| SUNDAY |
| 2:00 pm - 9:00 pm | Arrival and Check-in |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | NUCLEIC ACIDS |
| Discussion Leader: Y.-T. Chang (NYU) |
| Welcoming Remarks |
| 7:30 pm - 8:00 pm | T. Sheppard (Northwestern)
"Chemical Biology of DNA Damage and Modification" |
| 8:00 pm - 8:10 pm | Discussion |
| 8:10 pm - 8:40 pm | J. Puglisi (Stanford)
"RNA as a Drug Target" |
| 8:40 pm - 8:50 pm | Discussion |
| 8:50 pm - 9:20 pm | R. Breaker (Yale)
"Riboswitches: Metabolite Sensors in Messenger RNAs" |
| 9:20 pm - 9:30 pm | Discussion |
| MONDAY |
| 7:30 am - 8:30 am | Breakfast |
| 8:30 am | Photo Session |
| 9:00 am - 12:30 pm | COMPUTATIONAL DESIGN |
| Discussion Leader: A. Kennan (Colorado State) |
| 9:00 am - 9:30 am | I. Kuntz (UCSF)
"Molecular Recognition: Ligand and Scaffold Design Protocols" |
| 9:30 am - 9:40 am | Discussion |
| 9:40 am - 10:10 am | T. Stouch (Bristol-Myers Squibb)
"Computer Modeling and Simulation in Pharmaceutical Research: Pushing the Limits" |
| 10:10 am - 10:20 am | Discussion |
| 10:20 am | Coffee Break |
| 10:35 am - 11:05 am | H. Hellinga (Duke)
"Computational Design of Biologically Active Receptors and Sensors" |
| 11:05 am - 11:15 am | Discussion |
| 11:15 am - 11:45 am | C. Brooks (Scripps)
"Enzyme Catalysis, Conformational Substates and Protein Fluctuations: Hydride Transfer in Dihydrofolate Reductase" |
| 11:45 am - 11:55 am | Discussion |
| 11:55 am - 12:10 pm | Poster Talk I - M. Uesugi (Baylor)
"Small Molecules that Modulate Transcription and Differentiation" |
| 12:10 pm - 12:25 pm | Poster Talk II - K. Johnsson (EPFL)
"Chemical Approaches to Exploit Fusion Proteins" |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session I |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | CELLULAR IMAGING |
| Discussion Leader: S. Licht (MIT) |
| 7:30 pm - 8:00 pm | T. Meade (Northwestern)
"Seeing is Believing: Visualizing Gene Expression and Secondary Messengers by MRI" |
| 8:00 pm - 8:10 pm | Discussion |
| 8:10 pm - 8:40 pm | S. Michnick (U. Montreal)
"Protein Networking in Living Cells" |
| 8:40 pm - 8:50 pm | Discussion |
| 8:50 pm - 9:20 pm | R. Tsien (UCSD)
"Imaging Signal Transduction and Protein Sociology" |
| 9:20 pm - 9:30 pm | Discussion |
| TUESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | PROTEIN FUNCTION |
| Discussion Leader: M. K. Pflum (Wayne State) |
| 9:00 am - 9:30 am | B. Borhan (Michigan State)
"Engineering a Protein Mimic of Rhodopsin: Efforts toward Understanding the Wavelength Regulation of Color Vision" |
| 9:30 am - 9:40 am | Discussion |
| 9:40 am - 10:10 am | D. Kern (Brandeis)
"Enzymes in Action in the NMR Tube: Protein Dynamics During Catalysis and Signaling" |
| 10:10 am - 10:20 am | Discussion |
| 10:20 am | Coffee Break |
| 10:35 am - 11:05 am | M. Pirrung (Duke)
"Signal Transduction, Protein-Protein Interactions, and Synthetic Chemistry: Small Molecule Insulin Mimics" |
| 11:05 am - 11:15 am | Discussion |
| 11:15 am - 11:45 am | A. Kossiakoff (U. Chicago)
"Phage Display Evolved Protein-Protein Interfaces: Where General Principles Come to Die" |
| 11:45 am - 11:55 am | Discussion |
| 11:55 am - 12:10 pm | Poster Talk III - A. Basu (Brown)
"Glycolipid Interactions at Membranes"
|
| 12:10 pm - 12:25 pm | Poster Talk IV - L. Hsieh-Wilson (Caltech)
"New Insights into the Role of Carbohydrates in Modulating Protein Function" |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session I |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | NATURAL PRODUCTS AND BIOSYNTHESIS |
| Discussion Leader: L. Hsieh-Wilson (Caltech) |
| 7:30 pm - 8:00 pm | B. Moore (U. Arizona)
"Engineered Biosynthesis with Bacterial Iterative Polyketide Synthases" |
| 8:00 pm - 8:10 pm | Discussion |
| 8:10 pm - 8:40 pm | J. Noel (Salk)
"Evolution of Secondary Metabolic Pathways in Plants" |
| 8:40 pm - 8:50 pm | Discussion |
| 8:50 pm - 9:20 pm | C. Bertozzi (UC Berkeley)
"Chemical Approaches for Probing Posttranslational Modifications" |
| 9:20 pm - 9:30 pm | Discussion |
| WEDNESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | PROTEIN DESIGN |
| Discussion Leader: I. Ghosh (U. Arizona) |
| 9:00 am - 9:30 am | M. Waters (UNC)
"Molecular Recognition by -Hairpin Peptides: Design of Structure and Function" |
| 9:30 am - 9:40 am | Discussion |
| 9:40 am - 10:10 am | B. Imperiali (MIT)
"New Tools for Chemical Biology" |
| 10:10 am - 10:20 am | Discussion |
| 10:20 am | Coffee Break |
| 10:35 am - 11:05 am | J. Schneider (U. Delaware)
"Design and Efficacy of Functional Peptides" |
| 11:05 am - 11:15 am | Discussion |
| 11:15 am - 11:45 am | L. Serrano (EMBL)
"Protein Design and Amyloid Formation" |
| 11:45 am - 11:55 am | Discussion |
| 11:55 am - 12:25 pm | Poster Talk V - R. Roberts (Caltech)
"Expansion of the Genetic Code Using mRNA Display" |
| 12:10 pm - 12:30 pm | Business Meeting |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session II |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | MOLECULAR EVOLUTION |
| Discussion Leader: G. Weiss (UC Irvine) |
| 7:30 pm - 8:00 pm | D. Liu (Harvard)
"Expanding the Scope of Molecular Evolution" |
| 8:00 pm - 8:10 pm | Discussion |
| 8:10 pm - 8:40 pm | A. Dömling (Morphochem)
"Novel Chemotypes and Chemoinformatic Methods to Discover Protein-Protein Interaction Inhibitors" |
| 8:40 pm - 8:50 pm | Discussion |
| 8:50 pm - 9:20 pm | M. Reetz (Max Planck)
"Directed Evolution of Enantioselective Enzymes" |
| 9:20 pm - 9:30 pm | Discussion |
| THURSDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | DRUG DISCOVERY & TARGET VALIDATION |
| Discussion Leader: R. Weatherman (Purdue) |
| 9:00 am - 9:30 am | D. Hazuda (Merck)
"Mechanism-Based Inhibitors of Phosphotransferases: Lessons from HIV-1 Integrase" |
| 9:30 am - 9:40 am | Discussion |
| 9:40 am - 10:10 am | K. Deshayes (Genentech)
"Developing Small Molecules to Selectively Sensitize Cancer Cells to Apoptosis" |
| 10:10 am - 10:20 am | Discussion |
| 10:20 am | Coffee Break |
| 10:35 am - 11:05 am | N. Gray (GNF)
"Synthesis and Target Identification of Protein Kinase Inhibitors" |
| 11:05 am - 11:15 am | Discussion |
| 11:15 am - 11:45 am | K. Shokat (UCSF)
"Forward and Reverse Chemical Genetic Dissection of Cell Signaling" |
| 11:45 am - 11:55 am | Discussion |
| 11:55 am - 12:10 pm | Poster Talk VI - J. Taunton (UCSF)
"Design and Discovery of Electrophilic Protein Kinase Inhibitors" |
| 12:10 pm - 12:25 pm | Poster Talk VII - T. von Geldern (Abbott)
"Hepatoselective Glucocorticoid Antagonists and Diabetes" |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session II |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | MEMBRANE STRUCTURE & FUNCTION |
| Discussion Leader: S. Craig (Duke) |
| 7:30 pm - 8:00 pm | B. Peterson (Penn State)
"Construction of Non-Natural Cellular Receptors from Synthetic Molecules" |
| 8:00 pm - 8:10 pm | Discussion |
| 8:10 pm - 8:40 pm | S. Regen (Lehigh)
"Lipid-Lipid Recognition in Fluid Bilayers: Solving the Cholesterol Mystery" |
| 8:40 pm - 8:50 pm | Discussion |
| 8:50 pm - 9:20 pm | D. Thompson (Purdue)
"Rational Design of Plasmenyl Lipid Phase Transitions for Efficient Intracellular Drug Delivery" |
| 9:20 pm - 9:30 pm | Discussion |
| FRIDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Depart |
