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Translation Machinery in Health and Disease

Gordon Research Conference

Molecular Insights into Protein Synthesis in Health and Disease

February 23 - 28, 2025

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GRC Education Requirements: Undergraduates or those who have not obtained a bachelor's degree in science/engineering (or acceptable equivalent) are not eligible to apply to attend Gordon Research Conferences or Seminars.

Chairs

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Vice Chairs

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Sheraton Fairplex Hotel & Conference Center

601 West McKinley Ave.

Pomona, California, United States

Venue and Travel Information

Application Information

Applications for this meeting must be submitted by January 26, 2025. Please apply early, as some meetings become oversubscribed (full) before this deadline. If the meeting is oversubscribed, it will be stated here. Note: Applications for oversubscribed meetings will only be considered by the conference chair if more seats become available due to cancellations.

Conference Description

The Translation Machinery in Health and Disease GRC is a premier, international scientific conference focused on advancing the frontiers of science through the presentation of cutting-edge and unpublished research, prioritizing time for discussion after each talk and fostering informal interactions among scientists of all career stages. The conference program includes a diverse range of speakers and discussion leaders from institutions and organizations worldwide, concentrating on the latest developments in the field. The conference is five days long and held in a remote location to increase the sense of camaraderie and create scientific communities, with lasting collaborations and friendships. In addition to premier talks, the conference has designated time for poster sessions from individuals of all career stages, and afternoon free time and communal meals allow for informal networking opportunities with leaders in the field.

The Translation Machinery in Health and Disease GRC will highlight new molecular insights into translation including control during normal processes and how their dysregulation contributes to a wide array of diseases. Global and specialized translation will be discussed in the context of neurological disorders, cancer, pathogens and immunity, stress and aging, cellular condensates, mitochondria, ribosomopathies and rare diseases as well as the latest conceptual and technical advances that drive new discoveries in translation.

Related Meeting

This GRC will be held in conjunction with the "Translation Machinery in Health and Disease" Gordon Research Seminar (GRS). Those interested in attending both meetings must submit an application for the GRS in addition to an application for the GRC. Refer to the associated GRS program page for more information.

Conference Program

Sunday
2:00 pm - 9:00 pm	Arrival and Check-in
6:00 pm - 7:00 pm	Dinner
7:30 pm - 7:40 pm	Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm	Keynote Session: Novel Molecular Insights into Protein Synthesis and Translation Factors Discussion Leader:
7:40 pm - 8:10 pm	"tRNA Modification Coordination and as Drivers of Translation Quality Control"
8:10 pm - 8:20 pm	Discussion
8:20 pm - 8:50 pm	"Protein Synthesis in Neurons"
8:50 pm - 9:00 pm	Discussion
9:00 pm - 9:10 pm	Short Talk Selected from Poster Abstracts
9:10 pm - 9:15 pm	Discussion
9:15 pm - 9:25 pm	Short Talk Selected from Poster Abstracts
9:25 pm - 9:30 pm	Discussion
Monday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Molecular Insights into Dysregulated Translation in Cancer Discussion Leader:
9:00 am - 9:20 am	"Drivers of Amino Acid Substitutants in Cancer"
9:20 am - 9:30 am	Discussion
9:30 am - 9:50 am	"eIF5A-Dependent Feedback Inhibition from mRNA Translation Elongation to Initiation Induces Apoptosis in Tumor Cells"
9:50 am - 10:00 am	Discussion
10:00 am - 10:10 am	"eIF4E Partners with Ezrin in Localized Translation to Regulate Motility in AML Cells"
10:10 am - 10:15 am	Discussion
10:15 am - 10:45 am	Coffee Break
10:45 am - 11:05 am	"N4-Acetylcytidine and N1-Methylpseudouridine Yield Distinctive Outcomes on Synthetic mRNA Translation Rate and Fidelity"
11:05 am - 11:15 am	Discussion
11:15 am - 11:35 am	"Characterization of a White Matter Brain Disorder Model Caused by the Loss of Arginyl-tRNA Synthetase from the Multisynthetase Complex"
11:35 am - 11:45 am	Discussion
11:45 am - 11:55 am	"Robust eIF4B Levels Undermine Invasive Growth and Immune Evasion Mechanisms in Murine Triple Negative Breast Cancer Models"
11:55 am - 12:00 pm	Discussion
12:00 pm - 12:30 pm	Poster Previews
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
3:00 pm - 4:00 pm	The GRC Power Hour™ The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring. Organizers: and
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Probing Translation and Its Control in Aging and Stress Discussion Leader:
7:30 pm - 7:50 pm	"Translation Surveillance Systems Direct Metabolic Regulation"
7:50 pm - 8:00 pm	Discussion
8:00 pm - 8:20 pm	"Direct and Indirect Mechanisms of Eukaryotic Translational Control"
8:20 pm - 8:30 pm	Discussion
8:30 pm - 8:50 pm	"Dysregulated mRNA Translation Elicits Neuropsychiatric Disorders"
8:50 pm - 9:00 pm	Discussion
9:00 pm - 9:10 pm	"Mitochondrial Protein Heterogeneity Stems from the Stochastic Nature of Co-Translational Protein Targeting in Cell Senescence"
9:10 pm - 9:15 pm	Discussion
9:15 pm - 9:25 pm	"Human Tumor Suppressor Protein Pdcd4 Inhibits the eIF4F-Independent Function of eIF4A"
9:25 pm - 9:30 pm	Discussion
Tuesday
7:30 am - 8:30 am	Breakfast
8:30 am - 9:00 am	Group Photo
9:00 am - 12:30 pm	Translation in Neurons and Disruption in Disease Discussion Leader:
9:00 am - 9:20 am	"Extracellular Aminoacyl-tRNA Synthetases and Neuropilin 1 Interactions Regulate Vascular Permeability"
9:20 am - 9:30 am	Discussion
9:30 am - 9:50 am	"Transfer RNA Expression and Modification of Neurological Disorders"
9:50 am - 10:00 am	Discussion
10:00 am - 10:10 am	"5’-UTR-Mediated Tethering of eIF3 to 80S Ribosomes Promotes Co-Translational Folding of ER Membrane Proteins"
10:10 am - 10:15 am	Discussion
10:15 am - 10:45 am	Coffee Break
10:45 am - 11:05 am	"Role of ER and Lysosomes in Shaping Membrane Protein Synthesis"
11:05 am - 11:15 am	Discussion
11:15 am - 11:35 am	"Translation, Cell Stress, and tRNA Synthetase-Associated Peripheral Neuropathies"
11:35 am - 11:45 am	Discussion
11:45 am - 11:55 am	"mRNA Targeting to the Dermal-Epidermal Junction Controls Epithelial Tissue Organization"
11:55 am - 12:00 pm	Discussion
12:00 pm - 12:15 pm	Poster Previews
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Derailed Ribosomes and Human Disease Discussion Leader:
7:30 pm - 7:50 pm	"Regulating Ribosome Entry into Active Translation"
7:50 pm - 8:00 pm	Discussion
8:00 pm - 8:20 pm	"Concentration Matters: Defining Determinants of Ribosome Homeostasis"
8:20 pm - 8:30 pm	Discussion
8:30 pm - 8:50 pm	"In Situ Visualization of the Mammalian Translation Machinery"
8:50 pm - 9:00 pm	Discussion
9:00 pm - 9:20 pm	"Quality Control of Translation Machinery"
9:20 pm - 9:30 pm	Discussion
Wednesday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Translation and Immunity Discussion Leader:
9:00 am - 9:20 am	"Turning Pathogens into Cell Biology Tools"
9:20 am - 9:30 am	Discussion
9:30 am - 9:50 am	"Four Proteins from the Family of mtAP2s Transcription Factors Piece Together the Highly rRNA-Fragmented Mitoribosome in Toxoplasma Gondii"
9:50 am - 10:00 am	Discussion
10:00 am - 10:10 am	"Molecular Insights into the Translation Function of the Parasite Multi-tRNA Synthetase Complex"
10:10 am - 10:15 am	Discussion
10:15 am - 10:45 am	Coffee Break
10:45 am - 11:05 am	"Expanding World of tRNA Modifications in Health and Disease"
11:05 am - 11:15 am	Discussion
11:15 am - 11:35 am	"Coordinated Changes of tRNA Modifications for Cellular Protein Homeostasis"
11:35 am - 11:45 am	Discussion
11:45 am - 12:05 pm	"How Slow-Growing Bacteria Adapt to Abrupt Stress"
12:05 pm - 12:15 pm	Discussion
12:15 pm - 12:25 pm	"Structural Basis for Context-Specific Inhibition of the Ribosome by Macrolide Antibiotics"
12:25 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Localized Translation and Organelles Discussion Leader:
7:30 pm - 7:50 pm	"Unique Features of the Mitochondrial Translation System in Health and Disease"
7:50 pm - 8:00 pm	Discussion
8:00 pm - 8:20 pm	"Translation Dynamics in mRNA Localization to the Endoplasmic Reticulum"
8:20 pm - 8:30 pm	Discussion
8:30 pm - 8:50 pm	"Exploiting a Functional Domain from tRNA Synthetase as a Novel Immune Modulator for Cancer and Viral Therapy"
8:50 pm - 9:00 pm	Discussion
9:00 pm - 9:10 pm	"Why do Mammals Have So Many tRNA Isodecoder Genes?"
9:10 pm - 9:15 pm	Discussion
9:15 pm - 9:25 pm	"Codon-Specific Ribosome Pausing by tRNA Cleavage Induces Distinct Ribotoxic Stress Response"
9:25 pm - 9:30 pm	Discussion
Thursday
7:30 am - 8:30 am	Breakfast
8:30 am - 9:00 am	Business Meeting Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm	Global Methods for Dissecting Translation Discussion Leader:
9:00 am - 9:20 am	"Single Cell Measurements of mRNA Translation in the Brain"
9:20 am - 9:30 am	Discussion
9:30 am - 9:50 am	"Mining Noncanonical Peptides Using Ribosome Profiling"
9:50 am - 10:00 am	Discussion
10:00 am - 10:10 am	Short Talk Selected from Poster Abstracts
10:10 am - 10:15 am	Discussion
10:15 am - 10:25 am	Short Talk Selected from Poster Abstracts
10:25 am - 10:30 am	Discussion
10:30 am - 11:00 am	Coffee Break
11:00 am - 11:20 am	"Translational Fidelity"
11:20 am - 11:30 am	Discussion
11:30 am - 11:50 am	"Translation Elongation as a Rate Limiting Step of Protein Production"
11:50 am - 12:00 pm	Discussion
12:00 pm - 12:10 pm	"The Ribosome Lowers the Entropic Penalty of Protein Folding"
12:10 pm - 12:15 pm	Discussion
12:15 pm - 12:25 pm	Short Talk Selected from Poster Abstracts
12:25 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Molecular Snapshots of Translation Discussion Leader:
7:30 pm - 7:50 pm	"In-Cell Structural Analysis of Translation Regulation"
7:50 pm - 8:00 pm	Discussion
8:00 pm - 8:20 pm	"RNA Regulation in Male Germ Cells and Male Infertility"
8:20 pm - 8:30 pm	Discussion
8:30 pm - 8:50 pm	"Ribosomes in Gene Regulation: Controlling the Diversity of Proteins Made in Specific Cells, Tissues, and Organisms"
8:50 pm - 9:00 pm	Discussion
9:00 pm - 9:20 pm	"Spatiotemporal Understanding of Protein Synthesis"
9:20 pm - 9:30 pm	Discussion
Friday
7:30 am - 8:30 am	Breakfast
9:00 am	Departure

Contributors

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Conference History Translation Machinery in Health and Disease (GRS) Contribute Financially to This Conference

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Poster Information

Poster sessions are an integral part of the our conferences, and offer all conferees an opportunity to discuss their research.

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Diversity Funding

Financial assistance is available for qualified applicants through the GRC Carl Storm Underrepresented Minority Fellowship Program. This program provides a grant to underrepresented minority graduate students, postdocs, faculty and scientists to help fund their attendance at their first GRC meeting. Learn more.

Registration Fees

Conferee Single Room:

$1,730.00

Conferee Shared Room:

$1,470.00

Conferee Off-Site:

$1,280.00

Guest Single Room:

$1,540.00

Guest Shared Room:

$1,280.00

Guest Off-Site:

$1,090.00

Child 4-12 yrs Shared Room:

$640.00

Child 4-12 yrs Off-Site:

$545.00

Child Under 4 yrs Shared Room:

Free

Child Under 4 yrs Off-Site:

Free

Additional Fee Info

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