| SUNDAY |
| 2:00 pm - 9:00 pm | Arrival and Check-in |
| 6:00 pm | Dinner |
| 7:20 pm | Welcoming Remarks |
| 7:30 pm - 9:30 pm | TINKERING WITH THE CENTRAL PARADIGM |
| Discussion Leader: Danith Ly (Carnegie Mellon) |
| 7:30 pm - 8:00 pm | Scott Silverman (U. Illinois)
"DNA as a Catalyst and Scaffold: Unconventional Applications of DNA in Bioorganic Chemistry and Nanotechnology" |
| 8:00 pm - 8:10 pm | Discussion |
| 8:10 pm - 8:40 pm | Christine Chow (Wayne State)
"Discovery of New Ligands for Functional rRNA Targets" |
| 8:40 pm - 8:50 pm | Discussion |
| 8:50 pm - 9:20 pm | Jack Szostak (Harvard)
"Ribosomal Translation of Highly Modified Peptides" |
| 9:20 pm - 9:30 pm | Discussion |
| MONDAY |
| 7:30 am - 8:30 am | Breakfast |
| 8:30 am | Photo |
| 9:00 am - 12:30 pm | NATURE MIMICKED |
| Discussion Leader: Edward Driggers (Ensemble) |
| 9:00 am - 9:30 am | Virgil Percec (U. Pennsylvania)
"Porous Protein Mimics" |
| 9:30 am - 9:40 am | Discussion |
| 9:40 am - 10:10 am | Annelise Barron (Northwestern)
"Sequence-specific Peptoids as Mimics of Bioactive, Helical Peptides" |
| 10:10 am - 10:20 am | Discussion |
| 10:20 am | Coffee Break |
| 10:35 am - 11:05 am | Alan Kennan (Colorado State)
"Design and Mimicry of Coiled-Coil Structures" |
| 11:05 am - 11:15 am | Discussion |
| 11:15 am - 11:45 am | Stefan Matile (U. Geneva)
"Synthetic Multifunctional Pores" |
| 11:45 am - 11:55 am | Discussion |
| 11:55 am - 12:30 pm | Selected Poster Talks: |
| Reena Zutshi (ImaRx)
"Ultrasound Mediated Targeted Drug Delivery" |
| Clemens Richert (U. Karlsruhe)
"Accelerating Chemical Primer Extension" |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session I |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | NATURE REDESIGNED |
| Discussion Leader: Matt Francis (U.C. Berkeley) |
| 7:30 pm - 8:00 pm | Brian K. Shoichet (U.C. San Francisco)
"A High Throughput Assay for Promiscuous Inhibition" |
| 8:00 pm - 8:10 pm | Discussion |
| 8:10 pm - 8:40 pm | Lynne Regan (Yale)
"Creating Proteins with Novel Structures and Activities" |
| 8:40 pm - 8:50 pm | Discussion |
| 8:50 pm - 9:20 pm | Barrie Wilkinson (Biotica)
"Engineered Biosynthesis of Rapamycin Analogues - A Novel Approach to Structurally Distinct mTOR Inhibitors'" |
| 9:20 pm - 9:30 pm | Discussion |
| TUESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | SIGNALS AND PATHWAYS |
| Discussion Leader: Jennifer Kohler (Stanford) |
| 9:00 am - 9:30 am | Alice Ting (M.I.T.)
"Small-Molecule and Genetically-Encoded Reporters of Protein Trafficking and Protein-Protein Interactions" |
| 9:30 am - 9:40 am | Discussion |
| 9:40 am - 10:10 am | Maurizio Pellecchia (Burnham Institute)
"Targeting Cell-Death and Survival via Structure- and NMR-based Approaches" |
| 10:10 am - 10:20 am | Discussion |
| 10:20 am | Coffee Break |
| 10:35 am - 11:05 am | Thomas Engler (Lilly)
"The Effects of Potent and Selective GSK-3 Inhibitors on Insulin and Wnt Signaling Pathways In Vitro and In Vivo" |
| 11:05 am - 11:15 am | Discussion |
| 11:15 am - 11:45 am | Linda Hsieh-Wilson (Cal. Tech.)
"Decoding Structure-Activity Relationships of Carbohydrates in the Brain" |
| 11:45 am - 11:55 am | Discussion |
| 11:55 am - 12:30 pm | Selected Poster Talks: |
| Thea Norman (Ambrx)
"Engineering the next generation of therapeutic proteins" |
| Helen Blackwell (U. Wisconsin-Madison)
"Chemical Approaches to Modulate Bacterial Communication" |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session II |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | ENZYME MECHANISMS |
| Discussion Leader: Irene Lee (Case Western) |
| 7:30 pm - 8:00 pm | Mark Distefano (U. Minnesota)
"Mechanistic and Functional Analysis of Protein Prenylation" |
| 8:00 pm - 8:10 pm | Discussion |
| 8:10 pm - 8:40 pm | Judith Klinman (U.C. Berkeley)
"Quino-Cofactor Biogenesis" |
| 8:40 pm - 8:50 pm | Discussion |
| 8:50 pm - 9:20 pm | Craig Townsend (Johns Hopkins)
"Synthetic, Mechanistic and Engineering Studies of Unusual Biosynthetic Reactions" |
| 9:20 pm - 9:30 pm | Discussion |
| WEDNESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | CHEMICAL TOOLS |
| Discussion Leader: Neil Thomas (U. Nottingham) |
| 9:00 am - 9:30 am | Tim Dore (U. Georgia)
"New Photo-Removable Protecting Groups with Sensitivity to Two-Photon Excitation for Exploring Cellular Physiology" |
| 9:30 am - 9:40 am | Discussion |
| 9:40 am - 10:10 am | David Berkowitz (U. Nebraska)
"ISES-A New Tool for Catalytic & Targeted Synthesis" |
| 10:10 am - 10:20 am | Discussion |
| 10:20 am | Coffee Break |
| 10:35 am - 11:05 am | Bradley Smith (Notre Dame)
"Chemical Agents that Influence or Sense Biomembrane Structure/Function" |
| 11:05 am - 11:15 am | Discussion |
| 11:15 am - 11:45 am | Chad Mirkin (Northwestern)
"The Bio Barcode Assay: Towards PCR-like Sensitivity for Proteins" |
| 11:45 am - 11:55 am | Discussion |
| 11:55 am - 12:30 pm | Business Meeting |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session III |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | DISEASES AND THERAPIES I |
| Discussion Leader: Helma Wennemers (U. Basel) |
| 7:30 pm - 8:00 pm | Peter Toogood (Pfizer)
"Kinase Inhibitors for Treating Cancer" |
| 8:00 pm - 8:10 pm | Discussion |
| 8:10 pm - 8:40 pm | Ranabir Sinha Roy (Merck)
"Dipeptidyl Peptidase IV Inhibitors for the Treatment of Diabetes" |
| 8:40 pm - 8:50 pm | Discussion |
| 8:50 pm - 9:20 pm | Christian Wiesmann (Genentech)
"Met Receptor Activation by HGF" |
| 9:20 pm - 9:30 pm | Discussion |
| THURSDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | DISEASES AND THERAPIES II |
| Discussion Leader: Krishna Kumar (Tufts University) |
| 9:00 am - 9:30 am | Celia Schiffer (U. Massachusetts)
"Combating Drug Resistance: Lessons from HIV-1 Protease" |
| 9:30 am - 9:40 am | Discussion |
| 9:40 am - 10:10 am | Greg Weiss (U.C.Irvine)
"Combinatorial Libraries of HIV Proteins and Small Molecules" |
| 10:10 am - 10:20 am | Discussion |
| 10:20 am | Coffee Break |
| 10:35 am - 11:05 am | Cliff Barry (N.I.H.)
"Targeting Anaerobic Metabolism using Nitroimidazoles for Shortening the Duration of Treatment for Tuberculosis" |
| 11:05 am - 11:15 am | Discussion |
| 11:15 am - 11:45 am | Adrian Whitty (Biogen-Idec)
"Does size matter? Inhibition of TNFalpha by a Small Molecule" |
| 11:45 am - 11:55 am | Discussion |
| 11:55 am - 12:30 pm | Selected Poster Talks: |
| Jack Taunton (U.C. San Francisco)
"A substrate-specific small molecule inhibitor of the Sec61 translocation channel" |
| Paul Hergenrother (U. Illinois)
"Using Small Molecules to Directly Activate the Apoptotic Cascade in Cancer Cells" |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session IV |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | NEW PARADIGMS, NEW TECHNOLOGIES |
| Discussion Leader: Andrea Cochran (Genentech) |
| 7:30 pm - 8:00 pm | Henrik Pedersen (Nuevolution)
"Chemetics - a New Paradigm for Drug Discovery" |
| 8:00 pm - 8:10 pm | Discussion |
| 8:10 pm - 8:40 pm | M.G. Finn (Scripps)
"Azides and Alkynes: High-Energy Pieces Used On and In Proteins" |
| 8:40 pm - 8:50 pm | Discussion |
| 8:50 pm - 9:20 pm | Stuart Schreiber (Harvard)
"Small Molecules, Multidimensional Screening, and ChemBank" |
| 9:20 pm - 9:30 pm | Discussion |
| FRIDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Depart |
