Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Diverse Polymers Make the Cytoskeleton Work
7:40 pm - 8:10 pm
"Integration of Actin Dynamics and Adhesion in Innate Immunity"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:50 pm
"In Vitro Reconstitutions of Dynamic Microtubule Systems"
8:50 pm - 8:55 pm
Discussion
8:55 pm - 9:25 pm
"An Overview of the Functions of Intermediate Filaments in Cell Mechanics and Motility"
9:25 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
9:00 am - 9:15 am
"Ena/VASP Proteins in Cell Migration and Adhesion"
9:15 am - 9:25 am
Discussion
9:25 am - 9:40 am
"How Does a Cell with No Interphase Microtubules Build a Mitotic Spindle?"
9:40 am - 9:50 am
Discussion
9:50 am - 10:05 am
"The Flagellar Length Control System"
10:05 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 11:00 am
"Ciliary Assembly and Transport"
11:00 am - 11:10 am
Discussion
11:10 am - 11:20 am
"Using Contractility and Motility to Build Emergent Cell Behaviors: Lessons from the Unicellular Predator Lacrymaria olor "
11:20 am - 11:25 am
Discussion
11:25 am - 11:35 am
"The Actin Nucleator CYK-1/mDia Drives Chirality of Actomyosin Flows and Facilitates Left-Right Symmetry Breaking in Early C. elegans Embryos"
11:35 am - 11:40 am
Discussion
11:40 am - 11:50 am
"Cooperation Between a MyTH4-FERM Myosin and VASP Is Critical for Filopodia Initiation"
11:50 am - 11:55 am
Discussion
11:55 am - 12:05 pm
"Direct Observation of Individual Tubulin Dimers Binding to Growing Microtubules"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:20 pm
"Effect of Cytoplasm Density on Cytoskeleton Dynamics"
12:20 pm - 12:25 pm
Discussion
12:25 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hourâ„¢
The GRC Power Hourâ„¢ is designed to address challenges women face in science and issues of diversity and inclusion. The program supports the professional growth of all members of our communities by providing an open forum for discussion and mentoring.
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Modes and Mechanisms of Transport
7:30 pm - 7:45 pm
"Fragmentation and Rupture of Strained Actin Filaments"
7:45 pm - 7:55 pm
Discussion
7:55 pm - 8:10 pm
"Actin Dynamics Regulate Spatial Mixing of Mitochondria in Dividing Cells"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:30 pm
"Kif15 Supports the Mechanical Integrity of the Mammalian K-Fiber"
8:30 pm - 8:35 pm
Discussion
8:35 pm - 8:50 pm
"Structural Studies of Actin Severing, Microtubule Crinkling and Other 'Deviant' Filament Behaviors"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:15 pm
"Spatial Control of Microtubule Dynamics and Microtubule-Dependent Traffic by Septin GTPases"
9:15 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
General Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Cytoskeletal Patterning Through Evolution
9:00 am - 9:15 am
"Assembly of the Yeast Actin Fusion Focus"
9:15 am - 9:25 am
Discussion
9:25 am - 9:40 am
"Mechanical Tension Drives Cell Membrane Fusion"
9:40 am - 9:50 am
Discussion
9:50 am - 10:05 am
"Further Adventures in Cortical Excitability"
10:05 am - 10:15 am
Discussion
10:15 am - 10:45 am
Group Photo / Coffee Break
10:45 am - 11:00 am
"Microtubules in Mechanotransduction"
11:00 am - 11:10 am
Discussion
11:10 am - 11:25 am
"A Ubiquitin Ligase Pair Compete to Regulation Filopodia Stability and Axon Turning"
11:25 am - 11:35 am
Discussion
11:35 am - 11:50 am
"MAPping the Neuronal Landscape of Microtubule-Based Transport"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:15 pm
"Microtubules Dynamics in Development"
12:15 pm - 12:25 pm
Discussion
12:25 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Cytoskeletal Dynamics in Cell Division
7:30 pm - 7:45 pm
"Cytoskeletal Regulation in Late Cytokinesis"
7:45 pm - 7:55 pm
Discussion
7:55 pm - 8:10 pm
"Filament-Oriented Filament Assembly Provides Structural Memory to Build and Maintain Filament Alignment During Cytokinesis"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:35 pm
"Alternative Paths to Amphitelic Attachment and Their Significance for Proper Chromosome Segregation"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
"Microneedle Manipulation Reveals Local Reinforcement and Local Force Dissipation in the Mammalian Spindle"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
"Two Modes of Mechanical Regulation in Kinesin-Driven Disruption of Microtubule Bundles"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"CetZ1 in Cell Shape Control of Haloarchaea: Understanding the Functional Divergence of Tubulin Superfamily Proteins"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Membranes as Platforms for Cytoskeleton Assembly
9:00 am - 9:15 am
"Modulation of Acto-Myosin Dynamics During Cell Migration Through Complex Environments: Organelles as Cell Deformation Sensors"
9:15 am - 9:25 am
Discussion
9:25 am - 9:40 am
"Regulation of Cytoskeletal Dynamics and Homeostasis by Actin Filament Pointed-End Binding Proteins"
9:40 am - 9:50 am
Discussion
9:50 am - 10:00 am
"Mechanistic Contributions of Coronin 1B and Coronin 1C in Directed Migration"
10:00 am - 10:05 am
Discussion
10:05 am - 10:20 am
"Arp3B Is a Negative Regulator of Arp2/3 Driven Actin Dynamics"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:15 am
"Capping Protein Regulators at Membranes"
11:15 am - 11:25 am
Discussion
11:25 am - 11:35 am
"Self-Organization and Load Adaptation by the Mammalian Endocytic Actin Network"
11:35 am - 11:40 am
Discussion
11:40 am - 11:50 am
"Towards Understanding the Role of BAR Domain Proteins in Membrane Tension Sensing"
11:50 am - 11:55 am
Discussion
11:55 am - 12:05 pm
"Blebbing Assembles Septin Signaling Scaffolds to Drive NRAS/PI3K Survival Signaling in Melanoma Cells"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:20 pm
"Dynamic RhoA Regulation Establishes the Shape of a Contractility Gradient and Tissue Curvature"
12:20 pm - 12:25 pm
Discussion
12:25 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Insights from Reductionist Systems
7:30 pm - 7:45 pm
"The Structural Basis for the Regulation of Tubulin Dimer Biogenesis and Polymerization"
7:45 pm - 7:55 pm
Discussion
7:55 pm - 8:10 pm
"Cytoskeletal Organization in Artificial Confinement"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:35 pm
"Cytoskeletal Networks as Active Matter"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 9:00 pm
"Dynamics and Instabilities in Contracting Actin Networks"
9:00 pm - 9:10 pm
Discussion
9:10 pm - 9:20 pm
"Reconstituting the Eukaryotic Cytokinetic Machinery"
9:20 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
General Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Controlling Shape and Size of Cytoskeletal Assemblies
9:00 am - 9:15 am
9:15 am - 9:25 am
Discussion
9:25 am - 9:40 am
"Pathways for Actin Polymerization Mediated by Formins"
9:40 am - 9:50 am
Discussion
9:50 am - 10:00 am
"Defining the Divergent Structural and Cellular Mechanisms of the Actin Cytoskeleton in Giardia"
10:00 am - 10:05 am
Discussion
10:05 am - 10:20 am
"Kinetics of Microtubule Nucleation"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:15 am
"Polymerization as a Mechanism for Allosteric Tuning of Metabolic Enzyme Activity"
11:15 am - 11:25 am
Discussion
11:25 am - 11:40 am
"Reading, Writing and Erasing the Tubulin Tyrosination Cycle"
11:40 am - 11:50 am
Discussion
11:50 am - 12:00 pm
"Building a Minimal Functional Kinetochore: From Microtubule to Centromere"
12:00 pm - 12:05 pm
Discussion
12:05 pm - 12:15 pm
"Microtubules Form by Progressively Faster Tubulin Accretion, Not by Nucleation-Elongation"
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Frontiers in the Cytoskeleton
7:30 pm - 7:40 pm
"A Complex Containing Lysine-Acetylated Actin and Cyclase-Associated Protein Inhibits the Formin INF2"
7:40 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
"Structural-Functional Mechanism of Actin Nt-Acetylation"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:10 pm
"Dissecting the Formation and the Regulation of Actomyosin Structure at the Apical Adherens Junction"
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:25 pm
"Cytokinesis Without Myosin II in Chlamydomonas: Roles of Actin, Microtubules and Septin"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:40 pm
"Katanin Grips the Beta-Tubulin Tail Through an Electropositive Double Spiral to Sever Microtubules"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
"Cataclysmic Acceleration of Actin Depolymerization by Cyclase-Associated Protein and Cofilin Synergy"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
General Discussion
9:20 pm - 9:30 pm
Closing Remarks
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure