| SUNDAY |
| 4:00 pm - 9:00 pm | Arrival and Check-in |
| 5:00 pm - 6:00 pm | Welcome Reception on the Cloisters Lawn |
| 6:00 pm | Dinner |
| 7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
| 7:40 pm - 9:30 pm | STRATEGIES FOR THE DEVELOPMENT AND DEPLOYMENT OF NEW ANTIBIOTICS |
| Discussion Leader: Valerie Mizrahi (University of the Witwatersrand) |
| 7:40 pm - 7:45 pm | Welcome, Opening Remarks, & Announcements by Chair: Valerie Mizrahi |
| 7:45 pm - 8:25 pm | Christopher T. Walsh (Harvard Medical School)
"Antibiotics for TB: Present and Future" |
| 8:25 pm - 8:40 pm | Discussion |
| 8:40 pm - 9:15 pm | Nulda Beyers (Stellenbosch University)
"The impact of new drugs on the eradication of TB" |
| 9:15 pm - 9:30 pm | Discussion |
| MONDAY |
| 8:00 am - 9:00 am | Breakfast |
| 9:00 am - 12:30 pm | LESSONS FROM THE BROAD-SPECTRUM AREA |
| Discussion Leader: Bala Subramanian (Astrazeneca, India) |
| 9:00 am - 9:45 am | Trevor Trust (Astrazeneca)
"The experience of Helicobacter pylori" |
| 9:45 am - 10:00 am | Discussion |
| 10:00 am | Coffee Break / Group Photo |
| 10:30 am - 11:00 am | Steven Projan (Wyeth Research)
"Antibacterial drug discovery in the 21st Century" |
| 11:00 am - 11:10 am | Discussion |
| 11:10 am - 11:40 am | Richard Lee (University of Tennessee)
"Revisiting old targets in new ways" |
| 11:40 am - 11:50 am | Discussion |
| 11:50 am - 12:15 pm | Michael Fischbach (Harvard Medical School)
"Strategies for developing new TB antibiotics" |
| 12:15 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | SCIENTIFIC ISSUES IN PRECLINICAL AND EARLY CLINICAL DEVELOPMENT |
| Discussion Leader: Clifton E. Barry III (NIAID, NIH) |
| 7:30 pm - 8:00 pm | David McNeeley (Tibotec)
"Update on the clinical development of TMC207: a novel TB compound to treat drug-susceptible and drug-resistant tuberculosis" |
| 8:00 pm - 8:10 pm | Discussion |
| 8:10 pm - 8:35 pm | Gerry Davies (University of Liverpool)
"Pharmacokinetics and pharmacodynamics in clinical development of new anti-tuberculosis drugs" |
| 8:35 pm - 8:45 pm | Discussion |
| 8:45 pm - 9:15 pm | Anne Lenaerts (Colorado State University)
"Challenges in preclinical testing of new TB drugs" |
| 9:15 pm - 9:30 pm | Discussion |
| TUESDAY |
| 8:00 am - 9:00 am | Breakfast |
| 9:00 am - 12:30 pm | NEW TARGET AREAS |
| Discussion Leader: Harvey Rubin (University of Pennsylvania) |
| 9:00 am - 9:45 am | Peter Tonge (Stony Brook University, NY)
"Mycolic acid and menaquinone biosynthesis: Mining the Magic Mountain for novel TB drugs" |
| 9:45 am - 10:00 am | Discussion |
| 10:00 am | Coffee Break |
| 10:30 am - 10:55 am | Cynthia Dowd (George Washington University)
"The structural determinants of aerobic versus anaerobic antitubercular activities of nitroimidazoles" |
| 10:55 am - 11:05 am | Discussion |
| 11:05 am - 11:30 am | Dean Crick (Colorado State University)
"Targeting non-replicating Mycobacterium tuberculosis with menaquinone synthesis inhibitors" |
| 11:30 am - 11:35 am | Discussion |
| 11:35 am - 11:55 am | Anil Koul (Johnson & Johnson, Belgium)
"AtpE, an oligomeric and proteolipic subunit of ATP synthase, is the target for antimycobacterial activity of diarylquinolines" |
| 11:55 am - 12:00 pm | Discussion |
| 12:00 pm - 12:20 pm | Ramandeep Singh (NIAID, NIH)
"Suicide and survival of Mycobacterium tuberculosis" |
| 12:20 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | ENVIRONMENTAL RESPONSES AND DRUG TOLERANCE |
| Discussion Leader: David Sherman (Seattle Biomedical Research Institute) |
| 7:30 pm - 8:00 pm | Bruce Levin (Emory University)
"The population dynamics of antibiotic treatment failure in the absence of
resistance" |
| 8:00 pm - 8:10 pm | Discussion |
| 8:10 pm - 8:40 pm | Kevin Pethe (Novartis Institute for Tropical Diseases)
"Persistence mechanisms and drug tolerance in dormant mycobacteria" |
| 8:40 pm - 8:50 pm | Discussion |
| 8:50 pm - 9:15 pm | Neeraj Dhar (Rockefeller University)
"Single cell observational studies of INH persisters in mycobacteria" |
| 9:15 pm - 9:30 pm | Discussion |
| WEDNESDAY |
| 8:00 am - 9:00 am | Breakfast |
| 9:00 am - 12:30 pm | TARGETING MACROMOLECULAR SYNTHESIS AND TURNOVER |
| Discussion Leader: Thomas Dick (Novartis Institute for Tropical Diseases) |
| 9:00 am - 9:45 am | Carl Nathan (Cornell University)
"Targeting macromolecules at distinct phases of their life cycle: Synthesis,
repair and degradation" |
| 9:45 am - 10:00 am | Discussion |
| 10:00 am | Coffee Break |
| 10:30 am - 11:00 am | Rajesh Gokhale (NII, India)
"Multifunctional polyketide synthases for biosynthesis of complex mycobacterial lipids" |
| 11:00 am - 11:10 am | Discussion |
| 11:10 am - 11:40 am | Helena Boshoff (NIAID)
"Evaluating drug targets in peptidoglycan synthesis and remodeling" |
| 11:40 am - 11:50 am | Discussion |
| 11:50 am - 12:15 pm | Courtney Aldrich (University of Minnesota)
"Antitubercular nucleosides that inhibit siderophore biosynthesis" |
| 12:15 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:00 pm - 7:30 pm | Business Meeting |
| (Nominations for the next Vice Chair(s); Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair(s)) |
| 7:30 pm - 9:30 pm | REGULATION AND METABOLISM |
| Discussion leader: Tom Alber (UC Berkeley) |
| 7:30 pm - 8:00 pm | Jim Sacchettini (Texas A&M University)
"New drug targets from metabolic pathways" |
| 8:00 pm - 8:10 pm | Discussion |
| 8:10 pm - 8:40 pm | Vrinda Nandi (AstraZeneca, India)
"Targeting acetolactate synthase for novel anti-tubercular agents" |
| 8:40 pm - 8:50 pm | Discussion |
| 8:50 pm - 9:15 pm | Nicole Sampson (Stony Brook University)
"Purification and characterization of a putative 3β-hydroxysteroid dehydrogenase from Mycobacterium tuberculosis" |
| 9:15 pm - 9:30 pm | Discussion |
| THURSDAY |
| 8:00 am - 9:00 am | Breakfast |
| 9:00 am - 12:30 pm | NEW TECHNOLOGIES |
| Discussion Leader: Eric Rubin (Harvard) |
| 9:00 am - 9:25 am | John Overington (Inpharmatica, UK)
"Large-scale prioritisation of drug targets using a knowledge-based approach" |
| 9:25 am - 09:35 am | Discussion |
| 9:35 am - 10:00 am | Chris Abell (University of Cambridge, UK)
"Fragment based drug discovery - from crystal to clinic" |
| 10:00 am - 10:10 am | Discussion |
| 10:10 am | Coffee Break |
| 10:40 am - 11:05 am | Lalita Ramakrishnan (University of Washington)
"The zebrafish model to study mycobacterial replication dynamics and its relationship to antibiotic susceptibility" |
| 11:05 am - 11:15 am | Discussion |
| 11:15 am - 11:40 am | Sarah Fortune (Harvard School of Public Health)
"Separate but not equal: Genomic diversity in mycobacteria" |
| 11:40 am - 11:50 am | Discussion |
| 11:50 am - 12:15 pm | Tanya Parish (Barts and the London)
"Conditional gene expression in M. tuberculosis for target validation" |
| 12:15 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 5:30 pm | Poster Session |
| 5:30 pm | Reception on the Cloisters Lawn |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | GETTING DRUGS TO THEIR TARGETS |
| Discussion Leader: Ken Duncan (Bill & Melinda Gates Foundation) |
| 7:30 pm - 8:00 pm | Paul Tulkens (Université Catholique de Louvain, Belgium)
"Cellular uptake and disposition of antibiotics: how can they reach and act on their targets?" |
| 8:00 pm - 8:10 pm | Discussion |
| 8:10 pm - 8:40 pm | George Drusano (Ordway Research Institute)
"Suppression of drug resistance in Mycobacterium tuberculosis through dose and schedule choice" |
| 8:40 pm - 8:50 pm | Discussion |
| 8:50 pm - 9:20 pm | Chris Lipinski (Melior Discovery)
"Wrap-up and concluding comments" |
| 9:20 pm - 9:30 pm | Discussion |
| FRIDAY |
| 8:00 am - 9:00 am | Breakfast |
| 9:00 am | Departure |
