Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: Novel Molecular Insights into Protein Synthesis and Translation Factors
7:40 pm - 8:10 pm
"tRNA Modification Coordination and as Drivers of Translation Quality Control"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:50 pm
"Protein Synthesis in Neurons"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Short Talk Selected from Poster Abstracts
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Short Talk Selected from Poster Abstracts
9:25 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Molecular Insights into Dysregulated Translation in Cancer
9:00 am - 9:20 am
"Drivers of Amino Acid Substitutants in Cancer"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"eIF5A-Dependent Feedback Inhibition from mRNA Translation Elongation to Initiation Induces Apoptosis in Tumor Cells"
9:50 am - 10:00 am
Discussion
10:00 am - 10:10 am
"eIF4E Partners with Ezrin in Localized Translation to Regulate Motility in AML Cells"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
"Human Tumor Suppressor Protein Pdcd4 Inhibits the eIF4F-Independent Function of eIF4A"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Characterization of a White Matter Brain Disorder Model Caused by the Loss of Arginyl-tRNA Synthetase from the Multisynthetase Complex"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
"Robust eIF4B Levels Undermine Invasive Growth and Immune Evasion Mechanisms in Murine Triple Negative Breast Cancer Models"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
"Impact of HIV-1 5’ UTR Structure on Translation Initiation"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hourâ„¢
The GRC Power Hourâ„¢ is designed to address the interests and needs of all scientists and the challenges they face in their careers. Specifically, the program promotes meaningful conversations amongst colleagues of all career stages about barriers to career advancement and strategies to support the professional growth of all members of the community. The GRC Power Hourâ„¢ is open to all conference participants.
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Probing Translation and Its Control in Aging and Stress
7:30 pm - 7:50 pm
"Translation Surveillance Systems Direct Metabolic Regulation"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Dysregulated mRNA Translation Elicits Neuropsychiatric Disorders"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"Quality Control of Translation Machinery"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
"Codon-Specific Ribosome Pausing by tRNA Cleavage Induces Distinct Ribotoxic Stress Response"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Delineating the Mechanism of Repeat-Associated Non-AUG Translation Initiation in C9orf72 ALS"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Translation in Neurons and Disruption in Disease
9:00 am - 9:20 am
"Extracellular Aminoacyl-tRNA Synthetases and Neuropilin 1 Interactions Regulate Vascular Permeability"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Transfer RNA Expression and Modification of Neurological Disorders"
9:50 am - 10:00 am
Discussion
10:00 am - 10:10 am
"5’-UTR-Mediated Tethering of eIF3 to 80S Ribosomes Promotes Co-Translational Folding of ER Membrane Proteins"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
"Understanding FMRP-mediated Translational Regulation"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Role of ER and Lysosomes in Shaping Membrane Protein Synthesis"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"Translation, Cell Stress, and tRNA Synthetase-Associated Peripheral Neuropathies"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"How Does the Cell Distinguish a Physiological Pause from a Pathological Stall in Translation?"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Derailed Ribosomes and Human Disease
7:30 pm - 7:50 pm
"Regulating Ribosome Entry into Active Translation"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Concentration Matters: Defining Determinants of Ribosome Homeostasis"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"In Situ Visualization of the Mammalian Translation Machinery"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
"Predicting the Translation Efficiency of Messenger RNA in Mammalian Cells"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Regulation of Translation Initiation by Start Codon Methylation"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
9:00 am - 9:20 am
"Turning Pathogens into Cell Biology Tools"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Four Proteins from the Family of mtAP2s Transcription Factors Piece Together the Highly rRNA-Fragmented Mitoribosome in Toxoplasma Gondii "
9:50 am - 10:00 am
Discussion
10:00 am - 10:10 am
"Molecular Insights into the Translation Function of the Parasite Multi-tRNA Synthetase Complex"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
"Structural Basis for the Role of Hibernation Factors in Ribosomal Collisions"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Expanding World of tRNA Modifications in Health and Disease"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"Coordinated Changes of tRNA Modifications for Cellular Protein Homeostasis"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Nascent Peptide Folding Directly Impacts mRNA Translation and Stability"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Structural Basis for Context-Specific Inhibition of the Ribosome by Macrolide Antibiotics"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Localized Translation and Organelles
7:30 pm - 7:50 pm
"Unique Features of the Mitochondrial Translation System in Health and Disease"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Translation Dynamics in mRNA Localization to the Endoplasmic Reticulum"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"Exploiting a Functional Domain from tRNA Synthetase as a Novel Immune Modulator for Cancer and Viral Therapy"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
"Why do Mammals Have So Many tRNA Isodecoder Genes?"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Mitochondrial Protein Heterogeneity Stems from the Stochastic Nature of Co-Translational Protein Targeting in Cell Senescence"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Global Methods for Dissecting Translation
9:00 am - 9:20 am
"Single Cell Measurements of mRNA Translation in the Brain"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Mining Noncanonical Peptides Using Ribosome Profiling"
9:50 am - 10:00 am
Discussion
10:00 am - 10:10 am
"Functional Screen for Mediators of Onco-mRNA Translation Specificity"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
"Structural Basis for Aminoacylation of Cellular Modified tRNALys3 by Human Lysyl-tRNA Synthetase"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"Translation Elongation as a Rate Limiting Step of Protein Production"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"A New Protein-Dependent Riboswitch Activates Ribosomal Frameshifting"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"The Ribosome Lowers the Entropic Penalty of Protein Folding"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Molecular Snapshots of Translation
7:30 pm - 7:50 pm
"In-Cell Structural Analysis of Translation Regulation"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"RNA Regulation in Male Germ Cells and Male Infertility"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"Ribosomes in Gene Regulation: Controlling the Diversity of Proteins Made in Specific Cells, Tissues, and Organisms"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"Spatiotemporal Understanding of Protein Synthesis"
9:20 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure