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Nucleosides, Nucleotides & Oligonucleotides
Gordon Research Conference

Conference Information

Status

Active

Initial Year

1976

Discipline

Chemical

Categories

Meeting Cycle

24 Months

Conference Description

DNA is the storehouse of genetic information. Genes are duplicated during each cell division (replication), and they are transcribed into the corresponding RNAs (transcription) before translation into the proteins that are required for cell function. RNA is subsequently processed so that the non-coding parts are removed (processing), and it is then transported out of the nucleus (transport). Outside of the nucleus, proteins are assembled, based upon the triplet code, at ribosomal sites in the translation process. This complex interplay requires constant interaction between proteins and many other cofactors. The goal of this Conference is to highlight our current understanding of the various chemical steps through the use of synthetic "Nucleosides, Nucleotides and Oligonucleotides" and their analogs in order to design new therapeutic, analytical and diagnostic agents. The usefulness of these synthetic compounds is enormous. Synthetic nucleosides and nucleotides and their analogs, for example, have found application as many remarkable antiviral and antitumor drugs which are used widely in the clinic against many deadly bacterial and viral infections and against malignant tumors. Many drugs approved by the FDA as antiviral/antitumor agents are nucleoside-based compounds. The mechanism of action of many such nucleoside/nucleotide based inhibitors is through interaction/inhibition with/of the target enzymes (novel mechanism-based inactivators). The use of oligonucleotides and their analogs is, on the other hand, constantly revealing new methods to alter and to monitor gene expression by means of antisense RNA or DNA, triplex DNA, ribozymes, RNAi, CpG immune modulatory oligonucleotides, DNA oxidative damage, gene repair, DNA chips, and by other approaches. The design and synthesis of oligonucleotides and their analogs have opened doors to the understanding of the mechanisms of action of these compounds as potential therapeutic agents, including their uptake, stability, in both prokaryotic and eukaryotic organisms, and in both in vitro and in vivo systems, leading to lowered toxicity and improved efficacy. Oligonucleotides with fluorescent dyes provide unique molecular probe systems that are useful for the detection of PCR products and nucleic acid hybridization as well as for sequencing. Many revolutionary concepts involving specifically designed RNA and DNA oligonucleotides with novel functions have been shown to be useful in target validation and as new analytical and therapeutic agents. In this respect, new emerging areas include the design of nanoprobes, sensors and many sensitive diagnostic tools for the detection of single nucleotide polymorphism, high affinity binding (aptamers), catalytic activity (ribozymes and deoxyribozymes) and combinations of binding and catalytic properties (aptazymes).

This very brief summary of the field demonstrates how important the synthetic chemistry of "Nucleosides, Nucleotides and Oligonucleotides" is in the exploration and understanding of life, and how this knowledge has been invaluable in the design of new analytical and therapeutic agents. This opportunity to communicate with each other and to learn from our individual ideas and experiments at this GRC is undoubtedly of enormous value.

What is a GRC? Gordon Research Conferences (GRC) are 5-day meetings that bring scientists together from around the world to present and discuss unpublished research with other leaders in their field.

Related Conference

This Gordon Research Conference (GRC) series is related to the "Nucleosides, Nucleotides & Oligonucleotides" Gordon Research Seminar (GRS) series. Although a related GRS will typically be scheduled in conjunction with its parent GRC each time it meets, that may not always be the case. Refer to the individual meetings in the Meeting History section below for more details. For more information about the associated Gordon Research Seminar (GRS) series, click here.

What is a GRS? Gordon Research Seminars (GRS) are 2-day meetings that bring graduate students and post-docs together to discuss their cutting edge research among peers and mentors. Each GRS immediately precedes an associated Gordon Research Conference (GRC), and topics addressed at the GRS relate closely to the GRC.

Meeting History

YearMeeting NameDatesConference SiteChair(s)
2017 Nucleosides, Nucleotides & Oligonucleotides
Understanding the Chemistry of Nucleic Acid Components to Improve Human Health
Jun 25-30 Salve Regina University Cynthia J. Burrows
2015 Nucleosides, Nucleotides & Oligonucleotides
Exploring the Interface of Biology, Function, Chemistry and Drug Development
Jun 28 - Jul 3 Salve Regina University Vern L. Schramm
2013 Nucleosides, Nucleotides & Oligonucleotides Jun 30 - Jul 5 Salve Regina University William B. Parker
2011 Nucleosides, Nucleotides & Oligonucleotides Jul 3-8 Salve Regina University Piet Herdewijn
2009 Nucleosides, Nucleotides & Oligonucleotides Jul 5-10 Salve Regina University Varsha Gandhi
2007 Nucleosides, Nucleotides & Oligonucleotides Jul 1-6 Salve Regina University Jyoti Chattopadhyaya
2005 Nucleosides, Nucleotides & Oligonucleotides Jun 26 - Jul 1 Salve Regina University Donna S. Shewach
2003 Purines, Pyrimidines & Related Substances Jun 29 - Jul 4 Salve Regina University John A. Secrist
2001 Purines, Pyrimidines & Related Substances
Nucleosides & Nucleotides: Chemistry, Biology and Therapeutic Applications
Jul 1-6 Salve Regina University Carol E. Cass
1999 Purines, Pyrimidines & Related Substances Jul 4-9 Salve Regina University Vasu Nair
1997 Purines, Pyrimidines & Related Substances Jun 29 - Jul 4 Salve Regina University Barbara Ramsay. Shaw
1995 Purines, Pyrimidines & Related Substances Jul 2-7 Salve Regina University Victor E. Marquez
1993 Purines, Pyrimidines & Related Substances Jul 4-9 Salve Regina University William K. Plunkett
1991 Purines, Pyrimidines & Related Substances Jul 8-12 Salve Regina University Morris J. Robins
1989 Purines, Pyrimidines & Related Compounds Jul 10-14 Salve Regina University Robert E. Parks
1986 Purines, Pyrimidines & Related Compounds Jul 21-25 Plymouth State College Leroy B. Townsend
1984 Purines, Pyrimidines & Related Compounds Jul 23-27 Plymouth State College Yung-Chi Cheng
1981 Purines, Pyrimidines & Related Compounds Jun 29 - Jul 3 Plymouth State College John Montgomery
1976 Purines & Related Derivatives, Chemistry and Biology of Jun 28 - Jul 2 Plymouth State College George B. Brown
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