocelli (Dana-Farber Cancer Institute/Harvard Medical School, United States)
"Exploring Skeletal Muscle Cysteine Oxidation Shifts Immediately Post and in Recovery from Acute Exercise"
6:10 pm - 6:15 pm
Discussion
6:15 pm - 6:25 pm
Marta Bogacz (Friedrich Schiller University, Jena, Germany, Germany)
"Active Site Cysteine Positioning in a Trypanosoma brucei Dual-Function Peroxiredoxin Enables Adaptation to a Parasitic Life Style"
6:25 pm - 6:30 pm
Discussion
6:30 pm - 6:40 pm
Thomas Foy (Newcastle University, United Kingdom)
"A 2-Cys Peroxiredoxin Confers Redox Sensitivity on a p38-Related MAPK by Dual Independent Mechanisms"
6:40 pm - 6:45 pm
Discussion
6:45 pm - 6:55 pm
Haruna Takeda (Tohoku University, Japan)
"Mediator Complex Subunit 16 (MED16): Its Physiological Role and Redox-dependent Regulations"
6:55 pm - 7:00 pm
Discussion
7:00 pm - 7:10 pm
Lindsey Farris (Wake Forest University School of Medicine, United States)
"Novel Modification of Peroxiredoxin 3 After Mitochondrial Oxidative Stress"
7:10 pm - 7:15 pm
Discussion
7:15 pm - 7:25 pm
Anna Thompson (Georgia Institute of Technology, United States)
"A New Role for Cu/Zn Superoxide Dismutase in Fe/S Biogenesis"
7:25 pm - 7:30 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Tools to Monitor Thiol-Redox Modifications
Discussion Leaders: Tobias Dick (German Cancer Research Center (DKFZ), Germany) and Teresa Marker (German Cancer Research Center (DKFZ), Germany)
9:00 am - 9:10 am
Danny Schilling (German Cancer Research Center (DKFZ), Heidelberg, Germany, Germany)
"Exploring Endogenous Modulators of Protein Persulfidation Using a Novel Quantitative Assay"
9:10 am - 9:15 am
Discussion
9:15 am - 9:25 am
Ghulam Abbas (Institute of Synthetic Biology, Shenzhen Institute of Advanced Technology, CAS, China)
"Deciphering Subcellular Redox Dynamics in AML: Insights from Genetically Encoded Sensors and Live-cell Imaging"
9:25 am - 9:30 am
Discussion
9:30 am - 9:40 am
Vanesa Cepas López (University of Turin / Candiolo Cancer Institute IRCCS, Italy)
"An Approach to the Study of Single Cell Redox Dynamics by Using Cancer Patient-Derived Organoids (PDOs) and Compartment-Specific Genetically-Encoded Redox Biosensors"
9:40 am - 9:45 am
Discussion
9:45 am - 9:55 am
Daniel Kaufman (Ben-Gurion University in the Negev, Israel)
"An Electrochemical Method to Switch, Monitor, and Control Mucus Thiol-Disulfide in a Gut Model System"
9:55 am - 10:00 am
Discussion
10:00 am - 10:10 am
Julia Malo Pueyo (Redox Signaling Lab - Structural Biology Brussels - DBIT (VIB-VUB), Belgium)
"Understanding the Architecture of Human Redox-Relay Complexes"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
Radosveta Gencheva (Karolinska Institutet, Sweden)
"The Anticancer Compounds Auranofin, TRi-1 and TRi-2 have Distinct Cytotoxicity Profiles with Regards to Thioredoxin Reductase Inhibition"
10:25 am - 10:30 am
Discussion
10:30 am - 10:40 am
Patrick Tawiah (Illinois State University, United States)
"Exploring the Implications of a Novel Silver-Ruthenium-Based Surface Coating on the Bacterial Redox Homeostasis"
10:40 am - 10:45 am
Discussion
10:45 am - 10:55 am
Laura de Cubas Landaluce (Universitat Pompeu Fabra, Spain)
"Inter-Compartmental H2 O2 Fluxes and their Regulation by Scavengers, Transporters and Signaling Cascades Affect Cell Fitness"
10:55 am - 11:00 am
Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Mentorship Component: Navigating Your Career Path - How to Make Science More Inclusive
Discussion Leaders: Lisa Knoke (Ruhr University Bochum, Germany) and Utsav Dey Sarkar (Indian Institute of Science Education and Research, Pune, India)
1:30 pm - 2:30 pm
Panel Discussion
Navigating Your Scientific Career Path
Jan-Ulrik Dahl (Illinois State University, United States)
Maria Fedorova (Technical University Dresden, Germany)
Tobias Dick (German Cancer Research Center (DKFZ), Germany)
2:30 pm - 3:00 pm
Evaluation Period
Complete the GRS Evaluation Forms; Election of Future Chair(s)
3:00 pm
Seminar Concludes