Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: Enzymes in Signaling Pathways
7:40 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:15 pm
"Illuminating the Biochemical Activity Architecture of the Cell"
8:15 pm - 8:20 pm
Discussion
8:20 pm - 8:50 pm
"The Many Guises of Reactive Metabolite Signaling"
8:50 pm - 8:55 pm
Discussion
8:55 pm - 9:25 pm
"AI for Understanding Enzyme Function and for Pedicting the Effects of Missense Mutations on Biochemical Activity"
9:25 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Unlocking New Potential in Natural Products
9:00 am - 9:30 am
"Exploring Reaction Diversity of Mononuclear Non-Heme Iron Enzymes and Beyond"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
"The Fascinating Enzymes of Riboflavin Biosynthesis"
10:10 am - 10:20 am
Discussion
10:20 am - 10:30 am
Short Talk Selected from Poster Abstracts
10:30 am - 10:35 am
Discussion
10:35 am - 11:05 am
Coffee Break
11:05 am - 11:35 am
"Exploring SAM-Consuming Enzymes: Methyltransferases and Radical SAM Enzymes"
11:35 am - 11:45 am
Discussion
11:45 am - 11:55 am
Short Talk Selected from Poster Abstracts
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Short Talk Selected from Poster Abstracts
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Short Talk Selected from Poster Abstracts
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hourâ„¢
The GRC Power Hourâ„¢ is designed to address the interests and needs of all scientists and the challenges they face in their careers. Specifically, the program promotes meaningful conversations amongst colleagues of all career stages about barriers to career advancement and strategies to support the professional growth of all members of the community. The GRC Power Hourâ„¢ is open to all conference participants.
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Decoding Post-Translational Modifications
7:30 pm - 8:00 pm
"Advancing Drug Discovery by Targeting Protein Tyrosine Dephosphorylation"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
"Enzymatic Swiss Army Knives for Peptide Backbone Modifications"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
"Paradoxes of Protein SUMOylation: A Role for Biomolecular Condensates?"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Dynamics and Kinetics: Bridging Time, Motion, and Function
9:00 am - 9:30 am
"Kinetics and Mechanism of Retrotransposon Replication of RNA Affording Efficient, Site-Specific Insertion of Large Genes"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
"Using Statistical Structural Biology to Understand Enzymes"
10:10 am - 10:20 am
Discussion
10:20 am - 10:30 am
Short Talk Selected from Poster Abstracts
10:30 am - 10:35 am
Discussion
10:35 am - 11:05 am
Coffee Break
11:05 am - 11:35 am
"Nature's Switches: Harnessing Environmental Signals to Control Enzymatic Activity"
11:35 am - 11:45 am
Discussion
11:45 am - 11:55 am
Short Talk Selected from Poster Abstracts
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Short Talk Selected from Poster Abstracts
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Short Talk Selected from Poster Abstracts
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Innovative Paths in Enzyme-Driven Catalysis
7:30 pm - 8:00 pm
"Remarkable New Enzymology Involved in the Biosynthesis of the Thiamin Pyrimidine"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
"Giant Marine Enzymes in Giant Toxin Assembly Line Biosynthesis"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
"Design Principles for Rieske Chemistry"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Unlocking Therapeutic Potential of Enzyme Inhibition in Drug Development
9:00 am - 9:30 am
"Allosteric Activation of Metabolic Pathways as a Novel Antibiotic Strategy"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
"Bullet Time: MAT Isoform Selectivity Through Allosteric Braking"
10:10 am - 10:15 am
Discussion
10:15 am - 10:40 am
Coffee Break
10:40 am - 11:10 am
"Discovery and Characterization of Cyclic GMP-AMP Synthase Inhibitors"
11:10 am - 11:20 am
Discussion
11:20 am - 11:50 am
"MOPEDâ„¢: A Novel Platform for the Discovery of Molecular Glues"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Short Talk Selected from Poster Abstracts
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Short Talk Selected from Poster Abstracts
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Code Meets Catalysis: Exploring Computational Enzymology
7:30 pm - 8:00 pm
"Protein Functional Motion Prediction Led by Long Timescale Molecular Dynamics"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
"Long-Range Radical Transport in Ribonucleotide Reductase"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
"AI Protein Profiling (AiPP) for Proteome-Wide Discovery of Druggable Pockets and Ligandable Cysteines"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Unlocking Data with Machine Learning in High-Throughput Assays
9:00 am - 9:30 am
"Learning the Protein Structure Distribution with Ambient Diffusion"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
"Leveraging Evolutionary-Scale Enzymology to Map and Predict Catalytic Landscapes"
10:10 am - 10:20 am
Discussion
10:20 am - 10:30 am
Short Talk Selected from Poster Abstracts
10:30 am - 10:35 am
Discussion
10:35 am - 11:05 am
Coffee Break
11:05 am - 11:35 am
"Programmable Modulators of Conformationally Diverse Target Substrates via Generative Language Models"
11:35 am - 11:45 am
Discussion
11:45 am - 11:55 am
Short Talk Selected from Poster Abstracts
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Short Talk Selected from Poster Abstracts
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Short Talk Selected from Poster Abstracts
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Keynote Session: Unusual Chemistry Carried Out by Enzymes
7:30 pm - 8:15 pm
"Mechanistic Studies of Unusual Biosynthetic Enzymes"
8:15 pm - 8:30 pm
Discussion
8:30 pm - 9:15 pm
9:15 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure