Sunday, July 22
Evening | Catalysis in Macromolecular Assemblies |
Jack Kirsch, Chair
- Harry Noller (University of California, Santa Cruz)
"Structure and Function of Protein Polymerase: Clues to the Mechanism of Translation from the Structure of the Ribosome"
- Steve Benkovic (Penn. State Univeristy)
"DNA Replication by the T4 replisome"
Monday, July 23
Morning | Metalloproteins |
Joanne Stubbe, Chair
- Tom O'Halloran (Northwestern University)
"Mechanisms of Copper Enzyme Activation by Metallochaperone Proteins""
- Maria Vanoni (Universita' degli Studi dell' Insubria)
"Structure-function studies of glutamate synthase: a complex iron-sulfur flavoprotein."
- Marc Fontecave (CEA-Grenoble)
"The anaerobic ribonucleotide reductase: Mechanism of a primitive but complex protein radical generation reaction"
- Paul Ortiz de Montellano, (University of California, San Francisco)
"Heme Oxygenase: Refining our View of Hemoprotein Catalysis"
Monday, July 23
Evening | Enzyme Mechanisms I |
Karen Allen, Chair
- Steve Ealick (Cornell University)
"Structural and Mechanistic Insights into the
Ribokinase Superfamily of Small Molecule Kinases"
- Dick Wolfenden (Univ. of North Carolina)
"Plumbing the Depths of Chemical Time"
- Tom Leyh (Albert Einstein College of Medicine)
"Catalytic Strategies for the Activation of Sulfate"
Tuesday, July 24
Morning | Enzyme Mechanisms II |
Wallace Cleland, Chair
- Ron Breaker (Yale )
"Allosteric nucleic acid catalysts."
- Michael Gelb (Univ. of Washington)
"Piggy-Back Medicinal Enzymology for the Development of Agents Against Tropical Protozoan Diseases"
- Tom O'Brien (Sunesis Pharmaceuticals)
"Site-Directed Covalent Tethering Identifies Novel Enzyme Inhibitors"
- Kevin Felsenstein (Bristol-Myers-Squibb)
The Molecular Characterization of the "Gamma Secretase" Activity and the Development Alzheimer's Disease Therapeutics
Tuesday, July 24
Evening | Enzyme Dynamics |
Judith Klinman, Chair
- Tom Bruice (University of California, Santa Barbara)
"Comparison of ground state and transition state structures in enzyme catalysis"
- Sharon Hammes-Schiffer (Pennsylvania State University)
"Molecular dynamics studies of the relation between enzyme motion and activity"
- Bob Stroud (University of California, San Francisco)
"Mapping the reaction pathway through thymidylate synthase in four dimensions"
Wednesday, July 25
Morning | Coenzymes |
Paul Fitzpatrick, Chair
- Rowena Matthews (University of Michigan)
"Cobalamin-dependent methionine synthase: divide and conquer"
- Aziz Sancar (University of North Carolina)
"Photolyase/cryptochrome blue-light photoreceptors Use Light Energy to Repair DNA or Set the Circadian Clock"
- Martin Warren (Univ. London)
"Defining metal ion specificity in tetrapyrrole biosynthetic chelatases"
- Joan Broderick (MIchigan State)
"Pyruvate formate-lyase activating enzyme: a radical role for an iron-sulfur cluster"
- Joe Jarrett (U. Penn)
"Biotin synthase: a self-destructing single-turnover enzyme"
- Dexter Northrop (UW-Madison)
"Follow the protons: a low barrier hydrogen bond unifies the mechanisms of the aspartic proteases"
Wednesday, July 25
Evening | Signal Transduction |
Kenny Wong, Chair
- Natalie Ahn (University of Colorado, Boulder)
"Changes in protein dynamics following enzyme activation"
- Kevan Shokat (University of California, San Francisco)
"Unnatural ligands for engineered receptors: New tools for chemical genetics."
- Wonhwa Cho (University of Illinois, Chicago)
"Spatiotemporal Dynamics of Protein Kinase C Activation in the Living Cell"
Thursday, July 26
Morning | Proteomics/Emerging Techniques |
Greg Petsko, Chair
- Patsy Babbitt (UCSF, San Francisco)
"Understanding how nature re-engineers proteins"
- Andreas Plueckthun (University of Zurich)
"Ribosome Display: Protein evolution in a test tube"
- Sunney Xie (Harvard)
"Single Molecule Enzymology"
- Chris Whitman (Univ. of Texas, Austin)
"The Evolution of Enzymes for the Degradation of Aromatic Compounds"
Thursday, July 26
Evening | New Frontiers in Understanding Structure-Function |
Al Mildvan, Chair
- Barbara Imperiali (MIT)
"Peptidyl Motifs for Metal Ion Sensing"
- Chris Walsh (Harvard)
" Enzymatic Assembly Lines for Nonribosomal Peptide Antibiotics"
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