| SUNDAY |
| 2:00 pm - 11:00 pm | Arrival and Check-in |
| 6:00 pm | Dinner |
| 7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
| 7:40 pm - 9:30 pm | KEYNOTE LECTURE |
| 7:40 pm - 8:50 pm | Yixian Zheng (Carnegie Institute, Baltimore, MD)
"Mitotic spindle morphogenesis, beyond the microtubule cytoskeleton" |
| 8:50 pm - 9:00 pm | Discussion |
| 9:00 pm - | Opening Reception in Ware Campus Center |
| MONDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | SPINDLE ASSEMBLY |
| Discussion Leader: Alexey Khodjakov (Wadsworth Center, Albany, NY) |
| 9:00 am - 9:20 am | Alexey Khodjakov (Wadsworth Center, Albany, NY)
"Spindle assembly: A tale of two pathways" |
| 9:20 am - 9:30 am | Discussion |
| 9:30 am - 9:50 am | Isabelle Vernos (CRG) |
| 9:50 am - 10:00 am | Discussion |
| 10:00 am - 10:20 am | Gohta Goshima (Nagoya University, Nagoya, Japan)
"Mechanisms of Microtubule Generation during Mitotic Spindle Assembly" |
| 10:20 am - 10:30 am | Discussion |
| 10:30 am | Coffee Break / Group Photo |
| 11:00 am - 11:20 am | Melissa Gardner (University of Minnesota, Minneapolis, MN)
"Kinesin-5 motors promote length-dependent microtubule disassembly to mediate chromosome congression in budding yeast" |
| 11:20 am - 11:30 am | Discussion |
| 11:30 am - 11:40 am | Eric Griffis (UCSF, San Francisco, CA)
"Spindly, a novel protein essential for silencing the spindle assembly checkpoint, recruits dynein to the kinetochore" |
| 11:40 am - 11:45 am | Discussion |
| 11:45 am - 11:55 am | Mohan Gupta (Dana Farber, Cambridge, MA)
"A kinesin with dual motoring and depolymerizing activities controls microtubule dynamics during spindle positioning in budding yeast" |
| 11:55 am - 12:00 pm | Discussion |
| 12:00 pm - 12:10 pm | Ted Hinchcliffe (University of Notre Dame, South Bend, IN)
"The role of the centrosome in re-modelling a single interphase microtubule array into a bipolar mitotic spindle" |
| 12:10 pm - 12:15 pm | Discussion |
| 12:15 pm - 12:25 pm | Marcel Janson (Vrije University, Amsterdam, The Netherlands)
"Microtubule-driven multimerization recruits the cross-linker Ase1 towards microtubule overlap zones" |
| 12:25 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session I |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | CYTOKINESIS |
| Discussion Leader: Karen Oegema (UCSD, San Diego, CA) |
| 7:30 pm - 7:50 pm | Karen Oegema (UCSD, San Diego, CA)
"Distinct Signaling Mechanisms Drive Early and Late Steps in Furrow Formation and Ingression" |
| 7:50 pm - 8:00 pm | Discussion |
| 8:00 pm - 8:20 pm | Tom Pollard (Yale University, New Haven, CT)
"Assembly of the contractile ring in fission yeast" |
| 8:20 pm - 8:30 pm | Discussion |
| 8:30 pm - 8:50 pm | Doug Robinson (Johns Hopkins, Baltimore, MD)
"Dynamic cortical rearrangements and mechanosensing of dividing cells" |
| 8:50 pm - 9:00 pm | Discussion |
| 9:00 pm - 9:10 pm | Gilles Hickson (UCSF, San Francisco, CA)
"Anillin in the spatial control of cytokinesis" |
| 9:10 pm - 9:15 pm | Discussion |
| 9:15 pm - 9:25 pm | Fred Chang (Columbia University, New York, NY)
"Driving cytokinesis in interphase cells" |
| 9:25 pm - 9:30 pm | Discussion |
| TUESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | MOLECULAR MECHANISMS OF MOTOR PROTEINS |
| Discussion Leader: Susan Gilbert (University of Pittsburgh, Pittsburgh, PA) |
| 9:00 am - 9:20 am | Susan Gilbert (University of Pittsburgh, Pittsburgh, PA)
"A Tale of Two Kinesin-14 Motors" |
| 9:20 am - 9:30 am | Discussion |
| 9:30 am - 9:50 am | Enrique De La Cruz (Yale University, New Haven, CT)
"Mechanisms of myosin motors: It's all in the timing" |
| 9:50 am - 10:00 am | Discussion |
| 10:00 am - 10:20 am | David Warshaw (University of Vermont, Burlington, VT)
"In vitro molecular motor/cytoskeletal interactions: new entries to the intracellular toolbox" |
| 10:20 am - 10:30 am | Discussion |
| 10:30 am | Coffee Break |
| 11:00 am - 11:20 am | Jennifer Ross (University of Massachusetts, Amherst, MA)
"The Physics of Dynein/Dynactin: Flexible Form and Flexible Function" |
| 11:20 am - 11:30 am | Discussion |
| 11:30 am - 11:40 am | Sarah Woolner (University of Wisconsin, Madison, WI)
"Myosin-10 functions to anchor the mitotic spindle and maintain spindle integrity" |
| 11:40 am - 11:45 am | Discussion |
| 11:45 am - 11:55 am | Sarah Rice (Northwestern University, Chicago, IL)
"Mechanism of Kinesin-1 regulation by the tail domain: is the tail a GDI analog?" |
| 11:55 am - 12:00 pm | Discussion |
| 12:00 pm - 12:10 pm | Gary Brouhard (Max Planck Institute, Dresden, Germany)
"Single-molecule studies of the microtubule depolymerase MCAK and the microtubule polymerase XMAP215" |
| 12:10 pm - 12:15 pm | Discussion |
| 12:15 pm - 12:25 pm | Stephen J. King (University of Missouri, Columbia, MO)
"The role of the acidic tail of tubulin in dynein and dynactin interactions with microtubules" |
| 12:25 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session II |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | INTRACELLULAR TRANSPORT |
| Discussion Leader: Kristen Verhey (University of Michigan, Ann Arbor, MI) |
| 7:30 pm - 7:50 pm | Kristen Verhey (University of Michigan, Ann Arbor, MI)
"Regulation of Kinesin-1 Trafficking" |
| 7:50 pm - 8:00 pm | Discussion |
| 8:00 pm - 8:20 pm | Vladimir Gelfand (Northwestern University, Chicago, IL)
"Organelle transport in vivo: Moving on moving tracks" |
| 8:20 pm - 8:30 pm | Discussion |
| 8:30 pm - 8:50 pm | Omar Quintero (Mount Holyoke College, Hadley, MA)
"Myosin 19: A novel unconventional myosin involved in mitochondrial movement" |
| 8:50 pm - 9:00 pm | Discussion |
| 9:00 pm - 9:10 pm | Anna S. Akhmanova (Erasmus MC, Rotterdam, The Netherlands)
"Rab6, Bicaudal D and kinesin-1 regulate motility and targeting of exocytotic carriers" |
| 9:10 pm - 9:15 pm | Discussion |
| 9:15 pm - 9:25 pm | Paul Miller (Vanderbilt University, Nashville, TN)
"Role of CLASPs in Golgi Organization and Trafficking in Relation to Cell Motility" |
| 9:25 pm - 9:30 pm | Discussion |
| WEDNESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | CELL POLARITY AND SIGNALLING |
| Discussion Leader: Tony Bretscher (Cornell University, Ithaca, NY) |
| 9:00 am - 9:20 am | Tony Bretscher (Cornell University, Ithaca, NY)
"Regulation of the cell cortex by ERM proteins and their friends" |
| 9:20 am - 9:30 am | Discussion |
| 9:30 am - 9:50 am | W. James Nelson (Stanford University, Stanford, CA)
"Regulation of Post-Golgi Vesicle Trafficking by Septins, Microtubules and MAP4 in Polarized Epithelial Cells" |
| 9:50 am - 10:00 am | Discussion |
| 10:00 am - 10:20 am | Rong Li (Stowers Institute for Medical Research, Kansas City, MO)
"Quantitaitve analysis of dynamic modular organization of the polar cortical domain in budding yeast" |
| 10:20 am - 10:30 am | Discussion |
| 10:30 am | Coffee Break |
| 11:00 am - 11:20 am | Wallace Marshall (UCSF, San Francisco, CA)
"Cell Geometry: controlling orientation and position of cilia" |
| 11:20 am - 11:30 am | Discussion |
| 11:30 am - 11:40 am | Phong Tran (University of Pennsylvania, Philadelphia, PA)
"Cytoskeletal reorganization and new cell tip formation in shape-manipulated fission yeast" |
| 11:40 am - 11:45 am | Discussion |
| 11:45 am - 11:55 am | Anthony Koleske (Yale University, Yale, CT)
"Arg controls cell migration by inhibiting actomyosin contractility and regulating focal adhesion dynamics" |
| 11:55 am - 12:00 pm | Discussion |
| 12:00 pm - 12:10 pm | Alpha Yap (University of Queensland, Brisbane, Australia)
"Cadherins, Myosin VI and epithelial junctions" |
| 12:10 pm - 12:15 pm | Discussion |
| 12:15 pm - 12:25 pm | Dianne Cox (Albert Einstein College of Medicine, Bronx, NY)
"WASP activation in macrophages" |
| 12:25 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session III |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | MOVEMENT IN A THREE-DIMENSIONAL ENVIRONMENT |
| Discussion Leader: Denise Montell (Johns Hopkins University, Baltimore, MD) |
| 7:30 pm - 7:50 pm | Denise Montell (Johns Hopkins University, Baltimore, MD)
"Insights into the regulation of cell migration in vivo from genetics and live cell imaging" |
| 7:50 pm - 8:00 pm | Discussion |
| 8:00 pm - 8:20 pm | John Condeelis (Albert Einstein School of Medicine, Bronx, NY)
"Molecular mechanisms of chemotaxis in metastasis" |
| 8:20 pm - 8:30 pm | Discussion |
| 8:30 pm - 8:50 pm | Alissa Weaver (Vanderbilt University, Nashville, TN)
"Regulation of epithelial phenotype by Arp2/3 regulators" |
| 8:50 pm - 9:00 pm | Discussion |
| 9:00 pm - 9:10 pm | Robert S. Fischer (The Scripps Research Institute, La Jolla, CA)
"Branching morphogenesis of endothelial cells is regulated by myosin contractility" |
| 9:10 pm - 9:15 pm | Discussion |
| 9:15 pm - 9:25 pm | Jody Rosenblatt (University of Utah, Salt Lake City, UT)
"Directionality of apoptotic cell extrusion: the microtubule link" |
| 9:25 pm - 9:30 pm | Discussion |
| THURSDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | CYTOSKELETAL POLYMER DYNAMICS |
| Discussion Leader: Dyche Mullins (UCSF, San Francisco, CA) |
| 9:00 am - 9:20 am | Dyche Mullins (UCSF, San Francisco, CA)
"Capping protein controls the rate of actin nucleation by the Arp2/3 complex" |
| 9:20 am - 9:30 am | Discussion |
| 9:30 am - 9:50 am | Cécile Sykes (Curie Institute, Paris, France)
"Building cell movement step by step" |
| 9:50 am - 10:00 am | Discussion |
| 10:00 am - 10:20 am | Alan Hunt (University of Michigan, Ann Arbor, MI)
"Microtubule Assembly Dynamics at the Nanoscale" |
| 10:20 am - 10:30 am | Discussion |
| 10:30 am | Coffee Break |
| 11:00 am - 11:10 am | Jean-Louis Martiel (Joseph Fourier University & CNRS UMR 5525, Grenoble, France)
"Bead motility mediated by actin bundles" |
| 11:10 am - 11:15 am | Discussion |
| 11:15 am - 11:25 am | Holly Goodson (University of Notre Dame, South Bend, IN)
"Computational modeling of microtubule dynamic instability" |
| 11:25 am - 11:30 am | Discussion |
| 11:30 am - 11:40 am | Michel Steinmetz (Paul Scherrer Institute, Villigen, Switzerland)
"Key interaction modes of dynamic +TIP networks" |
| 11:40 am - 11:45 am | Discussion |
| 11:45 am - 11:55 am | Dorothy Schafer (University of Virginia, Charlottesville, VA)
"Barbed end capture by Ena/VASP proteins" |
| 11:55 am - 12:00 pm | Discussion |
| 12:00 pm - 12:30 pm | Business Meeting |
| (Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair) |
| 12:30 pm | Lunch |
| 1:30 pm - 6:00 pm | Free Time |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | KINETOCHORES AND MICROTUBULE-DRIVEN CHROMOSOME MOVEMENTS |
| Discussion Leader: Ted Salmon (University of North Carolina, Chapel Hill, NC) |
| 7:30 pm - 7:50 pm | Ted Salmon (University of North Carolina, Chapel Hill, NC)
"A View of the Kinetochore-Microtubule Interface from the Ndc80 Complex" |
| 7:50 pm - 8:00 pm | Discussion |
| 8:00 pm - 8:20 pm | Trisha Davis (University of Washington, Seattle, WA)
"Regulation of Mitotic Spindle Assembly: The Means to an End" |
| 8:20 pm - 8:30 pm | Discussion |
| 8:30 pm - 8:50 pm | David Sharp (Albert Einstein College of Medicine, Bronx, NY)
"Molecular Dissection of Anaphase A" |
| 8:50 pm - 9:00 pm | Discussion |
| 9:00 pm - 9:10 pm | Duane Compton (Dartmouth College, Hanover, NH)
"Mechanism of chromosome instability in human tumor cell lines" |
| 9:10 pm - 9:15 pm | Discussion |
| 9:15 pm - 9:25 pm | Kevin Vaughan (University of Notre Dame, North Bend, IN)
"Cytoplasmic dynein dephosphorylation functions as a molecular switch for the spindle assembly checkpoint" |
| 9:25 pm - 9:30 pm | Discussion |
| 9:30 pm - | Party in Ware Campus Center |
| FRIDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Depart |
