Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
7:40 pm - 8:00 pm
"Emerging Virus Glycoproteins: From Viral Entry to Vaccines and Antivirals"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:30 pm
"The Hantavirus Gn/Gc Spikes During Cell Entry and Transmission: A Balance Act of Molecular Transitions"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 8:55 pm
"Elucidating the Cellular Entry Requirements of Merkel Cell Polyomavirus"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
"Vaccinia Virus Hijacks ESCRT-mediated Multivesicular Body Formation for Virus Egress"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Norovirus MLKL-like Pore Forming Protein Initiates Programmed Cell Death for Viral Egress"
9:25 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
9:00 am - 9:20 am
"Cell-to-Cell Heterogeneity - Virus Entry, Persistence and Lytic Infection"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Noncoding RNA and Triphosphate Balance in Virus Infection"
9:50 am - 10:00 am
Discussion
10:00 am - 10:10 am
"Transcriptional Control of Nutrient Sensing in Viral Infections"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
"Host Cell Glycosylation Differentially Affects CCR5- and CXCR4-Tropic HIV-1 Infection"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Unexpected Virus-host Interactions that Enable Human Norovirus Entry and Replication in Intestinal Organoids"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
"Illuminating Virus Infection Biology in Toto with Zebrafish"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
"Species-Specific MARCO-virus Interactions Dictate Chikungunya Virus Viremia"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Mammalian ZAP and KHNYN Restrict CpG-enriched Avian Viruses"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Deficits in Mitochondrial Oxidative Phosphorylation Enhance SARS-CoV-2 Replication"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Viral Evolution and Adaptation
6:00 pm - 6:20 pm
"A Single Mutation in an Enteric Virus Alters Tropism and Sensitivity to Microbiota"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:50 pm
"SARS-CoV-2 vs Antibodies: You Win Some You Lose Some"
6:50 pm - 7:00 pm
Discussion
7:00 pm - 7:20 pm
"Interpreting the Evolution of SARS-CoV-2"
7:20 pm - 7:30 pm
Discussion
7:30 pm - 7:40 pm
"Evidence linking APOBEC3B genesis and evolution of innate immune antagonism by gamma-herpesvirus ribonucleotide reductases"
7:40 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
"Constraining Arboviruses to Their Arthropod Vectors"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Replication and Cellular Reorganization
9:00 am - 9:20 am
"Assembly of the Phage Nucleus During Bacteriophage Replication"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Infection-driven Rewiring of Membrane Contact Sites for Pro-Viral Organelle Remodeling"
9:50 am - 10:00 am
Discussion
10:00 am - 10:10 am
"Contributions of an Enteroviral Genome Replication Protein to Formation and Dynamics of the Virus-Assembly Organelle"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
"Transneuronal Dissemination of Mammalian Orthoreovirus"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Host Factors in Hepatovirus Replication"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
"In Vitro Reconstitution of Influenza Virus Genome Replication"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
"Structural and Functional Characterization of the Hantaan Virus Polymerase Complex"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Viral Manipulation of Cellular RNA Binding Proteins through Inhibition of Arginine Methylation"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Changes in SUMO-Modified Proteins in Epstein-Barr Virus Infection Identifies Reciprocal Regulation of the TRIM24/28/33 Complex and the Lytic Switch BZLF1"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
6:00 pm - 6:20 pm
"Post-Transcriptional Control of Gene Expression Tunes HCMV Reproduction to Physiological Stress Responses"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:40 pm
"Systematic Discovery of Thousands of ORFs in 700 Human Viruses"
6:40 pm - 6:45 pm
Discussion
6:45 pm - 6:55 pm
"RNA Binding Protein Discovery and Function in Herpesviruses"
6:55 pm - 7:00 pm
Discussion
7:00 pm - 7:10 pm
"A host shutoff RNase displays sequence-driven viral self/non-self discrimination"
7:10 pm - 7:15 pm
Discussion
7:15 pm - 7:25 pm
"Zika Virus Infection Leads to Induction of a R-Loop Signature in Human Neural Cells that Contributes to Growth Attenuation"
7:25 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
"A Virally Encoded Knock Out System Provides Fundamental Insights into Cytomegalovirus Infection"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Immune System Activation and Viral Immune Evasion
9:00 am - 9:20 am
"A Novel Translation Control Mechanism by the Poxvirus Host Restriction Factor SAMD9"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"SARS-CoV-2 Omicron Variants: Fusion, Replication and Neutralization"
9:50 am - 10:00 am
Discussion
10:00 am - 10:10 am
"A human-derived motif in CARD8 facilitates inflammasome activation via the detection of HIV-1 protease"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
"Sensing of Self DNA Amplifies Innate Immune Responses to Suppress Influenza Virus Replication"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Exploring the Dark Matter of Phage Genomes"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
"An Isoform of Dicer Protects Mammalian Stem Cells Against Multiple RNA Viruses"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
"An Epstein–Barr Virus Lytic Cycle Protein Interaction Map Reveals NLRP3 Inflammasome Evasion Via MAVS UFMylation"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Human Cytomegalovirus Exploits the Unfolded Protein Response to Evade Antibody Responses"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Novel Innate Sensing and Evasion Strategies During Poxvirus Infection"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
6:00 pm - 6:20 pm
"Viral Toxins: Comparative Mechanisms of Induction of Vascular Leak by Flavivirus NS1 and SARS-CoV-2 Spike Proteins"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:50 pm
"Mechanisms of Varicella Virus Pathogenesis and Dissemination"
6:50 pm - 7:00 pm
Discussion
7:00 pm - 7:10 pm
"The Entry Receptor LDLRAD3 is Critical for Venezuelan Equine Encephalitis Virus Pathogenesis and Neuroinvasion in Mice"
7:10 pm - 7:15 pm
Discussion
7:15 pm - 7:25 pm
"Tissue-Specific Host Responses are a Critical Component of the Increased Morbidity Observed During Influenza Virus and S. Pneumoniae Co-infection"
7:25 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
"Biological Sex and Pregnancy Impact Influenza Outcomes"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
9:00 am - 9:20 am
"Structure-Guided Coronavirus Vaccine Design"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Lost in Translation - SARS-CoV-2 Attenuation by Large Scale Genome Recoding"
9:50 am - 10:00 am
Discussion
10:00 am - 10:10 am
"A Novel DNA Vaccine Approach for Prophylactic and Therapeutic Vaccines"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
"Exploring Potential Indications for Remdesivir Beyond COVID-19"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Discovery and Characterization of a Broadly Neutralizing Human Antibody that Affords Pan-Hantavirus Protection"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"Chimeric Mouse Models to Study Emerging Zoonotic Viruses"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Weight Loss at the Time of Vaccination Increases Influenza Vaccine Efficacy in Obese Mice"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Targeting Host Glycosyltransferase Activity as a Broad-Spectrum Antiviral Strategy Against Influenza Viruses"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Latency, Persistence and Oncogenesis
6:00 pm - 6:20 pm
"Novel Function for Key Lymphatic Transcription Factor SOX18 in KSHV Replication"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:50 pm
"Oncogenic Gammaherpesvirus Reliance on STAT3 to Dampen Interferon Signaling and Support Latency in B Cells of the Host"
6:50 pm - 7:00 pm
Discussion
7:00 pm - 7:10 pm
"Papillomavirus Oncoproteins Control Host Cell Fate"
7:10 pm - 7:15 pm
Discussion
7:15 pm - 7:35 pm
"Heterogeneous Outcomes of Epstein-Barr Virus Infection"
7:35 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
"Host-Encoded CTCF Regulates CMV Latency via Chromatin Looping"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure