Tissue Repair and Regeneration

Gordon Research Conference

Exploring Innovations in Tissue Repair and Regeneration: From Bench to Therapies

June 7 - 12, 2015
Chair
Vice Chair
Colby-Sawyer College
541 Main Street
New London, New Hampshire, United States
 Venue and Travel Information

Conference Description

The primary goal in regenerative medicine is to facilitate the replacement of injured, diseased or aged tissues with fully functional counterparts, thus extending the healthy life expectancy of our aging population. As such the field of regenerative medicine has great potential in tackling many of the greatest health concerns and needs of the 21st century. The Gordon Research Conference on Tissue Repair and Regeneration (GRC-TRR) is the only major recurrent meeting focusing on the broad topic of regenerative medicine, from the basic mechanisms of tissue repair and regeneration, to their clinical applications.

The 2015 iteration of the Gordon Research on Tissue Repair and Regeneration will be held at Colby Sawyer College, New London, NH, June 7-11. The overarching aim of this edition of the GRC-TRR will be to assemble the greatest minds in regenerative biology under one roof to discuss the latest findings in the field. We have planned nine scientific sessions focusing on several topics relevant to regenerative medicine. The titles for the sessions are 1. The effects of aging on tissue repair and regeneration 2. Organ regeneration 3. Nuclear reprogramming and dedifferentiation 4. Model organisms of regeneration; 5. The roles of reactive oxygen species in tissue repair and regeneration 6. Stem cell therapies for tissue repair and regeneration 7. The stem cell niche 8. Skin repair and 9. Long coding RNAs and epigenetics in stem/progenitor cells. It is anticipated that exposure to this very diverse group of scientists will foster stimulating discussions and lead to productive collaborations, which will facilitate the development of the next generation of novel therapeutics in regenerative medicine. Following on the success of the last two Gordon Research Seminar (GRS) in 2011 and 2013, we will host a GRS pre-meeting for students once again, in conjunction with GRC-TRR, which will be held the two days prior to the main meeting. Apart from the formal presentations and daily poster sessions, there will be ample opportunities for informal gatherings for brainstorming sessions and the initiation of cross-disciplinary collaborations amongst the delegates attending the meeting.

Related Meeting

This GRC will be held in conjunction with the "Tissue Repair and Regeneration" Gordon Research Seminar (GRS). Those interested in attending both meetings must submit an application for the GRS in addition to an application for the GRC. Refer to the associated GRS program page for more information.

Conference Program

Sunday
2:00 pm - 9:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmEffects of Aging on Tissue Repair / Regeneration
Discussion Leader: Enrique Amaya (The University of Manchester, United Kingdom)
7:40 pm - 7:45 pmIntroduction by Discussion Leader
7:45 pm - 8:05 pmAmy Wagers (Harvard University, USA)
"Targeting Local and Systemic Factors to Restore Function in Aging Skeletal Muscle"
8:05 pm - 8:15 pmDiscussion
8:15 pm - 8:35 pmPura Munoz-Canoves (Universitat Pompeu Fabra and ICREA, Spain)
"Muscle Stem Cells in Aging and Disease"
8:35 pm - 8:45 pmDiscussion
8:45 pm - 8:55 pmSelected from Poster Abstracts: Elaine Emmerson (University of California, San Francisco, USA)
"Does Aging Disrupt Neuronal Cholinergic Progenitor Cell Communication Required to Maintain Tissue Homeostasis and Mediate Organ Regeneration?"
8:55 pm - 9:00 pmDiscussion
9:00 pm - 9:20 pmBradley Olwin (University of Colorado, Boulder, USA)
"Signalling in Stem Cell Self-Renewal in Aged Muscle"
9:20 pm - 9:30 pmDiscussion
Monday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmOrgan Regeneration
Discussion Leader: Leslie Gewin (Vanderbilt University, USA)
9:00 am - 9:05 amIntroduction by Discussion Leader
9:05 am - 9:25 amStuart Forbes (University of Edinburgh, United Kingdom)
"Cell-Based Therapies to Stimulate Liver Regeneration and Reduce Scarring"
9:25 am - 9:35 amDiscussion
9:35 am - 9:45 amSelected from Poster Abstracts: Donghun Shin (University of Pittsburgh, USA)
"Bromodomain and Extraterminal (BET) Proteins Regulate Biliary Driven Liver Regeneration"
9:45 am - 9:50 amDiscussion
9:50 am - 10:10 amNeil Chi (University of California, San Diego, USA)
"In Vivo Cardiac Reprogramming Contributes to Zebrafish Heart Regeneration"
10:10 am - 10:20 amDiscussion
10:20 am - 10:45 amCoffee Break
10:45 am - 11:05 amJarrod Dudakov (Memorial Sloan Kettering Cancer Center, USA)
"Innate Mechanisms Governing Endogenous Thymic Regeneration"
11:05 am - 11:15 amDiscussion
11:15 am - 11:35 amJeremy Duffield (Biogen Idec, USA)
"Reversing Fibrotic Kidney Diseases"
11:35 am - 11:45 amDiscussion
11:45 am - 11:55 amSelected from Poster Abstracts: Gilbert Weidinger (Ulm University, Germany)
"Spatially Resolved Genome-Wide Transcriptional Profiling Identifies Bone Morphogenetic Protein Signaling as Essential Regulator of Zebrafish Cardiomyocyte Regeneration"
11:55 am - 12:00 pmDiscussion
12:00 pm - 12:20 pmRick Livesey (University of Cambridge, United Kingdom)
"Ex Vivo Models of Human Neurodegenerative Diseases Using Human iPS Cells"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmNuclear Reprogramming and Dedifferentiation
Discussion Leader: Boris Hinz (University of Toronto, Canada)
7:30 pm - 7:35 pmIntroduction by Discussion Leader
7:35 pm - 7:55 pmPenney Gilbert (University of Toronto, Canada)
"Biochemical and Biophysical Niche Cue Synergy and the Aging Muscle Stem Cell"
7:55 pm - 8:05 pmDiscussion
8:05 pm - 8:15 pmSelected from Poster Abstracts: Vashe Chandrakanthan (University of New South Wales, Australia)
"Demethylation-Cytokine Induced (DCi) Reprogramming of Somatic Cells into Tissue Regenerative Multipotent Stem Cells"
8:15 pm - 8:20 pmDiscussion
8:20 pm - 8:40 pmKostas Kostarelos (University of Manchester, United Kingdom)
"In Vivo Induced Pluripotency of Adult Tissue as a Strategy for Regeneration and Repair"
8:40 pm - 8:50 pmDiscussion
8:50 pm - 9:00 pmSelected from Poster Abstracts: Sepideh Abbasi (University of Calgary, Canada)
"Investigating the Effect of Skin Wound Healing on the Fate of Hair Follicle Dermal Stem Cells and Their Progeny in a Hair Cycle Stage Dependent Manner"
9:00 pm - 9:05 pmDiscussion
9:05 pm - 9:15 pmSelected from Poster Abstracts: Jovica Ninkovic (Helmholtz Zentrum Munich, Germany)
"Cellular and Molecular Changes in Adult NSCs Allowing Successful Regeneration in the Adult Zebrafish Brain"
9:15 pm - 9:20 pmDiscussion
9:20 pm - 9:30 pmGeneral Discussion
Tuesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmModel Organisms of Regeneration
Discussion Leader: Kerstin Bartscherer (Max-Planck-Institute for Molecular Biomedicine, Germany)
9:00 am - 9:05 amIntroduction by Discussion Leader
9:05 am - 9:25 amPeter Reddien (Whitehead Institute, USA)
"The Regulation of Stem Cells in Planarian Regeneration"
9:25 am - 9:35 amDiscussion
9:35 am - 9:45 amSelected from Poster Abstracts: Tanya Shaw (King's College London, United Kingdom)
"Mechanisms of Wound Closure Following Acute Arm Injury in Octopus vulgaris"
9:45 am - 9:50 amDiscussion
9:50 am - 10:10 amMichael Levin (Tufts University, USA)
"Endogenous Bioelectric Signaling: Molecular Mechanisms of Patterning Regulation in Embryogenesis and Regeneration"
10:10 am - 10:20 amDiscussion
10:20 am - 10:45 amGroup Photo / Coffee Break
10:45 am - 11:05 amMichail Averof (Institut de Génomique Fonctionnelle de Lyon (IGFL), France)
"Cellular Basis of Arthropod Limb Regeneration: Old Questions, New Models"
11:05 am - 11:15 amDiscussion
11:15 am - 11:35 amJames Godwin (Monash University, Australia)
"Immunological Influences During Scarless Healing and Limb Regeneration in Salamanders"
11:35 am - 11:45 amDiscussion
11:45 am - 11:55 amSelected from Poster Abstracts: Rachel Smith-Bolton (University of Illinois at Urbana-Champaign, USA)
"Regulation of Regeneration in Drosophila Imaginal Discs"
11:55 am - 12:00 pmDiscussion
12:00 pm - 12:20 pmMax Yun (University College London, United Kingdom)
"Cellular Senescence During Regeneration of Complex Structures"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmThe Roles of Reactive Oxygen Species in Tissue Repair and Regeneration
Discussion Leader: Harshani Peiris (Buck Institute of Aging, USA)
7:30 pm - 7:35 pmIntroduction by Discussion Leader
7:35 pm - 7:55 pmAndrew Chisholm (University of California, San Diego, USA)
"Injury Induced ROS Production in C. elegans"
7:55 pm - 8:05 pmDiscussion
8:05 pm - 8:25 pmWill Wood (University of Bristol, United Kingdom)
"The Production and Roles for ROS During Epidermal Wound Healing in Drosophila"
8:25 pm - 8:35 pmDiscussion
8:35 pm - 8:45 pmSelected from Poster Abstracts: Paul McNeil (Medical College Georgia, USA)
"Antioxidants and Plasma Membrane Repair"
8:45 pm - 8:50 pmDiscussion
8:50 pm - 9:10 pmAsma Nusrat (University of Michigan, USA)
"Insights into the Role of Formyl Peptide Receptors in Regulating Mucosal Wound Repair"
9:10 pm - 9:20 pmDiscussion
9:20 pm - 9:30 pmGeneral Discussion
Wednesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmStem Cell Therapies for Repair / Regeneration
Discussion Leader: Michael Galko (University of Texas MD Anderson Cancer Center, USA)
9:00 am - 9:05 amIntroduction by Discussion Leader
9:05 am - 9:25 amDennis Clegg (University of California, Santa Barbara, USA)
"Derivation of RPE from Pluripotent Stem Cells for the Treatment of Eye Disease"
9:25 am - 9:35 amDiscussion
9:35 am - 9:45 amSelected from Poster Abstracts: Sophie New (University College London, United Kingdom)
"Autologous Somatic Stem Cells for Pediatric Airways Reconstruction"
9:45 am - 9:50 amDiscussion
9:50 am - 10:10 amThomas Reh (University of Washington, USA)
"Stimulating Regeneration in Mammalian Retina by Neurogenic Reprogramming Glial Cells"
10:10 am - 10:20 amDiscussion
10:20 am - 10:45 amCoffee Break
10:45 am - 10:55 amSelected from Poster Abstracts: Christopher Antos (DFG Research Center, Center for Regenerative Therapies Dresden, Germany)
"Calcineurin Controls Proportional Growth of Zebrafish Regenerating Fins"
10:55 am - 11:00 amDiscussion
11:00 am - 11:10 amSelected from Poster Abstracts: Sandra Rieger (MDI Biological Laboratory, USA)
"IKKa Serves as an Innate Surveillant for Hydrogen Peroxide-Dependent Wound Re-Epithelialization"
11:10 am - 11:15 amDiscussion
11:15 am - 11:35 amMichael Brand (Technische Universität Dresden, Germany)
"Regeneration of the Adult Zebrafish Brain: The Role of Lineage Conversion"
11:35 am - 11:45 amDiscussion
11:45 am - 11:55 amSelected from Poster Abstracts: Gufa Lin (University of Minnesota, USA)
"Stimulating Mouse Digit Regeneration by Embryonic Limb Progenitor Cell Transplantation"
11:55 am - 12:00 pmDiscussion
12:00 pm - 12:20 pmSteven Goldman (University of Copenhagen / University of Rochester, USA)
"Deriving Oligodendrocytes from iPS Cells for the Treatment of Myelination Related Diseases"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmStem Cell Niche
Discussion Leader: Luisa Dipietro (University of Illinois, Chicago, USA)
7:30 pm - 7:35 pmIntroduction by Discussion Leader
7:35 pm - 7:55 pmValentina Greco (Yale University, USA)
"Capturing Signaling and Cellular Mechanisms of Skin Regeneration by Two Photon in Live Mice"
7:55 pm - 8:05 pmDiscussion
8:05 pm - 8:25 pmGeorge Cotsarelis (University of Pennsylvania, USA)
"Regenerating Skin: From the Hair Follicle on Down"
8:25 pm - 8:35 pmDiscussion
8:35 pm - 8:45 pmSelected from Poster Abstracts: Nestor Oviedo (University of California, Merced, USA)
"Regulation of Stem Cell Behavior and Tissue Repair in the Adult Body"
8:45 pm - 8:50 pmDiscussion
8:50 pm - 9:10 pmBoris Hinz (University of Toronto, Canada)
"The Fibrogenic Fate of Mesenchymal Stem Cells: A Matter of Stress"
9:10 pm - 9:20 pmDiscussion
9:20 pm - 9:30 pmGeneral Discussion
Thursday
7:30 am - 8:30 amBreakfast
8:30 am - 9:00 amBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pmSkin Repair / Cancer
Discussion Leader: Sabine Eming (University of Cologne, Germany)
9:00 am - 9:05 amIntroduction by Discussion Leader
9:05 am - 9:25 amMarjana Tomic-Canic (University of Miami Miller School of Medicine, USA)
"Current and Potential Treatment Approaches for Diabetic Foot Ulcers"
9:25 am - 9:35 amDiscussion
9:35 am - 9:45 amSelected from Poster Abstracts: George Eisenhoffer (The University of Texas MD Anderson Cancer Center, USA)
"Visualizing Cell Turnover During Epithelial Tissue Homeostasis and Repair Using Developing Zebrafish"
9:45 am - 9:50 amDiscussion
9:50 am - 10:10 amSabine Werner (ETH Zurich, Switzerland)
"Cytoprotective Signaling Pathways in Wound Healing and Skin Cancer"
10:10 am - 10:20 amDiscussion
10:20 am - 10:45 amCoffee Break
10:45 am - 11:05 amMatthew Hardman (University of Manchester, United Kingdom)
"The Link Between the Microbiome and Inflammation During Normal and Chronic Healing"
11:05 am - 11:15 amDiscussion
11:15 am - 11:35 amMalcolm Maden (University of Florida, USA)
"Towards a More Regenerative Skin Wounding Outcome"
11:35 am - 11:45 amDiscussion
11:45 am - 11:55 amSelected from Poster Abstracts: Roshini Prakash (University of California, Los Angeles, USA)
"Cancer Metastatic and Brain Regenerative Niches: Similarities, Cellular Communication and Signaling"
11:55 am - 12:00 pmDiscussion
12:00 pm - 12:20 pmPaul Martin (University of Bristol, United Kingdom)
"Imaging Studies of Inflammation and Repair"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmlncRNAs and Progenitor Cells
Discussion Leader: Kimberly Mace (University of Manchester, United Kingdom)
7:30 pm - 7:35 pmIntroduction by Discussion Leader
7:35 pm - 7:55 pmPaola Arlotta (Harvard University, USA)
"Reprogramming Neuronal Diversity in the Cerebral Cortex"
7:55 pm - 8:05 pmDiscussion
8:05 pm - 8:25 pmDaniel Lim (University of California, San Francisco, USA)
"Regulation of Neural Development by Long Noncoding RNAs"
8:25 pm - 8:35 pmDiscussion
8:35 pm - 8:45 pmSelected from Poster Abstracts: Karen Echeverri (University of Minnesota, USA)
"Injury Induced Cytoskeleton Changes Regulates miR125b After Spinal Cord Injury in Axolotl"
8:45 pm - 8:50 pmDiscussion
8:50 pm - 9:10 pmEdward Morrisey (University of Pennsylvania, USA)
"Long Noncoding RNAs in Lung Development"
9:10 pm - 9:20 pmDiscussion
9:20 pm - 9:30 pmGeneral Discussion
Friday
7:30 am - 8:30 amBreakfast
9:00 amDeparture

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