Sunday
2:00 pm - 8:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: The Complexities of Epigenetic Mechanisms
Discussion Leader: Len Pennacchio (Lawrence Berkeley National Laboratory, USA)
7:40 pm - 7:50 pm
Opening Remarks
7:50 pm - 8:30 pm
Chunaram Choudhary (University of Copenhagen, Denmark)
"Quantifying the Landscape and Dynamics of the Acetylome"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:20 pm
Kathrin Plath (University of California, Los Angeles, USA)
"A New Mode of Xist Action"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Contribution of the Epigenome to Cardiac Development and Regeneration
Discussion Leader: Enzo Porrello (Murdoch Children's Research Institute, Australia)
9:00 am - 9:20 am
Laurie Boyer (Massachusetts Institute of Technology, USA)
"Molecular Drivers of Cardiomyocyte Maturation"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
James Martin (Baylor College of Medicine, USA)
"Hippo Signaling in Epigenetic Regulation of Heart Development and Regeneration"
9:50 am - 10:00 am
Discussion
10:00 am - 10:30 am
Group Photo / Coffee Break
10:30 am - 10:40 am
Michel Puceat (INSERM U1251, Aix Marseille University, France)
"A Lamin A/C Mutation Responsible for a Cardiomyopathy Impairs Epigenetic Regulation of Heart Development: Rescue of the Mouse Phenotype by a Chromatin Modifier Inhibitor"
10:40 am - 10:45 am
Discussion
10:45 am - 10:55 am
Liming Pei (Children's Hospital of Philadelphia / University of Pennsylvania, USA)
"Single-Cell Genomics Analysis of Postnatal Heart Development and Disease"
10:55 am - 11:00 am
Discussion
11:00 am - 11:20 am
Swetansu Hota (Gladstone Institutes / University of California, San Francisco, USA)
"Epigenetic Regulation of Cardiomyocyte Differentiation"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
Yun Huang (Institute of Biosciences and Technology, Texas A&M University, USA)
"TET Inactivation Perturbs Long-Range Chromatin Interactions During Cardiac Development "
11:40 am - 11:45 am
Discussion
11:45 am - 12:05 pm
Gergana Dobreva (Medical Faculty Mannheim, Heidelberg University, Germany)
"Transcriptional and Epigenetic Networks in Cardiovascular Lineage Commitment and Differentiation"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address challenges women face in science and issues of diversity and inclusion. The program supports the professional growth of all members of our communities by providing an open forum for discussion and mentoring.
Organizer: Federica Accornero (Ohio State University, USA)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
RNA Methylation and Editing in Cardiovascular Disease
Discussion Leader: Ralf Gilsbach (University of Freiburg, Germany)
7:30 pm - 7:50 pm
Federica Accornero (Ohio State University, USA)
"RNA Methylation in the Regulation of Cardiac Hypertrophy"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Susmita Sahoo (Icahn School of Medicine at Mount Sinai, USA)
"FTO-Regulated Cardiac Epitranscriptome in Disease and Therapeutics"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:40 pm
Suresh Verma (The University of Alabama at Birmingham, USA)
"RNA Methylation in Endothelial Cell Biology and Function"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
Christina Pagiatakis (Humanitas Clinical and Research Institute, Italy)
"TAZ: A New Player in the Epigenetic Regulation of Cardiomyocyte Hypertrophy"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Konstantinos Stellos (Newcastle University, United Kingdom)
"RNA Modifications in Health and Disease"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Impact of Mitochondria, Fat and Sex on the Epigenome in the Heart
Discussion Leader: Elisabeth Zeisberg (University of Goettingen, Germany)
9:00 am - 9:20 am
Johannes Backs (University Hospital Heidelberg, Germany)
"Regulation of Histone Deacetylase 4 by Lipid Droplet Associated Signaling"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Assam El-Osta (Monash University, Australia)
"Sex Based RNA Methylation in the Heart"
9:50 am - 10:00 am
Discussion
10:00 am - 10:30 am
Coffee Break
10:30 am - 10:40 am
Jing Zhou (Peking University Health Science Center, China)
"Hypermethylation of Mitochondrial DNA in Vascular Smooth Muscle Cells Impairs Arterial Contraction"
10:40 am - 10:45 am
Discussion
10:45 am - 10:55 am
Victoria Mauz (Institute of Experimental Cardiology, University Hospital Heidelberg, Germany)
"Protein Arginine Methyltransferases Regulate Cardiac Function and Energy Metabolism"
10:55 am - 11:00 am
Discussion
11:00 am - 11:20 am
Maha Abdellatif (Rutgers New Jersey Medical School, USA)
"Recruitment of Metabolic Enzymes to Chromatin"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Saptarsi Haldar (Amgen, USA)
"Targeting Transcription in Heart Failure"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
John Elrod (Temple University, USA)
"Mitochondria, Metabolism and Epigenetics in Cellular Reprogramming"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
2:00 pm - 4:00 pm
Poster Session
4:00 pm - 6:00 pm
The Role of Epigenetics in the Pathogenesis of Vascular Disease
Discussion Leader: Hui-Yao Lan (Chinese University of Hong Kong, Hong Kong SAR China)
4:00 pm - 4:20 pm
Rajat Gupta (Brigham and Women's Hospital, USA)
"Uncovering New Mechanisms of Vascular Disease in the Non-Coding Genome"
4:20 pm - 4:30 pm
Discussion
4:30 pm - 4:50 pm
Kathy Lui (Chinese University of Hong Kong, Hong Kong SAR China)
"The Role of RNA Modification in Vascular Regeneration"
4:50 pm - 5:00 pm
Discussion
5:00 pm - 5:20 pm
Yu Huang (Chinese University of Hong Kong, Hong Kong SAR China)
"Mechanical Stress, Endothelial Inflammation and Atherogenesis"
5:20 pm - 5:30 pm
Discussion
5:30 pm - 5:50 pm
Ralf Brandes (Goethe University Frankfurt, Germany)
"Regulation of Angiogenesis by lncRNAs"
5:50 pm - 6:00 pm
Discussion
6:00 pm - 7:00 pm
Dinner
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Chromatin Remodeling and Architecture in Cardiovascular Disease
Discussion Leader: Danny Leung (Hong Kong University of Science and Technology, Hong Kong SAR China)
9:00 am - 9:20 am
Rajan Jain (University of Pennsylvania, USA)
"Understanding How Genome Organization Instructs Cardiac Development"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Sarah Franklin (University of Utah School of Medicine, USA)
"Regulation of Hypertrophic Growth by the Smyd Family of Histone Methyltransferases"
9:50 am - 10:00 am
Discussion
10:00 am - 10:30 am
Coffee Break
10:30 am - 10:40 am
Alessandro Bertero (University of Washington, USA)
"Chromatin Compartment Dynamics in a Halploinsufficient Model of Cardiac Laminopathy"
10:40 am - 10:45 am
Discussion
10:45 am - 10:55 am
Jessica Pfleger (Temple University, USA)
"Genomic Binding Patterns of Forkhead Box Protein O1 Reveal Its Unique Role in Cardiac Hypertrophy"
10:55 am - 11:00 am
Discussion
11:00 am - 11:20 am
Thomas Vondriska (University of California, Los Angeles, USA)
"Integrating Structure and Accessibility in Models of Cardiac Chromatin"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Li Wang (State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, China)
"Transcriptomic and Epigenetic Profiling Reveal a Ground State of Cardiomyocyte Crucial for Heart Maturation and Regeneration"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Ralf Gilsbach (University of Freiburg, Germany)
"Identification and Functional Epigenetic Modulation of Chromatin Interactions in Cardiac Myocytes"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Targeting Nucleosomes and Enhancer RNAs for Direct Fibroblast Reprogramming and Anti-Fibrotic Therapy
Discussion Leader: Silke Sperling (Charité - Universitätsmedizin Berlin, Germany)
7:30 pm - 7:50 pm
Li Qian (University of North Carolina at Chapel Hill, USA)
"Molecular Barriers to Direct Cardiac Reprogramming"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Kunhua Song (University of Colorado Anschutz Medical Campus, USA)
"Epigenetic Regulation of Cardiac Gene Reprogramming in Response to Cell Signaling"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:40 pm
Michael Alexanian (Gladstone Institutes / University of California, San Francisco, USA)
"Targeting Enhancer-Signaling in Cardiac Fibrosis and Heart Failure Pathogenesis"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
Zongna Ren (State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, China)
"The Molecular Mechanisms Underlying the Development and Progression of Cardiac Remodeling"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Thierry Pedrazzini (University of Lausanne Medical School, Switzerland)
"Therapy for Heart Disease via Targeting Enhancer-Associated Long Noncoding RNAs"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Transcriptional Control of Cardiovascular Disease
Discussion Leader: Donald Menick (Medical University of South Carolina, USA)
9:00 am - 9:20 am
Gianluigi Condorelli (Humanitas University, Italy)
"New Cardiac Specific Non-Coding RNAs Regulating Cardiac Transcription Factors and Epigenetics"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Lutz Hein (University of Freiburg, Germany)
"Dynamics of the Epigenome in Cardiac Remodeling"
9:50 am - 10:00 am
Discussion
10:00 am - 10:10 am
Michelle Dubinsky (University of Toronto, Canada)
"In Vivo Function of Flow-Responsive cis-DNA Elements in the Endothelial Nitric Oxide Synthase Gene: A Role for Chromatin-Based Mechanisms"
10:10 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 11:05 am
Issei Komuro (Graduate School of Medicine, University of Tokyo, Japan)
"Molecular Mechanisms of Heart Failure Dissected by Single Cell RNA Seq Analysis"
11:05 am - 11:15 am
Discussion
11:15 am - 11:25 am
Zhong Wang (University of Michigan, USA)
"Acetyl-CoA Production by Specific Metabolites Promotes Heart Repair After Myocardial Infarction via Mediating Histone Acetylation"
11:25 am - 11:30 am
Discussion
11:30 am - 11:40 am
Chukwuemeka Anene-Nzelu (Genome Institute of Singapore, A*STAR / Cardiovascular Research Institute, NUS, Singapore)
"Using Epigenetics to Identify Genetic Determinants of Heart Failure"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
Katharina Schlereth (German Cancer Research Center / European Center for Angioscience, Heidelberg University , Germany)
"Dnmt3a: An Epigenetic Regulator During Postnatal Angiogenesis"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
Rui-Ping Xiao (Peking University, China)
"Glucose-Sensitive Cadiokine/Myokine MG53 Impairs Multiorgan Insulin Response"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Epigenetic Therapies for Cardiovascular Disease
Discussion Leader: Llewelyn Roderick (KU Leuven, Belgium)
4:00 pm - 4:20 pm
Joseph Hill (University of Texas Southwestern Medical Center, USA)
"Reversible Protein Acetylation and Disease-Related Myocardial Remodeling "
4:20 pm - 4:30 pm
Discussion
4:30 pm - 4:40 pm
Vasanth Vedantham (University of California, San Francisco, USA)
"Epigenetic Profiling of Cardiac Pacemaker Cells: Insights into the Origin and Regulation of Heart Rhythm"
4:40 pm - 4:45 pm
Discussion
4:45 pm - 5:05 pm
Zhi-Ping Liu (University of Texas Southwestern Medical Center, USA)
"Targeting Jumonji C Histone Lysine Demethylases in Pathological Cardiac Remodeling"
5:05 pm - 5:15 pm
Discussion
5:15 pm - 5:25 pm
Seitaro Nomura (University of Tokyo, Japan)
"Multiomics Dissection of Heart Failure for the Development of Cardiovascular Precision Medicine"
5:25 pm - 5:30 pm
Discussion
5:30 pm - 5:50 pm
Norman C.W. Wong (University of Calgary / Resverlogix, Canada)
"Epigenetic Modifying Therapy for Cardiovascular Disease that Targets BET Proteins"
5:50 pm - 6:00 pm
Discussion
6:00 pm - 7:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure
