Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: Therapeutic Strategies
7:40 pm - 8:05 pm
"Novel Vaccines and Immunotherapies to Eliminate the World's Most Common Congenital Infection: CMV"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:35 pm
"Molecular Basis of African Swine Fever Virus Virulence in View of Vaccine Development"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
"Novel Antiviral for Dengue Virus Targets Flaviviral Polyprotein Translocation into the ER"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
"All Birds with One Stone: The Proteostasis Network as a Target for Broad-acting Antivirals"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Molecular Basis for Potent Neutralization of Enterovirus D68 by Human Monoclonal Antibodies as a New Tool to Prevent Paralysis in Children"
9:25 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Immune System Activation and Viral Immune Evasion
9:00 am - 9:20 am
"Multiple Strategies of Evading the Innate Antiviral Response by the Dengue Virus NS5 Protein"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Virus-Host interaction Studies and the Search for a Cure Against Hepatitis B Virus"
9:50 am - 10:00 am
Discussion
10:00 am - 10:10 am
"Targeting Vulnerability of EBV Infection for Vaccine Development"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
"Varicella Zoster Virus Modulates IFN? Signaling to Favor Virus Spread"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Tiny Messengers: Peptides in Anti-Viral Innate Immunity"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
"Bispecific Antibodies Targeting Two Glycoproteins on SFTSV Synergistic Neutralization and Protection in a Mouse Model"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
"Short 5' UTRs are a Novel Molecular Pattern for Viral Inhibition by IFIT2 and IFIT3"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"CRISPR Screening Pipeline utilizing Virally Induced Remodeling of Cellular Antibody Affinity (VIRCAA) identifies JUNB as an Inflammatory Anti-viral Factor"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Antibodies Targeting Crimean-Congo Hemorrhagic Fever Virus GP38 Limit Vascular Leak and Viral Spread"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address the interests and needs of all scientists and the challenges they face in their careers. Specifically, the program promotes meaningful conversations amongst colleagues of all career stages about barriers to career advancement and strategies to support the professional growth of all members of the community. The GRC Power Hour™ is open to all conference participants.
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Viral and Host Gene Regulation
6:00 pm - 6:20 pm
"Defining the Landscape of Host Defenses Against Emergent Viruses"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:50 pm
"Mechanisms for Differential Interferon Signaling Across Lung Tissue During an Influenza Virus Infection"
6:50 pm - 7:00 pm
Discussion
7:00 pm - 7:20 pm
"HSV-1 and Chromatin Loops: Making the Right Connections to Initiate Reactivation"
7:20 pm - 7:30 pm
Discussion
7:30 pm - 7:40 pm
"Viral Hijacking of Pioneer Factor Activity Reveals a Novel Function for a Developmental Transcription Factor SOX18"
7:40 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
"Efficient and Accurate Detection of Viral Sequences at Single-Cell Resolution Reveals Putative Novel Viruses Perturbing Host Gene Expression"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
9:00 am - 9:20 am
"Decoding Anti-viral Immune Responses from the Cell to the Lactating Mammary"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Molecular Mechanisms of Mast Cell Detection of Dengue Virus"
9:50 am - 10:00 am
Discussion
10:00 am - 10:10 am
"Spatio-Temporal Analysis of Vaccinia Virus Infection and Host Response Dynamics Using Single-Cell Transcriptomics and Proteomics"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
"Regulation of Human Cytomegalovirus by a Host mRNA Deadenylase Complex"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"The Early Phase of HIV Replication"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
"Novel Antiviral Restriction Factors of HSV-1"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
"Glucose-Independent Human Cytomegalovirus Replication is Supported by Metabolites that Feed Upper Glycolytic Branches"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Structural Basis of Zika Virus NS5 Interaction with the Rootlet Fiber and its Link with Associated Ciliopathy"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Venezuelan Equine Encephalitis Virus Modulates the Proteome of 3D Brain Model Leading to Impaired Cell Migration"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
6:00 pm - 6:20 pm
"Impact of Paternal Viral Infection on Offspring Antiviral Immunity"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:50 pm
"From Viremia to Persistence: Exploring how Ebola Virus Colonizes the Central Nervous System"
6:50 pm - 7:00 pm
Discussion
7:00 pm - 7:20 pm
"An Integrated Framework for Evaluating Viral Zoonotic Threats"
7:20 pm - 7:30 pm
Discussion
7:30 pm - 7:40 pm
"A Human Cerebral Organoid Model to Investigate the Host-Pathogen Determinants of Ebola Virus Persistence in the Central Nervous System"
7:40 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
"Immune Cell Recruitment Promotes Paralysis in a Mouse Model of Enterovirus D68 Disease"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
9:00 am - 9:20 am
"Structural Studies of Bunyavirus Glycoprotein Complexes"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"TRIM21 Effects Intracellular Neutralization of Incoming Viruses Via Selective Autophagy"
9:50 am - 10:00 am
Discussion
10:00 am - 10:10 am
"Virion Entry Pathway Determines HCMV Infection Outcome"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
"TMEM30a Facilitates Murine Norovirus Entry and Persistent Enteric Infection by Limiting Exoplasmic Phosphatidylethanolamine"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Entry of Human Herpesvirus 6"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
"Virus Adaptation to Heparan Sulfate Comes with Capsid Stability Tradeoff"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
"SARS-CoV-2 ORF3a Drives Dynamic Dense Body Formation for Optimal Viral Infectivity"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Host Endosomal Factor WDR81 Regulates Programmed Cell Death via NF-kB-Mediated Survival Signaling"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Structural Insights into HIV-1 Env-Mediated Membrane Fusion Using Organoid Models and Microscopy Techniques"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
6:00 pm - 6:20 pm
"Regulation of Cutaneous Antiviral Immunity"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:50 pm
"Contributions of Merkel Cell Polyomavirus to Merkel Cell Carcinoma"
6:50 pm - 7:00 pm
Discussion
7:00 pm - 7:20 pm
"RNA Decay and Viral Infection: Deciphering the Viral-Host Arms Race to Control RNA Stability"
7:20 pm - 7:30 pm
Discussion
7:30 pm - 7:40 pm
"A Viral lncRNA Associates with the HSV-1 Genome and a Nuclear Membrane Protein to Regulate the Repression of Lytic Genes"
7:40 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
"Delta Viruses Spread Through a Viral Trojan Horse"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
9:00 am - 9:20 am
"Cytoplasmic mRNA Decay by Viral and Antiviral Nucleases Inhibits Cellular Transcription"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"G-quadruplex Regulation of Varicella-Zoster Virus Glycoprotein C Expression and Virion Release"
9:50 am - 10:00 am
Discussion
10:00 am - 10:10 am
"A Zebrafish-based In Vivo Model of Zika Virus Infection Unveils Alterations of the Glutamatergic Neuronal Development and NS4A as a Key Viral Determinant of Neuropathogenesis"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
"Membrane Tethering by the Host GTPase Atlastin-2 is Critical for Flavivirus Replication"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Dual Receptor Specificity for Sialic Acid and MHC Class II in Human and Avian Influenza A Virus"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
"Determining RNA-Binding Activity of IFIT3 and its Effect on Pro-viral Activity in Influenza A Virus Infection"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
"Noncanonical CircRNA Biogenesis Driven by Alpha and Gamma Herpesviruses"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Gammaherpesvirus Infection Elicits Transfer RNA Cleavage"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Surfaceome Profiling of the Human Cytomegalovirus RL11 Family Reveals Modulators of the Immune and Cardiovascular Systems"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Keynote Session: Viral Evolution and Adaptation
6:00 pm - 6:20 pm
"Genomic Surveillance and Characterization of Microbial Threats Facilitates Early Detection and Containment of Disease of Outbreaks in West Africa"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:50 pm
"What Ribosome Profiling Can Teach us About Zika Virus?"
6:50 pm - 7:00 pm
Discussion
7:00 pm - 7:20 pm
"SARS-CoV-2 Intrahost Persistence: Implications for Seasonality and Vaccination"
7:20 pm - 7:30 pm
Discussion
7:30 pm - 7:40 pm
"Structural Systems Virology Reveals the Proteome-Wide Atlas of Human Herpesvirus Protein Families and Their Interactions"
7:40 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
"Impact of Pre-Existing Immunity on Zoonotic Influenza Virus Transmission and Pathogenesis"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure