Sunday
4:00 pm - 8:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Paracrine Vascular Signaling
Signals within the vascular wall and between flowing blood and vascular cells that regulate the blood-brain barrier and vascular tone will be discussed.
7:40 pm - 7:45 pm
Opening Remarks
7:45 pm - 8:10 pm
"HDL and Flow Signaling Intersects S1P Biology at the Endothelium"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:45 pm
"Specialization of Vascular Cells in the CNS"
8:45 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
"Pannexins as a Key Regulator of Blood Pressure"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Vascular Development
Blood vascular growth in bone, intestine, heart and elsewhere will be addressed using mouse and fish genetic models.
9:00 am - 9:20 am
"Regulation of Organ Morphogenesis by Vascular Cells"
9:20 am - 9:30 am
Discussion
9:30 am - 9:40 am
"PRDM6 Mutations Impair Ductus Arteriosus Remodeling by Inhibiting TGFβ-Dependent Maturation of Vascular Smooth Muscle Cells"
9:40 am - 9:45 am
Discussion
9:45 am - 10:05 am
"Adventures in Asymmetry: Transcriptional and Cellular Interactions During Gut Vascular Morphogenesis"
10:05 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 11:05 am
"Linking Mechandotransduction and Transcriptional Regulation During Artery Development"
11:05 am - 11:15 am
Discussion
11:15 am - 11:25 am
"Regulation of Vegf Signaling by Natural and Synthetic Ligands"
11:25 am - 11:30 am
Discussion
11:30 am - 11:50 am
"Regulation of the Blood Brain Barrier in Development and Disease"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
"How Chromatin-Remodeling Impacts Vascular Development and Integrity"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Mechanotransduction in Vascular Development and Disease
How the mechanical forces exerted by blood and lymph shape vascular structures and determine vascular function will be discussed using in vitro systems and both fish and mouse in vivo analyses.
7:30 pm - 7:50 pm
"Impact of Mechanical Forces During the Morphogenesis of the Cardiovascular System"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Live Imaging of Vascular Development with Light Sheet Microscopy"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"Biomechanical and Transcriptional Regulation of Postnatal Lymphatic Vasculature"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"Endothelial Flow Signaling in Vascular Remodeling and Disease"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Specialized Vascular Beds
The
specialization of vessels in specific organs and their relation to human
disease will be discussed.
9:00 am - 9:20 am
"GPRC Signaling in Vascular Growth and Remodeling"
9:20 am - 9:30 am
Discussion
9:30 am - 9:40 am
"Transcytosis Regulation at the BBB"
9:40 am - 9:45 am
Discussion
9:45 am - 10:05 am
"Interactions Between Nervous and Vascular Systems in the CNS"
10:05 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 11:05 am
"Light-Response Pathways in the Regulation of Vascular Development"
11:05 am - 11:15 am
Discussion
11:15 am - 11:25 am
"Premedicine Bridges Hypoxia to Pathological Angiogenesis"
11:25 am - 11:30 am
Discussion
11:30 am - 11:50 am
"High 'Tek' Solutions for Glaucoma"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
"Guidance of Vascular Patterning"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Vascular
Immunology and Inflammation
The role of
immune and inflammatory responses in vessel function and disease will be
discussed by established and young investigators.
7:30 pm - 7:50 pm
"Regulation of Vascular Cell Adhesion in Inflammation"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:10 pm
"Unexpected Mechanisms of Cerebral Cavernous Malformation"
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:35 pm
"Regulatory Networks that Suppress the Pro-Flammatory Status of the Vascular Endothelium"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
"Regulation of VEGFR2-Mediated Endothelial Responses by Rap1 Under Physiological and Pathological Conditions"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"Myeloid Cells in Vascular Function and Inflammation"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
The Vascular Niche in Regeneration
The role of vascular cells in stem cell niches and their participation in organ regeneration will be discussed.
9:00 am - 9:20 am
"Vascular Niches in Health and Disease"
9:20 am - 9:30 am
Discussion
9:30 am - 9:40 am
"Shear Stress, Notch and VE-Cadherin: The Molecular Mechanism of Vascular Fusion"
9:40 am - 9:45 am
Discussion
9:45 am - 10:05 am
"VEGF and Vascular Stem Cell Niches"
10:05 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 11:05 am
"Angiocrine Contribution of the Vascular Niche to Fibrosis-Free Tissue-Specific Organ Regeneration"
11:05 am - 11:15 am
Discussion
11:15 am - 11:25 am
"VEGF Signaling Independent Endothelial Proliferation Is Regulated by aPKC via FoxO1"
11:25 am - 11:30 am
Discussion
11:30 am - 11:50 am
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Mechanisms Regulating Endothelial-to-Mesenchymal Transition (Endmt) and Vascular Remodeling in Acute Lung Injury"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Translation to
Vascular Therapies
Accomplished scientists who have worked in both academia and industry
will discuss the development and testing of new drugs to treat vascular
diseases.
7:30 pm - 7:55 pm
"A Novel Tie2 Agonistic Antibody for Vascular Therapies"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:30 pm
"Novel Therapies for Microvascular Disease"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:05 pm
"Protease-Activated Receptors: Bench to Bedside to Bench"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:30 pm
General Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Vascular Metabolism
How vascular cell types serve their own and neighboring cells' metabolic
needs will be discussed.
9:00 am - 9:20 am
"Endothelial Metabolism in and out of the Endothelial Cell"
9:20 am - 9:30 am
Discussion
9:30 am - 9:40 am
"The p110alpha Isoform of the PI3K Controls Endothelial Cell Rearrangements During Angiogenesis by Stimulating MLC Dephosphorylation"
9:40 am - 9:45 am
Discussion
9:45 am - 10:05 am
"Regulation of Endothelial Metabolism by FOXO Transcription Factors"
10:05 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 11:05 am
"Triglyceride Metabolism Along the Capillary Wall"
11:05 am - 11:15 am
Discussion
11:15 am - 11:25 am
"Regulation of Angiogenesis and Inflammation by miR-467 in Cancer and Insulin Resistance"
11:25 am - 11:30 am
Discussion
11:30 am - 11:50 am
"Metabolic Controls of Lymphatic Growth"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
"Angiopoietin-2 Signaling Switch in Vascular Inflammation"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Epigenetic Regulation of Vascular Biology and Disease
The emerging role of epigenetics in vascular biology and disease will be discussed.
7:30 pm - 7:50 pm
"Regulation of Vascular Inflammation by Noncoding RNAs"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Epigenetic Regulation of Endothelial Identity"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"Co-Translational Complex Assembly in Macrophages"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"Studying Novel Vascular-Associated Cell Populations Using the Zebrafish"
9:20 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure