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Translation Machinery in Health and Disease (GRS)

Gordon Research Seminar

Exploring the Therapeutic Potential of Translational Control

February 22 - 23, 2025

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GRC Education Requirements: Undergraduates or those who have not obtained a bachelor's degree in science/engineering (or acceptable equivalent) are not eligible to apply to attend Gordon Research Conferences or Seminars.

Chairs

and

Sheraton Fairplex Hotel & Conference Center

601 West McKinley Ave.

Pomona, California, United States

Venue and Travel Information

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Conference Description

The Translation Machinery in Health and Disease GRS provides a unique forum for young doctoral and post-doctoral researchers to present their work, discuss new methods, cutting edge ideas, and pre-published data, as well as to build collaborative relationships with their peers. Experienced mentors and trainee moderators will facilitate active participation in scientific discussion to allow all attendees to be engaged participants rather than spectators.

Translation of mRNA into protein is an essential process common to all domains of life. Despite this universality, regulatory mechanisms controlling translation are shockingly diverse across cell and tissue types, as well as between organisms. The power of understanding and exploiting the wide array of translational control mechanisms known to date has been harnessed for the development of antibiotics, antifungals, chemotherapies, and the blockbuster mRNA vaccines. The Translation Machinery in Health and Disease GRS seeks to connect young scientists studying protein synthesis hailing from a variety of approaches and model systems to share their expertise and learn about the diverse world of translational control.

Additionally, we will have a designated mentoring panel focused on careers in academia and industry, as well as representatives from several companies with special interests in recruiting trainees with expertise in translational control and RNA Biology.

Applicants for oral presentations will be considered beyond the initial abstract deadline until December 20th 2024.

Related Meeting

This GRS will be held in conjunction with the "Translation Machinery in Health and Disease" Gordon Research Conference (GRC). Those interested in attending both meetings must submit an application for the GRC in addition to an application for the GRS. Refer to the associated GRC program page for more information.

Conference Program

Saturday
1:00 pm - 5:00 pm	Arrival and Check-in
3:30 pm - 3:45 pm	Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
3:45 pm - 4:30 pm	Technology Development to Elucidate Translational Mechanisms Discussion Leader:
3:45 pm - 3:55 pm	"RNA-Linked CRISPR Screening Identifies Diverse Regulators of mRNA Translation and Stability"
3:55 pm - 4:00 pm	Discussion
4:00 pm - 4:10 pm	"A Subcellular Map of Translational Machinery Composition and Regulation"
4:10 pm - 4:15 pm	Discussion
4:15 pm - 4:25 pm	"Expanding the Scope of Studying tRNA Modifications by Sequencing"
4:25 pm - 4:30 pm	Discussion
4:30 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Fundamental Research and Therapeutics in Translation Machinery Discussion Leader:
7:30 pm - 7:40 pm	"The tRNA Multisynthetase Complex is Critical for the Cardiac Response to Stress"
7:40 pm - 7:45 pm	Discussion
7:45 pm - 7:55 pm	"Reduced Ribosome Biogenesis as a Key Driver of Ewing Sarcoma"
7:55 pm - 8:00 pm	Discussion
8:00 pm - 8:10 pm	"Links Between Metabolism and Protein Translation in the Melanocytic Lineage"
8:10 pm - 8:15 pm	Discussion
8:15 pm - 8:25 pm	"Evolution of Drug-Binding Residues in Bacterial Ribosomes"
8:25 pm - 8:30 pm	Discussion
8:30 pm - 8:40 pm	"Investigating the Role of EIF1AX-mediated Non-Canonical Translation in Ovarian Cancer"
8:40 pm - 8:45 pm	Discussion
8:45 pm - 8:55 pm	"Enhancing Translation of Targeted Endogenous mRNA in Mammalian Cells Using Programmable RNA-Binding and Exploring Potential Future Applications in Disease Therapy"
8:55 pm - 9:00 pm	Discussion
9:00 pm - 9:10 pm	"An Upstream Open Reading Frame is a Post-Transcriptional Repressor of KCNQ2 Expression"
9:10 pm - 9:15 pm	Discussion
9:15 pm - 9:25 pm	"Conformational Remodeling of mRNA by eIF4F in Eukaryotic Translation Initiation"
9:25 pm - 9:30 pm	Discussion
Sunday
7:30 am - 8:30 am	Breakfast
9:00 am - 11:00 am	Protein Synthesis Regulation and Disease Discussion Leader:
9:00 am - 9:10 am	"Investigating the Cause of the Cell-Type Specificity in Charcot-Marie-Tooth Disease Type 2D"
9:10 am - 9:15 am	Discussion
9:15 am - 9:25 am	"Larp1 is Required for Normal Brain Development and Spatial Memory"
9:25 am - 9:30 am	Discussion
9:30 am - 9:40 am	"Catalytic Inhibition of Threonine tRNA Synthetase Impairs Codon-Specific Translation Velocity and Activates Cellular Stress Responses"
9:40 am - 9:45 am	Discussion
9:45 am - 9:55 am	"Cryo-EM Structure of SerRS/SIRT2 Complex in Presence of a NAD+ Metabolite Reveals Cross Regulation Between Cellular Metabolism and Translation"
9:55 am - 10:00 am	Discussion
10:00 am - 10:10 am	"Deficiency of a tRNA Modification Enzyme Induces Glial Abundance Changes in the Mammalian Brain"
10:10 am - 10:15 am	Discussion
10:15 am - 10:25 am	"ATF4 Expression Mediates Neuromuscular Deficits in Mouse Models of tRNA Synthetase-Associated Charcot-Marie-Tooth Disease"
10:25 am - 10:30 am	Discussion
10:30 am - 10:40 am	"dORF Translation Enhances Canonical ORF Translation in Diverse Eukaryotic Species"
10:40 am - 10:45 am	Discussion
10:45 am - 10:55 am	"Ribosome Stalling Induced Mitochondrial Membrane Shedding"
10:55 am - 11:00 am	Discussion
11:00 am - 12:30 pm	Poster Session Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm	Lunch
1:30 pm - 2:30 pm	Mentorship Component: Exploring Careers in Science Discussion Leader:
1:30 pm - 2:00 pm	and "Navigating Career Transitions and Training in the US-European System"
2:00 pm - 2:30 pm	Discussion
2:30 pm - 3:00 pm	Evaluation Period Complete the GRS Evaluation Forms; Election of Future Chair(s)
3:00 pm	Seminar Concludes

Contributors

Conference Links

Conference History Translation Machinery in Health and Disease Contribute Financially to This Conference

Conference Fees

Poster Information

Poster sessions are an integral part of the our conferences, and offer all conferees an opportunity to discuss their research.

Preparing your GRC poster

Diversity Funding

Financial assistance is available for qualified applicants through the GRC Carl Storm Underrepresented Minority Fellowship Program. This program provides a grant to underrepresented minority graduate students, postdocs, faculty and scientists to help fund their attendance at their first GRC meeting. Learn more.

Registration Fees

Conferee Single Room:

$370.00

Conferee Shared Room:

$320.00

Conferee Off-Site:

$270.00

Guest Single Room:

$370.00

Guest Shared Room:

$320.00

Guest Off-Site:

$270.00

Child 4-12 yrs Shared Room:

$161.00

Child 4-12 yrs Off-Site:

$136.00

Child Under 4 yrs Shared Room:

Free

Child Under 4 yrs Off-Site:

Free

Additional Fee Info

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