Sunday
4:00 pm - 8:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Vascular Signaling Networks in Development and Disease
7:40 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:05 pm
"Arterial-Venous Programming in Development and Disease"
8:05 pm - 8:10 pm
Discussion
8:10 pm - 8:30 pm
"VEGF-B: The Yin and Yang in Angiogenesis"
8:30 pm - 8:35 pm
Discussion
8:35 pm - 8:55 pm
"Neural Progenitor Cell-Mediated Spatiotemporal Control of Spinal Cord Vascularization"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
"Energy Substrate Partitioning and Regulation in Endothelial Cells"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"The Alternative Splicing Regulator Nova2 Constrains Vascular Erk Signalling to Limit Specification of the Lymphatic Lineage"
9:25 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Vascular Specification and Guidance and Organ-Specific Vasculature
New cellular and molecular mechanisms responsible for vascular guidance and specification will be presented. Specific attributes of blood vessels organization in various organs will be discussed.
9:00 am - 9:20 am
"Neurovascular Communication During CNS Development"
9:20 am - 9:25 am
Discussion
9:25 am - 9:45 am
"Guidance of Vascular Barrier Formation"
9:45 am - 9:50 am
Discussion
9:50 am - 10:10 am
"Organotypic Differentiation, Regeneration and Angiocrine Functions of the Liver Vasculature"
10:10 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 11:05 am
"Specification of Hematopoietic Stem Cells from Hemogenic Endothelium"
11:05 am - 11:10 am
Discussion
11:10 am - 11:20 am
"MicroRNA-223 Establishes a Specialized Glycome that Limits Hematopoietic Stem Cell Production from Endothelium"
11:20 am - 11:25 am
Discussion
11:25 am - 11:35 am
"Mechanosensory Function of Kindlin3 in Microglia Is Crucial for Retinal Vascular Patterning"
11:35 am - 11:40 am
Discussion
11:40 am - 11:50 am
"Epithelial Vegfa Specifies a Distinct Endothelial Population in the Mouse Lung"
11:50 am - 11:55 am
Discussion
11:55 am - 12:05 pm
"Neural JNK3 Regulates Blood Flow Recovery After Hindlimb Ischemia in Mice via an Egr1/Creb1 Axis"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hourâ„¢
The GRC Power Hourâ„¢ is designed to address challenges women face in science and issues of diversity and inclusion. The program supports the professional growth of all members of our communities by providing an open forum for discussion and mentoring.
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Inflammatory Networks and Vascular Niche
7:30 pm - 7:50 pm
"Inflammation in the Vascular Wall"
7:50 pm - 7:55 pm
Discussion
7:55 pm - 8:15 pm
"Dendritic Cells in Vascular and Lymphatic Biology"
8:15 pm - 8:20 pm
Discussion
8:20 pm - 8:40 pm
"Early Vascular Development in Zebrafish and Mouse"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
"The Functional Contribution of Endothelial-to-Mesenchymal Transition to Organ Fibrosis"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
"Endothelial Pannexin1-Purinergic Signaling Axis Is a Key Regulator of the Cerebral Ischemic Response"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Dynamic Stroma Reorganization Drives Blood Vessel Dysmorphia During Glioma Progression: A Role for SLIT-ROBO Vascular Guidance Pathway"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Mechanobiology of Vascular and Lymphatic Systems
9:00 am - 9:20 am
"Systems Approach of Flow Regulation of KLF4-ITPR3 Axis in Endothelium"
9:20 am - 9:25 am
Discussion
9:25 am - 9:35 am
"Shear Stress Activation of the Klf2 Pathway"
9:35 am - 9:40 am
Discussion
9:40 am - 9:50 am
"Human Genetics in Vascular Mechanotransduction and Metabolism"
9:50 am - 9:55 am
Discussion
9:55 am - 10:15 am
"Directional Migration of Immune Cells: Chemokine Gradients, Traction Forces and Upstream Control"
10:15 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:10 am
"Development and Maintenance of Organ-Specific Lymphatic Vasculature"
11:10 am - 11:15 am
Discussion
11:15 am - 11:35 am
"Differentiation of Endothelial Cells and Establishment of Organ-Specific Vessels"
11:35 am - 11:40 am
Discussion
11:40 am - 11:55 am
"Focal Adhesion EphA2 Signaling Promotes Contractility to Drive Fibrillar Adhesion Formation and Fibronectin Deposition"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Opposing Functions of Beta1-Integrin in Control of Vascular Integrity and Inflammation-Induced Leakage"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Shear-Induced CCN1 Promotes Atheroprone Endothelial Phenotypes and Atherosclerosis"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Novel Regulatory Circuits in Vascular Development and Pathologies: Microvasculature and Long Non-Coding RNAs
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:55 pm
"Transcriptional and Epigenetic Alterations in Endothelium Post-S1P Receptor Signaling"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Long Non-Coding RNAs in Vasculature"
8:20 pm - 8:25 pm
Discussion
8:25 pm - 8:45 pm
"Impact of Clonal Hematopoiesis in Vascular Disease"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:10 pm
"Prion-Mediated Activation of Endothelial Cell Signaling Networks in Brain Development and Disease"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"The Combinatorial Roles of TCF7L2 and GATA6 in Vascular Smooth Muscle Differentiation and Prevention of Intimal Hyperplasia"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Recent Advances in Vascular Engineering, Targeting and Imaging
9:00 am - 9:20 am
"Imaging Neurovascular Interactions in Disease"
9:20 am - 9:25 am
Discussion
9:25 am - 9:45 am
"Targeted Cas9 Nanomedicines and DNA Barcodes"
9:45 am - 9:50 am
Discussion
9:50 am - 10:00 am
"Microengineered Human Blood Vessel for Next Generation Drug Discovery"
10:00 am - 10:05 am
Discussion
10:05 am - 10:35 am
Coffee Break
10:35 am - 10:55 am
"Tissue Specific Vascular Endothelium Contribute to Organotropic Metastasis"
10:55 am - 11:00 am
Discussion
11:00 am - 11:10 am
"Blood Vessel Regression in Adult Mammalian Brains"
11:10 am - 11:15 am
Discussion
11:15 am - 11:25 am
"Endothelial Cell Expressed Piezo1 Regulates Pressure-Induced Lung Vascular Permeability"
11:25 am - 11:30 am
Discussion
11:30 am - 11:40 am
"Foxc1 Regulation of mTOR Signaling During Physiological and Pathological Postnatal Retina Angiogenesis"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
"Age-Dependent Modulation of the Human Skin Microvasculature by Microenvironment and Serum"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Vascular Cell Fate and Disease
7:30 pm - 7:50 pm
"Perivascular Cells Are a Novel Source of Tissue Resident M2 Macrophages Important in Regulation of Vascular Integrity and Tissue Metabolism"
7:50 pm - 7:55 pm
Discussion
7:55 pm - 8:15 pm
"Regulation of Vascular Permeability"
8:15 pm - 8:20 pm
Discussion
8:20 pm - 8:40 pm
"Molecular Heterogeneity and Functional Specialization of Vascular Cells"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
"NCK-Dependent Pericyte Migration Promotes Pathological Neovascularization in Ischemic Retinopathy"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
"Genetic Inactivation of the Pluripotency Factor OCT4 Within Endothelial Cells Leads to Enhanced Atherosclerosis in Apoe-/- Mice"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Integrin-Specific Signaling Drives ER Stress to Promote JNK Signaling and Atherogenic Endothelial Activation"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Metabolic Control of Vasculature and Blood Vessels in Metabolic Diseases
9:00 am - 9:20 am
"Endocrine Function of Endothelium in Metabolism and Inflammation"
9:20 am - 9:25 am
Discussion
9:25 am - 9:35 am
"Control of Perivascular Adipose Tissue Development and Thermogenesis by Early B Cell Factor 2"
9:35 am - 9:40 am
Discussion
9:40 am - 10:00 am
"Molecular and Therapeutic Aspects of Blood-Brain Barrier Regulation"
10:00 am - 10:05 am
Discussion
10:05 am - 10:15 am
"Dual Roles of PKM2 in Endothelial Cell Proliferation and Vascular Permeability"
10:15 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:10 am
"Myeloid Cells in Vasculature"
11:10 am - 11:15 am
Discussion
11:15 am - 11:30 am
"Reducing VEGF-B Signalling Ameliorates Hepatic Steatosis and Prevents Development of Non-Alcoholic Fatty Liver Disease, Non-Alcoholic Steatohepatitis and Hepatocellular Carcinoma"
11:30 am - 11:35 am
Discussion
11:35 am - 11:45 am
"Exercise Promotes White Adipose Tissue Angiogenesis and Protects from Diet-Induced Metabolic Defects"
11:45 am - 11:50 am
Discussion
11:50 am - 12:00 pm
"PGC-1a/ARHGAP6 Axis Mediates Diabetic Vascular Dysfunction Through Diminution of Endothelial Glycolytic Flux"
12:00 pm - 12:05 pm
Discussion
12:05 pm - 12:15 pm
"Organ-Specific Heterogeneity in Endothelial Cell Hypoxia Response"
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Keynote Session: Mechanisms of Vascular Inflammation and Aging
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:00 pm
"Mitochondrial Control of Inflammation: Positive and Negative Control of the NLRP3 Inflammasome"
8:00 pm - 8:15 pm
Discussion
8:15 pm - 8:20 pm
Introduction by Discussion Leader
8:20 pm - 8:45 pm
"PAD4: The Nuclear Button of Inflammation and Aging"
8:45 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
General Discussion
9:20 pm - 9:30 pm
Closing Remarks
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure