Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: Frontiers in Neuronal Cell Fate and Connectivity
Discussion Leaders: Robert Johnston (Johns Hopkins University, United States) and Carol Schuurmans (Sunnybrook Research Institute, Canada)
7:40 pm - 8:25 pm
Claude Desplan (New York University, United States)
"Deterministic and Stochastic Specification of Neural Fates in the Drosophila Visual System"
8:25 pm - 8:35 pm
Discussion
8:35 pm - 9:20 pm
Magdalena Goetz (Ludwig Maximilians University of Munich, Germany)
"Novel Mechanisms of Neurogenesis and Neural Repair"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Retinal Patterning and Cell Fate Specification
Discussion Leader: Monica Vetter (University of Utah, United States)
9:00 am - 9:20 am
Sujata Rao (Cleveland Clinic, United States)
"Role of the Circadian Clock in Retinal Neurovascular Development"
9:20 am - 9:25 am
Discussion
9:25 am - 9:45 am
Makoto Sato (Kanazawa University, Japan)
"Tiling Mechanisms of the Drosophila Compound Eye"
9:45 am - 9:50 am
Discussion
9:50 am - 10:10 am
Monnier Philippe (University Health Network, Canada)
"Blood Borne ATP Regulates CNS Neuron Polarity"
10:10 am - 10:15 am
Discussion
10:15 am - 10:30 am
Jillian Pearring (University of Michigan, United States)
"Investigating the Photoreceptor Nuclear Migration Defect in RP2 Mice"
10:30 am - 10:35 am
Discussion
10:35 am - 11:05 am
Coffee Break
11:05 am - 11:25 am
Anna La Torre (University of California, Davis, United States)
"Sonic Hedgehog in Optic Cup Patterning"
11:25 am - 11:30 am
Discussion
11:30 am - 11:50 am
Michel Cayouette (Montreal Clinical Research Institute (IRCM), Canada)
"A Non-Canonical Planar Cell Polarity Pathway Triggered by Light Organizes Cone Photoreceptors in the Mouse Retina"
11:50 am - 11:55 am
Discussion
11:55 am - 12:10 pm
Mollie Woodworth (Bates College, United States)
"Postnatal Expression of Developmental Transcription Factors Directs Generation of Induced Retinal Ganglion Cells"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Issam Al Diri (Developmental Neurobiology Department, United States)
"Cis-Regulatory Control of Retinal Ganglion Cell Genesis and Axonogenesis"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hourâ„¢
The GRC Power Hourâ„¢ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizer: Kristen Koenig (University of Texas at Austin, United States)
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Non-Neuronal Cells and Tissues
Discussion Leader: Ryan MacDonald (University College London, United Kingdom)
6:00 pm - 6:20 pm
Sabine Fuhrmann (Vanderbilt University School of Medicine, United States)
"Investigation of Effects of Hippo Pathway Modulation on RPE Injury"
6:20 pm - 6:25 pm
Discussion
6:25 pm - 6:45 pm
Ruby Shalom-Feuerstein (Israel Institute of Technology, Israel)
"Eyes on Stem Cells: Deciphering Limbal Stem Cell Dynamics, Regulation and Repair"
6:45 pm - 6:50 pm
Discussion
6:50 pm - 7:10 pm
Jessica Treisman (NYU Langone Health, United States)
"A Fly's Eye View of Corneal Development"
7:10 pm - 7:15 pm
Discussion
7:15 pm - 7:35 pm
Peter Lwigale (Rice University, United States)
"Signaling from Periocular Neural Crest Cells Regulates Neurovascular Patterning in the Anterior Eye During Development"
7:35 pm - 7:40 pm
Discussion
7:40 pm - 7:55 pm
Gaia Gestri (University College London , United Kingdom)
"Retinal Coloboma in Yapnl13 Mutants is Due to Reduced RPE Contractility and is Enhanced by Mutations in Extracellular Matrix and Other Genes Associated with Congenital Defects of Eye Formation"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Building, Remodelling and Repairing Retinal Circuity
Discussion Leader: Melanie Samuel (Baylor College of Medicine, United States)
9:00 am - 9:20 am
Enrica Strettoi (Neuroscience Institute, Italian National Research Council (IN-CNR), Italy)
"Bystander Effects and Inflammatory Responses in Inherited Retinal Degeneration"
9:20 am - 9:25 am
Discussion
9:25 am - 9:45 am
Marla Feller (University of California, Berkeley, United States)
"A Role for Retinal Waves in the Establishment of Direction Selective Circuits in the Retina"
9:45 am - 9:50 am
Discussion
9:50 am - 10:10 am
Mathias Wernet (Freie Universität Berlin, Germany)
"The Synaptic Pathways Providing Visual Inputs to the Navigation Center in the Drosophila Central Brain"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
Dongpeng Hu (Okinawa Institute of Science and Technology Graduate University, Japan)
"Pull to Push: Filopodium-Mediated Homotypic Recognition Regulates Zebrafish Cone Mosaic"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Lisa Goodrich (Harvard Medical School, United States)
"Molecular Mechanisms of Synapse Development"
11:20 am - 11:25 am
Discussion
11:25 am - 11:45 am
Kirill Martemyanov (UF Scripps, University of Florida, United States)
"Molecular Principles Guiding Synaptic Connectivity of Photoreceptors"
11:45 am - 11:50 am
Discussion
11:50 am - 12:05 pm
Robert Hindges (King's College London, United Kingdom)
"Experience-Dependent Plasticity in the Retina"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
Ted Erclik (University of Toronto, Canada)
"Concurrent Temporal Patterning of Neural Progenitors in the Fly Visual System"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Central Visual Development and Sensory Integration
Discussion Leader: Julie Lefebvre (Hospital for Sick Children and University of Toronto, Canada)
6:00 pm - 6:25 pm
Thomas Clandinin (Stanford University, United States)
"How Does Functional Diversity Emerge Across Visual Processing Pathways?"
6:25 pm - 6:30 pm
Discussion
6:30 pm - 6:55 pm
Lucas Cheadle (Cold Spring Harbor Laboratory, United States)
"Non-Canonical Roles of Oligodendrocyte Precursor Cells in Visual Circuit Refinement and Remodeling"
6:55 pm - 7:00 pm
Discussion
7:00 pm - 7:25 pm
Tim Czopka (University of Edinburgh, United Kingdom)
"How the Form and Function of Retino-Tectal Circuitry is Shaped by Oligodendrocyte Precursor Cells"
7:25 pm - 7:30 pm
Discussion
7:30 pm - 7:40 pm
Dritan Agalliu (Columbia University Irving Medical Center, United States)
"Glutamatergic Neuronal Activity Regulates Angiogenesis and Blood-Retinal Barrier Maturation via Norrin/Beta-Catenin Signaling"
7:40 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
Salwan Butrus (UC Berkeley, United States)
"Single-Cell Multi-Omic Dissection of Experience-Dependent Cell Type Development in Mouse Visual Cortex"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Genome Wide Approaches in Retinal Development Disease and Aging
Discussion Leader: Brian Clark (Washington University School of Medicine in St. Louis, United States)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
Cagla Eroglu (Duke University Medical Center, United States)
"Astrocyte-Microglia Signaling Controls Developmental Synapse Remodeling in the Visual Cortex"
9:25 am - 9:30 am
Discussion
9:30 am - 9:50 am
Seth Blackshaw (Johns Hopkins University School of Medicine, United States)
"Gene Regulatory Networks Controlling Vertebrate Retinal Aging"
9:50 am - 9:55 am
Discussion
9:55 am - 10:15 am
Sui Wang (Stanford University, United States)
"Protecting the Retina from Diabetes-Induced Damage"
10:15 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:10 am
Vikki Weake (Purdue University, United States)
"Age-Dependent Epigenetic Changes in the Retina Alter the CIrcadian Transcriptome"
11:10 am - 11:15 am
Discussion
11:15 am - 11:35 am
Jens Rister (University of Massachusetts Boston, United States)
"A Mechanism that Stabilizes Vitamin A-Deficient and Rhodopsin-Mutant Drosophila Photoreceptors"
11:35 am - 11:40 am
Discussion
11:40 am - 12:00 pm
Tim Cherry (Seattle Children's/University of Washington, United States)
"Non-Coding Mechanisms of Retinal Development and Disease"
12:00 pm - 12:05 pm
Discussion
12:05 pm - 12:25 pm
Short Talk Selected from Poster Abstracts
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Development and Dysfunction of the Primate Retina
Discussion Leader: Rod Bremner (Lunenfeld Tanenbaum Research Institute, Canada)
6:00 pm - 6:20 pm
Yi-Rong Peng (UCLA, United States)
"Molecular Characterization of Foveal and Peripheral Cell Types in Human and Non-Human Primate Retinas: From Development to Evolution"
6:20 pm - 6:25 pm
Discussion
6:25 pm - 6:45 pm
Majlinda Lako (University of Newcastle Upon Tyne, United Kingdom)
"Spatiotemporal Single Cell Analyses Reveal a Transient Population of Retinal Progenitor Cells in the Ciliary Margin of Developing Human Retina"
6:45 pm - 6:50 pm
Discussion
6:50 pm - 7:10 pm
Tom Glaser (UC-Davis, United States)
"Homeotic Hotspot in the Human Genome - An Enhancer Trap with Eye and Brain Phenotypes"
7:10 pm - 7:15 pm
Discussion
7:15 pm - 7:35 pm
Jason Meyer (Indiana University School of Medicine, United States)
"Retinal Ganglion Cells and Glial Interactions in a Human Pluripotent Stem Cell Model of Neurodegeneration and Neuroinflammation"
7:35 pm - 7:40 pm
Discussion
7:40 pm - 7:55 pm
Levi Todd (SUNY Upstate Medical University , United States)
"Peripheral Immune Invasion Suppresses Mammalian Retinal Regeneration"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Emerging Systems for Studying Visual Development
Discussion Leader: Wei Li (NIH, United States)
9:00 am - 9:10 am
Karina Ascunce (Yale University, United States)
"Investigating Visual System Regeneration in S. Mediterranea"
9:10 am - 9:15 am
Discussion
9:15 am - 9:35 am
Joseph Corbo (Washington University in St. Louis, United States)
"Conservation of Retinal Cis -Regulatory Codes Over Half a Billion Years"
9:35 am - 9:40 am
Discussion
9:40 am - 10:00 am
Belinda Chang (University of Toronto, Canada)
"Molecular Evolution of Reptile Photoreceptors"
10:00 am - 10:05 am
Discussion
10:05 am - 10:25 am
Zuzana Musilova (Charles University in Prague, Czech Republic)
"See You in the Dark: Vision in Deep-Sea Fishes and Their Shallow-Water Larvae"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Mark Frye (University of California, Los Angeles, United States)
"A Tale of Two Visual Systems: Parallel Structural and Functional Pathways for Motion Guided and Feature Guided Behaviors"
11:20 am - 11:25 am
Discussion
11:25 am - 11:45 am
Todd Oakley (University of California, Santa Barbara, United States)
"The Rime of Ancient Eyes: Parallel, Convergent, and Path Dependent Evolution"
11:45 am - 11:50 am
Discussion
11:50 am - 12:05 pm
Eva Candal (Universidade de Santiago de Compostela, Spain)
"A Single-Nucleus RNA-Seq Atlas of the Postnatal Shark Retina"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
Akishi Onishi (Ritsumeikan University / RIKEN Baton Zone Program, Japan)
"Genetically Engineered Opossum, a Novel Non-Rodent Mammalian Model to Study the Pathogenesis of Inherited Retinal Diseases"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Cellular Regeneration, Repair and Stem Cells
Discussion Leader: Kapil Bharti (National Institutes of Health, United States)
6:00 pm - 6:20 pm
Marius Ader (TU Dresden, Germany)
"Transplantation of Human Photoreceptors into Mouse Models of Retinal Degeneration"
6:20 pm - 6:25 pm
Discussion
6:25 pm - 6:45 pm
David Gamm (University of Wisconsin-Madison, United States)
"M/L Cone Production, Characterization and Enrichment from Human Pluripotent Stem Cells"
6:45 pm - 6:50 pm
Discussion
6:50 pm - 7:10 pm
Muriel Perron (CNRS / Paris-Saclay University, France)
"The Ambivalent Role of Inflammation in Retinal Regeneration"
7:10 pm - 7:15 pm
Discussion
7:15 pm - 7:35 pm
Karl Wahlin (UC San Diego, United States)
"Exploring Retinal Cell Reprogramming Using Human Pluripotent Stem Cells"
7:35 pm - 7:40 pm
Discussion
7:40 pm - 7:55 pm
Michiko Mandai (Kobe City Eye Hospital, Japan)
"Donor Photoreceptor Connectivity in Vivo"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure