Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Visualizing Filament Organization and Dynamics at the Nanoscale
7:40 pm - 7:50 pm
Opening Remarks
7:50 pm - 8:00 pm
Introduction by Discussion Leader
8:00 pm - 8:30 pm
"The Structure of Vimentin Filament Using In Situ, Ghost Cells and In Vitro Analysis"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:10 pm
"Vimentin Cytoskeletal Dynamics and its Role ER Organization"
9:10 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Functional Insights into the Structure and Biophysics of Intermediate Filaments
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
"Intermediate Filament Mechanics – From Single Filaments to Networks (in cells)"
9:25 am - 9:35 am
Discussion
9:35 am - 9:55 am
"Measurement of Mechanical Strain on Lamin A/C and Vimentin Intermediate Filaments using FRET-force Biosensors"
9:55 am - 10:05 am
Discussion
10:05 am - 10:15 am
"Dissecting the Lateral and Longitudinal Assembly Kinetics of Vimentin with a Dual Wavelength Stopped-flow Approach"
10:15 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:10 am
"Self-Association of IF Head Domains as a Paradigm for Understanding the Relevance of Phase Separation to Cell Biology"
11:10 am - 11:20 am
Discussion
11:20 am - 11:30 am
"A General Mathematical Model for the in vitro Assembly Dynamics of Cytoplasmic IF Proteins"
11:30 am - 11:35 am
Discussion
11:35 am - 11:45 am
"Expression of Vimentin Alters Cell Mechanics, Cell-cell Adhesion, and Gene Expression Profiles Suggesting the Induction of a Hybrid EMT in Human Mammary Epithelial Cells"
11:45 am - 11:50 am
Discussion
11:50 am - 12:05 pm
"Quantitative Image-Based Drug Screen for Neurofilament Accumulation in Giant Axonal Neuropathy (GAN) Induced Pluripotent Stem Cell-Derived Motor Neurons (iPSC-MNs)"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Signaling and Cytoskeletal Crosstalk by Intermediate Filaments
7:30 pm - 7:50 pm
"Probing the Functional Link Between Shifts in Keratin Composition and Cell Mechanics During Epidermal Remodeling"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Intermediate Filaments as Integrator of Cytoskeletal Mechanics"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"SUMOylation of Intermediate Filaments and Cell Motility"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"Vimentin at the Crossroads of Signaling, Metabolism, and Migration"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Connecting the Nucleus, Cytoskeleton and Extracellular Environment
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
"Nesprins and Lamins LINC the Nucleus and Aging"
9:30 am - 9:40 am
Discussion
9:40 am - 10:00 am
"New Insights Into the Force Transmission Across the Nuclear Envelope"
10:00 am - 10:10 am
Discussion
10:10 am - 10:20 am
"Loss of SUN2 is Protective Against Injury-induced Lung Fibrosis"
10:20 am - 10:25 am
Discussion
10:25 am - 10:55 am
Coffee Break
10:55 am - 11:15 am
"The Desmosome as Cellular Integrator and Sensor"
11:15 am - 11:25 am
Discussion
11:25 am - 11:35 am
"Don’t Go Breaking My Heart – How LMNA Mutations Cause Heart Disease"
11:35 am - 11:40 am
Discussion
11:40 am - 11:50 am
"The Laminin-keratin Link Shields the Nucleus from Mechanical Deformation and Signalling"
11:50 am - 11:55 am
Discussion
11:55 am - 12:05 pm
"Vimentin Intermediate Filaments Integrate Actomyosin Contractility with Microtubule Stiffness in Cellular Response to Substrate Mechanics"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Integration of Muscle Mechanobiology by Intermediate Filaments in Health and Disease
7:30 pm - 7:50 pm
"Desmin Intermediate Filament Depolymerization is Required for Myosin and Actin Loss and Muscle Wasting"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Lamin-associated Skeletal Muscle Disease: From Microtubules to Modifier Genes"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:40 pm
"Dynamic Nuclear-sarcomeric Coupling in the Adult Cardiac Muscle"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
"Genetic Evidence for the LINC Complex as a Safe Therapeutic Target in Laminopathies"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"Sustaining Power: Building Energy Networks in Striated Muscle Cells"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Linking Intermediate Filaments to Neurodegenerative Diseases
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
"Neurofilament Dynamics in Health and Disease"
9:25 am - 9:35 am
Discussion
9:35 am - 9:55 am
"Reconstituted Neurofilament brushes: Insights into Disorder and Mechanobiology"
9:55 am - 10:05 am
Discussion
10:05 am - 10:15 am
"Advanced Brain Organoid Modeling of Mutant GFAP"
10:15 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:10 am
"Connecting IFs and Amyotrophic Lateral Sclerosis"
11:10 am - 11:20 am
Discussion
11:20 am - 11:40 am
"Astrocyte Intermediate Filaments and the Two-Edged Sword of Reactive Gliosis in Stroke"
11:40 am - 11:50 am
Discussion
11:50 am - 12:05 pm
"A novel upstream genomic element regulates tissue specificity of Lamin B1 overexpression in Autosomal Dominant Leukodystrophy"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Progenitors, Senescence and Cancer
7:30 pm - 7:50 pm
"Keratin-Dependent Regulation of Innate Immunity in Skin"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:10 pm
"Linking Genomic Instability, Sterile Inflammation, and Metabolic Problems in Laminopathies"
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:35 pm
"Skin Progenitor Cell Therapies – Personalized Medicine at its Most Potent"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
"Metastasising Fibroblasts Show an HDAC6-Dependent Increase in Migration Speed and Loss of Directionality Linked to Major Changes of the Vimentin Interactome"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:15 pm
"Distinct Roles for A-type Lamins in Genome Organization"
9:15 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pm
Mechanistic Insights into Intermediate Filament Diseases
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
"The Interaction Between Vimentin, Ferroptosis and Lipid Metabolism in Lung Cancer"
9:25 am - 9:35 am
Discussion
9:35 am - 9:45 am
"Colonic Epithelial Keratin 7 Expression Increases De Novo in a Subset of Inflammatory Bowel Disease"
9:45 am - 9:50 am
Discussion
9:50 am - 10:05 am
"Interactions of STIM1 and Desmin Define Novel Domains in Skeletal Muscle"
10:05 am - 10:10 am
Discussion
10:10 am - 10:40 am
Coffee Break
10:40 am - 11:00 am
"Redox Tuning of IF Function Through Posttranslational Modifications"
11:00 am - 11:10 am
Discussion
11:10 am - 11:20 am
"GFAP Interacts With and Regulates Vesicular Trafficking and Secretion in Human Astrocytes"
11:20 am - 11:25 am
Discussion
11:25 am - 11:35 am
"Vimentin Protein Contributes to Quiescent Neural Stem Cell Exit Through Proteasome Relocalization to the Aggresome and Protein Clearance"
11:35 am - 11:40 am
Discussion
11:40 am - 11:55 am
"Interplay of Stress Responses Underlying the Development of LMNA Cardiomyopathy"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
General Discussion
12:10 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Emerging Therapeutic Approaches for Intermediate Filament-Based Diseases
7:30 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:05 pm
"LINC Complex Disruption as a Therapeutic Target for Laminopathies"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:35 pm
"Modulating Cytoskeleton Dynamics to Treat Cardiomyopathy Caused by LMNA Mutations"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
"Extracellular Vimentin as a Target Against SARS-CoV-2 Host Cell Invasion"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
General Discussion
9:20 pm - 9:30 pm
Closing Remarks
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure