Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Establishing Vascular Heterogenity
7:40 pm - 8:00 pm
General Discussion
8:00 pm - 8:20 pm
"The Role of Environmental Factors in Vascular Heterogeneity"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"Coronary Cell Heterogeneity in Disease"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"Vascular Plasticity in Liver Growth and Regeneration"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Maintaining Vascular Heterogeneity: Resilience
9:00 am - 9:20 am
"Vascular Resilience and Cardiovascular Health: Adapting, Recovering, and Thriving Under Stress"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Insight into the Development of Intraosseous Vascular Malformations"
9:50 am - 10:00 am
Discussion
10:00 am - 10:10 am
"Mapping Vascular Developmental Pathways with in vivo Perturb-Seq"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
"Dynamic Resilience of Cardiac Endothelial Cells during Myocardial Remodeling"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Group Photo / Coffee Break
11:00 am - 11:20 am
"Maintenance of Lymphatic Function by Cell-Cell Junctions"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
Short Talk Selected from Poster Abstracts
11:40 am - 11:45 am
Discussion
11:45 am - 12:05 pm
"Vascular Diversity in the Brain"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address the interests and needs of all scientists and the challenges they face in their careers. Specifically, the program promotes meaningful conversations amongst colleagues of all career stages about barriers to career advancement and strategies to support the professional growth of all members of the community. The GRC Power Hour™ is open to all conference participants.
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Regulation by Mechanical Forces
7:30 pm - 7:50 pm
"Exploring the Mechanics of the Zebrafish Anteroposterior Axis"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"How Fluid Shear Stress Determines Endothelial Cell Phenotype"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:40 pm
"Flow Mediated Membrane Lipid Composition and Endothelial Cell Homeostasis"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
"Novel Players in Lymphatic Valve Formation"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"Vascular Differentiation and Morphogenesis"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Epigenetic Regulation and Epitranscriptomics
9:00 am - 9:20 am
"Leveraging Chromatin-Remodeling Enzymes To Study Vascular Development and Maintenance"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Decoding mRNA Translation Control during Angiogenesis"
9:50 am - 10:00 am
Discussion
10:00 am - 10:10 am
Short Talk Selected from Poster Abstracts
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
"An Epigenetic Link between Metabolism and Smooth Muscle Cell Differentiation in Acta2 p.R179 Cells"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Epigenetic Regulation of Vascular Smooth Muscle Cell Function in Disease"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
Short Talk Selected from Poster Abstracts
11:40 am - 11:45 am
Discussion
11:45 am - 12:05 pm
"Breaking the Pause: Signal-Dependent Transcription Control in Vascular Growth and Function"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Sex-Related Differences in Vascular Biology
7:30 pm - 7:50 pm
"Reproductive Hormone Effects on Endothelial Function in Humans"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Systems Genetics of Sex Differences in Vascular Cell Gene Regulation"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:40 pm
Short Talk Selected from Poster Abstracts
8:40 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
"Kdm5c, an X-Linked Epigenetic Modifier, Protects Females Against Aortic Pathology"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"Sex Differences in Atherosclerosis"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Imaging and Genomic Approaches
9:00 am - 9:20 am
"Artificial Intelligence and the Human Genome"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Whole Animal 3D Vascular Imaging"
9:50 am - 10:00 am
Discussion
10:00 am - 10:10 am
"Integrated Multiomic Analysis Identifies a Role for NF-KB Pathway in Coronary Microvascular Disease (CMVD)"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
"The Villus Stroma in Lymphatic-muscle Development and Stem Cell Homeostasis"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Identification and Function of Endothelial Cell Microproteins: Challenges and Opportunities"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
"Computational Analysis of EC Transcriptomics Reveals Cell Cycle as a Key Regulator of Flow-Dependent Artery Remodeling"
11:40 am - 11:45 am
Discussion
11:45 am - 12:05 pm
"Investigating Vascular Dynamics via 4D Imaging of Live Mouse Skin"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Cellular Damage, Repair and Regeneration
7:30 pm - 7:50 pm
"Mechanisms Underlying Vascular Repair in Hindlimb Ischemia"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Stomal Plasticity from Development to Decline"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:40 pm
"Understanding How Structural Components Shape Tissue and Cellular Dynamics by Imaging Live Mice"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
Short Talk Selected from Poster Abstracts
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"LINCing the Nucleus to Endothelial Cell Function in Blood Vessels"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
9:00 am - 9:20 am
"Sphingolipid Metabolism and Signaling in the Vascular System"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"The Effect of Shear Stress on Endothelial Lipid Droplet Metabolism"
9:50 am - 10:00 am
Discussion
10:00 am - 10:10 am
"Investigating the Role of Endothelial Dysfunction in Driving Diastolic Dysfunction in Mice with Inflammatory Arthritis"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
"Impaired Insulin Signaling in Smooth Muscle Cells Reduces Smooth Muscle Cell Contribution to Atherosclerotic Lesion Development"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Metabolic Mechanisms Controlling Lymphatic Vascular Development"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
"Loss of Endothelial PGC1α causes Metabolic Dysfunction-Associated Fatty Liver Disease"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
"Vascular Malformations in the Gastrointestinal Tract: A Novel VWF-Angiopoietin-Tie2 Organotypic Pathway"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
"Defining the Vascular Niche of Human Adipose Tissue Across Metabolic Conditions"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Congenital Vascular Disorders and Therapy
7:30 pm - 7:50 pm
"Somatic Mutation of Alk1 in Arterial Endothelial Cells Causes Epistaxis and Vascular Bleeding"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Transcriptional and Epigenetic Mechanisms in Endothelial Cells"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:40 pm
Short Talk Selected from Poster Abstracts
8:40 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
"RNA Binding Protein Regulatory Networks in Cardiovascular Development and Disease"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"Unraveling Mechanisms and Therapeutic Targets for HHT through Endothelial Cells Derived from Mutant iPSCs"
9:20 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure