| SUNDAY |
| 2:00 pm - 9:00 pm | Arrival and check-in |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Big Pictures |
| Discussion Leader: Peter Tonge (SUNY Stony Brook) |
| 7:30 pm | Welcome |
| 7:45 pm - 8:30 pm | Mark Stitt (Max-Planck-Institut für Molekulare Pflanzenphysiologie)
"Coordinate regulation of metabolism and growth by sugars and nutrients" |
| 8:30 pm - 9:15 pm | Frank Raushel (Texas A&M)
"The amidohydrolase superfamily: mechanisms, evolution, and transformation" |
| MONDAY |
| 7:30 am - 8:30 am | Breakfast |
| 8:45 am - 9:00 am | Group photo |
| 9:00 am - 12:30 pm | Enzymes in Disease |
| Discussion Leader: Holly Ellis (Auburn University) |
| 9:00 am - 9:45 am | John Blanchard (Albert Einstein College of Medicine)
"Bacterial N-acetyltransferases: From Resistance to Regulation" |
| 9:45 am - 10:30 am | Giovanna Scapin (Merck & Co., Inc.)
"The structure-based design of selective phosphotyrosine phosphatase 1B inhibitors" |
| 10:30 am | Coffee Break |
| 11:00 am - 11:45 am | Mark Harpel (Bristol-Myers Squibb)
"Kinetic Coupling and Mechanism-Driven Inhibition of Bacterial Glu-tRNAGln Amidotransferase" |
| 11:45 am - 12:30 pm | Rick Silverman (Northwestern University)
"Cannibalistic enzymology. Mechanism of inactivation of nitric oxide synthase by amidines" |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Metabolic Pathways |
| Discussion Leader: Ken Gruys (Monsanto) |
| 7:30 pm - 8:10 pm | Greg Stephanopoulos (MIT)
"Analysis and quantification of bioreaction metabolic networks" |
| 8:10 pm - 8:50 pm | Byron Froman (Monsanto)
"Metabolic Engineering of Omega 3 Fatty Acids in Seed Oil" |
| 8:50 pm - 9:30 pm | Hans Westerhoff (Free University)
"System Biology: how mechanisms matter for cell function" |
| TUESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Enzyme Evolution |
| Discussion Leader: Amnon Kohen (University of Iowa) |
| 9:00 am - 9:45 am | Patsy Babbitt (University of California, San Francisco)
"Interplay of conserved functionality and emergent specificity in mechanistically diverse enzyme superfamilies" |
| 9:45 am - 10:30 am | L. Aravind (National Center for Biotechnology Information)
"Origins of catalytic activity: The major evolutionary trends in the
invention of enzymes" |
| 10:30 am | Coffee Break |
| 11:00 am - 11:45 am | Danny Tawfik (Wiezmann Institute)
"Conformational diversity, functional promiscuity and enzyme evolution" |
| 11:45 am - 12:30 pm | Karen Allen (Boston University School of Medicine)
"Mechanisms of Phosphoryl Transfer in the HAD Superfamily" |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Enzyme Structure and Mechanism |
| Discussion Leader: Grover Waldrop (Louisiana State University) |
| 7:30 pm - 8:15 pm | Richard Armstrong (Vanderbilt University)
"Interrogation of membrane protein structure and dynamics with amide H/D exchange mass spectrometry" |
| 8:15 pm - 8:35 pm | Poster talk: Doug Goodwin (Auburn University)
"Integral involvement of an "inactive" domain in catalase-peroxidase structure and catalysis" |
| 8:35 pm - 9:20 pm | Hong Zhang (University of Texas Southwestern Medical Center)
"Riboflavin kinase: a unique small metabolite kinase with a dynamic active site" |
| WEDNESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Primordial Catalysts and the Origin of Life |
| Discussion Leader: Susan Miller (University of California, San Francisco) |
| 9:00 am - 9:20 am | Poster talk: Bruce Palfey (University of Michigan Medical School)
"Mechanistic studies of a novel flavin-dependent thymidylate synthase" |
| 9:20 am - 9:40 am | Poster talk: Christopher Francklyn (University of Vermont)
"Crystal structure of the HisZ-HisG ATP-PRP phosphoribosyltransferase from Lactococcus lactis: an evolutionary link between amino acid biosynthesis and protein synthesis" |
| 9:40 am - 10:25 am | Steve Benner (University of Florida)
"Resurrecting ancient proteins: Joining chemistry, function and history" |
| 10:25 am | Coffee Break |
| 11:00 am - 11:45 am | Rachel Green (Johns Hopkins School of Medicine)
"Mechanistic dissection of the RNA-only active site of the ribosome" |
| 11:45 am - 12:30 pm | Faqing Huang (University of Southern Mississippi)
"Coenzyme Synthesis and Utilization by RNA and the Origin of Common Structure of Adenine-Containing Coenzymes" |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Moonlighting |
| Discussion Leader: Chris Whitman (University of Texas) |
| 7:30 pm - 8:15 pm | Donald Becker (University of Nebraska)
"Flavin Dependent Manipulation of PutA: A Transcriptional Repressor and Membrane-Bound Proline Dehydrogenase" |
| 8:15 pm - 8:35 pm | Poster talk: David Palmer (University of Saskatchewan)
"Moonlighting or Gaslighting? MosA, a type-I aldolase from Sinorhizobium meliloti L530, is reported to be a methyltransferase as well" |
| 8:35 pm - 9:20 pm | Hermann Schindelin (SUNY Stony Brook)
"Gephyrin - A bridge between molybdenum cofactor biosynthesis and neuroreceptor anchoring" |
| THURSDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Cofactors |
| Discussion Leader: Anne-Frances Miller (University of Kentucky) |
| 9:00 am - 9:45 am | Lance Seefeldt (Utah State University)
"Insights into the nitrogenase mechanism" |
| 9:45 am - 10:30 am | Lindsay Eltis (University of British Columbia)
"Similarities and differences in aromatic ring-cleavage dioxygenases" |
| 10:30 am | Coffee Break |
| 11:00 am - 11:45 am | Joe Jarrett (University of Pennsylvania)
"Generating and controlling radicals in an AdoMet radical enzyme: the
structure and a proposed mechanism for biotin synthase" |
| 11:45 am - 12:30 pm | Colin Thorpe (University of Delaware)
"A New Enzyme Family for Oxidative Protein Folding: from Viruses to Human Growth Factors" |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Frontiers in Enzymology |
| Discussion Leader: John Gerlt (University of Illinois) |
| 7:30 pm - 8:30 pm | Judith Klinman (University of California, Berkeley)
"Linking Protein Flexibility to Catalysis" |
| 8:30 pm - 9:30 pm | Greg Petsko (Brandeis University)
"The Enzymology of Parkinson's Disease" |
| FRIDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Departure |
