Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Regulation of Protein Function
7:40 pm - 8:10 pm
"Novel Post-Translational Modifications that Regulates Cell Signaling Proteins in Cancer"
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:45 pm
"Redox Regulation of Protein Arginine Methyltransferase 1 (PRMT1)"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Mechanistic Features of Enzyme Cofactors
9:00 am - 9:30 am
"Polysaccharide Monooxygenases: Structure and Function"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
"Unraveling the Mechanisms of Heme Transport and Insertion into Hemeproteins"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Group Photo / Coffee Break
10:50 am - 11:20 am
"Intramolecular Electron Transfer for Self-Preservation and Bifunctional Catalysis"
11:20 am - 11:30 am
Discussion
11:30 am - 12:00 pm
"Thiamin Diphosphate… Don't We Already Know Everything About That?"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
"Exploring a Proton Relay Mechanism in the Folate Half-Reaction of E. coli Methylenetetrahydrofolate Reductase"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Natural Product Biosynthesis
7:30 pm - 8:00 pm
"Biosynthesis of the Antibiotic Core of a Large Class of Protein Synthesis Inhibitors"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
"Engineering the Biosynthesis of Unnatural Polyketides and Isoprenoids"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
"Discovery and Characterization of Radical Enzymatic Transformations in Natural Product Biosynthetic Pathways"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
9:00 am - 9:30 am
"PROTAC-Mediated Protein Degradation: The Chemical Equivalent of RNAi"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
"Leveraging Biochemical Assays to Discover and Characterize Inhibitors of Nucleic Acid-Processing Enzymes"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:20 am
"Regulating Cullin Function by Controlling Neddylation Through Targeting DCN1"
11:20 am - 11:30 am
Discussion
11:30 am - 11:45 am
"Malonyl-Thioester Isosteres as Probes of Enzyme Structure-Function Relationships"
11:45 am - 11:50 am
Discussion
11:50 am - 12:05 pm
"Kinetic Mechanism of a New Multicopper Oxidase: The Bilirubin Oxidase from Bacillus pumilus "
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
"Molecular Mechanism of Protein Palmitoylation Catalyzed by the DHHC Family of Integral Membrane Enzymes"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
7:30 pm - 8:00 pm
"Structure-Based Prediction of Protein-Protein and Protein-Ligand Interactions on a Genomic Scale"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
"Computational Methods for Modeling Protein Active Site Chemistry: What Are the Key Challenges to Achieving Chemically Accurate Predictions, and How Can They Be Effectively Addressed?"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
"Native Proteomics: Wholistic Characterization of Endogenous Protein Complexes from Human Cells"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
9:00 am - 9:30 am
"Dynamic Regulation of Enzyme Action In Vitro and In Vivo "
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
"When Enzymology Meets Biophysics in a GT-B Glycosyltransferase"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:20 am
"Redox-Mediated Allosteric Regulation of Proline Utilization A"
11:20 am - 11:30 am
Discussion
11:30 am - 12:00 pm
"Inhibition of Mycobacterium tuberculosis Isocitrate Lyase Using Masked Electrophiles"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
"Structural and Functional Characterization of NicC, a Decarboxylative Hydroxylase"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
7:30 pm - 8:00 pm
"Profiling the Protein-Ligand Interaction Landscape by Chemical Proteomics to Guide Drug Discovery"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
"Discovery of Bruton's Tyrosine Kinase Inhibitors"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
"Discovery of Mechanistically Diverse Protein Kinase Inhibitors"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Metabolic Pathways and Metabolomics
9:00 am - 9:30 am
"From Bits to Molecules: Computational Design of Novel Enzymatic Pathways"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
"Investigating Protein Deubiquitination Using Activity-Based Probes"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:20 am
"Small Molecules from the Human Microbiota"
11:20 am - 11:30 am
Discussion
11:30 am - 11:45 am
"Probing the Metabolism and Cellular Roles of 2',3'-Cyclic Nucleotide Monophosphates"
11:45 am - 11:50 am
Discussion
11:50 am - 12:05 pm
"Structure and Regulation of E. coli Cyclopropane Fatty Acid Synthase"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
"Beta-Ketoacyl-ACP Substrate Mimics for 3-Oxoacyl-ACP Utilizing AHL Synthases"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 5:30 pm
Poster Session
5:30 pm - 7:30 pm
Structural Basis for Enzyme Mechanisms
5:30 pm - 6:20 pm
"Form Follows Function: Evolution of Protein Scaffolds for Phosphoryl Group Transfer"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 7:20 pm
"One Protein, Two Enzymes"
7:20 pm - 7:30 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure
