Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: Principles of Immunometabolism
Discussion Leader: Julian Lum (BC Cancer, Canada)
7:40 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:10 pm
Erika Pearce (Johns Hopkins University, United States)
"Delineating the Metabolic Signals That Direct Immune Cell Differentiation and Function"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:45 pm
Navdeep Chandel (Northwestern University, United States)
"Mitochondria as Signaling Organelles Control Immunity"
8:45 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
Marcia Haigis (Harvard Medical School, United States)
"Role of Metabolites in Cancer and Aging"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
T Cell Activation and Differentation
Discussion Leader: Will Bailis (Children's Hospital of Philadelphia, United States)
9:00 am - 9:20 am
Christoph Hess (University of Basel / University of Cambridge, Switzerland)
"Human T Cell Metabolism: An Integrated Perspective"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Dawn Newcomb (Vanderbilt University Medical Center, United States)
"Sex Differences in CD4 T Cell Metabolism"
9:50 am - 10:00 am
Discussion
10:00 am - 10:15 am
Nikita Mani (Northwestern University Feinberg School of Medicine, United States)
"Acidity Induces Durable Enhancement of Treg Cell Suppressive Functions for Tumor Immune Evasion"
10:15 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:10 am
Dirk Brenner (Luxembourg Institute of Health, Luxembourg)
"Crossroads: Exploring the Interplay Between Metabolism and Immune Cell Function"
11:10 am - 11:20 am
Discussion
11:20 am - 11:40 am
Douglas Green (St. Jude Children's Research Hospital, United States)
"Perchance to Dream: Sleep and Inflammation"
11:40 am - 11:50 am
Discussion
11:50 am - 12:05 pm
Huidong Shi (Augusta University, United States)
"Enhanced Stat5 Activation Reprograms Metabolism in CD4 T Cells to Improve Antitumor Immunity"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
Tiffany Merlinsky (Memorial Sloan Kettering Cancer Center, United States)
"Investigating the Redox-Sensitive E3 Ubiquitin Ligase Pellino-1 as a Driver of T-Cell Dysfunction During Severe Lung Infection"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hourâ„¢
The GRC Power Hourâ„¢ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizers: Chrystal Paulos (Emory University, United States) and Sabrina Robichaud (Immunology Center of Georgia, United States)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Inflammation and Autoimmunity
Discussion Leader: Marco Orecchioni (Augusta University, United States)
7:30 pm - 7:50 pm
Claudia Kemper (National Institutes of Health, United States)
"The Complosome in Basic Cell Physiology"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Hongbo Chi (St. Jude Children’s Research Hospital, United States)
"Functional Genomics and Systems Immunology in Mapping the Metabolic Basis of Adaptive Immunity"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Yajaira Suarez (Yale University School of Medicine, United States)
"CholeSTEROL Homeostasis in Macrophage Immune Responses"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Chaoran Li (Emory University, United States)
"Metabolic Regulation of VAT Tregs at Homeostasis and During Obesity"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Metabolic Control of Innate Immunity
Discussion Leader: Denis Mogilenko (Vanderbilt University Medical Center, United States)
9:00 am - 9:20 am
Edward Pearce (Johns Hopkins University, United States)
"Metabolic Control of Innate Immune Cell Function and Fate"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
C. Henrique Serezani (Vanderbilt University Medical Center, United States)
"Linking Metabolic Memory, Inflammation and Susceptibility to Infections During Hyperglycemia"
9:50 am - 10:00 am
Discussion
10:00 am - 10:15 am
Stefanie K Wculek (Institute for Research in Biomedicine, Spain)
"Mitochondrial Metabolism Regulates the Immunogenic Responsiveness of Dendritic Cells"
10:15 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:10 am
Luke O'Neill (Trinity College Dublin, Ireland)
"A Break in Mitochondrial Endosymbiosis as a Basis for Inflammatory Diseases"
11:10 am - 11:20 am
Discussion
11:20 am - 11:40 am
Elina Zúñiga (University of California San Diego, United States)
"Plasmacytoid Dendritic Cell Exhaustion"
11:40 am - 11:50 am
Discussion
11:50 am - 12:05 pm
Alison Ringel (Massachusetts Institute of Technology / Ragon Institute, United States)
"T Cells and Immunotherapy in Aging"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
Andrew Monteith (University of Tennessee-Knoxville, United States)
"Mitochondria Sense Bacterial Lactate in the Phagosome and Drive Release of Neutrophil Extracellular Traps"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Microbiome Influence on Metabolism and Immunity
Discussion Leader: Margaret Alexander (University of Wisconsin, Madison, United States)
7:30 pm - 7:50 pm
Sunny Shin (University of Pennsylvania Perelman School of Medicine, United States)
"Inflammasome-Mediated Crosstalk Between Immune and Non-Immune Cells in Anti-Bacterial Defense"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Mariana Byndloss (Vanderbilt University Medical Center, United States)
"Disruption of Microbiota and Intestinal Epithelium Metabolic Interactions as A Key Driver of Childhood Obesity"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Aleksandar Kostic (Harvard Medical School, United States)
"Adenosine as a Universal Language: Gut Symbiont-Derived Extracellular Vesicles Drive Tolerogenic Reprogramming of the Intestines and Beyond"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Irene Bertolini (The Wistar Institute, United States)
"Microglia Derived Extracellular Vesicles induce the Infiltration of Myeloid Cells in Glioblastoma"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Obesity, Diabetes and Cardiovascular Disease
Discussion Leader: Mona Mashayekhi (Vanderbilt University Medical Center, United States)
9:00 am - 9:20 am
Ada Weinstock (University of Chicago Pritzker school of Medicine, United States)
"The Effects of Weight Loss and Regain on Local and Systemic Immune Responses"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Dequina Nicholas (University of California Irvine, United States)
"Why Recognize Protein When Fats Taste So Good? The Role of Lipids in Type 2 Diabetes Associated Inflammation"
9:50 am - 10:00 am
Discussion
10:00 am - 10:15 am
David Ngai (Columbia University Medical Center, United States)
"Efferocytosis-Induced Transinflammatory Signaling is Necessary for Tissue Repair"
10:15 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:10 am
Barbara Nikolajczyk (University of Kentucky, United States)
"Obesity Impacts T Cell Metabolism to Alter Human Inflammaging"
11:10 am - 11:20 am
Discussion
11:20 am - 11:40 am
Ekaterina Koltsova (Cedars-Sinai Medical Center, United States)
"Cytokines as Regulators of Microbiota and Metabolism in Atherosclerosis"
11:40 am - 11:50 am
Discussion
11:50 am - 12:05 pm
Julia Chini (University of Pennsylvania, United States)
"Liver-Derived CD9 Regulates Adipose Tissue Inflammation and Metabolic Dysfunction During Obesity"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
Daniel Ferguson (Washington University in St Louis, United States)
"Loss of Macrophage Mitochondrial Pyruvate Carrier in Metabolic Disease"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Obesity and Aging in Cancer
Discussion Leader: Caroline Bartman (University of Pennsylvania, United States)
7:30 pm - 7:50 pm
Alison Ringel (Massachusetts Institute of Technology / Ragon Institute, United States)
"Uncovering Age-Related Barriers to T Cell Immunity in Cancer"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Lydia Lynch (Harvard Medical School, United States)
"Lipid Homeostasis Regulates Anti-Tumor Immunity"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Liza Makowski (University of Tennessee Health Science Center, United States)
"Obesity, Bariatric Surgery, Microbial Derived Metabolites and Immunotherapy in Breast Cancer"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Evanna Mills (Dana-Farber Cancer Institute / Harvard Medical School, United States)
"Macrophage-Derived Itaconate is a Negative Regulator of Adaptive Thermogenesis"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Immunity in the Tumor Microenvironment
Discussion Leader: Santosha Vardhana (Memorial Sloan Kettering Cancer Center, United States)
9:00 am - 9:20 am
Chrystal Paulos (Emory University, United States)
"Augment T Cell Metabolism to Improve Adoptive Immunotherapy for Cancer"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Greg Delgoffe (University of Pittsburgh, United States)
"Postprandial Metabolic Changes Durably Affect Immune Responses to Infections and Cancer"
9:50 am - 10:00 am
Discussion
10:00 am - 10:15 am
Marah Runtsch (Medical University of Graz, Austria)
"The Tumor Microenvironment Drives Mitochondrial Metabolic Reprogramming in Neutrophils During Non-Small Cell Lung Cancer"
10:15 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:10 am
Russell Jones (Van Andel Institute, United States)
"Dietary Modulation of Anti-Tumor Immunity"
11:10 am - 11:20 am
Discussion
11:20 am - 11:40 am
Sonia Sharma (La Jolla Institute for Immunology, United States)
"Bio-Active Lipid Metabolites Regulate Response to Immune Checkpoint Blockade Therapy"
11:40 am - 11:50 am
Discussion
11:50 am - 12:05 pm
Tanmoy Saha (Harvard Medical School, United States)
"Mitochondrial Hijack by Cancer Cells Controls Immunometabolism"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
Kristine Bertheussen (Leiden University, The Netherlands)
"Studying Nutrient Uptake at the Single-Cell Level"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Translating Immunometabolism
Discussion Leader: Laurence Morel (University of Texas Health San Antonio, United States)
7:30 pm - 7:50 pm
Jonathan Powell (Calico, United States)
"Targeting Metabolism to Enhance Immunotherapy for Cancer"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Iain Kilty (Sitryx Therapeutics, United Kingdom)
"Targeting Immunometabolism in Chronic Inflammatory Diseases"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Frank Dorsey (Eli Lilly and Company, United States)
"Immunometabolites are Checkpoints that Regulate Immunity"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Tao Liang (University of Chinese Academy of Sciences, China)
"The Humoral-Immunomodulatory Function of Cholesterol-Uptaking Path"
9:20 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure