Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Establishing Vascular Heterogenity
7:40 pm - 7:45 pm
General Discussion
7:45 pm - 8:00 pm
Introduction by Discussion Leader
8:00 pm - 8:20 pm
"Mapping Vascular Developmental Pathways with in vivo Perturb-Seq"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"Vascular Diversity in the Brain"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"Endothelial Deletion of p53 Generates Transitional Endothelial Cells and Improves Lung Development During Neonatal Hyperoxia"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Maintaining Vascular Heterogeneity: Resilience
9:00 am - 9:15 am
General Discussion
9:15 am - 9:35 am
"Vascular Resilience and Cardiovascular Health: Adapting, Recovering, and Thriving Under Stress"
9:35 am - 9:45 am
Discussion
9:45 am - 10:05 am
"Regulation of Cardiovscular Resilience"
10:05 am - 10:15 am
Discussion
10:15 am - 10:25 am
"Dynamic Resilience of Cardiac Endothelial Cells in Neovascular Maturation during Myocardial Remodeling"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Group Photo / Coffee Break
11:00 am - 11:20 am
"Maintenance of Lymphatic Vascular"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
"Contributions of Persistent Injury-Associated Endothelial Cell States to Tissue Regeneration"
11:40 am - 11:45 am
Discussion
11:45 am - 12:05 pm
"Coronary Cell Heterogeneity in Disease"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Regulation by Mechanical Forces
7:30 pm - 7:50 pm
"Mechanical Inputs Patterning the Vertebrate AP Axis"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"How Fluid Shear Stress Determines Endothelial Cell Phenotype"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:40 pm
"Flow Mediated Membrane Lipid Composition and Endothelial Cell Homeostasis"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
"Rictor, an mTORC2 Protein, Regulates Murine Lymphatic Valve Formation Through the AKT-FOXO1 Signaling"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"Nuclear SUN Proteins Regulate Endothelial Cell-Matrix Interactions and Barrier Function"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Epigenetic Regulation and Epitranscriptomics
9:00 am - 9:20 am
"Reconstructing the Human Musculo-Skeletal System in vitro"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Leveraging Chromatin-Remodeling Enzymes To Study Vascular Development and Maintenance"
9:50 am - 10:00 am
Discussion
10:00 am - 10:10 am
"An Epigenetic Link between Metabolism and Smooth Muscle Cell Differentiation in Acta2 p.R179 Cells"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
"Villus Myofibroblasts are the Intestinal Niche for Lymphatic Muscle and Intestinal Stem Cell Function"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Epigenetic Control of SMC Contractility and Adaptive Remodeling"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
"RNA Binding Protein Regulatory Networks in Cardiovascular Development and Disease"
11:40 am - 11:45 am
Discussion
11:45 am - 12:05 pm
"Mapping Chromatin Landscape and Regulatory Logic behind Lymphatic Endothelial Cell Differentiation"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Sex-Related Differences in Vascular Biology
7:30 pm - 7:50 pm
"Reproductive Hormone Effects on Endothelial Function in Humans"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Systems Genetics of Sex Differences in Vascular Cell Gene Regulation"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:40 pm
"Loss of Endothelial CD2AP Causes Sex-Dependent Cerebrovascular Dysfunction"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
"Kdm5c, an X-Linked Epigenetic Modifier, Protects Females Against Aortic Pathology"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"Sex Differences in Atherosclerosis"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Imaging and Genomic Approaches
9:00 am - 9:20 am
"Artificial Intelligence and the Human Genome"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Whole Animal 3D Vascular Imaging"
9:50 am - 10:00 am
Discussion
10:00 am - 10:10 am
"Understanding How Structural Components Shape Tissue Dynamics and Function during Skin Vasculature Maturation and Homeostasis in Live Mice"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
"Integrated Multiomic Analysis Identifies a Role for NF-KB Pathway in Coronary Microvascular Disease (CMVD)"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Identification and Function of Endothelial Cell Microproteins: Challenges and Opportunities"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
"Computational Analysis of EC Transcriptomics Reveals Cell Cycle as a Key Regulator of Flow-Dependent Artery Remodeling"
11:40 am - 11:45 am
Discussion
11:45 am - 12:05 pm
"Sphingolipid Metabolism and Signaling in the Vascular System"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Cellular Damage, Repair and Regeneration
7:30 pm - 7:50 pm
"Regenerative Potential of Spiny Mice"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Mechanisms Underlying Vascular Repair in Hindlimb Ischemia"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:40 pm
"Cellular and Molecular Mechanisms of Lung Artery Growth"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
"Stomal Plasticity from Development to Decline"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"Vascular Differentiation and Morphogenesis"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
9:00 am - 9:20 am
"Transcriptional and Epigenetic Mechanisms in Endothelial Cells"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
9:50 am - 10:00 am
Discussion
10:00 am - 10:10 am
"Impaired Insulin Signaling in SMCs Reduces SMC Contribution to Atherosclerotic Lesion Development"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
"Exploring the Role of Endothelial Cells in Diastolic Dysfunction Associated with Inflammatory Arthritis"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Understanding Endothelial Cell Behaviors in Adipose Tissue"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
"Loss of Endothelial PGC1a causes Metabolic Dysfunction-Associated Steatotic Liver Disease"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
"Vascular Malformations in the Gastrointestinal Tract: A Novel VWF-Angiopoietin-Tie2 Organotypic Pathway"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
"Defining the Vascular Niche of Human Adipose Tissue Across Metabolic Conditions"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Congenital Vascular Disorders and Therapy
7:30 pm - 7:50 pm
"Vascular Malformations: Genetic Causes, Preclinical Models and Clinical Trials."
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Pathogenic Mechanisms of PIK3CA-Driven Vascular Malformations"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:40 pm
"Reversal of Vein of Galen Aneurysmal Malformation by Stimulation of Flow-Mediated Vessel Fusion"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
"Somatic Mutation of Alk1 in Arterial Endothelial Cells Causes Epistaxis and Vascular Bleeding"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"Unraveling Mechanisms and Therapeutic Targets for HHT through Endothelial Cells Derived from Mutant iPSCs"
9:20 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure