Find a Conference

California Wildfire Update (as of 1/21/2025 at 5PM EST) - We are currently operating safely at all California venues and all conferences are scheduled to proceed as planned. click here for more details

Transglutaminases in Human Disease Processes

Gordon Research Conference

Molecular Dissection of Human Diseases Pathogenesis

June 29 - July 4, 2014
Chair
Vice Chair
Renaissance Tuscany Il Ciocco
Via Giovanni Pascoli
Lucca (Barga), Lucca, Italy
 Venue and Travel Information

Conference Description

Transglutaminases are a large family of structurally and functionally related proteins widely distributed in all living organisms. These enzymes are dysregulated and contribute to the pathogenesis of the most relevant human diseases, such as cancer, tissue fibrosis, infectious diseases, celiac disease, neurodegenerative disorders, and skin diseases. The 3rd Gordon Conference on "Transglutaminases in Human Disease Processes" will explore the frontiers on this rapidly expanding field. The meeting will cover cutting-edge research on the biology of transglutaminases with themes focusing on the biochemical pathways and cellular mechanisms involving Transglutaminases in human health and disease processes. Sessions will cover recent advances related to the following topics:

  • Transglutaminases as regulators of cell survival and cell death modalities
  • Transglutaminases as regulators of inflammatory disease
  • Transglutaminases in oncogenesis and metastasis development
  • Transglutaminases in cardiovascular and neurodegenerative diseases
  • Transglutaminases in celiac diseases
  • Transglutaminases in matrix remodeling, aberrant wound healing and organ fibrosis
  • Transglutaminases applications in biotechnology
  • Approaches to inhibit Transglutaminase activity in human diseases

The 2014 Gordon Research Conference will bring together the world’s leading researchers in this active field at Il Ciocco Hotel in Tuscany, Italy. This beautiful site is located on a natural park and provides an excellent setting for formal lectures and informal out-of-session discussions. In the spirit of the GRC Conference each talk will be structured to include ample time for discussion providing a unique platform for established investigators to present new findings and debate the important issues in the field as well as for junior scientists to participate in discussions. The poster sessions are an essential element to the success of the Conference, they represent a great opportunity for Post-Docs and graduate students to present their work under an informal relaxed atmosphere that fosters networking and idea sharing. The program will also include short talks selected from poster presentations.

Conference Program

SUNDAY
4:00 pm - 8:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmInflammation and Cell Death Regulation
7:40 pm - 7:50 pmWelcome/Introduction by the Chairs: Mauro Piacentini and Tim Johnson
7:50 pm - 8:30 pmPeter Vandenabeele (VIB, Ghent University, Belgium)
"Regulation and Molecular Mechanisms of Necroptosis, a Form of Regulated Necrosis"
8:30 pm - 8:40 pmDiscussion
8:40 pm - 9:20 pmLaszlo Fesus (University of Debrecen)
"Structural and Functional Stabilization of the Neutrophil Extracellular Trap"
9:20 pm - 9:30 pmDiscussion
MONDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmTransglutaminases in Oncogenesis and Metastasis Development
9:00 am - 9:15 amDiscussion Leader: Simone Beninati (University of Rome "Tor Vergata", Italy)
9:15 am - 9:45 amSoo-Youl Kim (National Cancer Center, Seoul, Korea)
"Transglutaminase 2 is a Beautiful Target for Renal Cell Carcinoma"
9:45 am - 9:55 amDiscussion
9:55 am - 10:25 amDaniela E. Matei (Indiana University School of Medicine, Indianapolis, USA)
"The Transglutaminase/Fibronectin/Integrin Complex, a Target in Ovarian Cancer"
10:25 am - 10:35 amDiscussion
10:35 amCoffee Break
11:10 am - 11:40 amKevin D. Brown (College of Medicine, University of Florida, USA)
"Oxidative Stress Shapes Breast Cancer Phenotype Through the TG2/NF-KappaB Signaling Loop"
11:40 am - 11:50 amDiscussion
11:50 am - 12:20 pmLei Xu (University of Rochester, New York)
"GPR56 Inhibits Melanoma Growth by Internalizing and Degrading TG2"
12:20 pm - 12:30 amDiscussion
12:30 pmLunch
1:30 pm - 4:30 pmFree Time
4:30 pm - 6:00 pmPoster Session
6:00 pm - 8:00 pmTransglutaminases as Regulators of Cell Survival and Cell Death Modalities
6:00 pm - 6:15 pmDiscussion Leader: Soichi Kojima (Riken University, Tokyo, Japan)
6:15 pm - 6:45 pmGail Johnson (University of Rochester, USA)
"Transglutaminase 2: Is Conformation the Key?"
6:45 pm - 6:55 pmDiscussion
6:55 pm - 7:25 pmIn-Gyu Kim (Seoul National University College of Medicine, Korea)
"The Mechanism of Oxidative Stress Induced Transglutaminase 2 Activation"
7:25 pm - 7:35 pmDiscussion
7:35 pm - 7:50 pmShort Talk: Mari Kaartinen (McGill University, Canada)
"Factor XIII-A Is a Negative Regulator of Adipogenesis and Acts as a Switch Between Preadipocyte Proliferation and Differentiation via Modulating Plasma Fibronectin Assembly into Matrix"
7:50 pm - 8:00 pmDiscussion
8:00 pmDinner
TUESDAY
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmTransglutaminases as Regulators of Inflammatory Disease
9:00 am - 9:15 amDiscussion Leader: Zsuzsa Szondy (University of Debrecen)
9:15 am - 9:45 amShun Kawabata (Faculty of Sciences, Kyushu University, Fukuoka, Japan)
"Transglutaminase-Catalyzed Relish Crosslinking Suppresses Innate Immune Signaling in the Drosophila"
9:45 am - 9:55 amDiscussion
9:55 am - 10:25 amKapil Mehta (MD Anderson Cancer Center, USA)
"TG2 - Reprogramming of Inflammatory Signaling and Its Impact on Cancer Progression"
10:25 am - 10:35 amDiscussion
10:35 amCoffee Break
11:10 am - 11:40 amLuigi Maiuri (San Raffaele Scientific Institute, Milan, Italy)
"Transglutaminase 2: A Pivot of Proteostasis Network in Cystic Fibrosis"
11:40 am - 11:50 amDiscussion
11:50 am - 12:20 pmAnne-Marie Van Dam (VU University Medical Center, Amsterdam, The Netherlands)
"Tissue Transglutaminase in the Pathogenesis of Multiple Sclerosis, a Neuroinflammatory Disorder"
12:20 pm - 12:30 amDiscussion
12:30 pmLunch
1:30 pm - 4:30 pmFree Time
4:30 pm - 6:00 pmPoster Session
6:00 pm - 8:00 pmTransglutaminases in Celiac Disease
6:00 pm - 6:15 pmDiscussion Leader: Daniele Sblattero (University of Piemonte, Italy)
6:15 pm - 6:45 pmLudvig Sollid (University of Oslo, Norway)
"Transglutaminase 2: Autoantibody Target and Generator of T-Cell Epitopes"
6:45 pm - 6:55 pmDiscussion
6:55 pm - 7:25 pmKatri Lindfors (University of Finland Tampere)
"In Vivo Effects of Celiac Disease Patient Antibodies"
7:25 pm - 7:35 pmDiscussion
7:35 pm - 7:50 pmShort Talk: Magdalena Adamczyk (Cardiff University, UK)
"Signalling Regulating Active TG2 Release from Cells"
7:50 pm - 8:00 pmDiscussion
8:00 pmDinner
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmTransglutaminases in Cardiovascular and Neurodegenerative Diseases
9:00 am - 9:15 amDiscussion Leader: Carlo Bergamini (University of Ferrara, Italy)
9:15 am - 9:45 amMauro Piacentini (University of Rome "Tor Vergata", Italy)
"TG2: The Guardian of the Proteome?"
9:45 am - 9:55 amDiscussion
9:55 am - 10:25 amMicha Wilhelmus (VU University Medical Center, Amsterdam, The Netherlands)
"Tissue Transglutaminase: An Attractive Therapeutic Target in Alzheimer's Disease?"
10:25 am - 10:35 amDiscussion
10:35 amCoffee Break
11:10 am - 11:40 amManuela Basso (University of Trieste, Italy)
"Understanding Transglutaminase Upregulation in Neuronal Stress"
11:40 am - 11:50 amDiscussion
11:50 am - 12:20 pmMartin Griffin (Aston University, Aston Triangle, Birmingham, UK)
"The Importance of TG2 in Growth Factor Regulation in Angiogenesis"
12:20 pm - 12:30 amDiscussion
12:30 pmLunch
1:30 pm - 4:30 pmFree Time
4:30 pm - 6:00 pmPoster Session
6:00 pm - 8:00 pmTransglutaminases in the Skin
6:00 pm - 6:15 pmDiscussion Leader: Eleonora Candi (University of Rome "Tor Vergata", Italy)
6:15 pm - 6:45 pmRichard Eckert (University of Maryland School of Medicine, Baltimore, USA)
"Type II Transglutaminase and Survival of Cancer Stem Cells"
6:45 pm - 6:55 pmDiscussion
6:55 pm - 7:25 pmK. Hitomi (Nagoya University, Chikusa, Nagoya, Japan)
"Characterization of the Substrate Peptides for Skin TGs and Applications for Detection of Activities and Substrates"
7:25 pm - 7:35 pmDiscussion
7:35 pm - 7:50 pmShort Talk: Martin Stieler (Margburg University, Germany)
"Crystal Structure of Blood Coagulation Factor XIII in the Active Conformation"
7:50 pm - 8:00 pmDiscussion
8:00 pmDinner
THURSDAY
7:30 am - 8:30 amBreakfast
8:30 am - 9:00 amBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pmTransglutaminases in Matrix Remodeling and Organ Fibrosis
9:00 am - 9:30 amDiscussion Leader: Tim Johnson (UCB New Medicines, UK)
9:30 am - 10:00 amPatricia J. Sime (University of Rochester, New York, USA)
"Transglutaminase 2 in Lung Fibrosis: From Bench to Bedside"
10:00 am - 10:15 amDiscussion
10:15 amCoffee Break
11:00 am - 11:30 amElisabetta Verderio (Nottingham Trent University, Nottingham, UK)
"Transglutaminase-2 Interactome in Experimental Kidney Fibrosis"
11:30 am - 11:45 amDiscussion
11:45 am - 12:15 pmMaria Nurminskaya (University of Maryland School of Medicine, Baltimore, USA)
"TG2-Dependent Heterotropic Ossification"
12:15 pm - 12:30 amDiscussion
12:30 pmLunch
1:30 pm - 4:30 pmFree Time
4:30 pm - 6:00 pmPoster Session
6:00 pm - 8:00 pmApproaches to Inhibit Transglutaminase Activity in Human Diseases and to Apply It to Biotechnology
6:00 pm - 6:15 pmDiscussion Leader: Saïd El Alaoui (Covalab, Lyon, France)
6:15 pm - 6:45 pmChaitan Khosla (Stanford University, USA)
"Chemical Biology of Transglutaminase 2"
6:45 pm - 6:55 pmDiscussion
6:55 pm - 7:25 pmFuchsbauer H. Lothar (University of Applied Sciences of Darmstadt,Germany)
"Tracing the Role of Transglutaminase in Streptomycetes"
7:25 pm - 7:35 pmDiscussion
7:35 pm - 7:50 pmJeffrey Keillor (University of Ottawa, Ottawa, Canada)
"Inhibition and Conformational Regulation of Transglutaminase"
7:50 pm - 8:00 pmDiscussion
8:00 pmDinner
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDeparture

Contributors

Conference Links

Conference History
Additional Fee Info

Enzymes, Coenzymes and Metabolic Pathways
July 20 - 25, 2025
Enzymes, Coenzymes and Metabolic Pathways
July 26 - 31, 2026
Polyamines
July 13 - 18, 2025


Contact Us

MyGRC Account
Check your application status, complete your registration, update your poster, change your rooming preference, make a bus reservation, print an invitation letter, print a receipt (which includes verification that you are presenting a poster) or print an invoice by logging into your account.

GRC Venues
Everything you need to know, to plan your trip.

FAQs
Instant answers to common questions.

Tell us how we can help

Call us and leave a detailed message at: 401-783-4011

*This voicemail is only checked once daily. Due to high volume of requests during the conference season, responses may be delayed.

You have no notifications