Sunday |
2:00 pm - 9:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | Keynote Session: Regulation of Microtubule Dynamics |
| Discussion Leader: Fred Chang (Columbia University, USA) |
7:40 pm - 8:15 pm | Joe Howard (Yale Univeristy, USA) "Regulation of Microtubule Dynamics by Kinesins and Other MAPs: A Synthesis" |
8:15 pm - 8:30 pm | Discussion |
8:30 pm - 8:50 pm | Gary Brouhard (McGill University, Canada) "Microtubule Quaternary Structure and Nucleation" |
8:50 pm - 9:00 pm | Discussion |
9:00 pm - 9:20 pm | David Ehrhart (Carnegie Institute, USA) "Organization of Cortical Microtubules in Plants" |
9:20 pm - 9:30 pm | Discussion |
Monday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Molecular Control of Actin and Microtubules |
| Discussion Leader: Thomas Pollard (Yale University, USA) |
9:00 am - 9:20 am | David Kovar (University of Chicago, USA) "Self-Organization of Functionally Diverse Actin Filament Networks" |
9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Alphee Michelot (CNRS/CEA Grenoble, France) "Dissecting Principles Governing Actin Assembly Using Yeast Extracts" |
9:50 am - 10:00 am | Discussion |
10:00 am - 10:30 am | Coffee Break |
10:30 am - 10:50 am | Michael Murrell (Yale University, USA) "Actomyosin Sliding During Contraction Is Attenuated in Disordered Assemblies" |
10:50 am - 11:00 am | Discussion |
11:00 am - 11:20 am | Bruce Goode (Brandeis University, USA) "Mechanisms for Coordinating Microtubule and Actin Dynamics in Yeast and Mammals" |
11:20 am - 11:30 am | Discussion |
11:30 am - 11:40 am | Shashank Shekhar (Institute for Integrative Biology of the Cell (I2BC), CNRS, France) "Interaction of Capping Protein and Formin at the Barbed End of the Actin Filament" |
11:40 am - 11:45 am | Discussion |
11:45 am - 11:55 am | Peter Bieling (University of California, San Francisco, USA) "The Mechanobiochemistry of Motile Actin Networks" |
11:55 am - 12:00 pm | Discussion |
12:00 pm - 12:10 pm | Luke Rice (University of Texas Southwestern Medical Center, USA) "The aβ-Tubulin Conformational Cycle Controls Microtubule Catastrophe, Nucleation, and Shrinking" |
12:10 pm - 12:15 pm | Discussion |
12:15 pm - 12:25 pm | Antonina Roll-Mecak (National Institutes of Health, USA) "Multivalent Microtubule Recognition by Tubulin Tyrosine Ligase-Like Family Glutamylases" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Assembly of Cytoskeletal Structures |
| Discussion Leader: Jeff Moore (University of Colorado School of Medicine, USA) |
7:30 pm - 7:50 pm | Phong Tran (University of Pennsylvania School of Medicine, USA) "Spindle Dynamics and Chromosome Segregation" |
7:50 pm - 8:00 pm | Discussion |
8:00 pm - 8:20 pm | Daniel Needleman (Harvard University, USA) "Biophysics of Spindle Assembly and Chromosome Segregation" |
8:20 pm - 8:30 pm | Discussion |
8:30 pm - 8:40 pm | Sadie Sarah Wignall (Northwestern University, USA) "Mechanisms of Kinetochore-Independent Chromosome Segregation in C. elegans Oocytes" |
8:40 pm - 8:45 pm | Discussion |
8:45 pm - 9:05 pm | Thomas Surrey (The Francis Crick Institute, United Kingdom) "Control of Microtubule Nucleation and Dynamic Instability" |
9:05 pm - 9:15 pm | Discussion |
9:15 pm - 9:25 pm | Jawdat Al-Bassam (University of California, Davis, USA) "Structural Mechanisms of Microtubule Polymerase Multiple TOG Domains in Accelerating aβ-Tubulin Polymerization" |
9:25 pm - 9:30 pm | Discussion |
Tuesday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Design of Cell Shape |
| Discussion Leader: Jennifer Zallen (Sloan-Kettering Institute, USA) |
9:00 am - 9:20 am | Amy Gladfelter (Dartmouth College, USA) "Septins Sense Micron Scale Curvature" |
9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | K.C. Huang (Stanford University, USA) "Physical Principles of Bacterial Morphogenesis" |
9:50 am - 10:00 am | Discussion |
10:00 am - 10:30 am | Group Photo / Coffee Break |
10:30 am - 10:40 am | Randy Morgenstein (Princeton University, USA) "The Mechanism and Function of MreB Rotation: RodZ Is a Linker that Mediates Robust Growth" |
10:40 am - 10:45 am | Discussion |
10:45 am - 11:05 am | Ewa Paluch (University College London, United Kingdom) "Actin Cortex Architecture and Mechanics in Cell Morphogenesis" |
11:05 am - 11:15 am | Discussion |
11:15 am - 11:25 am | Andrew Goryachev (University of Edinburgh, United Kingdom) "The Cell Cortex Is an Excitable System" |
11:25 am - 11:30 am | Discussion |
11:30 am - 11:40 am | Aastha Mathur (European Molecular Biology Laboratory, Germany) "Role of Cytoskeleton in Morphological Changes of Blood Platelets" |
11:40 am - 11:45 am | Discussion |
11:45 am - 11:55 am | Hirokazu Tanimoto (Institut Jacques Monod, France) "The Geometry of Sperm Microtubule Asters Determines Their Speed and Directionality" |
11:55 am - 12:00 pm | Discussion |
12:00 pm - 12:10 pm | Ruijun Zhu (Columbia University, USA) "Distinct LINCages Between the Nuclear Envelope and the Cytoskeleton Actively Maintain Nuclear Position" |
12:10 pm - 12:15 pm | Discussion |
12:15 pm - 12:25 pm | Eric Folker (Boston College, USA) "A Role for the Nucleus in Sarcomere Assembly" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Moving Chromosomes |
| Discussion Leader: Daniel Needleman (Harvard University, USA) |
7:30 pm - 7:50 pm | Alexey Khodjakov (Wadsworth Center, USA) "Dynamic Changes in the Kinetochore Architecture Facilitate Spindle Assembly" |
7:50 pm - 8:00 pm | Discussion |
8:00 pm - 8:20 pm | Bungo Akiyoshi (Oxford University, United Kingdom) "Unconventional Kinetochores" |
8:20 pm - 8:30 pm | Discussion |
8:30 pm - 8:50 pm | Kerry Bloom (University of North Carolina, USA) "Forces in Mitosis: A Balancing Act Between Centromere Springs and Dynamic Microtubules" |
8:50 pm - 9:00 pm | Discussion |
9:00 pm - 9:20 pm | Ekaterina Grishchuk (University of Pennsylvania, USA) "Kinetochore-Microtubule Interactions" |
9:20 pm - 9:30 pm | Discussion |
Wednesday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Cell Locomotion |
| Discussion Leader: John Cooper (Washington University in St. Louis, USA) |
9:00 am - 9:20 am | Margaret Gardel (The University of Chicago, USA) "Controlling Contractility by Actin Cytoskeletal Architecture" |
9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Alexander Verkhovsky (EPFL Lausanne, Switzerland) "Shape-Motion Feedback in Rapidly Migrating Cells" |
9:50 am - 10:00 am | Discussion |
10:00 am - 10:30 am | Coffee Break |
10:30 am - 10:50 am | Colleen Skau (National Institutes of Health, USA) "A Novel Actin-Adhesion Structure Requiring the Formin FMN2 Positions the Nucleus and Protects It from Mechanical Damage" |
10:50 am - 11:00 am | Discussion |
11:00 am - 11:20 am | Tam Mignot (CNRS-Université Aix Marseille, France) "Moving Parts and Fixed Anchor Points: Surface Motility in a Bacterium" |
11:20 am - 11:30 am | Discussion |
11:30 am - 11:40 am | Alba Diz-Muñoz (University of California, San Francisco / University of California, Berkeley, USA) "Dissecting the Mechanism that Neutrophils Use to Sense, Interpret and Regulate Plasma Membrane Tension" |
11:40 am - 11:45 am | Discussion |
11:45 am - 11:55 am | Lillian Fritz-Laylin (University of California, San Francisco, USA) "Leading Edge Protrusions in Fast-Moving Amoeboid Cells Have an Intrinsically Two-Dimensional Character" |
11:55 am - 12:00 pm | Discussion |
12:00 pm - 12:10 pm | Stephanie Gupton (University of North Carolina, USA) "A Filopodial Off Switch for Axon Guidance" |
12:10 pm - 12:15 pm | Discussion |
12:15 pm - 12:25 pm | Torsten Wittmann (University of California, San Francisco, USA) "Spatiotemporal Control of Microtubule Dynamics by Light" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair |
7:30 pm - 9:30 pm | Cell Division |
| Discussion Leader: David Burgess (Boston College, USA) |
7:30 pm - 7:50 pm | Thomas Pollard (Yale University, USA) "Mechanism of Cytokinesis" |
7:50 pm - 8:00 pm | Discussion |
8:00 pm - 8:20 pm | Julie Canman (Columbia University, USA) "A Role for the Cortical PAR Proteins and Cell Polarity in Cytokinesis" |
8:20 pm - 8:30 pm | Discussion |
8:30 pm - 8:50 pm | Ann Miller (University of Michigan, USA) "Remodeling of Cell-Cell Junctions and Formation of Nascent Tricellular Junctions During Cytokinesis in Vertebrate Epithelial Tissues" |
8:50 pm - 9:00 pm | Discussion |
9:00 pm - 9:20 pm | Peter Lenart (European Molecular Biology Laboratory, Germany) "How Is Polar Body Cytokinesis Similar to and Different from Somatic Division?" |
9:20 pm - 9:30 pm | Discussion |
Thursday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Control of Cellular Motors |
| Discussion Leader: William Bement (University of Wisconsin-Madison, USA) |
9:00 am - 9:20 am | Jeffrey Nirschl (University of Pennsylvania, USA) "Mechanisms and Regulation of Organellar Recruitment and Transport Initiation" |
9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Lukas Kapitein (Utrecht University, The Netherlands) "Navigating the Cytoskeleton: Novel Tools to Dissect and Direct Intracellular Transport" |
9:50 am - 10:00 am | Discussion |
10:00 am - 10:30 am | Coffee Break |
10:30 am - 10:50 am | Matthew Tyska (Vanderbilt University Medical Center, USA) "Intramicrovillar Transport in Brush Border Assembly" |
10:50 am - 11:00 am | Discussion |
11:00 am - 11:10 am | Andrew Carter (Cambridge University, United Kingdom) "The Structure of the Dynactin Complex and Its Interaction with Dynein" |
11:10 am - 11:15 am | Discussion |
11:15 am - 11:25 am | Trina Schroer (Johns Hopkins University, USA) "Structure-Function Analysis of Dynein-Dynactin Binding Mediated by Coupling Scaffolds" |
11:25 am - 11:30 am | Discussion |
11:30 am - 11:40 am | Hugo Santoyo Arellano-Santoyo (Dana Farber Cancer Institute, USA) "Towards an Understanding of the Molecular Mechanism of the Unique Biomechanical Properties of the Yeast Kinesin-8 Kip3" |
11:40 am - 11:45 am | Discussion |
11:45 am - 11:55 am | Kevin Vaughan (University of Notre Dame, USA) "StARD9 Is a Novel Kinesin Required for Motility and Tubulation of Late Endosomes/Lysosomes Containing NPC1" |
11:55 am - 12:00 pm | Discussion |
12:00 pm - 12:10 pm | Makito Miyazaki (Waseda University, Japan) "Cell-Sized Spherical Confinement Induces the Spontaneous Formation of Contractile Actomyosin Rings In Vitro" |
12:10 pm - 12:15 pm | Discussion |
12:15 pm - 12:25 pm | Jordan Beach (National Heart, Lung, and Blood Institute, NIH, USA) "Myosin 18A Coassembles with Nonmuscle Myosin 2 to Form Mixed Bipolar Filaments" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Mechanical Crosstalk Between Cells |
| Discussion Leader: Clare Waterman (National Institutes of Health, USA) |
7:30 pm - 7:50 pm | Olivier Hamant (ENS Lyon, France) "Reading Shape Through Mechanical Signals" |
7:50 pm - 8:00 pm | Discussion |
8:00 pm - 8:20 pm | Otger Campas (University of California, Santa Barbara, USA) "Sensing Forces Between Cells" |
8:20 pm - 8:30 pm | Discussion |
8:30 pm - 8:50 pm | Jennifer Zallen (Sloan-Kettering Institute, USA) "Shaping the Embryo: Integrating Signals and Forces in Development" |
8:50 pm - 9:00 pm | Discussion |
9:00 pm - 9:10 pm | Ronen Zaidel-Bar (National University of Singapore, Singapore) "Actin-Bundling Protein Plastin/Fimbrin Regulates Cortical Contractility in Early C. elegans Embryogenesis" |
9:10 pm - 9:15 pm | Discussion |
9:15 pm - 9:25 pm | Adam Martin (Massachusetts Institute of Technology, USA) "Compliance Sensing by Actomyosin Self-Organization Coordinates Epithelial Tension and Tissue Shape" |
9:25 pm - 9:30 pm | Discussion |
Friday |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |