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Craniofacial Morphogenesis & Tissue Regeneration
Gordon Research Conference

Insights into Gene Networks, Disease Models and Evolutionary Mechanisms in Craniofacial Morphogenesis

Dates

March 13-18, 2016

Location

Four Points Sheraton / Holiday Inn Express
Ventura, CA

Organizers

Chair:
Patrick Tam

Vice Chair:
Ophir D. Klein

Meeting Description

The ultimate aim of craniofacial research is to understand the causes underlying craniofacial malformations and to develop diagnostics and therapies for these disorders. An in-depth, interdisciplinary understanding of the developmental biology and disease processes is an essential foundation for insights into the mechanisms of craniofacial morphogenesis and the translation of scientific outcomes to the clinical management of developmental disorders of the head and face. Such in-depth work probes the cellular events and molecular switches that control tissue patterning and the morphogenetic processes that shape craniofacial tissues and organs. The scientific program will highlight recent advances in the knowledge of the genetic and epigenetic mechanisms that control the specification of craniofacial cell populations and tissue architecture and the functional output and the evolutionary changes in gene networks. This will be accompanied by discussions on how these processes drive tissue diversity and the formshaping process, and how distinctive features of the vertebrate head evolved. There will be invited presentations by leading researchers on new findings in craniofacial morphogenesis, with specific focus on the functional attributes of the gene network and the intersection with signalling activity. The meeting will also feature sessions on the functional genomics of craniofacial syndromes, development of animal models and the disease-causing mechanism and on the application of tissue engineering in regenerative repair.

The conference will be attended by researchers who have diverse expertise to foster stimulating discussions and productive collaborations across different fields. The conference will also provide unique opportunities for junior investigators and graduate students to present their work either in poster format or as a short talk selected from submitted abstracts. The collegial atmosphere of the main conference and the associated Gordon Research Seminar, and the informal setting of poster sessions and platform presentation, will facilitate personal interactions and sharing of knowledge, and will help to identify future directions in basic and clinical research of craniofacial morphogenesis.

Related Meeting

This GRC was held in conjunction with the "Craniofacial Morphogenesis & Tissue Regeneration" Gordon Research Seminar (GRS). Refer to the associated GRS program page for more information.

Contributors

Final Meeting Program

Sunday
4:00 pm - 8:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmKeynote Session: Phenomics and Mutagenesis Screen; Epithelial and Mesenchymal Morphogenesis: Genomics and Imaging
Discussion Leader: Ophir Klein (University of California, San Francisco, USA)
7:40 pm - 8:20 pmLee Niswander (University of Colorado School of Medicine, USA)
"Phenomics and Mutagenesis Screen"
8:20 pm - 8:35 pmDiscussion
8:35 pm - 9:15 pmMark Krasnow (Stanford University School of Medicine, USA)
"Elucidating Development and Stem Cells at Single Cell Resolution"
9:15 pm - 9:30 pmDiscussion
Monday
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmFunctional Genomics and Clinical Genetics
Discussion Leader: Paul Trainor (Stowers Institute for Medical Research, USA)
9:00 am - 9:30 amRichard Maas (Brigham and Women's Hospital, Harvard Medical School, USA)
"Functional Genomics of Craniofacial Development"
9:30 am - 9:40 amDiscussion
9:40 am - 9:55 amSteve Twigg (University of Oxford, United Kingdom)
"A Recurrent Mosaic Mutation of SMO (Smoothened) Is the Major Cause of Curry-Jones Syndrome"
9:55 am - 10:00 amDiscussion
10:00 am - 10:30 amCoffee Break
10:30 am - 11:00 amBernice Morrow (Albert Einstein College of Medicine, USA)
"Craniofacial Anomalies in 22q11 Deletion Syndrome"
11:00 am - 11:10 amDiscussion
11:10 am - 11:40 amCarol Wicking (University of Queensland, Australia)
"Ciliopathies: From Human Gene Discovery to Animal Models"
11:40 am - 11:50 amDiscussion
11:50 am - 12:00 pmGeneral Discussion
12:00 pm - 12:30 pmPoster Previews
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmModelling Developmental Errors
Discussion Leader: Paul Sharpe (King's College London, United Kingdom)
7:30 pm - 8:00 pmJeffrey Bush (University of California, San Francisco, USA)
"Mouse Genetic and Human iPSC Models of Craniofrontonasal Syndrome Reveal Basic Mechanisms of Eph/Ephrin Boundary Formation"
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:40 pmJoan Richtsmeier (Pennsylvania State University, USA)
"Chondrocranial and Dermatocranial Associations in Evolution, Development and Disease"
8:40 pm - 8:50 pmDiscussion
8:50 pm - 9:05 pmMaria Rita Passos-Bueno (Universidade de Sao Paulo, Brazil)
"Modeling Craniofacial Syndromes with the Use of Induced Pluripotent Stem Cells"
9:05 pm - 9:10 pmDiscussion
9:10 pm - 9:25 pmIrfan Saadi (University of Kansas Medical Center, USA)
"SPECC1L Cytoskeletal Protein Regulates Cell Adhesion and Migration Through PI3K-AKT Signaling During Craniofacial Morphogenesis"
9:25 pm - 9:30 pmDiscussion
Tuesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmEvolution and Functional Anatomy
Discussion Leader: Jeffrey Streelman (Georgia Institute of Technology, USA)
9:00 am - 9:30 amAnne Huysseune (Ghent University, Belgium)
"Evo-Devo of the Dentition"
9:30 am - 9:40 amDiscussion
9:40 am - 9:55 amNeal Anthwal (King's College London, United Kingdom)
"Break Down of Meckel's Cartilage Provides Clues to the Evolution of Mammals"
9:55 am - 10:00 amDiscussion
10:00 am - 10:30 amCoffee Break
10:30 am - 11:00 amCraig Miller (University of California, Berkeley, USA)
"Fishing for the Genetic Basis of Craniofacial Development, Evolution, and Regeneration"
11:00 am - 11:10 amDiscussion
11:10 am - 11:25 amPierre Le Pabic (University of California, Irvine, USA)
"Developmental Basis of Head Shape Evolution in East African Rift Lake Cichlids"
11:25 am - 11:30 amDiscussion
11:30 am - 11:45 amTetsuto Miyashita (University of Alberta, Canada)
"Independent Evolutionary Origins of Serial Patterns in the Vertebrate Head as Corroborated by Compatible Fossil and Developmental Evidence"
11:45 am - 11:50 amDiscussion
11:50 am - 12:00 pmGeneral Discussion
12:00 pm - 12:30 pmPoster Previews
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmGene Network and Switches
Discussion Leader: Ralph Marcucio (University of California, San Francisco, USA)
7:30 pm - 8:00 pmRobert Cornell (University of Iowa, USA)
"Evidence that Common, Non-Coding Variants Near ARHGAP29 Are Pathogenic for Orofacial Clefting"
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:40 pmTatjana Sauka-Spengler (University of Oxford, United Kingdom)
"Pioneering Chromatin for Neural Crest Specification"
8:40 pm - 8:50 pmDiscussion
8:50 pm - 9:05 pmYuji Mishina (University of Michigan School of Dentistry, USA)
"Enhanced BMP Signaling in Neural Crest Cells Leads to Craniosynostosis"
9:05 pm - 9:10 pmDiscussion
9:10 pm - 9:25 pmJacqueline Hecht (The University of Texas Health Science Center at Houston, USA)
"CRISPLD2: From Gene Function to New NSCLP Candidate Gene"
9:25 pm - 9:30 pmDiscussion
Wednesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmTissue Patterning: Cellular Mechanisms
Discussion Leader: Marianne Bronner (California Institute of Technology, USA)
9:00 am - 9:30 amCarole LaBonne (Northwestern University, USA)
"Rethinking the Zwischenstrang: Cellular Mechanisms Underlying the Genesis of Neural Crest"
9:30 am - 9:40 amDiscussion
9:40 am - 9:55 amLaura Ahtiainen (University of Helsinki, Finland)
"Cellular Mechanisms Driving Tooth Budding Morphogenesis"
9:55 am - 10:00 amDiscussion
10:00 am - 10:30 amCoffee Break
10:30 am - 11:00 amJames Martin (Baylor College of Medicine, USA)
"Hippo Signaling in Craniofacial Development"
11:00 am - 11:10 amDiscussion
11:10 am - 11:40 amMai Har Sham (The University of Hong Kong, Hong Kong SAR China)
"Eya1 and Notch Signaling in Branchial Epithelium Development"
11:40 am - 11:50 amDiscussion
11:50 am - 12:05 pmJimmy Hu (University of California, San Francisco, USA)
"The Regulation of Adult Incisor Stem Cells by YAP/TAZ and Hippo Signalling"
12:05 pm - 12:10 pmDiscussion
12:10 pm - 12:25 pmEric Liao (Harvard Medical School, USA)
"Diverse Roles for Wnt Pathway Members in Regulation of Axial Patterning and Convergent Extension During Palate Morphogenesis"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmOrgan Formation
Discussion Leader: Yang Chai (University of Southern California, USA)
7:30 pm - 8:00 pmClare Baker (University of Cambridge, United Kingdom)
"The Development and Evolution of Lateral Line Electroreceptors"
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:40 pmMatthew Hoffman (National Institute of Dental and Craniofacial Research, NIH, USA)
"Regulatory Inputs Driving Salivary Gland Development and Regeneration"
8:40 pm - 8:50 pmDiscussion
8:50 pm - 9:05 pmAndrea Streit (King's College London, United Kingdom)
"Making Inner Ears: A Gene Network Approach"
9:05 pm - 9:10 pmDiscussion
9:10 pm - 9:25 pmDavid Clouthier (University of Colorado Anschutz Medical Campus, USA)
"Hand2 and Twist1 Control Vascular Development of the Lower Jaw"
9:25 pm - 9:30 pmDiscussion
Thursday
7:30 am - 8:30 amBreakfast
8:30 am - 9:00 amBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pmTissue Engineering and Repairs
Discussion Leader: Irma Thesleff (University of Helsinki, Finland)
9:00 am - 9:30 amWarren Grayson (Johns Hopkins University, USA)
"3D-Printed Scaffolds and Stem Cells for Regeneration of Vascularized Craniofacial Bone"
9:30 am - 9:40 amDiscussion
9:40 am - 9:55 amKaren Liu (King's College London, United Kingdom)
"SOSTDC1-Dependent Repair of Calvarial Bone Defects Using Adipose-Derived Stem Cells"
9:55 am - 10:00 amDiscussion
10:00 am - 10:30 amCoffee Break
10:30 am - 11:00 amDerk Joester (Northwestern University, USA)
"Interfaces and Interphases in Tooth Biominerals"
11:00 am - 11:10 amDiscussion
11:10 am - 11:25 amHu Zhao (Baylor College of Dentistry, USA)
"In Vivo Identity and Niche of Periodontal Ligament Stem Cells"
11:25 am - 11:30 amDiscussion
11:30 am - 11:45 amEric Van Otterloo (University of Colorado Anschutz Medical Campus, USA)
"Tissue Specific Redundancy of TFAP2 Family Members During Craniofacial Patterning"
11:45 am - 11:50 amDiscussion
11:50 am - 12:00 pmGeneral Discussion
12:00 pm - 12:30 pmPoster Previews
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmFormshaping: Skull and Face
Discussion Leader: James Martin (Baylor College of Medicine, USA)
7:30 pm - 8:00 pmSevan Hopyan (The Hospital for Sick Children, Canada)
"Branchial Arch Morphogenesis"
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:25 pmAmy Merrill-Brugger (University of Southern California, USA)
"Connecting Tendon to Bone in Craniofacial Development"
8:25 pm - 8:30 pmDiscussion
8:30 pm - 8:45 pmDany Adams (Tufts University, USA)
"Craniofacial Morphogenesis Regulation by Ion-Flux Dependent Signals: The Etiology of Craniofacial Anomalies Associated with Channelopathies"
8:45 pm - 8:50 pmDiscussion
8:50 pm - 9:20 pmRalph Marcucio (University of California, San Francisco, USA)
"Murder, Transformation, and Rebirth in the Skeletal System"
9:20 pm - 9:30 pmDiscussion
Friday
7:30 am - 8:30 amBreakfast
9:00 amDeparture

Funding for this conference was made possible (in part) by 1R13DE025777-01 from NIDCR. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
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