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Transglutaminases in Human Disease Processes

Gordon Research Conference

Known and Emerging Transglutaminase-Related Diseases and New Methods for Detection and Treatment

June 12 - 17, 2022
Chair
Vice Chair

Conference Description

This meeting will allow the opportunity for discussion of recent results relating the activities of all transglutaminase enzymes with cardiovascular diseases, neurological diseases, cancer and signaling disorders, celiac disease and inflammation, fibrosis and remodeling disorders. Additionally, this meeting will focus on emerging diseases associated with this class of enzymes, and new methods for their investigation.

Related Meeting

This GRC will be held in conjunction with the "Transglutaminases in Human Disease Processes" Gordon Research Seminar (GRS). Those interested in attending both meetings must submit an application for the GRS in addition to an application for the GRC. Refer to the associated GRS program page for more information.

Conference Program

Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Clinical Relevance of Tissue Transglutaminase
Discussion Leader:
7:40 pm - 7:50 pm
Opening Remarks
7:50 pm - 8:30 pm
"Progress In Understanding The Role Of Transglutaminase 2 In Cancer"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:20 pm
"Transglutaminases And Gluten: A Dangerous Combination"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Emerging Diseases
Discussion Leader:
9:00 am - 9:20 am
Introduction by Discussion Leader
9:20 am - 9:50 am
"Factor XIII-A In Adipose Tissue Inflammation and Metabolic Health"
9:50 am - 10:00 am
Discussion
10:00 am - 10:30 am
Coffee Break
10:30 am - 11:00 am
"Protein Monoaminylation In Brain: Novel Mechanisms of Neural Development, Plasticity and Disease"
11:00 am - 11:10 am
Discussion
11:10 am - 11:40 am
"Role of Reversible Ubiquitination Catalyzed by Transglutaminases in Bacterial Virulence"
11:40 am - 11:50 am
Discussion
11:50 am - 12:20 pm
"Transglutaminases, Mucus Barrier Integrity and Disease"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizers: and
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Emerging Research Tools
Discussion Leader:
7:30 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:10 pm
"Arterial Aging: Fresh Perspectives from the Novel Tgm2-C277S Knock-In Mouse"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:45 pm
"Leech Peptide Tridegin and its Analogs are Valuable Tools to Inhibit Transglutaminase FXIIIa Activity"
8:45 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
"New Insights into a Small Molecule Inhibitor Which Stabilizes the Open Conformation of Tissue Transglutaminase"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Cardiovascular Diseases
Discussion Leader:
9:00 am - 9:20 am
Introduction by Discussion Leader
9:20 am - 9:50 am
"The Ins And Outs of Platelet FXIII-A"
9:50 am - 10:00 am
Discussion
10:00 am - 10:30 am
Coffee Break
10:30 am - 11:00 am
"Probing the Impact of Transglutaminase Activity on Vascular Remodeling and Function in Pregnancy"
11:00 am - 11:10 am
Discussion
11:10 am - 11:40 am
"Role of Transglutaminase 2 in Cellular Senescence"
11:40 am - 11:50 am
Discussion
11:50 am - 12:20 pm
"The Role of Transglutaminase in Tissue Engineered Vascular Graft"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Neurological Diseases
Discussion Leader:
7:30 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:10 pm
"Transglutaminase 2 Modulates Gene Expression in Astrocytes"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:45 pm
"Tissue Transglutaminase in Central Nervous System Myelination"
8:45 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
"In Vitro and In Vivo Approaches to Determine the Role of Tissue Transglutaminase in Multiple Sclerosis Related Pathogenic Processes"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Cancer and Signaling Disorders
Discussion Leader:
9:00 am - 9:20 am
Introduction by Discussion Leader
9:20 am - 9:50 am
"Tissue Transglutaminase Mechanistically Links the Integrin Adhesion Machinery and B-Catenin Pathway in Ovarian Cancer"
9:50 am - 10:00 am
Discussion
10:00 am - 10:30 am
Coffee Break
10:30 am - 11:00 am
"TG2 Regulates EMT Through Binding a Key EMT Suppressor in Ovarian Cancer"
11:00 am - 11:10 am
Discussion
11:10 am - 11:40 am
"Inhibition of Transglutaminase Type 2 in Breast Cancer Cells"
11:40 am - 11:50 am
Discussion
11:50 am - 12:20 pm
"Breaking Down Barriers: Understanding the Role of Transglutaminase-2 in the Cancer Extracellular Matrix"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Celiac Disease and Inflammation
Discussion Leader:
7:30 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:10 pm
"TG2 and Celiac Disease – From Bench to Bedside"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:45 pm
"Role of Transglutaminase 2 in Endotoxin-Induced Liver Inflammation"
8:45 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
"Erythrocyte TG2: A Missing Component in Chronic Kidney Disease"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Fibrosis and Remodeling
Discussion Leader:
9:00 am - 9:20 am
Introduction by Discussion Leader
9:20 am - 9:50 am
"The "EV Factor": The Role of Extracellular Vesicles-Associated TG2"
9:50 am - 10:00 am
Discussion
10:00 am - 10:30 am
Coffee Break
10:30 am - 11:00 am
"Characterization of Substrates Crosslinked by Transglutaminase in Fibrotic Diseases"
11:00 am - 11:10 am
Discussion
11:10 am - 11:40 am
"Is Targeting TG2 with an Inhibitory Antibody a Cross Organ Approach for the Treatment of Fibrosis?"
11:40 am - 11:50 am
Discussion
11:50 am - 12:20 pm
"Transglutaminases and Fibrinogen in the Injured Liver: FXIII and Beyond"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Keynote Session: Activation and Inactivation of Tissue Transglutaminase
Discussion Leader:
7:30 pm - 7:50 pm
Introduction by Discussion Leader
7:50 pm - 8:00 pm
Short Talk Selected from Poster Abstracts
8:00 pm - 8:05 pm
Discussion
8:05 pm - 8:15 pm
Short Talk Selected from Poster Abstracts
8:15 pm - 8:20 pm
Discussion
8:20 pm - 8:30 pm
Short Talk Selected from Poster Abstracts
8:30 pm - 8:35 pm
Discussion
8:35 pm - 9:15 pm
"Mechanisms for TG2-Mediated Gluten Antigen Presentation in Celiac Disease"
9:15 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure

Contributors

Gordon Research Conferences

Conference Links

Conference History Transglutaminases in Human Disease Processes (GRS)
Additional Fee Info

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July 26 - 31, 2026
Polyamines
July 13 - 18, 2025


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