Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: Bridging Structure, Cell and Computational Biology
7:40 pm - 7:55 pm
Introduction by Discussion Leader
7:55 pm - 8:15 pm
"Dynamic Allostery: Make Sense of Disappearing Densities"
8:15 pm - 8:25 pm
Discussion
8:25 pm - 8:45 pm
"Deciphering Viral Fusion and Nuclear Transport In Situ "
8:45 pm - 8:55 pm
Discussion
8:55 pm - 9:15 pm
"Molecular Simulations Add Detail, Dynamics and Disorder to CryoET"
9:15 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Advances in Instrumentation and Hardware
9:00 am - 9:15 am
Introduction by Discussion Leader
9:15 am - 9:35 am
"CryoSTEM Tomography in 2D, 3D, 4D, and More"
9:35 am - 9:50 am
Discussion
9:50 am - 10:10 am
"Enhancing Cryo-ET Contrast: Ongoing Work at CZ Imaging Institute"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:10 am
"Preventing Specimens from Interacting with the Air-Water Interface"
11:10 am - 11:25 am
Discussion
11:25 am - 11:45 am
"Advances in Integrated Light Microscopy and Focused Ion Beam Milling for Cryo-ET Sample Preparation"
11:45 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
Late-Breaking Topic
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hourâ„¢
The GRC Power Hourâ„¢ is designed to address the interests and needs of all scientists and the challenges they face in their careers. Specifically, the program promotes meaningful conversations amongst colleagues of all career stages about barriers to career advancement and strategies to support the professional growth of all members of the community. The GRC Power Hourâ„¢ is open to all conference participants.
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Advances in Algorithms and Software
7:30 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:05 pm
"Simulating the Cellular Context in Cryo-ET: Applications and Challenges"
8:05 pm - 8:20 pm
Discussion
8:20 pm - 8:40 pm
"New Developments in NextPYP for In Situ Structure Determination"
8:40 pm - 8:55 pm
Discussion
8:55 pm - 9:15 pm
Late-Breaking Topic
9:15 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Time-Resolved Studies and Structural Dynamics
9:00 am - 9:15 am
Introduction by Discussion Leader
9:15 am - 9:35 am
"Prospects and Challenges of Nanofluidic Systems for Time-Resolved CryoEM Imaging"
9:35 am - 9:50 am
Discussion
9:50 am - 10:10 am
"Dissecting the Mechanisms of Eukaryotic Translation Initiation by Integrating Biochemical and Time-Resolved Cryo-EM Studies"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:10 am
"Investigating the Mechanisms of Bidirectional Transport by Dynein and Kinesin with Cryo-EM"
11:10 am - 11:25 am
Discussion
11:25 am - 11:45 am
"Unravelling the Enzymatic Machinery of COâ‚‚ Fixation and Energy Conservation in Anaerobic Life Using Integrative Structural Biology"
11:45 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
"Expanding Single Particle Analysis Towards (More) Native Samples"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Selected Poster Presentations
7:30 pm - 7:40 pm
Short Talk Selected from Poster Abstracts
7:40 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
Short Talk Selected from Poster Abstracts
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:10 pm
Short Talk Selected from Poster Abstracts
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:25 pm
Short Talk Selected from Poster Abstracts
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:40 pm
Short Talk Selected from Poster Abstracts
8:40 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
Short Talk Selected from Poster Abstracts
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Short Talk Selected from Poster Abstracts
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Short Talk Selected from Poster Abstracts
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Molecular Structure and Function In Situ
9:00 am - 9:15 am
Introduction by Discussion Leader
9:15 am - 9:35 am
"Unveiling Molecular Crowding In Situ "
9:35 am - 9:50 am
Discussion
9:50 am - 10:10 am
"Integrated Structural Biology of the Native Malarial Translation Machinery and its Inhibition by an Antimalarial Drug"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:10 am
"In Situ Structure and Arrangement of the Mitochondrial Oxidative Phosphorylation Machinery"
11:10 am - 11:25 am
Discussion
11:25 am - 11:45 am
"High-Resolution In Situ Structures of Mammalian Respiratory Supercomplexes"
11:45 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
Late-Breaking Topic
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Advancing 3DEM with Community Challenges and Contributions
7:30 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:05 pm
"The Inaugural Flatiron Institute Cryo-EM Conformational Heterogeneity Challenge"
8:05 pm - 8:20 pm
Discussion
8:20 pm - 8:40 pm
"Annotating CryoET Volumes: A Machine Learning Challenge"
8:40 pm - 8:55 pm
Discussion
8:55 pm - 9:15 pm
Late-Breaking Topic
9:15 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Multiscale, Correlative and Integrative Approaches
9:00 am - 9:15 am
Introduction by Discussion Leader
9:15 am - 9:35 am
"Unlocking the Potential of Multimodal Imaging: Essential Considerations"
9:35 am - 9:50 am
Discussion
9:50 am - 10:10 am
"Correlative Cryo Soft X-Ray Tomography Workflows: From CLXM to CLXEM"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:10 am
"Cartography of Human Organelles in Composition, Space and Time: A Lens to Understand Cellular States"
11:10 am - 11:25 am
Discussion
11:25 am - 11:45 am
"Building Structural and Spatial Interactomes by Cross-Linking Mass Spectrometry"
11:45 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
"Charting the Protein Universe for New Unknown Biology with the Help of AI"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Selected Poster Presentations
7:30 pm - 7:40 pm
Short Talk Selected from Poster Abstracts
7:40 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
Short Talk Selected from Poster Abstracts
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:10 pm
Short Talk Selected from Poster Abstracts
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:25 pm
Short Talk Selected from Poster Abstracts
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:40 pm
Short Talk Selected from Poster Abstracts
8:40 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
Short Talk Selected from Poster Abstracts
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Short Talk Selected from Poster Abstracts
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Short Talk Selected from Poster Abstracts
9:25 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure