Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Establishing Vascular Heterogenity
7:40 pm - 7:45 pm
General Discussion
7:45 pm - 8:00 pm
Introduction by Discussion Leader
8:00 pm - 8:20 pm
"Mapping Vascular Developmental Pathways with in vivo Perturb-Seq"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"Vascular Diversity in the Brain"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"Endothelial Deletion of p53 Generates Transitional Endothelial Cells and Improves Lung Development During Neonatal Hyperoxia"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Maintaining Vascular Heterogeneity: Resilience
9:00 am - 9:15 am
General Discussion
9:15 am - 9:35 am
"Vascular Resilience and Cardiovascular Health: Adapting, Recovering, and Thriving Under Stress"
9:35 am - 9:45 am
Discussion
9:45 am - 10:05 am
"Regulation of Cardiovscular Resilience"
10:05 am - 10:15 am
Discussion
10:15 am - 10:25 am
"Dynamic Resilience of Cardiac Endothelial Cells in Neovascular Maturation during Myocardial Remodeling"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Group Photo / Coffee Break
11:00 am - 11:20 am
"Maintenance of Lymphatic Vascular"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
"Contributions of Persistent Injury-Associated Endothelial Cell States to Tissue Regeneration"
11:40 am - 11:45 am
Discussion
11:45 am - 12:05 pm
"Coronary Cell Heterogeneity in Disease"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address the interests and needs of all scientists and the challenges they face in their careers. Specifically, the program promotes meaningful conversations amongst colleagues of all career stages about barriers to career advancement and strategies to support the professional growth of all members of the community. The GRC Power Hour™ is open to all conference participants.
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Regulation by Mechanical Forces
7:30 pm - 7:50 pm
"Mechanical Inputs Patterning the Vertebrate AP Axis"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"How Fluid Shear Stress Determines Endothelial Cell Phenotype"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:40 pm
"Flow Mediated Membrane Lipid Composition and Endothelial Cell Homeostasis"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
"Rictor, an mTORC2 Protein, Regulates Murine Lymphatic Valve Formation Through the AKT-FOXO1 Signaling"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"Nuclear SUN Proteins Regulate Endothelial Cell-Matrix Interactions and Barrier Function"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Epigenetic Regulation and Epitranscriptomics
9:00 am - 9:20 am
"Reconstructing the Human Musculo-Skeletal System in vitro"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Leveraging Chromatin-Remodeling Enzymes To Study Vascular Development and Maintenance"
9:50 am - 10:00 am
Discussion
10:00 am - 10:10 am
"An Epigenetic Link between Metabolism and Smooth Muscle Cell Differentiation in Acta2 p.R179 Cells"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
"Villus Myofibroblasts are the Intestinal Niche for Lymphatic Muscle and Intestinal Stem Cell Function"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Epigenetic Control of SMC Contractility and Adaptive Remodeling"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
"RNA Binding Protein Regulatory Networks in Cardiovascular Development and Disease"
11:40 am - 11:45 am
Discussion
11:45 am - 12:05 pm
"Mapping Chromatin Landscape and Regulatory Logic behind Lymphatic Endothelial Cell Differentiation"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Sex-Related Differences in Vascular Biology
7:30 pm - 7:50 pm
"Reproductive Hormone Effects on Endothelial Function in Humans"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Systems Genetics of Sex Differences in Vascular Cell Gene Regulation"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:40 pm
"Loss of Endothelial CD2AP Causes Sex-Dependent Cerebrovascular Dysfunction"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
"Kdm5c, an X-Linked Epigenetic Modifier, Protects Females Against Aortic Pathology"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"Sex Differences in Atherosclerosis"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Imaging and Genomic Approaches
9:00 am - 9:20 am
"Artificial Intelligence and the Human Genome"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Whole Animal 3D Vascular Imaging"
9:50 am - 10:00 am
Discussion
10:00 am - 10:10 am
"Understanding How Structural Components Shape Tissue Dynamics and Function during Skin Vasculature Maturation and Homeostasis in Live Mice"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
"Integrated Multiomic Analysis Identifies a Role for NF-KB Pathway in Coronary Microvascular Disease (CMVD)"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Identification and Function of Endothelial Cell Microproteins: Challenges and Opportunities"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
"Computational Analysis of EC Transcriptomics Reveals Cell Cycle as a Key Regulator of Flow-Dependent Artery Remodeling"
11:40 am - 11:45 am
Discussion
11:45 am - 12:05 pm
"Sphingolipid Metabolism and Signaling in the Vascular System"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Cellular Damage, Repair and Regeneration
7:30 pm - 7:50 pm
"Regenerative Potential of Spiny Mice"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Mechanisms Underlying Vascular Repair in Hindlimb Ischemia"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:40 pm
"Cellular and Molecular Mechanisms of Lung Artery Growth"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
"Stomal Plasticity from Development to Decline"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"Vascular Differentiation and Morphogenesis"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
9:00 am - 9:20 am
"Transcriptional and Epigenetic Mechanisms in Endothelial Cells"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
9:50 am - 10:00 am
Discussion
10:00 am - 10:10 am
"Impaired Insulin Signaling in SMCs Reduces SMC Contribution to Atherosclerotic Lesion Development"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
"Exploring the Role of Endothelial Cells in Diastolic Dysfunction Associated with Inflammatory Arthritis"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Understanding Endothelial Cell Behaviors in Adipose Tissue"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
"Loss of Endothelial PGC1a causes Metabolic Dysfunction-Associated Steatotic Liver Disease"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
"Vascular Malformations in the Gastrointestinal Tract: A Novel VWF-Angiopoietin-Tie2 Organotypic Pathway"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
"Defining the Vascular Niche of Human Adipose Tissue Across Metabolic Conditions"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Congenital Vascular Disorders and Therapy
7:30 pm - 7:50 pm
"Vascular Malformations: Genetic Causes, Preclinical Models and Clinical Trials."
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Pathogenic Mechanisms of PIK3CA-Driven Vascular Malformations"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:40 pm
"Reversal of Vein of Galen Aneurysmal Malformation by Stimulation of Flow-Mediated Vessel Fusion"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
"Somatic Mutation of Alk1 in Arterial Endothelial Cells Causes Epistaxis and Vascular Bleeding"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"Unraveling Mechanisms and Therapeutic Targets for HHT through Endothelial Cells Derived from Mutant iPSCs"
9:20 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure