Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
7:40 pm - 8:10 pm
"Common Pitfalls in Preclinical Cancer Target Validation"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:40 pm
"Harnessing the Paracrine-cGAMP-STING Pathway for the Treatment of Cancer and Autoimmunity"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:00 pm
Short Talk Selected from Poster Abstracts
9:00 pm - 9:10 pm
Discussion
9:10 pm - 9:30 pm
General Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
AI, Evolution and Systems Chemical Biology
9:00 am - 9:20 am
"Proteomics Across Deep Evolutionary Time to Decode Human Genetics"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Expansion of the Ligandable Proteome Through AI-Driven Proteome-Wide Reactive Fragment Screening"
9:50 am - 10:00 am
Discussion
10:00 am - 10:30 am
Coffee Break
10:30 am - 10:50 am
"Programmable Biosynthesis of New-to-Nature Small Molecules"
10:50 am - 11:00 am
Discussion
11:00 am - 11:20 am
"Identification of Protein Misfolding Inhibitors by Directed Evolution"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"Chemical Proteomic Approaches to Study Post-Translational and Pharmacological Landscapes of Immune Dysfunction"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Short Talk Selected from Poster Abstracts
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hourâ„¢
The GRC Power Hourâ„¢ is designed to address the interests and needs of all scientists and the challenges they face in their careers. Specifically, the program promotes meaningful conversations amongst colleagues of all career stages about barriers to career advancement and strategies to support the professional growth of all members of the community. The GRC Power Hourâ„¢ is open to all conference participants.
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
7:30 pm - 7:50 pm
"Tripping Hypae and Remodeling Cell Walls with Chemical Glycobiology"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"30 Years of Covalent Probes Targeting Hydrolases: From 'Tools' to Imaging Agents"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"Activity-Based Protein Profiling for Ligand Discovery on a Global Scale"
8:50 pm - 9:10 pm
Discussion
9:10 pm - 9:30 pm
General Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
NGS-Based Chemical Biology
9:00 am - 9:20 am
"Pushing the Boundaries of Synthetic Biology"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Navigating the Proteome with Induced Proximity"
9:50 am - 10:00 am
Discussion
10:00 am - 10:30 am
Coffee Break
10:30 am - 10:50 am
"Sequence Space Exploration in Phosphotyrosine Signaling Proteins"
10:50 am - 11:00 am
Discussion
11:00 am - 11:20 am
"A High-Throughput Synthetic Biology and Chemistry Platform for Building Small Molecule Correctors"
11:20 am - 11:30 am
Discussion
11:30 am - 11:45 am
Poster Previews
11:45 am - 12:05 pm
"Parallel Methods for Studying Signaling Enzyme Function and Druggability"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Short Talk Selected from Poster Abstracts
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Chemical Control of Nucleic Acid Function
7:30 pm - 7:50 pm
"The Secret Building Blocks of RNA: From Decoding to Therapeutic Harnessing"
7:50 pm - 7:55 pm
Discussion
7:55 pm - 8:15 pm
"Circular RNAs in Health & Disease"
8:15 pm - 8:20 pm
Discussion
8:20 pm - 8:40 pm
"Enabling Technologies for Revealing Druggable Paths in RNA Biology"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 9:05 pm
"Chemical Degradation of N-Myc for the Treatment of Pediatric Neuroblastoma"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:30 pm
General Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Imaging and Molecular Detection
9:00 am - 9:20 am
"Visualizing Living Systems with Shortwave Infrared Light"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Imaging Tools and Technologies Inspired by Nature’s Light-Emitting Chemistry"
9:50 am - 10:00 am
Discussion
10:00 am - 10:30 am
Coffee Break
10:30 am - 10:50 am
"New Enzyme Chemistry to Decipher Post-Translational Modification Function"
10:50 am - 11:00 am
Discussion
11:00 am - 11:20 am
"Imaging and Engineering the Central Dogma"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"Engineering Synthetic Interfaces for Noninvasive Control and Monitoring of the Brain."
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Short Talk Selected from Poster Abstracts
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
7:30 pm - 7:50 pm
"Illuminating Acetyl-CoA in Live Cells"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:10 pm
"Subcellular Metaboproteomics Reveals MTCH2-Mediated Polyamine Import in Mitochondria"
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:25 pm
"Novel Approaches to Modulating Mitochondrial Metabolism"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"Biocatalysis and Complex Molecule Synthesis"
8:50 pm - 9:10 pm
Discussion
9:10 pm - 9:30 pm
General Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Translational Chemical Biology
9:00 am - 9:20 am
"The Exquisite Effects of Lipid Nanoparticle Chemistry on RNA Delivery and Organ Specificity"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Expanding the Alphabet and Topology of Synthetic mRNAs for Therapeutics"
9:50 am - 10:00 am
Discussion
10:00 am - 10:30 am
Coffee Break
10:30 am - 10:50 am
"Chemoproteomic Strategies for Studying (de)ISGylation Pathways"
10:50 am - 11:00 am
Discussion
11:00 am - 11:20 am
"Small Molecule Inhibitors of Aberrant Chromatin Association in AML"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"Targeting Histone Lysine Acetylation in Cancer"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"A Novel and High Throughput Chemoproteomic Platform to Identify Druggable Pockets and Chemical Probes for Classically Intractable Proteins"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Proximity-Induced Modalities
7:30 pm - 7:50 pm
"Rewriting Protein Modifications in Cells"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Reimagining Druggability Using Chemoproteomic Platforms"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 9:00 pm
"Modularity in Therapeutic Design"
9:00 pm - 9:10 pm
Discussion
9:10 pm - 9:30 pm
General Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure